Phytol: A review of biomedical activities

Biological effects of essential oils—A review

Bakkali, F., Averbeck, S., Averbeck, D., & Idaomar, M. (2008) · Food and Chemical Toxicology · doi:10.1016/j.fct.2007.09.106 · Cited by 7,929 · see citing works

Origin and physiological roles of inflammation

Medzhitov, R. (2008) · Nature · doi:10.1038/nature07201 · Cited by 6,618 · see citing works

The mechanisms of action of PPARs

Berger, J., & Moller, D. E. (2002) · Annual Review of Medicine · doi:10.1146/annurev.med.53.082901.104018 · Cited by 2,659 · see citing works

Integrating cell-signalling pathways with NF-κB and IKK function

Perkins, N. D. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2083 · Cited by 2,350 · see citing works

Introduction to NF-κB: players, pathways, perspectives

Gilmore, T. D. (2006) · Oncogene · doi:10.1038/sj.onc.1209954 · Cited by 2,227 · see citing works

Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens

Nathan, C., & Shiloh, M. U. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.16.8841 · Cited by 1,469 · see citing works

Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors

Dreyer, C., Krey, G. D., Keller, H., Givel, F., Helftenbein, G., & Wahli, W. (1992) · Cell · doi:10.1016/0092-8674(92)90031-7 · Cited by 1,373 · see citing works

The Kyoto protocol of IASP Basic Pain Terminology ☆

Loeser, J. D., & Treede, R. (2008) · Pain · doi:10.1016/j.pain.2008.04.025 · Cited by 1,240 · see citing works

In vitro antibacterial activity of some plant essential oils

Prabuseenivasan, S., Jayakumar, M., & Savarimuthu Ignacimuthu, S. J. (2006) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-6-39 · Cited by 1,031 · see citing works

The Peroxisome Proliferator-Activated Receptor: A Family of Nuclear Receptors Role in Various Diseases

Tyagi, S., Gupta, P., Saini, A., Kaushal, C., & Sharma, S. (2011) · Journal of Advanced Pharmaceutical Technology & Research · doi:10.4103/2231-4040.90879 · Cited by 1,017 · see citing works

Antibacterial activity and mechanism of cinnamon essential oil against Escherichia coli and Staphylococcus aureus

Zhang, Y., Liu, X., Wang, Y., Jiang, P., & Quek, S. Y. (2015) · Food Control · doi:10.1016/j.foodcont.2015.05.032 · Cited by 943 · see citing works

From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions

Feige, J. N., Gelman, L., Michalik, L., Desvergne, B., & Wahli, W. (2006) · Progress in Lipid Research · doi:10.1016/j.plipres.2005.12.002 · Cited by 786 · see citing works

Benzodiazepine pharmacology and central nervous system-mediated effects.

(2013) · Europe PMC (PubMed Central) · Cited by 650 · see citing works

The NF-κB Regulatory Network

Brasier, A. R. (2006) · Cardiovascular Toxicology · doi:10.1385/ct:6:2:111 · Cited by 528 · see citing works

Hooked on benzodiazepines: GABAA receptor subtypes and addiction

Tan, K. R., Rudolph, U., & Lüscher, C. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.01.004 · Cited by 363 · see citing works

Antinociceptive and Antioxidant Activities of Phytol In Vivo and In Vitro Models

Bertozzo, C. C. D. M. S., Salvadori, M. G. D. S. S., Mota, V. G., Costa, L. M., de Almeida, A. A. C., de Oliveira, G. A. L., Costa, J. P., de Sousa, D. P., de Freitas, R. M., & de Almeida, R. N. (2013) · Neuroscience Journal · doi:10.1155/2013/949452 · Cited by 346 · see citing works

Self-report bias and underreporting of depression on the BDI-II

Hunt, M., Auriemma, J., & Cashaw, A. C. A. (2003) · Journal of Personality Assessment · doi:10.1207/s15327752jpa8001_10 · Cited by 301 · see citing works

Phytol, a diterpene alcohol, inhibits the inflammatory response by reducing cytokine production and oxidative stress

Silva, R. O., Sousa, F. B. M., Damasceno, S., et al. (2013) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.12049 · Cited by 271 · see citing works

Antimicrobial activity of essential oils

Andrade, B. F. M. T., Barbosa, L. N., Probst, I. D. S., & Júnior, A. F. (2013) · Journal of Essential Oil Research · doi:10.1080/10412905.2013.860409 · Cited by 269 · see citing works

Transcription coactivators for peroxisome proliferator-activated receptors.

