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MicroRNA-146a disrupts hematopoietic differentiation and survival

Starczynowski, Daniel T., Kuchenbauer, Florian, Wegrzyn, Joanna, Rouhi, Arefeh, Petriv, Oleh, Hansen, Carl L., Humphries, R. Keith, Karsan, Aly·2011·Experimental Hematology
DOI 10.1016/j.exphem.2010.09.011
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Abstract

Objective MicroRNAs (miRNAs) are short noncoding RNAs capable of exerting dramatic effects by postranscriptionally regulating numerous messenger RNA targets. Toll-like receptor-4 (TLR-4) activation by lipopolysaccharide (LPS) induces the expression of three miRNAs in myeloid cells. The aim of this study was to investigate the in vivo consequences of expressing one of the LPS-induced miRNA, miR-146a, in bone marrow cells. Material and methods The role of miR-146a in hematopoiesis was investigated by using retroviral infection and overexpression of miR-146a in mouse hematopoietic stem/progenitor cells, followed by bone marrow transplantations. Results miR-146a is mainly expressed in primitive hematopoietic stem cells and T lymphocytes. Overexpression of miR-146a in hematopoietic stem cells, followed by bone marrow transplantation, resulted in a transient myeloid expansion, decreased erythropoiesis, and impaired lymphopoiesis in select anatomical locations. Enforced expression of miR-146a also impaired bone marrow reconstitution in recipient mice and reduced survival of hematopoietic stem cells. Conclusions Our results indicate that miR-146a, an LPS-induced miRNA, regulates multiple aspects of hematopoietic differentiation and survival. Furthermore, the consequences of miR-146a expression in hematopoietic cells mimics some of the reported effects with acute LPS exposure.

