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Tet2 restrains inflammatory gene expression in macrophages
Open accessAbstract
Tet methylcytosine dioxygenase 2 (TET2) is one of the earliest and most frequently mutated genes in clonal hematopoiesis of indeterminate potential (CHIP) and myeloid cancers, including myelodysplastic syndromes (MDS) and chronic myelomonocytic leukemia (CMML). TET2 catalyzes the oxidation of 5-methylcytosine to 5-hydroxymethylcytosine, leading to DNA demethylation, and also affects transcription by recruiting histone modifiers. Inactivating TET2 mutations cause epigenetic dysregulation, clonal hematopoietic stem cell (HSC) dominance, and monocytic lineage skewing. Here, we found that Tet2 was the most highly expressed Tet enzyme in murine macrophage (MΦ) differentiation. Tet2 transcription was further induced by lipopolysaccharide (LPS), but not interleukin (IL)-4, stimulation, potentially in a nuclear factor κβ-dependent manner. Tet2 loss did not affect early LPS gene responses in vitro, but increased Il-1b, Il-6, and Arginase 1 (Arg1) mRNA expression at later stages of stimulation in bone-marrow-derived MΦs (BMMΦs). Tet2-deficient peritoneal MΦs, however, demonstrated profound, constitutive expression of LPS-induced genes associated with an inflammatory state in vivo. In contrast, Tet2 deficiency did not affect alternative MΦ gene expression significantly in response to IL-4. These results suggested impaired resolution of inflammation in the absence of Tet2 both in vitro and in vivo. For the first time, we also detected TET2 mutations in BMMΦs from MDS and CMML patients and assayed their effects on LPS responses, including their potential influence on human IL-6 expression. Our results show that Tet2 restrains inflammation in murine MΦs and mice, raising the possibility that loss of TET2 function in MΦs may alter the immune environment in the large elderly population with TET2-mutant CHIP and in TET2-mutant myeloid cancer patients.
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In the citing paper
“A role for TET2 during the resolution of inflammation has also been described in bone-derived macrophages (Cull et al., 2017).”
From TET2 Regulates the Neuroinflammatory Response in Microglia (2019) · cites this paper as Cull et al., 2017
In the citing paper
“Since many CH-associated mutations themselves contribute to increased inflammatory signaling, including mutations in TET2, FLT3, JAK2, STAT1, CBL, and RAS (Azrakhsh et al., 2019; Cull et al., 2017; Jaiswal et al., 2017)”
From Chronic infection drives Dnmt3a-loss-of-function clonal hematopoiesis via IFNγ signaling (2021) · cites this paper as Cull et al., 2017
In the citing paper
“in the context of CHIP, Tet2 loss-of-function mutations in myeloid cells result in increased proinflammatory responses, with reported increases in both IL-124,43 and IL-6 production,27”
From Aging drives Tet2 +/− clonal hematopoiesis via IL-1 signaling (2023) · cites this paper as [43]
In the citing paper
“also found that Il1b, IL8 family chemokines, and other inflammatory mediators show increased expression in Tet2-deficient macrophages challenged with low-density lipoprotein or endotoxin 79,86,92”
From Clonal hematopoiesis in human aging and disease (2019) · cites this paper as [92]
In the citing paper
“Subsequent studies have confirmed the over-expression of Il6”
From Clonal hematopoiesis in human aging and disease (2019) · cites this paper as [92]
Citations
Cites
Macrophage activation and polarization: nomenclature and experimental guidelines
Murray, P. J., Allen, J. E., Biswas, S. K., Fisher, E. A., Gilroy, D. W., Goerdt, S., Gordon, S., Hamilton, J. A., Ivashkiv, L. B., Lawrence, T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.008 · Cited by 6,337
Age-related clonal hematopoiesis associated with adverse outcomes
Jaiswal, S., Fontanillas, P., Flannick, J., Manning, A., Grauman, P. V., Mar, B. G., Lindsley, R. C., Mermel, C. H., Burtt, N., Chavez, A., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1408617 · Cited by 4,841
Clonal hematopoiesis and risk of atherosclerotic cardiovascular disease
