Macrophage development from HSCs requires PU.1-coordinated microRNA expression
Open accessAbstract
The differentiation of HSCs into myeloid lineages requires the transcription factor PU.1. Whereas PU.1-dependent induction of myeloid-specific target genes has been intensively studied, negative regulation of stem cell or alternate lineage programs remains incompletely characterized. To test for such negative regulatory events, we searched for PU.1-controlled microRNAs (miRs) by expression profiling using a PU.1-inducible myeloid progenitor cell line model. We provide evidence that PU.1 directly controls expression of at least 4 of these miRs (miR-146a, miR-342, miR-338, and miR-155) through temporally dynamic occupation of binding sites within regulatory chromatin regions adjacent to their genomic coding loci. Ectopic expression of the most robustly induced PU.1 target miR, miR-146a, directed the selective differentiation of HSCs into functional peritoneal macrophages in mouse transplantation assays. In agreement with this observation, disruption of Dicer expression or specific antagonization of miR-146a function inhibited the formation of macrophages during early zebrafish (Danio rerio) development. In the present study, we describe a PU.1-orchestrated miR program that mediates key functions of PU.1 during myeloid differentiation.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Heinz, S., Benner, C., Spann, N., Bertolino, E., Lin, Y. C., Laslo, P., Cheng, J. X., Murre, C., Singh, H., & Glass, C. K. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.05.004 · Cited by 13,382 · see citing works
Self-citationIn silico prediction of protein-protein interactions in human macrophages
Souiai, O., Guerfali, F. Z., Miled, S. B., Brun, C., & Benkahla, A. (2014) · BMC Research Notes · doi:10.1186/1756-0500-7-157 · Cited by 10,785 · see citing works
Significance analysis of microarrays applied to the ionizing radiation response
Tusher, V. G., Tibshirani, R., & Chu, G. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.091062498 · Cited by 10,568 · see citing works
Taganov, K. D., Boldin, M. P., Chang, K.-J., & Baltimore, D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605298103 · Cited by 4,317 · see citing works
MicroRNAs Modulate Hematopoietic Lineage Differentiation
Chen, C.-Z., Li, L., Lodish, H. F., & Bartel, D. P. (2004) · Science · doi:10.1126/science.1091903 · Cited by 3,257 · see citing works
Identification of tissue-specific microRNAs from mouse
Lagos-Quintana, M., Rauhut, R., Yalcin, A., Meyer, J., Lendeckel, W., & Tuschl, T. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00809-6 · Cited by 2,859 · see citing works
c-Myc-regulated microRNAs modulate E2F1 expression
O’Donnell, K. A., Wentzel, E. A., Zeller, K. I., Dang, C. V., & Mendell, J. T. (2005) · Nature · doi:10.1038/nature03677 · Cited by 2,812 · see citing works
Effective targeted gene ‘knockdown’ in zebrafish
Nasevicius, A., & Ekker, S. C. (2000) · Nature Genetics · doi:10.1038/79951 · Cited by 2,485 · see citing works
Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages
Scott, E. W., Simon, M. C., Anastasi, J., & Singh, H. (1994) · Science · doi:10.1126/science.8079170 · Cited by 1,532 · see citing works
Tacke, F., Alvarez, D., Kaplan, T. J., Jakubzick, C., Spanbroek, R., Llodra, J., Garin, A., Liu, J., Mack, M., van Rooijen, N., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci28549 · Cited by 1,323 · see citing works
MicroRNAs Regulate Brain Morphogenesis in Zebrafish
Giraldez, A. J., Cinalli, R. M., Glasner, M. E., Enright, A. J., Thomson, J. M., Baskerville, S., Hammond, S. M., Bartel, D. P., & Schier, A. F. (2005) · Science · doi:10.1126/science.1109020 · Cited by 1,124 · see citing works
Regulation of progenitor cell proliferation and granulocyte function by microRNA-223
Johnnidis, J. B., Harris, M. H., Wheeler, R. T., Stehling-Sun, S., Lam, M. H., Kirak, O., Brummelkamp, T. R., Fleming, M. D., & Camargo, F. D. (2008) · Nature · doi:10.1038/nature06607 · Cited by 1,062 · see citing works
Haematopoietic stem cells derive directly from aortic endothelium during development
Bertrand, J. Y., Chi, N. C., Santoso, B., Teng, S., Stainier, D. Y. R., & Traver, D. J. (2010) · Nature · doi:10.1038/nature08738 · Cited by 1,053 · see citing works
Fazi, F., Rosa, A., Fatica, A., Gelmetti, V., Marchis, M. L. D., Nervi, C., & Bozzoni, I. (2005) · Cell · doi:10.1016/j.cell.2005.09.023 · Cited by 984 · see citing works
<i>miR-146a</i> is a significant brake on autoimmunity, myeloproliferation, and cancer in mice
Boldin, M. P., Taganov, K. D., Rao, D. S., Yang, L., Zhao, J. L., Kalwani, M., Garcia-Flores, Y., Luong, M., Devrekanli, A., Xu, J., et al. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20101823 · Cited by 861 · see citing works
Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutants
Traver, D., Paw, B. H., Poss, K. D., Penberthy, W. T., Lin, S., & Zon, L. I. (2003) · Nature Immunology · doi:10.1038/ni1007 · Cited by 800 · see citing works
Ontogeny and behaviour of early macrophages in the zebrafish embryo
Herbomel, P., Thisse, B., & Thisse, C. (1999) · Development · doi:10.1242/dev.126.17.3735 · Cited by 799 · see citing works
The Biology of Hematopoietic Stem Cells
Morrison, S. J., Uchida, N., & Weissman, I. L. (1995) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cb.11.110195.000343 · Cited by 774 · see citing works
O'Connell, R. M., Rao, D. S., Chaudhuri, A. A., Boldin, M. P., Taganov, K. D., Nicoll, J., Paquette, R. L., & Baltimore, D. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20072108 · Cited by 681 · see citing works
Identification of miR-145 and miR-146a as mediators of the 5q– syndrome phenotype
Starczynowski, D. T., Kuchenbauer, F. C., Argiropoulos, B., Sung, S., Morin, R. D., Muranyi, A., Hirst, M., Hogge, D. E., Marra, M. A., Wells, R. A., et al. (2009) · Nature Medicine · doi:10.1038/nm.2054 · Cited by 655 · see citing works
Multilineage Transcriptional Priming and Determination of Alternate Hematopoietic Cell Fates
Laslo, P., Spooner, C. J., Warmflash, A., Lancki, D. W., Lee, H.-J., Sciammas, R., Gantner, B. N., Dinner, A. R., & Singh, H. (2006) · Cell · doi:10.1016/j.cell.2006.06.052 · Cited by 632 · see citing works
Peri, F., & Nüsslein-Volhard, C. (2008) · Cell · doi:10.1016/j.cell.2008.04.037 · Cited by 617 · see citing works
miR-19 is a key oncogenic component of mir-17-92Preprint
Olive, V., Bennett, M. J., McGann, J. C., Ma, C., Jiang, I., Cordon‐Cardo, C., Li, Q.-J., Lowe, S. W., Hannon, G. J., & He, L. (2009) · Genes & Development · doi:10.1101/gad.1861409 · Cited by 585 · see citing works
Myc-Induced T Cell Leukemia in Transgenic Zebrafish
Langenau, D. M., Traver, D. J., Ferrando, A. A., Kutok, J. L., Aster, J. C., Kanki, J. P., Lin, S., Prochownik, E. V., Trede, N. S., Zon, L. I., et al. (2003) · Science · doi:10.1126/science.1080280 · Cited by 541 · see citing works
The microRNA-producing enzyme Dicer1 is essential for zebrafish development
Wienholds, E., Koudijs, M., van Eeden, F. V., Cuppen, E., & Plasterk, R. (2003) · Nature Genetics · doi:10.1038/ng1251 · Cited by 519 · see citing works
Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1.
Rosenbauer, F., Wagner, K., Kutok, J. L., Iwasaki, H., Le Beau, M. M., Okuno, Y., Akashi, K., Fiering, S., & Tenen, D. G. (2004) · Nature Genetics · doi:10.1038/ng1361 · Cited by 506 · see citing works
Self-citationFontana, L., Pelosi, E., Greco, P., Racanicchi, S., Testa, U., Liuzzi, F., Croce, C. M., Brunetti, E., Grignani, F., & Peschle, C. (2007) · Nature Cell Biology · doi:10.1038/ncb1613 · Cited by 446 · see citing works
Myelopoiesis in the zebrafish, Danio rerio
Bennett, C. M., Kanki, J. P., Rhodes, J., Liu, T. X., Paw, B. H., Kieran, M. W., Langenau, D. M., Delahaye-Brown, A., Zon, L. I., Fleming, M. D., et al. (2001) · Blood · doi:10.1182/blood.v98.3.643 · Cited by 423 · see citing works
MicroRNA fingerprints during human megakaryocytopoiesis
Garzon, R., Pichiorri, F., Palumbo, T., Iuliano, R., Cimmino, A., Aqeilan, R. I., Volinia, S., Bhatt, D., Alder, H., Marcucci, G., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600587103 · Cited by 414 · see citing works
PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding
Zhang, P., Zhang, X., Iwama, A., Yu, C., Smith, K. A., Mueller, B. U., Narravula, S., Torbett, B. E., Orkin, S. H., & Tenen, D. G. (2000) · Blood · doi:10.1182/blood.v96.8.2641 · Cited by 368 · see citing works
MicroRNA-Mediated Control of Cell Fate in Megakaryocyte-Erythrocyte Progenitors
Lü, J., Guo, S., Ebert, B. L., Zhang, H., Peng, X. P., Bosco, J., Pretz, J. L., Schlanger, R., Wang, J. Y., Mak, R. H., et al. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.03.012 · Cited by 336 · see citing works
MicroRNA miR-125a controls hematopoietic stem cell number
Guo, S., Lü, J., Schlanger, R., Zhang, H., Wang, J. Y., Fox, M. C., Purton, L. E., Fleming, H. E., Cobb, B. S., Merkenschlager, M., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913574107 · Cited by 330 · see citing works
Curtale, G., Citarella, F., Carissimi, C., Goldoni, M., Carucci, N., Fulci, V., Franceschini, D., Meloni, F., Barnaba, V., & Macino, G. (2009) · Blood · doi:10.1182/blood-2009-06-225987 · Cited by 297 · see citing works
DeKoter, R. P., Walsh, J. C., & Singh, H. (1998) · The EMBO Journal · doi:10.1093/emboj/17.15.4456 · Cited by 296 · see citing works
