A BDNF autocrine loop in adult sensory neurons prevents cell death

Acheson, Ann; Conover, Joanne C.; Fandl, James P.; DeChiara, Thomas M.; Russell, Michelle; Thadani, Anu; Squinto, Stephen P.; Yancopoulos, George D.; Lindsay, Ronald M.

doi:10.1038/374450a0

Cited by 765Nerve injury and regenerationPain Mechanisms and TreatmentsHereditary Neurological Disorders

A BDNF autocrine loop in adult sensory neurons prevents cell death

Acheson, Ann, Conover, Joanne C., Fandl, James P., DeChiara, Thomas M., Russell, Michelle, Thadani, Anu, Squinto, Stephen P., Yancopoulos, George D. +1 more·1995·Nature

DOI 10.1038/374450a0

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Abstract

During the initial phase of their development, sensory neurons of the dorsal root ganglion (DRG) require target-derived trophic support for their survival, but as they mature they lose this requirement. Because many of these neurons express BDNF (brain-derived neurotrophic factor) messenger RNA, we hypothesized that BDNF might act as an autocrine survival factor in adult DRG neurons, thus explaining their lack of dependence on exogenous growth factors. When cultured adult DRG cells were treated with antisense oligonucleotides to BDNF, expression of BDNF protein was reduced by 80%, and neuronal survival was reduced by 35%. These neurons could be rescued by exogenous BDNF or neurotrophin-3, but not by other growth factors. Similar results were obtained with single-neuron microcultures, whereas microcultures derived from mutant mice lacking BDNF were unaffected by antisense oligonucleotides. Our results strongly support an autocrine role for BDNF in mediating the survival of a subpopulation of adult DRG neurons.

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Through an autocrine loop initiated by BDNF, newly generated neurons are better protected against cell death.
“Through an autocrine loop initiated by BDNF, these newly generated neurons are also better protected against cell death (Acheson et al., 1995).”
From Exercise-Mediated Neurogenesis in the Hippocampus via BDNF (2018) · cites this paper as Acheson et al., 1995

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Authors: Acheson, A., Conover, J. C., Fandl, J. P., DeChiara, T. M., Russell, M., Thadani, A., Squinto, S. P., Yancopoulos, G. D., & Lindsay, R. M.
Affiliations: Regeneron (United States) (US)
ORCID: Conover, Joanne C.
Lindsay, Ronald M.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1995-03
Volume: 374
Issue: 6521
Pages: 450-453
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/374450a0
OpenAlex: W2000304313
Cited by: 765
References: 32
Citations by year: 2026: 12 · 2025: 19 · 2024: 21 · 2023: 23 · 2022: 30 · 2021: 33 · 2020: 25 · 2019: 28 · 2018: 42 · 2017: 35 · 2016: 27 · 2015: 28 · 2014: 27 · 2013: 26 · 2012: 17
FWCI: 16.28
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Hereditary Neurological Disorders
Keywords: brain-derived neurotrophic factor, autocrine signaling, dorsal root ganglion neurons, sensory neuron survival, neuronal cell death, neurotrophin-3, antisense oligonucleotides, growth factor dependence
MeSH terms: Aging, Animals, Cells, Cultured, Ganglia, Spinal, Nerve Tissue Proteins, Neurons, Afferent, Polysaccharides, RNA, Messenger, Oligonucleotides, Antisense, Cell Death, Brain-Derived Neurotrophic Factor, Mice

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A BDNF autocrine loop in adult sensory neurons prevents cell death

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