Yu, S.-T., & Reddy, J. (2007) · Biochimica et Biophysica Acta · doi:10.1016/j.bbalip.2007.01.008 · Cited by 252 · see citing works

Phytol degradation products as biogeochemical tracers in aquatic environments

Rontani, J., & Volkman, J. K. (2003) · Organic Geochemistry · doi:10.1016/s0146-6380(02)00185-7 · Cited by 242 · see citing works

Clustered DNA lesion repair in eukaryotes: Relevance to mutagenesis and cell survival

Sage, É., & Harrison, L. (2010) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2010.12.010 · Cited by 233 · see citing works

Phytol, a Diterpene Alcohol from Chlorophyll, as a Drug against Neglected Tropical Disease Schistosomiasis Mansoni

de Moraes, J., de Oliveira, R. N., Costa, J. P., et al. (2014) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0002617 · Cited by 219 · see citing works

A Salvage Pathway for Phytol Metabolism in Arabidopsis

Ischebeck, T., Zbierzak, A. M., Kanwischer, M., & Dörmann, P. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509222200 · Cited by 209 · see citing works

Food additives, contaminants and other minor components: effects on human gut microbiota—a review

Roca-Saavedra, P., Mendez-Vilabrille, V., Miranda, J. M., Lamas, A., Nebot, C., Cardelle‐Cobas, A., Cepeda, A., & Cepeda, A. (2017) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-017-0564-2 · Cited by 196 · see citing works

Depression and anxiety in epilepsy

Jackson, M. J. (2005) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2004.060467 · Cited by 192 · see citing works

Posttraumatic Stress Disorder: Clinical Features, Pathophysiology, and Treatment

Vieweg, W. V. R., Julius, D. A., Fernandez, A., Beatty-Brooks, M., Hettema, J. M., & Pandurangi, A. K. (2006) · The American Journal of Medicine · doi:10.1016/j.amjmed.2005.09.027 · Cited by 186 · see citing works

A Bioinformatics Analysis of Memory Consolidation Reveals Involvement of the Transcription Factor c-Rel

Levenson, J. M., Choi, S., Lee, S.-Y., Cao, Y. A., Ahn, H. J., Worley, K. C., Pizzi, M., Liou, H.-C., & Sweatt, J. D. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5646-03.2004 · Cited by 171 · see citing works

Modulation of Vigilance in the Primary Hypersomnias by Endogenous Enhancement of GABAA Receptors

Rye, D., Bliwise, D., Parker, K., Trotti, L., Saini, P., Fairley, J., Freeman, A. A. H., García, P., Owens, M. J., Ritchie, J., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004685 · Cited by 170 · see citing works

Furtherin vitroevaluation of antiradical and antimicrobial activities of phytol

Pejin, B., Savic, A. G., Sokóvić, M., et al. (2014) · Natural Product Research · doi:10.1080/14786419.2013.869692 · Cited by 162 · see citing works

Biphasic Effects of Geranylgeraniol, Teprenone, and Phytol on the Growth of Staphylococcus aureus

Inoue, Y. H., Hada, T., Shiraishi, A., et al. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.5.1770-1774.2005 · Cited by 155 · see citing works

Phytanic acid metabolism in health and disease

Wanders, R. J. A., Komen, J. C., & Ferdinandusse, S. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.06.006 · Cited by 143 · see citing works

Phytanic acid: production from phytol, its breakdown and role in human disease

van den Brink, D. M., & Wanders, R. J. A. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5463-y · Cited by 134 · see citing works

Phytol/Phytanic Acid and Insulin Resistance: Potential Role of Phytanic Acid Proven by Docking Simulation and Modulation of Biochemical Alterations

Elmazar, M. M., El-Abhar, H. S., Schaalan, M. F., & Farag, N. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0045638 · Cited by 133 · see citing works

In vitro anti-quorum sensing activity of phytol

Pejin, B., Ćirić, A., Glamočlija, J., Nikolić, M., & Sokóvić, M. (2014) · Natural Product Research · doi:10.1080/14786419.2014.945088 · Cited by 128 · see citing works

PPAR‐γAgonists and Their Effects on IGF‐I Receptor Signaling: Implications for Cancer

Belfiore, A., Genua, M., & Malaguarnera, R. (2009) · PPAR Research · doi:10.1155/2009/830501 · Cited by 116 · see citing works