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  1. McGettrick, 2007, Toll-like receptors: key activators of leucocytes and regulator of haematopoiesis, Br J Haematol, 139, 185, 10.1111/j.1365-2141.2007.06802.x · DOI
  2. Nagai, 2006, Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment, Immunity, 24, 801, 10.1016/j.immuni.2006.04.008 · DOI
  3. Baltimore, 2008, MicroRNAs: new regulators of immune cell development and function, Nat Immunol, 9, 839, 10.1038/ni.f.209 · DOI
  4. O’Connell, 2007, MicroRNA-155 is induced during the macrophage inflammatory response, Proc Natl Acad Sci U S A, 104, 1604, 10.1073/pnas.0610731104 · DOI · Paper page
  5. Liu, 2009, miR-147, a microRNA that is induced upon Toll-like receptor stimulation, regulates murine macrophage inflammatory responses, Proc Natl Acad Sci U S A, 106, 15819, 10.1073/pnas.0901216106 · DOI · Paper page
  6. Bartel, 2004, MicroRNAs: genomics, biogenesis, mechanism, and function, Cell, 116, 281, 10.1016/S0092-8674(04)00045-5 · DOI
  7. O’Connell, 2008, Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder, J Exp Med, 205, 585, 10.1084/jem.20072108 · DOI · Paper page
  8. O’Connell, 2009, Inositol phosphatase SHIP1 is a primary target of miR-155, Proc Natl Acad Sci U S A, 106, 7113, 10.1073/pnas.0902636106 · DOI · Paper page
  9. Monticelli, 2005, MicroRNA profiling of the murine hematopoietic system, Genome Biol, 6, R71, 10.1186/gb-2005-6-8-r71 · DOI · Paper page
  10. Labbaye, 2008, A three-step pathway comprising PLZF/miR-146a/CXCR4 controls megakaryopoiesis, Nat Cell Biol, 10, 788, 10.1038/ncb1741 · DOI
  11. Pedersen, 2008, MicroRNAs in the immune response, Cytokine, 43, 391, 10.1016/j.cyto.2008.07.016 · DOI
  12. Cameron, 2008, Epstein-Barr virus growth/latency III program alters cellular microRNA expression, Virology, 382, 257, 10.1016/j.virol.2008.09.018 · DOI
  13. Cameron, 2008, Epstein-Barr virus latent membrane protein 1 induces cellular MicroRNA miR-146a, a modulator of lymphocyte signaling pathways, J Virol, 82, 1946, 10.1128/JVI.02136-07 · DOI
  14. Starczynowski, 2010, Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype, Nat Med, 16, 49, 10.1038/nm.2054 · DOI · Paper page
  15. Kuchenbauer, 2008, In-depth characterization of the microRNA transcriptome in a leukemia progression model, Genome Res, 18, 1787, 10.1101/gr.077578.108 · DOI
  16. Heuser, 2009, Loss of MLL5 results in pleiotropic hematopoietic defects, reduced neutrophil immune function, and extreme sensitivity to DNA demethylation, Blood, 113, 1432, 10.1182/blood-2008-06-162263 · DOI
  17. Kent, 2009, Prospective isolation and molecular characterization of hematopoietic stem cells with durable self-renewal potential, Blood, 113, 6342, 10.1182/blood-2008-12-192054 · DOI
  18. Heuser, 2009, Modeling the functional heterogeneity of leukemia stem cells: role of STAT5 in leukemia stem cell self-renewal, Blood, 114, 3983, 10.1182/blood-2009-06-227603 · DOI
  19. Argiropoulos, 2008, Linkage of Meis1 leukemogenic activity to multiple downstream effectors including Trib2 and Ccl3, Exp Hematol, 36, 845, 10.1016/j.exphem.2008.02.011 · DOI
  20. Stark, 2005, Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17, Immunity, 22, 285, 10.1016/j.immuni.2005.01.011 · DOI
  21. Chandra, 2008, Endotoxemia down-regulates bone marrow lymphopoiesis but stimulates myelopoiesis: the effect of G6PD deficiency, J Leukoc Biol, 83, 1541, 10.1189/jlb.1207838 · DOI
  22. Van den Berghe, 1997, 5q-, twenty-five years later: a synopsis, Cancer Genet Cytogenet, 94, 1, 10.1016/S0165-4608(96)00350-0 · DOI
  23. Starczynowski, 2008, High-resolution whole genome tiling path array CGH analysis of CD34+ cells from patients with low-risk myelodysplastic syndromes reveals cryptic copy number alterations and predicts overall and leukemia-free survival, Blood, 112, 3412, 10.1182/blood-2007-11-122028 · DOI
  24. Garzon, 2008, MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia, Blood, 111, 3183, 10.1182/blood-2007-07-098749 · DOI
  25. Li, 2008, Distinct microRNA expression profiles in acute myeloid leukemia with common translocations, Proc Natl Acad Sci U S A, 105, 15535, 10.1073/pnas.0808266105 · DOI
  26. Kondo, 1997, Identification of clonogenic common lymphoid progenitors in mouse bone marrow, Cell, 91, 661, 10.1016/S0092-8674(00)80453-5 · DOI · Paper page
  27. Song, 2005, CD11b+/Gr-1+ immature myeloid cells mediate suppression of T cells in mice bearing tumors of IL-1beta-secreting cells, J Immunol, 175, 8200, 10.4049/jimmunol.175.12.8200 · DOI
  28. Kent, 2009, Prospective isolation and molecular characterization of hematopoietic stem cells with durable self-renewal potential, Blood, 113, 6342, 10.1182/blood-2008-12-192054 · DOI
  29. Ikuta, 1992, Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation, Proc Natl Acad Sci U S A, 89, 1502, 10.1073/pnas.89.4.1502 · DOI
  30. Weng, 2006, c-Myc is an important direct target of Notch1 in T-cell acute lymphoblasticleukemia/lymphoma, Genes Dev, 20, 2096, 10.1101/gad.1450406 · DOI

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Metadata

Authors
Starczynowski, D. T., Kuchenbauer, F., Wegrzyn, J., Rouhi, A., Petriv, O., Hansen, C. L., Humphries, R. K., & Karsan, A.
Venue
Experimental Hematology
Publisher
Elsevier BV
Published
2011-02
Volume
39
Issue
2
Pages
167-178.e4
ISSN
0301-472X
DOI
10.1016/j.exphem.2010.09.011
Cited by
84
References
3
Language
en
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