Jaiswal, S., Natarajan, P., Silver, A. J., Gibson, C. J., Bick, A. G., Shvartz, E., McConkey, M., Gupta, N., Gabriel, S., Ardissino, D., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1701719 · Cited by 2,683
The Immunological Genome Project: networks of gene expression in immune cells
The Immunological Genome Project Consortium, Heng, T. S. P., Painter, M. W., Elpek, K., Lukacs-Kornek, V., Mauermann, N., Turley, S. J., Koller, D., Kim, F. S., Wagers, A. J., et al. (2008) · Nature Immunology · doi:10.1038/ni1008-1091 · Cited by 1,864
Clinical and biological implications of driver mutations in myelodysplastic syndromes
Papaemmanuil, E., Gerstung, M., Malcovati, L., Tauro, S., Gundem, G., Van Loo, P., Yoon, C. J., Ellis, P., Wedge, D. C., Pellagatti, A., et al. (2013) · Blood · doi:10.1182/blood-2013-08-518886 · Cited by 1,832
Mutation in TET2 in Myeloid Cancers
Delhommeau, F., Dupont, S., Valle, V. D., James, C., Trannoy, S., Massé, A., Kosmider, O., Le Couedic, J.-P., Robert, F., Alberdi, A., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810069 · Cited by 1,776
Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice
Fuster, J. J., MacLauchlan, S., Zuriaga, M. A., Polackal, M. N., Ostriker, A. C., Chakraborty, R., Wu, C.-L., Sano, S., Muralidharan, S., Rius, C., et al. (2017) · Science · doi:10.1126/science.aag1381 · Cited by 1,536
Landscape of genetic lesions in 944 patients with myelodysplastic syndromes
Haferlach, T., Nagata, Y., Grossmann, V, Okuno, Y., Bacher, U., Nagae, G., Schnittger, S., Sanada, M., Kon, A., Alpermann, T., et al. (2014) · Leukemia · doi:10.1038/leu.2013.336 · Cited by 1,532
Gene-specific control of inflammation by TLR-induced chromatin modifications
Foster, S. L., Hargreaves, D. C., & Medzhitov, R. (2007) · Nature · doi:10.1038/nature05836 · Cited by 1,344
Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation
Moran-Crusio, K., Reavie, L., Shih, A., Abdel-Wahab, O., Ndiaye-Lobry, D., Lobry, C., Figueroa, M. E., Vasanthakumar, A., Patel, J., Zhao, X., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.06.001 · Cited by 1,339
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Li, L., Xiang, Y., Cai, Y., & Luo, F. (2026) · Microorganisms · doi:10.3390/microorganisms14030515 · Cited by 5
Neuendorff, N. R., Frenzel, L. P., Leuschner, F., & Fremd, C. (2020) · Journal of Geriatric Oncology · doi:10.1016/j.jgo.2020.09.006 · Cited by 5
Salybekov, A. A., & Hassanpour, M. (2023) · Biomedicines · doi:10.3390/biomedicines11082288 · Cited by 6
Ten-eleven translocation-2-mediated macrophage activation promotes liver regeneration
Chen, Y., Meng, L., Xu, N., Chen, H., Wei, X., Lu, D., Wang, S., & Xu, X. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-023-01407-7 · Cited by 5
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Evans, M. A., & Walsh, K. X. (2026) · Immunological Reviews · doi:10.1111/imr.70094 · Cited by 6
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Evans, M. A., Chavkin, N. W., Sano, S., Sun, H., Sardana, T., Ravi, R., Doviak, H., Wang, Y., Yura, Y., Polizio, A. H., et al. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1487867 · Cited by 4
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Ren, J. (2025) · Journal of Radiation Research and Applied Sciences · doi:10.1016/j.jrras.2025.102072 · Cited by 3
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McClatchy, J., Strogantsev, R., Wolfe, E., Lin, H., Mohammadhosseini, M., Davis, B. A., Eden, C. O., Goldman, D., Fleming, W., Conley, P., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.09.15.507688 · Cited by 2
Dong, Z., Sepúlveda, H., Arteaga-Vazquez, L. J., Blouin, C., Fernandez, J. A., Binder, M., Chou, W., Tien, H., Patnaik, M. M., Faulkner, G. J., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.30.578015 · Cited by 2
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Kodosaki, E., Daniels-Morgan, A., Hassan, N., Webb, R., Morris, K., & Kelly, C. (2023) · Neurological Research · doi:10.1080/01616412.2023.2257422 · Cited by 2
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Liu, Y., Desai, P. M., Nadeem, O., Woyach, J. A., & Alsouqi, A. (2025) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk-25-473650 · Cited by 1
