Exposure to bisphenol A appears to impair hippocampal neurogenesis and spatial learning and memory
Abstract
Bisphenol A (BPA) is widely used in the manufacture of plastics and epoxy resins, and is known to affect reproductive organ growth and development. However, the effects of BPA on hippocampal neurogenesis are unclear in young adult mice. Therefore, the present study was conducted to examine the effects of BPA on hippocampal neurogenesis and learning as well as memory performance in young adult mice. BPA (1, 5, and 20 mg/kg/day) was administered orally to mice for 2 weeks. It was found that high-dose BPA (20 mg/kg/day) decreased the number of newly generated cells in hippocampus, but that low-dose BPA (1 mg/kg) increased the survival of newly generated cells in hippocampi of young mice. Furthermore, high-dose BPA (20mg/kg/day) was found to impair learning and memory performance significantly. However, no significant differences were observed between high- and low-dose treated mice in terms of levels of brain-derived neurotrophic factor (BDNF) or reactive oxygen species production in hippocampus. In addition, BPA treatment did not induce neuronal loss or damage or astrocyte activation. These data suggest that exposure to BPA causes fluctuations in hippocampal neurogenesis in young adult mice that result in spatial learning and memory impairment via a BDNF-independent pathway.
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BPA may negatively affect neurogenesis in DG.
“BPA may negatively affect neurogenesis in DG3441”
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High dose bisphenol A impairs hippocampal neurogenesis in female mice across generations
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- Authors
- Kim, M. E., Park, H. R., Gong, E. J., Choi, S. Y., Kim, H. S., & Lee, J.
- Affiliations
- Pusan National University (KR)
- Corresponding author
- Lee, Jaewon
- Venue
- Food and Chemical Toxicology
- Publisher
- Elsevier BV
- Published
- 2011-12
- Volume
- 49
- Issue
- 12
- Pages
- 3383-3389
- ISSN
- 0278-6915 (ISSN-L)
- OpenAlex
- W2050986988
- Cited by
- 95
- References
- 4
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 11 · 2023: 5 · 2022: 6 · 2021: 5 · 2020: 5 · 2019: 2 · 2018: 5 · 2017: 11 · 2016: 8 · 2015: 8 · 2014: 9 · 2013: 10 · 2012: 3
- FWCI
- 2.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Food and Chemical Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Food and Drug Safety Evaluation, Korea FDA (09182 NTP 599)
- National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST) (20090083538)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- bisphenol A, hippocampal neurogenesis, spatial learning and memory, dose-dependent effects, young adult mice, reactive oxygen species, endocrine disruptors, plastic exposure
- MeSH terms
- Bisphenol A Compounds, Animals, Benzhydryl Compounds, Dose-Response Relationship, Drug, Hippocampus, Male, Memory, Memory Disorders, Mice, Inbred C57BL, Phenols, Reactive Oxygen Species, Maze Learning, Brain-Derived Neurotrophic Factor, Mice, Neurogenesis
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