Cited by 484Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeurology and Historical Studies

Alzheimer's disease: The amyloid cascade hypothesis: An update and reappraisal

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Hardy, John·2006·Journal of Alzheimer s Disease

Abstract

Here I recap the scientific and personal background of the delineation of the amyloid cascade hypothesis for Alzheimer's disease that I wrote with Gerry Higgins and the events leading to the writing of that influential review.

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Crossref · 10.3233/jad-2006-9s317

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13 of 13 references verified0 citation errors · 0 not checkable

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  • All high-penetrance AD genetic risk alleles (APOE ε4 allele, Down syndrome, APP mutations and duplications, PSEN1 and PSEN2 mutations) have been linked in various experimental systems with increased Aβ deposition and increased formation of putative toxic Aβ peptide species.

    “All high-penetrance AD genetic risk alleles (i.e. APOE ε4 allele, Down syndrome, APP mutations and duplications, PSEN1 and PSEN2 mutations) have been linked in various experimental systems with increased Aβ deposition and increased formation of putative toxic Aβ peptide species (46, 55-57).”

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Cites

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Research works printed but not linked: 2

  1. P. St. George Hyslop et al., Genetic linkage studies suggest that Alzheimer's disease is not a single homogenous disorder, Nature 347 (1990), 194-197.
  2. C. Van Broeckhoven, J. Haan, E. Bakker, J.A. Hardy, W. Van Hul, A. Wehnert, M. Vegter-Van der Vlis and R.A.C. Roos, The beta-amyloid precursor protein gene is tightly linked to the locus causing Hereditary Cerebral Hemorrhage with Amy- loidosis of Dutch Type, Science 248 (1990), 488-490.

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Authors
Hardy, J.
Affiliations
National Institutes of Health (US)
Corresponding author
Hardy, John
Venue
Journal of Alzheimer s Disease
Published
2006-07-27
Volume
9
Issue
s3
Pages
151-153
ISSN
  • 1387-2877 (ISSN-L)
  • 1875-8908
OpenAlex
W1746907828
Cited by
475
References
13
Citations by year
2026: 12 · 2025: 15 · 2024: 21 · 2023: 22 · 2022: 17 · 2021: 29 · 2020: 35 · 2019: 30 · 2018: 34 · 2017: 28 · 2016: 22 · 2015: 31 · 2014: 25 · 2013: 29 · 2012: 25
FWCI
14.14
Type
journal article
Language
en
Open access
Locations
  • Journal of Alzheimer s Disease (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Neurology › Neurology and Historical Studies
Keywords
Alzheimer's disease, amyloid hypothesis
MeSH terms
Alzheimer Disease, Brain, Humans, Amyloid beta-Peptides

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