Fukao, T., Fukuda, Y., Kiga, K., Sharif, J., Hino, K., Enomoto, Y., Kawamura, A., Nakamura, K., Takeuchi, T., & Tanabe, M. (2007) · Cell · doi:10.1016/j.cell.2007.02.048 · Cited by 292 · see citing works
Epigenetic silencing of the intronic microRNA hsa-miR-342 and its host gene EVL in colorectal cancer
Grady, W. M., Parkin, R. K., Mitchell, P. S., Lee, J. H., Kim, Y.-H., Tsuchiya, K. D., Washington, M. K., Paraskeva, C., Willson, J. K. V., Kaz, A. M., et al. (2008) · Oncogene · doi:10.1038/onc.2008.10 · Cited by 292 · see citing works
Rosenbauer, F., Owens, B. M., Yu, L., Tumang, J. R., Steidl, U., Kutok, J. L., Clayton, L. K., Wagner, K., Scheller, M., Iwasaki, H., et al. (2006) · Nature Genetics · doi:10.1038/ng1679 · Cited by 237 · see citing works
Self-citationImpaired Micro-RNA Pathways Diminish Osteoclast Differentiation and Function
Sugatani, T., & Hruska, K. A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m805777200 · Cited by 233 · see citing works
Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization
Popovic, R., Riesbeck, L. E., Velu, C. S., Chaubey, A., Zhang, J., Achille, N. J., Erfurth, F. E., Eaton, K., Lü, J., Grimes, H. L., et al. (2009) · Blood · doi:10.1182/blood-2008-04-154310 · Cited by 220 · see citing works
Lieschke, G. J., Oates, A. C., Paw, B. H., Thompson, M. A., Hall, N. E., Ward, A. C., Ho, R. K., Zon, L. I., & Layton, J. E. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0657 · Cited by 206 · see citing works
Gfi1 regulates miR-21 and miR-196b to control myelopoiesis
Velu, C. S., Baktula, A. M., & Grimes, H. L. (2009) · Blood · doi:10.1182/blood-2008-11-190215 · Cited by 163 · see citing works
Jurkin, J., Schichl, Y. M., Köffel, R., BAUER, T. L., Richter, S., Konradi, S., Geßlbauer, B., & Strobl, H. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903021 · Cited by 152 · see citing works
MicroRNAs expression signatures are associated with lineage and survival in acute leukemias
Wang, Y., Li, Z., He, C., Wang, D., Yuan, X., Chen, J., & Jin, J. (2010) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2009.12.010 · Cited by 144 · see citing works
Two distinct auto-regulatory loops operate at the PU.1 locus in B cells and myeloid cells
Leddin, M., Perrod, C., Hoogenkamp, M., Ghani, S., Assi, S., Heinz, S., Wilson, N. K., Follows, G., Schönheit, J., Vockentanz, L., et al. (2011) · Blood · doi:10.1182/blood-2010-08-302976 · Cited by 131 · see citing works
Self-citationMIR-23A microRNA cluster inhibits B-cell development
Kong, K. Y., Owens, K., Rogers, J. H., Mullenix, J. B., Velu, C. S., Grimes, H. L., & Dahl, R. E. (2010) · Experimental Hematology · doi:10.1016/j.exphem.2010.04.004 · Cited by 111 · see citing works
Romania, P., Lulli, V., Pelosi, E., Biffoni, M., Peschle, C., & Marziali, G. (2008) · British Journal of Haematology · doi:10.1111/j.1365-2141.2008.07382.x · Cited by 104 · see citing works
MicroRNA-146a disrupts hematopoietic differentiation and survival
Starczynowski, D. T., Kuchenbauer, F. C., Węgrzyn, J., ROUHI, A. M., Petriv, O. I., Hansen, C. L., Humphries, R. K., & Karsan, A. (2010) · Experimental Hematology · doi:10.1016/j.exphem.2010.09.011 · Cited by 103 · see citing works
Effect of transcription-factor concentrations on leukemic stem cells
Rosenbauer, F., Koschmieder, S., Steidl, U. G., & Tenen, D. G. (2005) · Blood · doi:10.1182/blood-2005-02-0717 · Cited by 98 · see citing works
Self-citationMicroRNA expression in maturing murine megakaryocytes
Opalinska, J., Bersenev, A., Zhang, Z., Schmaier, A. A., Choi, J. K., Yao, Y., D'Souza, J., Tong, W., & Weiss, M. J. (2010) · Blood · doi:10.1182/blood-2010-06-292920 · Cited by 96 · see citing works
Marchis, M. D. D., Ballarino, M., Salvatori, B., Puzzolo, M., Bozzoni, I., & Fatica, A. (2009) · Leukemia · doi:10.1038/leu.2008.372 · Cited by 89 · see citing works
Transcriptomic profiling identifies a PU.1 regulatory network in macrophages
Weigelt, K., Lichtinger, M., Rehli, M., & Langmann, T. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.01.067 · Cited by 36 · see citing works
Dekoninck, A., Calomme, C., Nizet, S., de Launoit, Y., Burny, A., Ghysdael, J., & Lint, C. M. V. (2003) · Oncogene · doi:10.1038/sj.onc.1206392 · Cited by 34 · see citing works
Flagged first, then by citations
1 of the 53 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Menezes, S., Melandri, D., Anselmi, G., Perchet, T., Loschko, J., Dubrot, J., Patel, R., Gautier, E. L., Hugues, S., Longhi, M. P., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.12.001 · Cited by 288 · see citing works
The Kaleidoscope of Microglial Phenotypes
Dubbelaar, M. L., Kracht, L., Eggen, B. J. L., & Boddeke, E. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01753 · Cited by 271 · see citing works
