The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Aging impairs mitochondrial respiratory capacity in classical monocytes
Open accessAbstract
Aging is a critical healthcare concern, with age-related inflammation disposing individuals to a variety of diseases. Monocytes are affected by the aging process, with increased inflammation and impaired cellular functions such as phagocytosis. Mechanisms by which aging alters monocyte function are unknown, but recent research suggests that the balance of metabolic processes determine immune cell phenotype and function. Given the known association between aging and mitochondrial dysfunction in other tissues, we hypothesized that aging would impair mitochondrial function in monocytes. To test this, we isolated classical monocytes from young and older adults and tested mitochondrial function by a Seahorse assay. Aging reduced mitochondrial respiratory capacity and spare capacity in monocytes. Mitochondrial dysfunction is a potential mechanism by which aging alters monocyte phenotype and may impair inflammatory functions, especially in low-glucose environments where oxidative metabolism is necessary to meet energy demands.
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“It has been observed that respiratory capacity steadily declines with age in CD14 + monocytes as a consequence of mitochondrial dysfunction (144).”
From The impact of ageing on monocytes and macrophages (2021) · cites this paper as [144]
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Cites
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Grün, L. K., Maurmann, R. M., Scholl, J. N., Fogaça, M. E., Schmitz, C. R. R., Dias, C. K., Gasparotto, J., Padoin, A. V., Mottin, C. C., Klamt, F., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26625589
Immunoregulatory effect of metformin in monocytes exposed to SARS-CoV-2 spike protein subunit 1
Maurmann, R. M., Davis, K. L., Mosalmanzadeh, N., Schmitt, B. L., & Pence, D. (2026) · Immunometabolism · doi:10.1097/in9.0000000000000078
“As we have previously described [35] , this procedure yields a highly pure (>85”
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Vasilopoulos, T., Turano, P. S., Garza‐Martinez, L., Akbulut, E., Konda, M., Herbig, U., Fitzgerald-Bocarsly, P. A., & Martínez‐Zamudio, R. I. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.09.09.750459
Metadata
- Authors
- Pence, B. D., & Yarbro, J. R.
- Affiliations
- University of Memphis (US)
- Corresponding author
- Pence, Brandt D.
- Venue
- Experimental Gerontology
- Publisher
- Elsevier BV
- Published
- 2018-07
- Volume
- 108
- Pages
- 112-117
- ISSN
- 0531-5565 (ISSN-L)
- OpenAlex
- W2798053566
- Cited by
- 120
- References
- 40
- Citations by year
- 2026: 11 · 2025: 8 · 2024: 19 · 2023: 11 · 2022: 17 · 2021: 21 · 2020: 18 · 2019: 10 · 2018: 5
- FWCI
- 4.80
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Experimental Gerontology (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- University of Memphis
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- aging, classical monocytes, mitochondrial respiratory capacity, mitochondrial dysfunction, spare respiratory capacity, age-related inflammation, monocyte phenotype, oxidative metabolism, glucose metabolism, immune cell function
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Aging, Female, Flow Cytometry, Humans, Immunity, Innate, Inflammation, Male, Middle Aged, Mitochondria, Monocytes, Phagocytosis, Cell Respiration, Young Adult
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