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Cited by 74Gut microbiota and healthGarlic and Onion StudiesNatural Products and Biological Research

Effect of red pepper Capsicum annuum var. conoides and garlic Allium sativum on plasma lipid levels and cecal microflora in mice fed beef tallow

Kuda, Takashi, Iwai, Akiko, Yano, Toshihiro·2004·Food and Chemical Toxicology
DOI 10.1016/j.fct.2004.06.007
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Abstract

Antihyperlipidemia or hypocholesterolaemic and antibacterial activities of red hot pepper and garlic are well known. To determine the effect of the dietary spices ingested to suppress blood lipids on the intestinal condition, we examined plasma lipid levels and cecal microflora in mice that were fed diets containing 19% (w/w) beef tallow and 2% red pepper Capsicum annuum var. conoides 'Takanotume' (RP) or garlic Allium sativum 'White' (GP) for 4-weeks. Plasma triacylglyceride level was suppressed by the spices. RP lowered cecal bacteroidaceae, a predominant bacterial group (from 9.4 to 9.0 log CFU/g), bifidobacteria (from 8.7 to 7.6 log CFU/g), and staphylococci. Although GP increased the cecal weight including their contents, significant differences were not shown in the cecal microflora. These results suggest that RP can affect the intestinal condition and host health through the disturbance of intestinal microflora.

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Crossref · 10.1016/j.fct.2004.06.007

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  • Allicin degradation products are commonly isolated from oil, aqueous and chloroform garlic extracts and are present as (E) and (Z) isomers, where (E)-ajoene is usually found in double amounts.

    “These degradation products are commonly isolated from oil, aqueous and chloroform garlic extracts and are present as (E) and (Z) isomers, where (E)-ajoene is usually found in double amounts [44].”

    From Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review (2020) · cites this paper as [44]

  • Allicin and garlic oil showed potent antifungal effects against Candida albicans, Ascosphaera apisin, and A. niger and acted by penetrating the cellular membrane and organelle membranes like mitochondria, leading to organelle destruction and cell death.

    “Moreover, allicin and garlic oil showed potent antifungal effects against Candida albicans, Ascosphaera apisin, and A. niger [44] and they acted by penetrating the cellular membrane as well as organelles membranes like the mitochondria and leading to organelles destruction and cell death [57].”

    From Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review (2020) · cites this paper as [44]

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Authors
Kuda, T., Iwai, A., & Yano, T.
Corresponding author
Kuda, Takashi
ORCID
Kuda, Takashi
Venue
Food and Chemical Toxicology
Publisher
Elsevier BV
Published
2004-10
Volume
42
Issue
10
Pages
1695-1700
ISSN
0278-6915 (ISSN-L)
DOI
10.1016/j.fct.2004.06.007
OpenAlex
W2069179910
Cited by
74
References
27
Citations by year
2026: 2 · 2025: 7 · 2024: 6 · 2023: 9 · 2022: 4 · 2021: 4 · 2020: 2 · 2019: 5 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 7 · 2013: 4 · 2012: 3
FWCI
0.47
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Food and Chemical Toxicology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Garlic and Onion Studies
  • Health Sciences › Medicine › Surgery › Natural Products and Biological Research
Keywords
red pepper, garlic, spices, plasma lipid levels, triglycerides, cecal microbiota, beef tallow, Bacteroidaceae, Bifidobacterium, Staphylococcus, gut microbiota, hypolipidemic effect
MeSH terms
Animals, Body Weight, Capsicum, Cattle, Cecum, Diet, Dietary Fats, Epididymis, Feces, Garlic, Glycerides, Hydrogen-Ion Concentration, Lipids, Male, Mice, Inbred ICR, Organ Size, Mice

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