Phytol in a pharma-medico-stance

Islam, M. T., de Alencar, M. V. O. B., Machado, K. D. C., Machado, K. D. C., Cavalcante, A. A. D. C. M., de Sousa, D. P., & de Freitas, R. M. (2015) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2015.07.010 · Cited by 115 · see citing works

Phytol induces ROS mediated apoptosis by induction of caspase 9 and 3 through activation of TRAIL, FAS and TNF receptors and inhibits tumor progression factor Glucose 6 phosphate dehydrogenase in lung carcinoma cell line (A549)

Thakor, P., Subramanian, R. B., Thakkar, S. S., et al. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.05.066 · Cited by 115 · see citing works

Anxiolytic-like effects of phytol: Possible involvement of GABAergic transmission

Costa, J. P., de Oliveira, G. A. L., de Almeida, A. A. C., Islam, M. T., de Sousa, D. P., & de Freitas, R. M. (2013) · Brain Research · doi:10.1016/j.brainres.2013.12.003 · Cited by 112 · see citing works

Rotenone-like Action of the Branched-chain Phytanic Acid Induces Oxidative Stress in Mitochondria

Schönfeld, P., & Reiser, G. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513198200 · Cited by 103 · see citing works

Anticonvulsant effect of phytol in a pilocarpine model in mice

Costa, J. P., Ferreira, P. M. P., de Sousa, D. P., et al. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.06.055 · Cited by 99 · see citing works

Effects of dietary phytol and phytanic acid in animals

Steinberg, D. H., Avigan, J., Mize, C. E., Baxter, J. H., Cammermeyer, J., Fales, H. M., & Highet, P. F. (1966) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39251-8 · Cited by 93 · see citing works

The reappraisal of benzodiazepines in the treatment of anxiety and related disorders

Starcevic, V. (2014) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2014.963057 · Cited by 90 · see citing works

Antimicrobial Activity, Toxicity and Stability of Phytol as a Novel Surface DisinfectantPreprint

Ghaneian, M. T., Ehrampoush, M. H., Jebali, A., et al. (2015) · SSRN Electronic Journal · Cited by 86 · see citing works

Antitubercular potential of some semisynthetic analogues of phytol

Saikia, D., Parihar, S., Chanda, D., et al. (2009) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2009.11.107 · Cited by 78 · see citing works

Phytol Induces Apoptosis and ROS-Mediated Protective Autophagy in Human Gastric Adenocarcinoma AGS Cells

(2015) · Biochemistry & Analytical Biochemistry · doi:10.4172/2161-1009.1000211 · Cited by 62 · see citing works

Phytol suppresses melanogenesis through proteasomal degradation of MITF via the ROS-ERK signaling pathway

Ko, G., & Cho, S. K. (2018) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2018.02.033 · Cited by 59 · see citing works

Phytol increases adipocyte number and glucose tolerance through activation of PI3K/Akt signaling pathway in mice fed high-fat and high-fructose diet

Wang, J., Hu, X., Ai, W., Zhang, F., Yang, K., Wang, L., Zhu, X., Gao, P., Shu, G., Jiang, Q., et al. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.05.160 · Cited by 55 · see citing works

Oxygen toxicity, free radicals and antioxidants in human disease: biochemical implications in atherosclerosis and the problems of premature neonates.

Rice-Evans, C. A., & Gopinathan, V. (1995) · PubMed · Cited by 54 · see citing works

Metabolism of phytol to phytanic acid in the mouse, and the role of PPARα in its regulation

Gloerich, J., van den Brink, D. M., Ruiter, J. P. N., van Vlies, N., Vaz, F. M., Wanders, R. J. A., & Ferdinandusse, S. (2006) · Journal of Lipid Research · doi:10.1194/jlr.m600050-jlr200 · Cited by 53 · see citing works

Extraction and purification of phytol from Abutilon indicum: cytotoxic and apoptotic activity

Thakor, P., Mehta, J. B., Patel, R., et al. (2016) · RSC Advances · doi:10.1039/c5ra24464a · Cited by 53 · see citing works

Phytanic acid consumption and human health, risks, benefits and future trends: A review

Roca-Saavedra, P., Mariño-Lorenzo, P., Miranda, J. M., Porto-Arias, J. J., Lamas, A., Vázquez, B. I., Franco, C. M., & Cepeda, A. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2016.10.074 · Cited by 53 · see citing works

Evaluation of toxic, cytotoxic and genotoxic effects of phytol and its nanoemulsion