Wei, Y., Nazari-Jahantigh, M., Chan, L., Zhu, M., Heyll, K., Corbalán-Campos, J., Hartmann, P., Thiemann, A., Weber, C., & Schober, A. (2013) · Circulation · doi:10.1161/circulationaha.112.000736 · Cited by 233 · see citing works
MicroRNAs, new effectors and regulators of NF‐κB
Boldin, M., & Baltimore, D. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01089.x · Cited by 216 · see citing works
Li, K., Ching, D., Luk, F. S., & Raffaı̈, R. L. (2015) · Circulation Research · doi:10.1161/circresaha.117.305844 · Cited by 210 · see citing works
Tumor-Associated Macrophages as Multifaceted Regulators of Breast Tumor Growth
Munir, M. T., Kay, M., Kang, M.-H., Rahman, M. M., Al‐Harrasi, A., Choudhury, M., Moustaïd‐Moussa, N., Hussain, F., & Rahman, S. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126526 · Cited by 191 · see citing works
MicroRNA-mediated control of macrophages and its implications for cancer
Squadrito, M. L., Etzrodt, M., Palma, M. D., & Pittet, M. J. (2013) · Trends in Immunology · doi:10.1016/j.it.2013.02.003 · Cited by 188 · see citing works
Immuno‐miRs: critical regulators of T‐cell development, function and ageing
Kroesen, B., Teteloshvili, N., Smigielska‐Czepiel, K., Brouwer, E., Boots, A. M. H., van den Berg, A., & Kluiver, J. L. (2014) · Immunology · doi:10.1111/imm.12367 · Cited by 168 · see citing works
miRNA–transcription factor interactions: a combinatorial regulation of gene expression
Arora, S., Rana, R., Chhabra, A., Jaiswal, A., & Rani, V. (2013) · Molecular Genetics and Genomics · doi:10.1007/s00438-013-0734-z · Cited by 166 · see citing works
Sima, C., & Glogauer, M. (2013) · Periodontology 2000 · doi:10.1111/prd.12032 · Cited by 164 · see citing works
The transcription factor PU.1 is critical for viability and function of human brain microglia
Smith, A. M., Gibbons, H. M., Oldfield, R. L., Bergin, P. M., Mee, E. W., Faull, R. L. M., & Dragunow, M. (2013) · Glia · doi:10.1002/glia.22486 · Cited by 141 · see citing works
MicroRNA 146 (Mir146) Modulates Spermatogonial Differentiation by Retinoic Acid in Mice1
Huszar, J. M., & Payne, C. J. (2012) · Biology of Reproduction · doi:10.1095/biolreprod.112.103747 · Cited by 140 · see citing works
Robertson, K. A., Hsieh, W. Y., Forster, T., Blanc, M., Lu, H., Crick, P. J., Yutuc, E., Watterson, S., Martin, K., Griffiths, S. J., et al. (2016) · PLoS Biology · doi:10.1371/journal.pbio.1002364 · Cited by 122 · see citing works
Mohr, S., Doebele, C., Comoglio, F., Berg, T., Beck, J., Bohnenberger, H., Alexe, G., Corso, J., Ströbel, P., Wachter, A., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.03.001 · Cited by 120 · see citing works
Ordas, A., Kanwal, Z., Lindenberg, V., Rougeot, J., Mink, M., Spaink, H. P., & Meijer, A. H. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-696 · Cited by 113 · see citing works
MicroRNA-155 as an inducer of apoptosis and cell differentiation in Acute Myeloid Leukaemia
Palma, C. A., Sheikha, D. A., Lim, T. K., Bryant, A. J., Vu, T. T., Jayaswal, V., & Ma, D. D. F. (2014) · Molecular Cancer · doi:10.1186/1476-4598-13-79 · Cited by 105 · see citing works
Jin, H., Li, L., Xu, J., Zhen, F., Zhu, L., Liu, P. P., Zhang, M., Zhang, W., & Wen, Z. (2012) · Blood · doi:10.1182/blood-2011-12-398362 · Cited by 105 · see citing works
Comprehensive overview of microRNA function in rheumatoid arthritis
Peng, X., Wang, Q., Li, W., Ge, G., Peng, J., Xu, Y., Yang, H., Bai, J., & Geng, D. (2023) · Bone Research · doi:10.1038/s41413-023-00244-1 · Cited by 102 · see citing works
miRNA regulation of innate immunity
Momen‐Heravi, F., & Bala, S. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.3mir1117-459r · Cited by 101 · see citing works
Wang, S., Zhang, X., Ju, Y., Zhao, B. L., Yan, X., Hu, J., Shi, L., Yang, L., Ma, Z., Chen, L., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202100 · Cited by 99 · see citing works
Architecture of a lymphomyeloid developmental switch controlled by PU.1, Notch and Gata3
Del Real, M. M., & Rothenberg, E. V. (2013) · Development · doi:10.1242/dev.088559 · Cited by 95 · see citing works
Characterization of micro RNA expression profiles in L eishmania‐infected human phagocytes
Geraci, N., Tan, J. C., & McDowell, M. A. (2014) · Parasite Immunology · doi:10.1111/pim.12156 · Cited by 94 · see citing works
Pospisil, V., Vargova, K., Kokavec, J., Rybarova, J., Savvulidi, F., Jonasova, A., Necas, E., Zavadil, J., Laslo, P., & Stopka, T. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.317 · Cited by 93 · see citing works
Trino, S., Lamorte, D., Caivano, A., Laurenzana, I., Tagliaferri, D., Falco, G., Vecchio, L. D., Musto, P., & Luca, L. D. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19020460 · Cited by 89 · see citing works
