Cited by 269NF-κB Signaling PathwaysNatural Compounds in Disease TreatmentImmune Response and Inflammation

Inhibitory action of novel aromatic diamine compound on lipopolysaccharide‐induced nuclear translocation of NF‐κB without affecting IκB degradation

Shin, Hyun-Mo, Kim, Min-Hee, Kim, Byung Hak, Jung, Sang-Hun, Kim, Yeong Shik, Park, Hye Ji, Hong, Jin Tae, Min, Kyung Rak +1 more·2004·FEBS Letters

Abstract

4‐Methyl‐N 1‐(3‐phenyl‐propyl)‐benzene‐1,2‐diamine (JSH‐23) is a novel chemically synthetic compound. The aromatic diamine JSH‐23 compound exhibited inhibitory effect with an IC 50 value of 7.1 μM on nuclear factor (NF)‐κB transcriptional activity in lipopolysaccharide (LPS)‐stimulated macrophages RAW 264.7, and interfered LPS‐induced nuclear translocation of NF‐κB without affecting IκB degradation. This mechanism of action is very rare for controlling NF‐κB activation. Furthermore, the compound inhibited not only LPS‐induced expressions of tumor necrosis factor‐α, interleukin (IL)‐1β, IL‐6 and inducible nitric oxide synthase and cyclooxygenase‐2 but also LPS‐induced apoptosis of the RAW 264.7 cells.

Integrity signals

Registry

Crossref · 10.1016/j.febslet.2004.06.056

Cites

24 of 24 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Shin, H.-M., Kim, M.-H., Kim, B. H., Jung, S.-H., Kim, Y. S., Park, H. J., Hong, J. T., Min, K. R., & Kim, Y.
Affiliations
  • Chungbuk National University (KR)
  • Chungnam National University (KR)
  • Seoul National University (KR)
Corresponding author
Kim, Youngsoo
Venue
FEBS Letters
Publisher
Wiley
Published
2004-07
Volume
571
Issue
1-3
Pages
50-54
ISSN
  • 0014-5793 (ISSN-L)
  • 1873-3468
OpenAlex
W2086559549
Cited by
269
References
24
Citations by year
2026: 19 · 2025: 20 · 2024: 18 · 2023: 14 · 2022: 12 · 2021: 25 · 2020: 15 · 2019: 10 · 2018: 18 · 2017: 14 · 2016: 9 · 2015: 18 · 2014: 11 · 2013: 7 · 2012: 8
FWCI
2.65
Type
journal article
Language
en
Open access
closed
Locations
  • FEBS Letters (publishedVersion)
  • PubMed (publishedVersion)
Funders
Korea Science and Engineering Foundation
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
  • Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
JSH-23, aromatic diamines, NF-κB nuclear translocation, lipopolysaccharide, macrophages, RAW 264.7 macrophages, IκB degradation, NF-κB transcriptional activity, TNF-α, IL-1β, interleukin-6, inducible nitric oxide synthase, cyclooxygenase-2, apoptosis, anti-inflammatory agents
MeSH terms
NF-KappaB Inhibitor alpha, Animals, Cell Line, Cell Nucleus, Cell Survival, Escherichia coli, Gene Expression Regulation, Inflammation, Kinetics, Lipopolysaccharides, Macrophages, Cytokines, NF-kappa B, Nitric Oxide Synthase, Reverse Transcriptase Polymerase Chain Reaction, I-kappa B Proteins, Protein Transport, Mice, Nitric Oxide Synthase Type II

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review