Islam, M. T., Streck, L., de Alencar, M. V. O. B., et al. (2017) · Chemosphere · doi:10.1016/j.chemosphere.2017.02.145 · Cited by 53 · see citing works

Phytol stimulates the browning of white adipocytes through the activation of AMP-activated protein kinase (AMPK) α in mice fed high-fat diet

Zhang, F., Ai, W., Hu, X., Meng, Y., Yuan, C., Su, H., Wang, L., Zhu, X., Gao, P., Shu, G., et al. (2018) · Food & Function · doi:10.1039/c7fo01817g · Cited by 52 · see citing works

Phytol-loaded PLGA nanoparticle as a modulator of Alzheimer’s toxic Aβ peptide aggregation and fibrillation associated with impaired neuronal cell function

Sathya, S., Shanmuganathan, B., Saranya, S., Sethuraman, V., Kandasamy, R., & Devi, K. P. (2017) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2017.1391822 · Cited by 51 · see citing works

Further evidence for GABA-ergic mechanisms in the action of benzodiazepines.

Vv, Z., Ostrovskaya, R. U., Kozhechkin, S. N., et al. (1977) · PubMed · Cited by 51 · see citing works

Phytol induces programmed cell death in human lymphoid leukemia Molt 4B cells.

Komiya, T., Kyohkon, M., Ohwaki, S., et al. (1999) · International Journal of Molecular Medicine · doi:10.3892/ijmm.4.4.377 · Cited by 50 · see citing works

Prevention of Vitamin A Teratogenesis by Phytol or Phytanic Acid Results from Reduced Metabolism of Retinol to the Teratogenic Metabolite, All-trans-retinoic Acid

Arnhold, T. (2002) · Toxicological Sciences · doi:10.1093/toxsci/66.2.274 · Cited by 49 · see citing works

Anti-scratching Behavioral Effect of the Essential Oil and Phytol Isolated fromArtemisia princepsPamp. in Mice

Ryu, K., Choi, J.-Y., Chung, S., et al. (2010) · Planta Medica · doi:10.1055/s-0030-1250119 · Cited by 49 · see citing works

Activation of Caspase‐9/3 and Inhibition of Epithelial Mesenchymal Transition are Critically Involved in Antitumor Effect of Phytol in Hepatocellular Carcinoma Cells

Kim, C., Lee, H. J., Jung, J. H., Kim, Y. H., Jung, D., Sohn, E. J., Lee, J. H., Woo, H. J., Baek, N., Kim, Y. C., et al. (2015) · Phytotherapy Research · doi:10.1002/ptr.5342 · Cited by 47 · see citing works

Preparation of phytol-loaded nanoemulsion and screening for antioxidant capacity

Islam, M. T., Streck, L., Paz, M. F. C. J., et al. (2016) · International Archives of Medicine · doi:10.3823/1941 · Cited by 46 · see citing works

Phytol Derivatives as Drug Resistance Reversal Agents

Upadhyay, H. C., Dwivedi, G. R., Roy, S., et al. (2014) · ChemMedChem · doi:10.1002/cmdc.201402027 · Cited by 44 · see citing works

Phytol-induced Hepatotoxicity in Mice

Mackie, J. T., Atshaves, B. P., Payne, H. R., McIntosh, A. L., Schroeder, F., & Kier, A. B. (2009) · Toxicologic Pathology · doi:10.1177/0192623308330789 · Cited by 42 · see citing works

Neurochemical evidence that phytanic acid induces oxidative damage and reduces the antioxidant defenses in cerebellum and cerebral cortex of rats

Leipnitz, G., Amaral, A. U., Zanatta, Â., Seminotti, B., Fernandes, C. G., Knebel, L. A., Vargas, C. R., & Wajner, M. (2010) · Life Sciences · doi:10.1016/j.lfs.2010.06.015 · Cited by 37 · see citing works

Phytol, SSADH inhibitory diterpenoid ofLactuca sativa

Bang, M., Choi, S. Y., Jang, T.-O., et al. (2002) · Archives of Pharmacal Research · doi:10.1007/bf02976937 · Cited by 36 · see citing works

Two natural products, trans-phytol and (22E)-ergosta-6,9,22-triene-3β,5α,8α-triol, inhibit the biosynthesis of estrogen in human ovarian granulosa cells by aromatase (CYP19)

Guo, J., Yuan, Y. F., Lu, D., Du, B., Xiong, L., Shi, J., Yang, L., Liu, W., Yuan, X., Zhang, G., et al. (2014) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2014.05.008 · Cited by 35 · see citing works

