CoChat
Sign Up
Cited by 38Aluminum toxicity and tolerance in plants and animalsHeavy Metal Exposure and ToxicityTrace Elements in Health

The DOI matches its Crossref record.

Investigation of the aluminium biokinetics in humans: a 26Al tracer study

Steinhausen, C., Kislinger, G., Winklhofer, C., Beck, E., Hohl, C., Nolte, E., Ittel, Thomas H., Alvarez-Brückmann, Michael J.L.·2004·Food and Chemical Toxicology
DOI 10.1016/j.fct.2003.09.010
Open this paper in CoChat — free account

Abstract

Despite the well-known toxicity of aluminium in chronic renal failure, a solid database on its biokinetics has been difficult to establish. A highly sensitive method using (26)Al as tracer and accelerator mass spectrometry (AMS) for detection was used. No perturbing background and saturation effects were taken into account using a delta function input of aluminium in time. Aluminium absorption, distribution, speciation and excretion in six healthy volunteers and in two patients with chronic renal failure were investigated following administration of a single oral or i.v. dose of (26)Al. Serial samples of blood and urine were taken. In a speciation study, the time dependence of the binding of (26)Al to low-molecular weight molecules in serum was investigated. The measured data were compared and interpreted with simulations in an open compartmental model. Fractional absorption, distribution, excretion and time constants for the aluminium transport were determined. Typical intestinal absorption rates for AlCl(3) were found to be in the range of 10(-3). The ultrafiltrable percentage of aluminium in serum of one volunteer was estimated to be 5.6+/-0.8%. Differences between healthy volunteers and patients with chronic renal failure were deduced. The employed method using (26)Al and ams has proven to be highly sensitive for investigations of aluminium biokinetics at the ultra-trace element level. With the model, the measured values of (26)Al in serum and urine were used to precisely determine absorption, speciation, distribution, retention and excretion of aluminium in humans.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.fct.2003.09.010