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Göttgens, B., & Ghiaur, G. (2022) · doi:10.1182/ashsap8.chapter01 · Cited by 1
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Koh, Y., Park, C., Cho, G., Ryu, G., Park, J.-M., Yoon, H., Oh, Y. M., Lee, C., An, H., Sun, C.-H., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-4672454/v1 · Cited by 1
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Páramo, J. A. (2018) · Medicina Clínica · doi:10.1016/j.medcli.2018.04.007
Páramo, J. A. (2018) · Medicina Clínica (English Edition) · doi:10.1016/j.medcle.2018.07.006
Haase, D. T. (2019) · best practice onkologie · doi:10.1007/s11654-019-00167-6
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TSE, C. (2022) · Cronfa (Swansea University) · doi:10.23889/suthesis.60060
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Agarwal, Y., Ramani, M. D., Manikandan, S., Bonar, K. A., Montilla, J., Gaskill, P. J., & Matt, S. M. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1779072
Li, M., & Mailloux, R. J. (2026) · Journal of Cellular Biochemistry · doi:10.1002/jcb.70104
Yamaguchi, Y., Puri, V., Jania, C. M., Cassidy, O. G., Bolzan, L. R., Mozes, G. D., Brown, E. A., Domènech, S., Miller, C. M., Levi, A. B., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-10270484/v1
Streck, E., Harloff, M., Freuer, D., Dintner, S., Dedegkikas, D., Jost, D., Kling, E., Märkl, B., Trepel, M., Hyhlik-Dürr, A., et al. (2026) · JVS Vascular Science · doi:10.1016/j.jvssci.2026.100442
IL-1-mediated cancer-adapted hematopoiesis in aging and clonal hematopoiesis
Caiado, F., Gonullu, N. G., & Manz, M. G. (2026) · Seminars in Immunology · doi:10.1016/j.smim.2026.102055
Gioti, K., Trapali, M., Belouka, I., Chaniotis, D. I., & Beloukas, A. I. (2026) · Cells · doi:10.3390/cells15171615
Ünsal, Ş. E. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1943135
Yamaguchi, Y., Puri, V., Jania, C. M., Cassidy, O. G., Bolzan, L. R., Mozes, G. D., Brown, E. A., Domènech, S., Miller, C., Levi, A. B., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-10270484/v2
Gholami, D., Ourang, Z., Saatchi, M., Yousefabadi, E. R., Esmaeilzadeh, E., Akhlaghi, M., Kavosi, H., & Khorshid, H. R. K. (2025) · Reports of Biochemistry and Molecular Biology · doi:10.66224/rbmb.14.2.314
Zhang, X., Li, R., Sun, L., Zheng, Y., Zhou, T., Xia, Y., Yi, M., Che, D., & Geng, S. (2026) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2026.10.016
Metadata
- Authors
- Cull, A. H., Snetsinger, B., Buckstein, R., Wells, R. A., & Rauh, M. J.
- Affiliations
- Queen's University (CA)
- Sunnybrook Health Science Centre (CA)
- Corresponding author
- Rauh, Michael J.
- Venue
- Experimental Hematology
- Publisher
- Elsevier BV
- Published
- 2017-11
- Volume
- 55
- Pages
- 56-70.e13
- ISSN
- 0301-472X (ISSN-L)
- OpenAlex
- W2749902186
- Cited by
- 295
- References
- 62
- Citations by year
- 2026: 23 · 2025: 39 · 2024: 34 · 2023: 37 · 2022: 43 · 2021: 37 · 2020: 34 · 2019: 24 · 2018: 17 · 2017: 7
- FWCI
- 17.28
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Experimental Hematology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Queen's University
- Canada Foundation for Innovation
- Ontario Institute for Cancer Research
- Southeastern Ontario Academic Medical Organization
- Women's Giving Circle/University Hospitals Kingston Foundation
- Queen's University Terry Fox Foundation Training Program in Transdisciplinary Cancer Research
- Topics
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- TET2, macrophages, inflammation resolution, 5-hydroxymethylcytosine, DNA demethylation, clonal hematopoiesis of indeterminate potential, myelodysplastic syndrome, chronic myelomonocytic leukemia, lipopolysaccharide response, NF-κB, interleukin-6, IL-1β, arginase-1, alternative macrophage activation, epigenetic dysregulation
- MeSH terms
- Animals, Arginase, Cell Differentiation, Cell Line, Cells, Cultured, DNA-Binding Proteins, Gene Expression Regulation, Humans, Inflammation, Lipopolysaccharides, Macrophages, Mice, Inbred C57BL, Mutation, Myelodysplastic Syndromes, Proto-Oncogene Proteins, Leukemia, Myelomonocytic, Chronic, Interleukin-6, Mice, Knockout, Dioxygenases, Interleukin-1beta
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