Nuclear factor-κB is a critical mediator of stress-impaired neurogenesis and depressive behavior
Open accessAbstract
Proinflammatory cytokines, such as IL-1β, have been implicated in the cellular and behavioral effects of stress and in mood disorders, although the downstream signaling pathways underlying these effects have not been determined. In the present study, we demonstrate a critical role for NF-κB signaling in the actions of IL-1β and stress. Stress inhibition of neurogenesis in the adult hippocampus, which has been implicated in the prodepressive effects of stress, is blocked by administration of an inhibitor of NF-κB. Further analysis reveals that stress activates NF-κB signaling and decreases proliferation of neural stem-like cells but not early neural progenitor cells in the adult hippocampus. We also find that depressive-like behaviors caused by exposure to chronic stress are mediated by NF-κB signaling. Together, these data identify NF-κB signaling as a critical mediator of the antineurogenic and behavioral actions of stress and suggest previously undescribed therapeutical targets for depression.
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Social defeat stress induces downstream inflammatory signaling pathways, such as NFkB, and increases monocyte trafficking throughout a number of CNS structures known to control depression and anxiety behavior.
“Our results are interesting in light of recent studies showing that social defeat stress induces downstream inflammatory signaling pathways, such as NFkB (26, 35 -37), and increases monocyte trafficking (29) throughout a number of CNS structures known to control depression and anxiety behavior.”
From Individual differences in the peripheral immune system promote resilience versus susceptibility to social stress (2014) · cites this paper as [36]
The Results (p. 3) show that acute immobilization stress increased NFκB activation in hippocampal neural stem-like cells, and the Discussion (p. 4) describes stress-activated IL-1β/NFκB signaling. The paper does not test social defeat stress specifically, so it supports the NFκB point but not that stress-model qualifier. Monocyte trafficking is attached to a different citation (29) and is not assessed here. (LLM, conf=0.86)
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Cites
Kessler, R. C., Berglund, P., Demler, O., Jin, R., Koretz, D., Merikangas, K. R., Rush, A. J., Walters, E. E., & Wang, P. S. (2003) · JAMA · doi:10.1001/jama.289.23.3095 · Cited by 7,988 · see citing works
From inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395 · see citing works
Missing Pieces in the NF-κB Puzzle
Ghosh, S., & Karin, M. (2002) · Cell · doi:10.1016/s0092-8674(02)00703-1 · Cited by 3,638 · see citing works
Astrocytes give rise to new neurons in the adult mammalian hippocampus
Seri, B., Garcı́a-Verdugo, J. M., McEwen, B. S., & Alvarez-Buylla, A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07153.2001 · Cited by 1,495 · see citing works
Adult hippocampal neurogenesis in depression
Sahay, A., & Hen, R. (2007) · Nature Neuroscience · doi:10.1038/nn1969 · Cited by 1,206 · see citing works
A mechanism converting psychosocial stress into mononuclear cell activation
Bierhaus, A., Wolf, J., Andrassy, M., Rohleder, N., Humpert, P. M., Petrov, D., Ferstl, R., von Eynatten, M., Wendt, T., Rudofsky, G., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0438019100 · Cited by 926 · see citing works
IL-1β is an essential mediator of the antineurogenic and anhedonic effects of stress
Koo, J. W., & Duman, R. S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708092105 · Cited by 862 · see citing works
Self-citationPace, T. W. W., Mletzko, T. C., Alagbe, O., Musselman, D. L., Nemeroff, C. B., Miller, A. H., & Heim, C. M. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.9.1630 · Cited by 810 · see citing works
Fluoxetine targets early progenitor cells in the adult brain
Encinas, J. M., Vaahtokari, A., & Enikolopov, G. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601992103 · Cited by 637 · see citing works
Munhoz, C. D., Lepsch, L. B., Kawamoto, E. M., Malta, M. B., Lima, L. D. S., Werneck Avellar, M. C., Sapolsky, R. M., & Scavone, C. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4398-05.2006 · Cited by 274 · see citing works
Shin, H.-M., Kim, M.-H., Kim, B. H., Jung, S.-H., Kim, Y. S., Park, H. J., Hong, J. T., Min, K. R., & Kim, Y. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.06.056 · Cited by 269 · see citing works
Zhou, Q., Hu, Y., Hua, Y., Hu, M., Luo, C., Han, X., Zhu, X., Wang, B., Xu, J., & Zhu, D. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04914.x · Cited by 225 · see citing works
An update on regional brain volume differences associated with mood disorders