Biosynthesis of Phytol in the Cyanobacterium Synechocystis sp. UTEX 2470: Utilization of the Non-Mevalonate Pathway

Proteau, P. (1998) · Journal of Natural Products · doi:10.1021/np980006q · Cited by 32 · see citing works

Peroxisomal trans‐2‐enoyl‐CoA reductase is involved in phytol degradation

Gloerich, J., Ruiter, J. P. N., van den Brink, D. M., Ofman, R., Ferdinandusse, S., & Wanders, R. J. A. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.03.011 · Cited by 30 · see citing works

A Phytol‐Enriched Diet Activates PPAR‐α in the Liver and Brown Adipose Tissue to Ameliorate Obesity‐Induced Metabolic Abnormalities

An, J.-Y., Jheng, H., Nagai, H., Sanada, K., Takahashi, H., Iwase, M., Watanabe, N., Kim, Y.-I., Teraminami, A., Takahashi, N., et al. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700688 · Cited by 29 · see citing works

Phytol-induced pathology in 2-hydroxyacyl-CoA lyase (HACL1) deficient mice. Evidence for a second non-HACL1-related lyase

Mezzar, S., de Schryver, E., Asselberghs, S., Meyhi, E., Morvay, P. L., Baes, M. I., & Veldhoven, P. P. V. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2017.06.004 · Cited by 28 · see citing works

Novel immunomodulatory effects of phytanic acid and its related substances in mice

Nakanishi, T., Anraku, M., Suzuki, R., Kono, T., Erickson, L., & Kawahara, S. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.12.028 · Cited by 26 · see citing works

Phytanic acid induces Neuro2a cell death via histone deacetylase activation and mitochondrial dysfunction

Nagai, K. (2015) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2015.01.006 · Cited by 25 · see citing works

The presence of phytol in brown and blue-green algae and its relationship to evolution

de Souza, N. J., & Nes, W. R. (1969) · Phytochemistry · doi:10.1016/s0031-9422(00)85865-3 · Cited by 25 · see citing works

Characterization of the Final Step in the Conversion of Phytol into Phytanic Acid

van den Brink, D. M., van Miert, J. N. I., Dacremont, G., Rontani, J., & Wanders, R. J. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501861200 · Cited by 25 · see citing works

Phytol a Natural Diterpenoid with Pharmacological Applications on Central Nervous System: A Review

Costa, J. P., Oliveira, J. D. S., Rezende, L. M., et al. (2015) · Recent Patents on Biotechnology · doi:10.2174/187220830803150605162745 · Cited by 24 · see citing works

Phytol isolated from watermelon (Citrullus lanatus) sprouts induces cell death in human T-lymphoid cell line Jurkat cells via S-phase cell cycle arrest

Itoh, T., Ono, A., Kawaguchi, K., Teraoka, S., Harada, M., Sumi, K., Andô, M., Tsukamasa, Y., Ninomiya, M., Koketsu, M., et al. (2018) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.03.033 · Cited by 23 · see citing works

Reactive nitrogen species mediate oxidative stress and astrogliosis provoked by in vivo administration of phytanic acid in cerebellum of adolescent rats: A potential contributing pathomechanism of cerebellar injury in peroxisomal disorders

Borges, C. G., Canani, C. R., Fernandes, C. G., et al. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.07.028 · Cited by 21 · see citing works

Molecular signatures of phytol-derived immunostimulants in the context of chemokine–cytokine microenvironment and enhanced immune response

Aachoui, Y., Chowdhury, R. R., Fitch, R. W., et al. (2011) · Cellular Immunology · doi:10.1016/j.cellimm.2011.07.001 · Cited by 20 · see citing works

Toxic effects of phytol and retinol on human glioblastoma cells are associated with modulation of cholesterol and fatty acid biosynthetic pathways

Facchini, G., Ignarro, R. S., Rodrigues-Silva, E., et al. (2017) · Journal of Neuro-Oncology · doi:10.1007/s11060-017-2672-9 · Cited by 20 · see citing works

The effect of the phytol-rich fraction from Lacistema pubescens against Leishmania amazonensis is mediated by mitochondrial dysfunction

da Silva, J. M., Antinarelli, L. M. R., Ribeiro, A. D. D. C., et al. (2015) · Experimental Parasitology · doi:10.1016/j.exppara.2015.09.009 · Cited by 19 · see citing works

Synthetic adjuvants for vaccine formulations: Evaluation of new phytol derivatives in induction and persistence of specific immune response