miRNA in Macrophage Development and Function
Roy, S. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6728 · Cited by 87 · see citing works
Orsini, M., Chateauvieux, S., Rhim, J., Gaigneaux, A., Cheillan, D., Christov, C., Dicato, M. A., Morceau, F., & Diederich, M. F. (2018) · Cell Death and Differentiation · doi:10.1038/s41418-018-0245-x · Cited by 75 · see citing works
Hsieh, J.-Y., Huang, T.-S., Cheng, S., Lin, W., Tsai, T.-N., Lee, O. K., & Wang, H. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt666 · Cited by 73 · see citing works
Xu, S., Hu, H.-T., Li, H. L., & Chang, S. (2019) · Cells · doi:10.3390/cells8101140 · Cited by 72 · see citing works
ETS transcription factors in hematopoietic stem cell development
Ciau‐Uitz, A., Wang, L., Patient, R. K., & Liu, F. (2013) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2013.07.010 · Cited by 70 · see citing works
Long and Short Non-Coding RNAs as Regulators of Hematopoietic Differentiation
Morceau, F., Chateauvieux, S., Gaigneaux, A., Dicato, M. A., & Diederich, M. F. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140714744 · Cited by 69 · see citing works
Narayan, N., Morenos, L., Phipson, B., Willis, S. N., Brumatti, G., Eggers, S., Lalaoui, N., Brown, L. M., Kosasih, H. J., Bartolo, R. C., et al. (2016) · Leukemia · doi:10.1038/leu.2016.279 · Cited by 64 · see citing works
Shen, C., Chen, M.-T., Zhang, X.-H., Yin, X.-L., Ning, H.-M., Su, R., Lin, H.-S., Song, L., Wang, F., Ma, Y.-N., et al. (2016) · PLOS Genetics · doi:10.1371/journal.pgen.1006259 · Cited by 62 · see citing works
RetractedmiR-142-3p acts as an essential modulator of neutrophil development in zebrafish
Fan, H.-B., Liu, Y., Wang, L., Du, T., Dong, M., Gao, L., Meng, Z.-Z., Jin, Y., Chen, Y., Deng, M., et al. (2014) · Blood · doi:10.1182/blood-2013-12-545012 · Cited by 61 · see citing works
The role of mi RNA s in mast cells and other innate immune cells
Montagner, S., Orlandi, E. M., Merante, S., & Monticelli, S. (2013) · Immunological Reviews · doi:10.1111/imr.12042 · Cited by 60 · see citing works
Morris, V., Zhang, A., Yang, T., Stirewalt, D. L., Ramamurthy, R., Meshinchi, S., & Oehler, V. G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075815 · Cited by 59 · see citing works
Huber, R., Pietsch, D., Günther, J., Welz, B., Vogt, N., & Brand, K. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1322-4 · Cited by 59 · see citing works
Sun, Y., Sun, J., Toubai, T., Nieves, E. C., Mathewson, N. D., Tamaki, H., Evers, R., & Reddy, P. R. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202911 · Cited by 59 · see citing works
The Y in and Y ang of micro RNA s: leukemia and immunity
So, A. Y., Zhao, J. L., & Baltimore, D. (2013) · Immunological Reviews · doi:10.1111/imr.12043 · Cited by 57 · see citing works
The potential role of miRNA in regulating macrophage polarization
Khayati, S., Dehnavi, S., Sadeghi, M., Afshari, J. T., Esmaeili, S., & Mohammadi, M. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e21615 · Cited by 56 · see citing works
Small and Long Regulatory RNAs in the Immune System and Immune Diseases
Stachurska, A., Zorro, M. M., van der Sijde, M. R., & Withoff, S. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00513 · Cited by 48 · see citing works
RUNX1: A MicroRNA Hub in Normal and Malignant Hematopoiesis
Rossetti, S., & Sacchi, N. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14011566 · Cited by 46 · see citing works
Role of microRNA-146a in normal and malignant hematopoietic stem cell function
Zhao, J. L., & Starczynowski, D. T. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00219 · Cited by 45 · see citing works
Role of MicroRNAs in the development and function of innate immune cells
Kingsley, S. M. K., & Bhat, B. V. (2017) · International Reviews of Immunology · doi:10.1080/08830185.2017.1284212 · Cited by 43 · see citing works
MicroRNAs in tumor immunity: functional regulation in tumor-associated macrophages
Chen, C., Liu, J., & Luo, Y. (2019) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b1900452 · Cited by 41 · see citing works
Pathogenic microRNA’s in myeloid malignancies
Khalaj, M., Tavakkoli, M., Stranahan, A. W., & Park, C. Y. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00361 · Cited by 40 · see citing works
Czimmerer, Z., Varga, T., Kiss, M., Vázquez, C., Doan‐Xuan, Q. M., Rückerl, D., Tattikota, S. G., Yan, X., Nagy, Z. S., Dániel, B., et al. (2016) · Genome Medicine · doi:10.1186/s13073-016-0315-y · Cited by 40 · see citing works
Novotny, G. W., Lundh, M., Backe, M. B., Christensen, D. P., Hansen, J. B., Dahllöf, M. S., Pallesen, E. M. H., & Mandrup-Poulsen, T. R. (2012) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2012.09.014 · Cited by 37 · see citing works
