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Cited by 64Drug-Induced Hepatotoxicity and ProtectionProtein Hydrolysis and Bioactive PeptidesMedicinal plant effects and applications

Antihepatotoxic effect of corn peptides against Bacillus Calmette-Guerin/lipopolysaccharide-induced liver injury in mice

Guo, Hui, Sun, Jie, He, Hui, Yu, Guo-Cai, Du, Jing·2009·Food and Chemical Toxicology
DOI 10.1016/j.fct.2009.06.041
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Abstract

Hepatitis is a severe disease with a high incidence rate around the world [Hwang, J.M., Tseng, T.H., Tsai, Y.Y., Lee, H.J., Chou, F.P., Wang, C.J., Chu, C.Y., 2005. Protective effects of baicalein on tert-butyl hydroperoxide-induced hepatic toxicity in rat hepatocytes. J. Biomed. Sci. 12, 389-397]. Corn gluten meal is a byproduct of starch industry with abundant protein. However, the application of corn protein is limited because of its low solubility and short of essential amino acids such as lysine and tryptophan. The hepatoprotective activity of corn peptides (CP) from corn gluten meal hydrolysate was evaluated against Bacillus Calmette-Guerin (BCG)/lipopolysaccharide (LPS) induced immunological liver injury (ILI) in mice. Results showed that ILI was manifested by a significant increase in levels of serum aspartate aminotransferase (AST)/alanine aminotransferase (ALT) and liver malondialdehyde (MDA)/nitric oxide (NO) levels (p<0.01), and by a significant decrease in levels of superoxide dismutase (SOD)/glutathione peroxidase (GPX) and glutathione (GSH) in liver (p<0.01). Pretreatment of mice with CP reversed these altered parameters to normal values. The effect of CP was further demonstrated by histopathological examination of liver sections. The best hepatoprotective effect of CP treatment was observed at the dose of 600 mg/kg bw, which was evidenced from biochemical parameters and liver histopathological characters. Results of this study revealed that CP could afford a s…