Aachoui, Y., Schulte, M., Fitch, R. W., et al. (2011) · Cellular Immunology · doi:10.1016/j.cellimm.2011.07.009 · Cited by 19 · see citing works

Phytol Is a Novel Tumor Promoter on ICR Mouse Skin

Kagoura, M., Matsui, C., & Morohashi, M. (1999) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1999.tb00758.x · Cited by 17 · see citing works

Free-radical decarboxylation of carboxylic acids as a concerted abstraction and fragmentation reaction

Denisov, E. T., & Shestakov, A. F. (2013) · Kinetics and Catalysis · doi:10.1134/s0023158413010059 · Cited by 17 · see citing works

Efficacy of phytol-derived diterpenoid immunoadjuvants over alum in shaping the murine host's immune response to Staphylococcus aureus

Chowdhury, R. R., Fitch, R. W., & Ghosh, S. K. (2013) · Vaccine · doi:10.1016/j.vaccine.2012.12.069 · Cited by 16 · see citing works

The Effect of Essential Oil Intake on Changes of Plasma Antioxidant Status in Mice

Faix, S., Juhás, Š., & Faixová, Z. (2007) · Acta Veterinaria Brno · doi:10.2754/avb200776030357 · Cited by 13 · see citing works

Phytol May Inspire New Medicinal Foods for the Treatment of Heart Disease

Pejin, B., Kartali, T., Stanimirović, B., et al. (2014) · Asian Journal of Chemistry · doi:10.14233/ajchem.2014.18571 · Cited by 13 · see citing works

Diol- and triol-types of phytol induce apoptosis in lymphoid leukemia Molt 4B cells

Hibasami, H., Kyohkon, M., Owaki, S., et al. (2002) · International Journal of Molecular Medicine · doi:10.3892/ijmm.10.5.555 · Cited by 12 · see citing works

Effect of Dietary Phytol on the Expression of α-Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase, a Key Enzyme of Tryptophan-niacin Metabolism, in Rats

Matsuda, H., Ryo-ta, G. O. M. I., Hirai, S., & Egashira, Y. (2013) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.130029 · Cited by 6 · see citing works

Histological evaluation of rat mammary tumours after treatment with retinoic acid analogues — phytol, TTNPB and vitamin D3 analogue seocalcitol

Líška, J., Ondková, S., Macejová, D., et al. (2011) · Biologia · doi:10.2478/s11756-011-0024-3 · Cited by 2 · see citing works

Quantitative relationships between molecular descriptors, chromatographic retention behavior, andin vitroantituberculosis activity of phytol derivatives

Singh, R., Meena, A., Negi, A. S., et al. (2012) · Journal of Planar Chromatography – Modern TLC · doi:10.1556/jpc.25.2012.1.2 · Cited by 2 · see citing works

Molecular Evaluation of RNase from Aspergillus niger and Phytol of Nymphaea pubescens as Cytoskeletol targeting elements in Cancer

Chikati, R. (2013) · Epidemiology Open Access · Cited by 2 · see citing works

Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation

Sharifi-Rad, J., Rapposelli, S., Sestito, S., Herrera-Bravo, J., Arancibia-Diaz, A., Salazar, L. A., Yeskaliyeva, B., Beyatli, A., Leyva-Gómez, G., González-Contreras, C., et al. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12091515 · Cited by 125 · see citing works

Phytol metabolism in the bovine

Patton, S., & Benson, A. A. (1966) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(66)90140-8 · Cited by 91 · see citing works

Effects of dietary phytol and phytanic acid in animals

Steinberg, D. H., Avigan, J., Mize, C. E., Baxter, J. H., Cammermeyer, J., Fales, H. M., & Highet, P. F. (1966) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39251-8 · Cited by 93 · see citing works

Metabolism of long-chain isoprenoid alcohols Incorporation of phytol and dihydrophytol into the lipids of rat brain

Su, K. L., & Schmid, H. H. O. (1975) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(75)90050-8 · Cited by 13 · see citing works

Phytol and Phytyl Fatty Acid Esters: Occurrence, Concentrations, and Relevance

Krauß, S., & Vetter, W. (2018) · European Journal of Lipid Science and Technology · doi:10.1002/ejlt.201700387 · Cited by 25 · see citing works

Phytanic and Pristanic Acid Are Naturally Occuring Ligands

Zomer, A. W. M., van der Saag, P. T., & Poll‐The, B. T. (2003) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-9072-3_32 · Cited by 3 · see citing works