MicroRNAs: As Critical Regulators of Tumor- Associated Macrophages
Chatterjee, B., Saha, P., Bose, S., Shukla, D., Chatterjee, N., Kumar, S., Tripathi, P. P., & Srivastava, A. K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197117 · Cited by 37 · see citing works
miR-146a and miR-155 Expression Levels in Acute Graft-Versus-Host Disease Incidence
Atarod, S., Ahmed, M. M., Lendrem, C., Pearce, K. F., Cope, W., Norden, J., Wang, X., Collin, M. P., & Dickinson, A. M. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00056 · Cited by 34 · see citing works
Tu, J., Xing, Y., Guo, Y., Tang, F. R., Guo, L., & Xi, T. (2012) · International Immunopharmacology · doi:10.1016/j.intimp.2012.08.015 · Cited by 34 · see citing works
Tang, Y., Tao, Y., Wang, L., Yang, L., Jing, Y., Jiang, X., Li, L., Yang, Z., Wang, X., Peng, M., et al. (2020) · The FASEB Journal · doi:10.1096/fj.201903183rrr · Cited by 33 · see citing works
The mirn23a microRNA cluster antagonizes B cell development
Kurkewich, J. L., Bikorimana, E., Nguyen, T. A., Klopfenstein, N., Zhang, H., Hallas, W. M., Stayback, G., McDowell, M. A., & Dahl, R. E. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.1hi0915-398rr · Cited by 33 · see citing works
Alemdehy, M. F., & Erkeland, S. J. (2012) · Current Opinion in Hematology · doi:10.1097/moh.0b013e328353d4e9 · Cited by 30 · see citing works
Positive Correlation of STAT1 and miR-146a with Anemia in Patients with Systemic Lupus Erythematosus
Dominguez‐Gutierrez, P. R., Ceribelli, A., Satoh, M., Sobel, E. S., Reeves, W. H., & Chan, E. K. L. (2013) · Journal of Clinical Immunology · doi:10.1007/s10875-013-9973-3 · Cited by 30 · see citing works
microRNAs in the regulation of dendritic cell functions in inflammation and atherosclerosis
Busch, M., & Zernecke, A. (2012) · Journal of Molecular Medicine · doi:10.1007/s00109-012-0864-5 · Cited by 29 · see citing works
Aggressive acute myeloid leukemia in PU.1/p53 double-mutant mice
Bašová, P., Pospíšil, V., Savvulidi, F. G., Burda, P., Vargová, K., Staněk, L., Dluhošová, M., Kužmová, E., Jonasova, A. T., Steidl, U. G., et al. (2013) · Oncogene · doi:10.1038/onc.2013.414 · Cited by 28 · see citing works
Epigenetic Regulation in the Pathogenesis of Sjögren Syndrome and Rheumatoid Arthritis
Ibáñez-Cabellos, J. S., Seco-Cervera, M., Osca-Verdegal, R., Pallardó, F. V., & García‐Giménez, J. L. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.01104 · Cited by 28 · see citing works
Smith, N. C. P., Wajnberg, G., Chacko, S. M., Woldemariam, N. T., Lacroix, J., Crapoulet, N., Ayre, D. C., Lewis, S. M., Rise, M. L., Andreassen, R., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.587931 · Cited by 27 · see citing works
Yu, T., Ju, Z., Luo, M., Hu, R., Teng, Y., Xie, L., Zhong, C., Chen, L., Hou, W., Xiong, Y., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-55100-2 · Cited by 26 · see citing works
The roles of miR-146a in the differentiation of Jurkat T-lymphoblasts
Saki, N., Abroun, S., Soleimani, M., Mortazavi, Y., Kaviani, S., & Arefian, E. (2013) · Hematology · doi:10.1179/1607845413y.0000000105 · Cited by 26 · see citing works
Spinello, I., Quaranta, M. T., Paolillo, R., Pelosi, E., Cerio, A., Saulle, E., Coco, F. L., Testa, U., & Labbaye, C. (2015) · Haematologica · doi:10.3324/haematol.2014.120295 · Cited by 26 · see citing works
Insight into microRNAs’ involvement in hematopoiesis: current standing point of findings
Nassiri, S. M., Afshar, N. A., & Almasi, P. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03504-3 · Cited by 25 · see citing works
Liang, G., Malmuthuge, N., Guan, L. L., & Griebel, P. J. (2014) · Molecular Immunology · doi:10.1016/j.molimm.2014.10.014 · Cited by 25 · see citing works
MicroRNA-Regulated Pathways in Hematological Malignancies: How to Avoid Cells Playing Out of Tune
Fatica, A., & Fazi, F. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms141020930 · Cited by 24 · see citing works
Function and significance of MicroRNAs in benign and malignant human stem cells
Utikal, J. S., Abba, M. L., Novak, D., Moniuszko, M., & Allgayer, H. (2015) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2015.07.001 · Cited by 23 · see citing works
Jia, W., Liang, D., Li, N., Liu, M., Dong, Z., Li, J., Dong, X., Yue, Y., Hu, P., Yao, J., et al. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.005079 · Cited by 23 · see citing works
Ablation of miR-146b in mice causes hematopoietic malignancy
Mitsumura, T., Ito, Y., Chiba, T., Matsushima, T., Kurimoto, R., Tanaka, Y., Kato, T., Uchida, K., Ito, T., Yamamoto, K., et al. (2018) · Blood Advances · doi:10.1182/bloodadvances.2018017954 · Cited by 22 · see citing works