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References 32 · Cited by 64

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  1. Babu, 2001, Antioxidant and hepatoprotective effect of Acanthus ilicifolius, Fitoterapia, 72, 272, 10.1016/S0367-326X(00)00300-2 · DOI
  2. Balakirev, 1997, Modulation of the mitochondrial permeability transition by nitric oxide, Eur. J. Biochem., 246, 710, 10.1111/j.1432-1033.1997.00710.x · DOI
  3. Beutler, 1963, Improved method for the determination of blood glutathione, J. Lab. Clin. Med., 61, 882
  4. Bhandarkar, 2004, Antihepatotoxic effect of Nymphaea stellata willd., against carbon tetrachloride-induced hepatic damage in albino rats, J. Ethnopharmacol., 91, 61, 10.1016/j.jep.2003.11.020 · DOI
  5. Bradford, 1976, A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein–dye binding, Anal. Biochem., 72, 248, 10.1016/0003-2697(76)90527-3 · DOI · Paper page
  6. Chang, 2004, Study on anti-fatigue effect of corn-peptide, Shipin Kexue., 25, 173
  7. Comporti, 1985, Lipid peroxidation and cellular damage in toxic liver injury, Lab. Invest., 53, 599
  8. Ferluga, 1981, Tuberculin hypersensitivity hepatitis in mice infected with Mycobacterium bovis (BCG), Am. J. Pathol., 105, 82
  9. Girish, 2004, Evaluation of hepatoprotective effect of Amalkadi Ghrita against carbon tetrachloride-induced hepatic damage in rats, J. Ethnopharmacol., 90, 229, 10.1016/j.jep.2003.09.037 · DOI · Paper page
  10. Gowri Shankar, 2008, Hepatoprotective and antioxidant effects of Commiphora berryi (Arn) Engl bark extract against CCl4-induced oxidative damage in rats, Food Chem. Toxicol., 46, 3182, 10.1016/j.fct.2008.07.010 · DOI
  11. Guler, 2004, Inhibition of inducible nitric oxide synthase protects against liver injury induced by mycobacterial infection and endotoxins, J. Hepatol., 41, 773, 10.1016/j.jhep.2004.07.031 · DOI
  12. He, 2008, The hepatoprotective effects of Ganoderma lucidum peptides against carbon tetrachloride-induced liver injury in mice, J. Food Biochem., 32, 628, 10.1111/j.1745-4514.2008.00191.x · DOI
  13. Huang, 2005, Study on immunoloregulation effect of peptide S-8300 from shark liver, Chin. J. Nat. Med., 3, 121
  14. Hwang, 2005, Protective effects of baicalein on tert-butyl hydroperoxide-induced hepatic toxicity in rat hepatocytes, J. Biomed. Sci., 12, 389, 10.1007/s11373-005-1572-8 · DOI
  15. Jayakumar, 2006, Antioxidant activity of the oyster mushroom, Pleurotus ostreatus, on CCl4-induced liver injury in rats, Food Chem. Toxicol., 44, 1989, 10.1016/j.fct.2006.06.025 · DOI
  16. Kim, 1996, A nitric oxide production bioassay for interferongamma, J. Immunol. Methods, 198, 203, 10.1016/S0022-1759(96)00162-7 · DOI
  17. Kim, 2004, Preparation of corn gluten hydrolysate with angiotensin I converting enzyme inhibitory activity and its solubility and moisture sorption, Process Biochem., 39, 989, 10.1016/S0032-9592(03)00205-X · DOI
  18. Lozano, 2003, Immunomodulatory activity of TNF-a during acute liver injury induced by d-galactosamine and its protection by PGE1 in rats, Int. Immunopharmacol., 3, 197, 10.1016/S1567-5769(02)00259-X · DOI
  19. Luo, 1997, Comprehensive exploitation of corn and new extraction processing of oil and protein from corn, China Oils Fats, 22, 17
  20. Ohkawa, 1979, Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction, Anal. Biochem., 95, 351, 10.1016/0003-2697(79)90738-3 · DOI
  21. Reitman, 1957, Colorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminases, Am. J. Clin. Pathol., 28, 56, 10.1093/ajcp/28.1.56 · DOI
  22. Roos, 1959, Protection of phagocytic leucocytes by endogenous glutathione: studies in a family with glutathione reductase deficiency, Blood, 53, 851, 10.1182/blood.V53.5.851.851 · DOI
  23. Rotruck, 1973, Selenium: biochemical role as a component of glutathione peroxidase, Science, 179, 588, 10.1126/science.179.4073.588 · DOI
  24. Situnayake, 1990, Lipid peroxidation and hepatic antioxidants in alcoholic liver disease, Gut, 31, 1311, 10.1136/gut.31.11.1311 · DOI
  25. Thiemerann, 1995, The multiple organ dysfunction syndrome caused by endotoxin in the rat: attenuation of liver dysfunction by inhibitors of nitric oxide synthase, Br. J. Pharacol., 116, 2845, 10.1111/j.1476-5381.1995.tb15935.x · DOI
  26. Tung, 2009, Protective effect of Acacia confusa bark extract and its active compound gallic acid against carbon tetrachloride-induced chronic liver injury in rats, Food Chem. Toxicol., 47, 1385, 10.1016/j.fct.2009.03.021 · DOI
  27. Vaca, 1988, Interaction of lipid peroxidation product with DNA, Mutat. Res., 195, 137, 10.1016/0165-1110(88)90022-X · DOI
  28. Wills, 2006, Protective effect of Lygodium flexuosum (L.) Sw. (Lygodiaceae) against d-galactosamine induced liver injury in rats, J. Ethnopharmacol., 108, 116, 10.1016/j.jep.2006.04.028 · DOI
  29. Xu, 2002, Study on the preparation of corn functional oligopeptides and its SOD-like activity, Chin. J. Biochem. Pharm., 23, 78
  30. Yamaguchi, M., Nishikiori, F., Ito, M., Furukawa, Y., 1997. The effects of corn peptide ingestion on facilitating alcohol metabolism in healthy men. Biosci. Biotech. Biochem. 6l (9), 1474–1481. · DOI
  31. Zhang, 2002, Study on nitric oxide and liver injury, Progr. Anat. Sci., 8, 75
  32. Zou, 2006, Prevention of hepatic injury by a traditional Chinese formulation, BJ-JN, in mice treated with Bacille-Calmette-Guerin and lipopolysaccharide, J. Ethnopharmacol., 107, 442, 10.1016/j.jep.2006.04.006 · DOI

Authors
Guo, H., Sun, J., He, H., Yu, G.-C., & Du, J.
Affiliations
  • Huazhong Agricultural University (CN)
  • General Mills (United States) (US)
Corresponding author
He, Hui
ORCID
Venue
Food and Chemical Toxicology
Publisher
Elsevier BV
Published
2009-10
Volume
47
Issue
10
Pages
2431-2435
ISSN
0278-6915 (ISSN-L)
DOI
10.1016/j.fct.2009.06.041
OpenAlex
W2088283894
Cited by
64
References
32
Citations by year
2026: 1 · 2024: 2 · 2023: 2 · 2022: 5 · 2021: 7 · 2020: 4 · 2019: 1 · 2018: 6 · 2017: 9 · 2016: 3 · 2015: 4 · 2014: 3 · 2013: 5 · 2012: 5
FWCI
3.56
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Food and Chemical Toxicology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Ministry of Science and Technology of the People's Republic of China
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Protein Hydrolysis and Bioactive Peptides
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal plant effects and applications
Keywords
corn peptides, corn gluten meal, hepatoprotection, immune-mediated liver injury, oxidative stress, antioxidant enzymes, malondialdehyde, nitric oxide, glutathione, aspartate aminotransferase, alanine aminotransferase
MeSH terms
Administration, Oral, Alanine Transaminase, Animals, Antioxidants, Aspartate Aminotransferases, Zea mays, Disease Models, Animal, Glutens, Lipopolysaccharides, Liver, Male, Mice, Inbred Strains, Mycobacterium bovis, Oxidoreductases, Peptides, Plant Extracts, Plant Proteins, Dietary, Oxidative Stress, Mice, Chemical and Drug Induced Liver Injury

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