Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats
Abstract
In the autoradiograms of young rats injected with thymidine‐H 3 many of the granule cells of the dentate gyrus were found labeled. The number of labeled cells declined rapidly with increased age at the time of injection. Histological studies showed the presence in young rats of a large germinal matrix of mitotic cells in the ependymal and subependymal layers of the third and lateral ventricles. The areal extent and cell population of this germinal pool declined rapidly from birth on, with a transient rise with a peak at about 15 days. During this latter period the number of “undifferentiated” cells near the granular layer of the dentate gyrus showed a rapid rise with a subsequent decline. The decline in the number of “undifferentiated” cells was accompanied by a rise in the number of differentiated granule cells. Cell counts in homologous parts of the dentate gyrus indicated a six‐fold increase in the number of differentiated granule cells from birth to three months. We postulated that undifferentiated cells migrate postnatally from the forebrain ventricles to the hippocampus where they become differentiated. The possible functional significance of delayed hippocampal neurogenesis is discussed with reference to our finding of incorporation of testosterone‐H 3 by cells of the hippocampus, implicating that they may function as receptors of gonadal hormones.
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The dentate gyrus of the hippocampus is the brain region where the most active neurogenesis has been documented to take place.
“The dentate gyrus of the hippocampus is the brain region where the most active neurogenesis has been documented to take place23–25.”
From Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB (2021) · cites this paper as [23]
Adult neurogenesis within the DG is well-established in rodents.
“since adult neurogenesis within the DG is well-established in rodents (Altman & Das 1965).”
From Perineuronal net deglycosylation associates with tauopathy‐induced gliosis and neurodegeneration (2024) · cites this paper as Altman & Das 1965
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Hippocampal Neurogenesis: Regulation by Stress and Antidepressants
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Murine features of neurogenesis in the human hippocampus across the lifespan from 0 to 100 years
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Understanding the broad influence of sex hormones and sex differences in the brain
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Neural stem cells from adult hippocampus develop essential properties of functional CNS neurons
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Short‐term and long‐term survival of new neurons in the rat dentate gyrus
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Genetic influence on neurogenesis in the dentate gyrus of adult mice
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Cell types, lineage, and architecture of the germinal zone in the adult dentate gyrus
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Retrospective Birth Dating of Cells in Humans
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Self-citationDifferentiation of adult hippocampus-derived progenitors into olfactory neurons in vivo
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- Authors
- Altman, J., & Das, G. D.
- Affiliations
- Massachusetts Institute of Technology (US)
- Venue
- Journal of Comparative Neurology
- Publisher
- Wiley
- Published
- 1965-06
- Volume
- 124
- Issue
- 3
- Pages
- 319-335
- ISSN
- 0021-9967 (ISSN-L)
- 1096-9861
- OpenAlex
- W1980499453
- Cited by
- 3,592
- References
- 18
- Citations by year
- 2026: 55 · 2025: 79 · 2024: 66 · 2023: 92 · 2022: 112 · 2021: 131 · 2020: 130 · 2019: 136 · 2018: 116 · 2017: 128 · 2016: 132 · 2015: 143 · 2014: 142 · 2013: 145 · 2012: 160
- FWCI
- 6.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Comparative Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- dentate gyrus granule cells, germinal matrix, ependymal layer, undifferentiated cells, cell migration, rat brain development
- MeSH terms
- Animals, Animals, Newborn, Autoradiography, Cell Differentiation, Hippocampus, Testosterone, Thymidine, Tritium, Rats, In Vitro Techniques
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