The α-synuclein burden hypothesis of Parkinson disease and its relationship to Alzheimer disease
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Studies on experimental PD models argue that dopamine neurons are very susceptible to both oxidative stress and inflammation.
“Studies on experimental PD models argue that dopamine neurons are very susceptible to both oxidative stress and inflammation [121,122],”
From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [121]
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“Numerous studies in experimental PD models indicate that dopamine neurons are particularly vulnerable to both oxidative stress and inflammatory attack (McGeer and McGeer, 2008; Pott Godoy et al., 2008).”
BackgroundThe Role of Neuroinflammation in Dementias
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Beneficial Effects of Spirulina Consumption on Brain Health
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- Authors
- McGeer, P. L., & McGeer, E. G.
- Affiliations
- University of British Columbia (CA)
- Corresponding author
- McGeer, Patrick L.
- ORCID
- McGeer, Patrick L.
- Venue
- Experimental Neurology
- Publisher
- Elsevier BV
- Published
- 2008-08
- Volume
- 212
- Issue
- 2
- Pages
- 235-238
- ISSN
- 0014-4886 (ISSN-L)
- OpenAlex
- W2003026668
- Cited by
- 41
- References
- 46
- Citations by year
- 2025: 1 · 2022: 5 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 6 · 2016: 3 · 2015: 3 · 2014: 3 · 2013: 1 · 2012: 1
- FWCI
- 0.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Experimental Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- Parkinson's disease, alpha-synuclein, Lewy body pathology, dopaminergic neuron loss, neurodegeneration, oxidative stress, mitochondrial dysfunction, proteostasis, deep brain stimulation, stem cell transplantation, genome editing, gene transfer, neuroprotection, Alzheimer's disease, translational research
- MeSH terms
- Alzheimer Disease, Humans, Parkinson Disease, alpha-Synuclein
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