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 34

  1. Barker, 1997, AMS measurements to study uptake and distribution of 26Al in mice and the role of the transferrin receptor in Al absorption mechanism, Nucl. Instr. and Meth. B, 123, 275, 10.1016/S0168-583X(96)00704-5 · DOI
  2. Berend, 2001, Acute aluminum encephalopathy in a dialysis center caused by a cement mortar water distribution pipe, Kidney Int., 59, 746, 10.1046/j.1523-1755.2001.059002746.x · DOI
  3. Cannata-Andia, 1998, Hypokinetic azotemic osteodystrophy, Kidney Int., 54, 1000, 10.1046/j.1523-1755.1998.00080.x · DOI
  4. Caramelo, 1995, Mechanisms of aluminum-induced microcytosis: lessons from accidental aluminum intoxication, Kidney Int., 47, 164, 10.1038/ki.1995.19 · DOI
  5. Day, 1991, Aluminum absorption studied by 26Al tracer, Lancet, 337, 1345, 10.1016/0140-6736(91)93016-3 · DOI · Paper page
  6. Day, 1994, Biological chemistry of Al studied using 26Al and AMS, Nucl Instr. and Meth. B, 92, 463, 10.1016/0168-583X(94)96055-0 · DOI
  7. Diaz-Corte, 2001, Effect of aluminium load on parathyroid hormone synthesis, Nephrol. Dial. Transplant, 16, 742, 10.1093/ndt/16.4.742 · DOI
  8. Dunea, 2001, Dialysis dementia, Asaio J., 47, 192, 10.1097/00002480-200105000-00002 · DOI
  9. Fernandez-Martin, 2000, Aluminum exposure in chronic renal failure in iberoamerica at the end of the 1990s, Am. J. Med. Sci., 320, 96, 10.1097/00000441-200008000-00006 · DOI
  10. Fernandez-Martin, 1998, Prevention of aluminium exposure through dialysis fluids. Analysis of changes in the last 8 years, Nephrol. Dial. Transplant, 13, 78, 10.1093/ndt/13.suppl_3.78 · DOI
  11. Harris, 1992, Equilibrium model for speciation of aluminum in serum, Clin. Chem., 38, 1809, 10.1093/clinchem/38.9.1809 · DOI
  12. Hdez-Jaras, 1998, Accidental aluminum intoxication in patients undergoing acetate-free biofiltration, Nephron, 78, 274, 10.1159/000044935 · DOI
  13. Hohl, 1994, Medical application of 26Al, Nucl. Instr. and Meth. B, 92, 478, 10.1016/0168-583X(94)96058-5 · DOI
  14. Ittel, 1993, Determinants of gastrointestinal absorption and distribution of aluminium in health and uraemia, Nephrol. Dial. Transplant, 8, 17, 10.1093/ndt/8.supp1.17 · DOI
  15. Ittel, 1997, Ultrasensitive analysis of the intestinal absorption and compartmentalization of aluminium in uraemic rats, Nephrol. Dial. Transplant, 12, 1369, 10.1093/ndt/12.7.1369 · DOI
  16. Jouhanneau, 1993, Gastrointestinal absorption of aluminum in rats using 26Al and accelerator mass spectrometry, Clin. Nephrol., 40, 244
  17. Jouhanneau, 1997, Gastrointestinal absorption, tissue retention, and urinary excretion of dietary aluminum in rats determined by using 26Al, Clin. Chem., 43, 1023, 10.1093/clinchem/43.6.1023 · DOI · Paper page
  18. King, 1997, The influence of dissolved silicate on the physiological chemistry of Al, studied in humans using tracer 26Al and AMS, Nucl. Instr. and Meth. B, 123, 254, 10.1016/S0168-583X(96)00699-4 · DOI
  19. King, 1997, Determination of aluminium-26 in biological materials by accelerator mass spectrometry, Analyst, 122, 1049, 10.1039/a702002c · DOI
  20. Kislinger, 1997, Investigations of the human aluminium biokinetics with 26Al and AMS, Nucl. Instr. Meth. B, 123, 259, 10.1016/S0168-583X(96)00624-6 · DOI
  21. Lin, 1997, Aluminum utensils contribute to aluminum accumulation in patients with renal disease, Am. J. Kidney Dis., 30, 653, 10.1016/S0272-6386(97)90489-3 · DOI · Paper page
  22. Meirav, 1990, Application of AMS in Al metabolism studies, Nucl. Instr. and Meth. B, 52, 536, 10.1016/0168-583X(90)90472-7 · DOI
  23. Meirav, 1991, Accelerator mass spectrometry, Am. J. Physiol., 260, F466
  24. Nolte, 2001, Compartmental model for aluminium biokinetics, Hum. Exp. Toxicol., 20, 111, 10.1191/096032701673730925 · DOI
  25. Ohman, 1994, Citrate as the main small molecule binding Al3+ in serum, Clin. Chem., 40, 598, 10.1093/clinchem/40.4.598 · DOI
  26. Priest, 1995, Human metabolism of aluminium-26 and gallium-67 injected as citrates, Hum. Exp. Toxicol., 14, 287, 10.1177/096032719501400309 · DOI
  27. Priest, 1996, The bioavailability of 26Al-labelled aluminium citrate and aluminium hydroxide in volunteers, Biometals, 9, 221, 10.1007/BF00817919 · DOI
  28. Salahudeen, 2000, Race-dependent survival disparity on hemodialysis, Am. J. Kidney Dis., 36, 1147, 10.1053/ajkd.2000.19828 · DOI
  29. Schonholzer, 1997, Intestinal absorption of trace amounts of aluminium in rats studied with 26aluminium and accelerator mass spectrometry, Clin. Sci. (Lond.), 92, 379, 10.1042/cs0920379 · DOI
  30. Smans, 2000, Transferrin-mediated uptake of aluminium by human parathyroid cells results in reduced parathyroid hormone secretion, Nephrol. Dial. Transplant, 15, 1328, 10.1093/ndt/15.9.1328 · DOI
  31. Steinhausen, 1996, Medical application of 26Al, Nucl. Instr. and Meth. B, 113, 479, 10.1016/0168-583X(95)01378-4 · DOI
  32. Winklhofer, 2000, Effect of iron status on the absorption, speciation and tissue distribution of aluminium in rats, Nucl. Instr. Meth. B, 172, 920, 10.1016/S0168-583X(00)00228-7 · DOI
  33. Wrobel, 1995, Aluminium and silicon speciation in human serum by ion-exchange high-performance liquid chromatography–electrothermal atomic absorption spectrometry and gel electrophoresis, Analyst, 120, 809, 10.1039/AN9952000809 · DOI
  34. Yumoto, 1997, 26Al uptake and accumulation in the rat brain, Nucl. Instr. and Meth. B, 123, 279, 10.1016/S0168-583X(96)00429-6 · DOI

Cited by

Sorted by citations

Metadata

Authors
Steinhausen, C., Kislinger, G., Winklhofer, C., Beck, E., Hohl, C., Nolte, E., Ittel, T. H., & Alvarez-Brückmann, M. J. L.
Affiliations
  • Technical University of Munich (DE)
  • RWTH Aachen University (DE)
Corresponding author
Nolte, E.
ORCID
Venue
Food and Chemical Toxicology
Publisher
Elsevier BV
Published
2004-03
Volume
42
Issue
3
Pages
363-371
ISSN
0278-6915 (ISSN-L)
DOI
10.1016/j.fct.2003.09.010
OpenAlex
W2076928358
Cited by
38
References
0
Citations by year
2024: 1 · 2022: 5 · 2021: 3 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 2 · 2013: 1 · 2012: 2
FWCI
1.96
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Food and Chemical Toxicology (publishedVersion)
  • PubMed (publishedVersion)
  • RWTH Publications (RWTH Aachen) (submittedVersion)
Funders
  • Deutsche Forschungsgemeinschaft
  • Bundesministerium für Bildung und Forschung
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
  • Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Keywords
accelerator mass spectrometry, chronic kidney disease, aluminum speciation, aluminum absorption, ultratrace elements, compartmental model, aluminum chloride
MeSH terms
Administration, Oral, Aluminum, Body Fluid Compartments, Humans, Injections, Intravenous, Kidney Failure, Chronic, Male, Models, Biological, Particle Accelerators, Radioisotopes, Mass Spectrometry

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review