Cited by 380Nitric Oxide and Endothelin EffectsTraumatic Brain Injury and Neurovascular DisturbancesNeuroprotection in Cerebral Ischemia

The DOI matches its Crossref record; 108 of the 109 references it cites were found in a registry or an index.

The role of the nitric oxide pathway in brain injury and its treatment — From bench to bedside

Open access

Abstract

Nitric oxide (NO) is a key signalling molecule in the regulation of cerebral blood flow. This review summarises current evidence regarding the role of NO in the regulation of cerebral blood flow at rest, under physiological conditions, and after brain injury, focusing on subarachnoid haemorrhage, traumatic brain injury, and ischaemic stroke and following cardiac arrest. We also review the role of NO in the response to hypoxic insult in the developing brain. NO depletion in ischaemic brain tissue plays a pivotal role in the development of subsequent morbidity and mortality through microcirculatory disturbance and disordered blood flow regulation. NO derived from endothelial nitric oxide synthase (eNOS) appears to have neuroprotective properties. However NO derived from inducible nitric oxide synthase (iNOS) may have neurotoxic effects. Cerebral NO donor agents, for example sodium nitrite, appear to replicate the effects of eNOS derived NO, and therefore have neuroprotective properties. This is true in both the adult and immature brain. We conclude that these agents should be further investigated as targeted pharmacotherapy to protect against secondary brain injury.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.expneurol.2014.10.017

Cites

108 of 108 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

1 retracted

Show all 109 references

Cited by

Sorted by citations

Items 301–377 of 377

Metadata

Authors
Garry, P. S., Ezra, M., Rowland, M. J., Westbrook, J., & Pattinson, K. T. S.
Affiliations
John Radcliffe Hospital (GB)
Corresponding author
Garry, P.S.
Venue
Experimental Neurology
Publisher
Elsevier BV
Published
2015-01
Volume
263
Pages
235-243
ISSN
0014-4886 (ISSN-L)
OpenAlex
W2055065148
Cited by
380
References
109
Citations by year
2026: 13 · 2025: 26 · 2024: 25 · 2023: 34 · 2022: 35 · 2021: 51 · 2020: 53 · 2019: 36 · 2018: 28 · 2017: 36 · 2016: 30 · 2015: 13
FWCI
3.08
Type
journal article
Language
en
Open access
Locations
  • Experimental Neurology (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
  • Oxford University Clinical Academic Graduate School
  • Medical Research Council
Topics
  • Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
  • Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
  • Life Sciences › Neuroscience › Neurology › Neuroprotection in Cerebral Ischemia
Keywords
nitric oxide, cerebral autoregulation, brain injury, subarachnoid hemorrhage, traumatic brain injury, ischemic stroke, cardiac arrest, hypoxia, developing brain, endothelial nitric oxide synthase, inducible nitric oxide synthase, neuroprotection, sodium nitrite, nitric oxide donors, secondary brain injury, microcirculation
MeSH terms
Animals, Brain Injuries, Cerebrovascular Circulation, Humans, Nitric Oxide, Signal Transduction, Nitric Oxide Synthase

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review