The DOI matches its Crossref record; 108 of the 109 references it cites were found in a registry or an index.
The role of the nitric oxide pathway in brain injury and its treatment — From bench to bedside
Open accessAbstract
Nitric oxide (NO) is a key signalling molecule in the regulation of cerebral blood flow. This review summarises current evidence regarding the role of NO in the regulation of cerebral blood flow at rest, under physiological conditions, and after brain injury, focusing on subarachnoid haemorrhage, traumatic brain injury, and ischaemic stroke and following cardiac arrest. We also review the role of NO in the response to hypoxic insult in the developing brain. NO depletion in ischaemic brain tissue plays a pivotal role in the development of subsequent morbidity and mortality through microcirculatory disturbance and disordered blood flow regulation. NO derived from endothelial nitric oxide synthase (eNOS) appears to have neuroprotective properties. However NO derived from inducible nitric oxide synthase (iNOS) may have neurotoxic effects. Cerebral NO donor agents, for example sodium nitrite, appear to replicate the effects of eNOS derived NO, and therefore have neuroprotective properties. This is true in both the adult and immature brain. We conclude that these agents should be further investigated as targeted pharmacotherapy to protect against secondary brain injury.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Nitric oxide species at low doses is critical for maintaining healthy microglia and neuron function, but at high doses can induce necrosis or apoptosis [53].”
From Polyphenol Microbial Metabolites Exhibit Gut and Blood–Brain Barrier Permeability and Protect Murine Microglia against LPS-Induced Inflammation (2019) · cites this paper as [53]
Citations
Cites
1 retracted
Pluta, R. M. (2008) · Acta neurochirurgica. Supplementum · doi:10.1007/978-3-211-75718-5_28 · Cited by 63
RetractedNITRIC OXIDE AND MACROPHAGE FUNCTION
MacMicking, J. D., Xie, Q. W., & Nathan, C. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.323 · Cited by 4,245
Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress
Cai, H., & Harrison, D. G. (2000) · Circulation Research · doi:10.1161/01.res.87.10.840 · Cited by 3,839
SPREADING DEPRESSION OF ACTIVITY IN THE CEREBRAL CORTEX
Leão, A. A. P. (1944) · Journal of Neurophysiology · doi:10.1152/jn.1944.7.6.359 · Cited by 2,686
Glial and neuronal control of brain blood flow
Attwell, D., Buchan, A. M., Charpak, S., Lauritzen, M., MacVicar, B. A., & Newman, E. A. (2010) · Nature · doi:10.1038/nature09613 · Cited by 2,511
van Gijn, J., Kerr, R. S. C., & Rinkel, G. J. E. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60153-6 · Cited by 1,703
Superoxide generation by endothelial nitric oxide synthase: The influence of cofactors
Vásquez-Vivar, J., Kalyanaraman, B., Martásek, P., Hogg, N., Masters, B. S. S., Karoui, H., Tordo, P., & Pritchard, K. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9220 · Cited by 1,484
Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease
Reiter, C. D., Wang, X., Tanus-Santos, J. E., Hogg, N., Cannon, R. O., Schechter, A. N., & Gladwin, M. T. (2002) · Nature Medicine · doi:10.1038/nm1202-799 · Cited by 1,330
Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease
Girouard, H., & Iadecola, C. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00966.2005 · Cited by 1,311
Dreier, J. P. (2011) · Nature Medicine · doi:10.1038/nm.2333 · Cited by 1,132
Cited by
Sorted by citations
Fricker, M., Tolkovsky, A. M., Borutaitė, V., Coleman, M. P., & Brown, G. C. (2018) · Physiological Reviews · doi:10.1152/physrev.00011.2017 · Cited by 1,148
Arginase: A Multifaceted Enzyme Important in Health and Disease
Caldwell, R. W., Rodriguez, P. C., Toque, H. A., Narayanan, S. P., & Caldwell, R. B. (2018) · Physiological Reviews · doi:10.1152/physrev.00037.2016 · Cited by 495
Arginase: an old enzyme with new tricks
Caldwell, R. B., Toque, H. A., Narayanan, S. P., & Caldwell, R. W. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.03.006 · Cited by 358
Uzdensky, A. B. (2019) · APOPTOSIS · doi:10.1007/s10495-019-01556-6 · Cited by 293
Anti-Inflammatory Targets for the Treatment of Reperfusion Injury in Stroke
Mizuma, A., & Yenari, M. A. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00467 · Cited by 228
Metadata
- Authors
- Garry, P. S., Ezra, M., Rowland, M. J., Westbrook, J., & Pattinson, K. T. S.
- Affiliations
- John Radcliffe Hospital (GB)
- Corresponding author
- Garry, P.S.
- Venue
- Experimental Neurology
- Publisher
- Elsevier BV
- Published
- 2015-01
- Volume
- 263
- Pages
- 235-243
- ISSN
- 0014-4886 (ISSN-L)
- OpenAlex
- W2055065148
- Cited by
- 380
- References
- 109
- Citations by year
- 2026: 13 · 2025: 26 · 2024: 25 · 2023: 34 · 2022: 35 · 2021: 51 · 2020: 53 · 2019: 36 · 2018: 28 · 2017: 36 · 2016: 30 · 2015: 13
- FWCI
- 3.08
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Experimental Neurology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Oxford University Clinical Academic Graduate School
- Medical Research Council
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Life Sciences › Neuroscience › Neurology › Neuroprotection in Cerebral Ischemia
- Keywords
- nitric oxide, cerebral autoregulation, brain injury, subarachnoid hemorrhage, traumatic brain injury, ischemic stroke, cardiac arrest, hypoxia, developing brain, endothelial nitric oxide synthase, inducible nitric oxide synthase, neuroprotection, sodium nitrite, nitric oxide donors, secondary brain injury, microcirculation
- MeSH terms
- Animals, Brain Injuries, Cerebrovascular Circulation, Humans, Nitric Oxide, Signal Transduction, Nitric Oxide Synthase
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