MicroRNAs in Control of Stem Cells in Normal and Malignant Hematopoiesis
Roden, C., & Lü, J. (2016) · Current Stem Cell Reports · doi:10.1007/s40778-016-0057-1 · Cited by 21 · see citing works
ApoE Attenuates Atherosclerosis via miR-146a
Fish, J. E., & Cybulsky, M. I. (2015) · Circulation Research · doi:10.1161/circresaha.115.306733 · Cited by 20 · see citing works
Micro RNA control of myelopoiesis and the differentiation block in acute myeloid leukaemia
Palma, C. A., Tonna, E., David, D. F., & Lutherborrow, M. A. (2012) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01514.x · Cited by 19 · see citing works
Sisti, F., Wang, S., Brandt, S. L., Glosson, N. L., Mayo, L. D., Son, Y. M., Sturgeon, S. M., Filgueiras, L. R., Jancar, S., Wong, H. R., et al. (2018) · Science Signaling · doi:10.1126/scisignal.aai9085 · Cited by 19 · see citing works
Smith, N. C. P., Christian, S. L., Woldemariam, N. T., Clow, K. A., Rise, M. L., & Andreassen, R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21113989 · Cited by 18 · see citing works
Crosstalk between Tumor-Associated Macrophages and MicroRNAs: A Key Role in Tumor Microenvironment
Zhou, X., Chen, B., Zhang, Z., Huang, Y., Li, J., Wei, Q., Cao, D., & Ai, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113258 · Cited by 17 · see citing works
Testa, U., & Pelosi, E. (2014) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428194.2014.955019 · Cited by 16 · see citing works
Identifying microRNA determinants of human myelopoiesis
Rajasekhar, M., Schmitz, U., Flamant, S., Wong, J. J. L., Bailey, C. G., Ritchie, W., Holst, J., & Rasko, J. E. J. (2018) · Scientific Reports · doi:10.1038/s41598-018-24203-7 · Cited by 16 · see citing works
Identification of the microRNA networks contributing to macrophage differentiation and function
Zhou, H., Zhang, J., Eyers, F., Xiang, Y., Herbert, C. A., Tay, H. L., Foster, P. S., & Yang, M. (2016) · Oncotarget · doi:10.18632/oncotarget.8933 · Cited by 16 · see citing works
Patni, H., Chaudhary, R., & Kumar, A. (2024) · Nanoscale · doi:10.1039/d4nr02795g · Cited by 15 · see citing works
Cassidy, B. R., Sonntag, W. E., Leenen, P. J. M., & Drevets, D. A. (2022) · Immunity & Ageing · doi:10.1186/s12979-022-00281-0 · Cited by 14 · see citing works
Liu, Y., Qin, L., Wang, J., Xie, X., Zhang, Y., Li, C., Guan, Z., Qian, L., Chen, L., Hu, J., et al. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2100618 · Cited by 14 · see citing works
Classification of pediatric acute myeloid leukemia based on miRNA expression profiles
Obulkasim, A., Katsman-Kuipers, J. E., Verboon, L., Sanders, M. A., Touw, I. P., Jongen‐Lavrencic, M., Pieters, R., Klusmann, J., Zwaan, C. M., van den Heuvel‐Eibrink, M. M., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.16525 · Cited by 14 · see citing works
Cannabinoid-induced changes in the immune system: The role of microRNAs
Bhatt, H. K., Song, D., Musgrave, G., & Rao, S. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107832 · Cited by 12 · see citing works
Elemam, N. M., Mekky, R. Y., El-Ekiaby, N. M., Sobky, S. A. E., Din, M. A. M. E., Esmat, G., & Abdelaziz, A. I. (2015) · Human Immunology · doi:10.1016/j.humimm.2015.09.021 · Cited by 11 · see citing works
Krsmanovic, P., Móciková, H., Chramostová, K., Klánová, M., Trnková, M., Pešta, M., Laslo, P., Pytlík, R., Stopka, T., Trněný, M., et al. (2022) · Cancers · doi:10.3390/cancers14092305 · Cited by 11 · see citing works
Noncoding RNAs in Acute Myeloid Leukemia: From Key Regulators to Clinical Players
Fatica, A. (2012) · Scientifica · doi:10.6064/2012/925758 · Cited by 10 · see citing works
So, E. Y., Winchester, T., & Ouchi, T. (2017) · Cancer Biology & Therapy · doi:10.1080/15384047.2017.1281498 · Cited by 10 · see citing works
Motaei, J., Yaghmaie, M., Ahmadvand, M., Pashaiefar, H., & Kerachian, M. A. (2019) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2019.08.004 · Cited by 10 · see citing works
Hu, G., Liu, L., Miao, X., Zhao, Y., & Li, X. (2022) · Poultry Science · doi:10.1016/j.psj.2022.101977 · Cited by 9 · see citing works
Zou, D., Yin, J., Ye, Z., Zeng, Q., Tian, C., Wang, Y., Chen, Q., & Chen, R. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.00886 · Cited by 9 · see citing works
Boshtam, M., Rahimmanesh, I., Shariati, L., Najaflu, M., Khanahmad, H., Mirian, M., Zarepour, A., Zarrabi, A., & Kouhpayeh, S. (2023) · Cells · doi:10.3390/cells12040635 · Cited by 9 · see citing works
miRNAs: Biosynthesis, mechanism of action, and applications in biological systems
Liu, K., & Cai, W. (2025) · Gene Reports · doi:10.1016/j.genrep.2025.102208 · Cited by 7 · see citing works
miR-155 in Acute Myeloid Leukemia: Not Merely a Prognostic Marker?
Joyce, C. E., & Novina, C. D. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2012.48.3180 · Cited by 7 · see citing works
Combined Approach to Leukemic Differentiation Using Transcription Factor PU.1-Enhancing Agents
Bašová, P., Paszeková, H., Minařík, Ľ., Dluhošová, M., Burda, P., & Stopka, T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126729 · Cited by 7 · see citing works
Advances in the role of microRNAs in lipid metabolism-related anti-atherosclerotic drug discovery
Wang, L., Yang, Y., & Hong, B. (2013) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2013.798639 · Cited by 7 · see citing works
Fishing for microRNAs in Toxicology
Freeman, J. L., Weber, G. J., & Sepúlveda, M. S. (2013) · Wiley eBooks · doi:10.1002/9781118695999.ch4 · Cited by 7 · see citing works
Mammoli, F., Parenti, S., Lomiento, M., Gemelli, C., Atene, C. G., Grande, A., Corradini, R., Manicardi, A., Fantini, S., Zanocco‐Marani, T., et al. (2019) · Experimental Cell Research · doi:10.1016/j.yexcr.2019.05.026 · Cited by 6 · see citing works
Noncoding RNAs as novel immunotherapeutic tools against cancer
Kaur, M., Kaur, B., Konar, M., & Sharma, S. (2022) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2021.11.011 · Cited by 5 · see citing works
Pathophysiology of miR-146a in lung cancer. Prospects of rising of efficiency of targeted therapy
Иванович, В. В., Romashova, J. E., & Shabanov, P. D. (2021) · Reviews on Clinical Pharmacology and Drug Therapy · doi:10.17816/rcf194359-381 · Cited by 4 · see citing works
miR-146a Influences Energy Metabolism, Cell Differentiation and Innate Immunity
Huszar, J. M. (2013) · Journal of Postgenomics Drug & Biomarker Development · doi:10.4172/2153-0769.1000119 · Cited by 4 · see citing works
Translation Regulation by microRNAs in Acute Leukemia
Kontos, C. K., Vasilatou, D., Papageorgiou, S. G., & Scorilas, A. (2014) · Wiley-VCH eBooks · doi:10.1002/3527600906.mcb.20130010 · Cited by 4 · see citing works
MicroRNA: role in macrophage polarisation and colorectal cancer pathogenesis
Lin, H., Zhou, J., He, Y., Zhu, Y., Chen, P., Yan, H., Huang, J., Gong, E. S., & Wang, X. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1619526 · Cited by 3 · see citing works
- Authors
- Ghani, S., Riemke, P., Schönheit, J., Lenze, D., Stumm, J., Hoogenkamp, M., Lagendijk, A., Heinz, S., Bonifer, C., Bakkers, J., Abdelilah-Seyfried, S., Hummel, M., & Rosenbauer, F.
- Affiliations
- Max Delbrück Center (DE)
- Charité – Universitätsmedizin Berlin (DE)
- University of Leeds (GB)
- Royal Netherlands Academy of Arts and Sciences (NL)
- University of California San Diego (US)
- Max-Delbrück-Center for Molecular Medicine, Berlin, Germany;
- ORCID
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2011-08-25
- Volume
- 118
- Issue
- 8
- Pages
- 2275-2284
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC10251560
- OpenAlex
- W1997338207
- Semantic Scholar
- bba41cf0cb9c3fbfc741609f6c4d1fe95d7ff8ab
- Cited by
- 123
- References
- 53
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 4 · 2023: 5 · 2022: 7 · 2021: 3 · 2020: 6 · 2019: 9 · 2018: 8 · 2017: 6 · 2016: 10 · 2015: 5 · 2014: 11 · 2013: 28 · 2012: 11
- FWCI
- 10.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (publishedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- KNAW research portal (Royal Academy of Art and Sciences (KNAW)) (submittedVersion, other-oa)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- PU.1, microRNA, hematopoietic stem cells, macrophage differentiation, myeloid differentiation, miR-146a, miR-155, miR-342, miR-338, Dicer, transcriptional regulation, peritoneal macrophages, zebrafish development, chromatin binding sites
- MeSH terms
- Proto-Oncogene Protein Spi-1, Animals, Cell Differentiation, Cell Line, Hematopoietic Stem Cells, Mice, Inbred C57BL, Proto-Oncogene Proteins, Zebrafish, Trans-Activators, Macrophages, Peritoneal, Cell Lineage, RNA, Small Interfering, MicroRNAs, Myelopoiesis, Mice, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review