Campbell, S., & MacQueen, G. (2006) · Current Opinion in Psychiatry · doi:10.1097/01.yco.0000194371.47685.f2 · Cited by 198 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The role of inflammation in depression: from evolutionary imperative to modern treatment target
Miller, A. H., & Raison, C. L. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2015.5 · Cited by 3,942 · see citing works
Reactive Astrocytes: Production, Function, and Therapeutic Potential
Liddelow, S. A., & Barres, B. A. (2017) · Immunity · doi:10.1016/j.immuni.2017.06.006 · Cited by 2,336 · see citing works
The brain reward circuitry in mood disorders
Russo, S. J., & Nestler, E. J. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3381 · Cited by 1,870 · see citing works
Self-citationRaison, C. L., Rutherford, R. E., Woolwine, B. J., Shuo, C., Schettler, P., Drake, D. F., Haroon, E., & Miller, A. H. (2013) · JAMA Psychiatry · doi:10.1001/2013.jamapsychiatry.4 · Cited by 1,617 · see citing works
Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications
Felger, J. C., & Lotrich, F. E. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.04.060 · Cited by 1,180 · see citing works
Sucrose preference test for measurement of stress-induced anhedonia in mice
Liu, M.-Y., Yin, C.-Y., Zhu, L.-J., Zhu, X.-H., Xu, C., Luo, C.-X., Chen, H., Zhu, D.-Y., & Zhou, Q.-G. (2018) · Nature Protocols · doi:10.1038/s41596-018-0011-z · Cited by 1,026 · see citing works
Haroon, E., Raison, C. L., & Miller, A. H. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.205 · Cited by 1,000 · see citing works
Lian, H., Yang, L., Cole, A., Sun, L., Chiang, A. C.-A., Fowler, S. W., Shim, D. J., Rodriguez-Rivera, J., Taglialatela, G., Jankowsky, J. L., et al. (2015) · Neuron · doi:10.1016/j.neuron.2014.11.018 · Cited by 697 · see citing works
Hodes, G. E., Pfau, M. L., Leboeuf, M., Golden, S. A., Christoffel, D. J., Bregman, D., Rebusi, N., Heshmati, M., Aleyasin, H., Warren, B. L., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1415191111 · Cited by 692 · see citing works
Self-citationIntegrating neuroimmune systems in the neurobiology of depression
Wohleb, E. S., Franklin, T., Iwata, M., & Duman, R. S. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.69 · Cited by 668 · see citing works
Self-citationNeuroimmune mechanisms of depression
Hodes, G. E., Kana, V., Menard, C., Merad, M., & Russo, S. J. (2015) · Nature Neuroscience · doi:10.1038/nn.4113 · Cited by 585 · see citing works
Self-citationPathogenesis of depression: Insights from human and rodent studies
Ménard, C., Hodes, G. E., & Russo, S. J. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2015.05.053 · Cited by 593 · see citing works
Self-citationThe inflammasome: Pathways linking psychological stress, depression, and systemic illnesses
Iwata, M., Ota, K. T., & Duman, R. S. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.12.008 · Cited by 580 · see citing works
Self-citationInflammasome signaling affects anxiety- and depressive-like behavior and gut microbiome composition
Wong, M.-L., Inserra, A., Lewis, M. D., Mastronardi, C. A., Leong, L., Choo, J., Kentish, S., Xie, P., Morrison, M., Wesselingh, S. L., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.46 · Cited by 568 · see citing works
Animal Models of Depression: Molecular Perspectives
Krishnan, V., & Nestler, E. J. (2011) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2010_108 · Cited by 528 · see citing works
Self-citationHow might circadian rhythms control mood? Let me count the ways
McClung, C. A. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.02.019 · Cited by 507 · see citing works
Inflammation in psychiatric disorders: what comes first?
Bauer, M. E., & Teixeira, A. L. (2019) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13712 · Cited by 500 · see citing works
The role of inflammation and the gut microbiome in depression and anxiety
Peirce, J. M., & Alviña, K. (2019) · Journal of Neuroscience Research · doi:10.1002/jnr.24476 · Cited by 466 · see citing works
Epigenetics of the depressed brain: role of histone acetylation and methylation
Sun, H., Kennedy, P. J., & Nestler, E. J. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.73 · Cited by 413 · see citing works
Self-citationIwata, M., Ota, K. T., Li, X.-Y., Sakaue, F., Li, N., Dutheil, S., Banasr, M., Duric, V., Yamanashi, T., Kaneko, K., et al. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.11.026 · Cited by 387 · see citing works
Self-citationMolecular adaptations of the blood–brain barrier promote stress resilience vs. depression
Dudek, K. A., Dion-Albert, L., Lebel, M., LeClair, K., Labrecque, S., Tuck, E., Ferrer Perez, C., Golden, S. A., Tamminga, C., Turecki, G., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1914655117 · Cited by 361 · see citing works
Self-citationHigh-Fat Diet Induced Anxiety and Anhedonia: Impact on Brain Homeostasis and Inflammation
Dutheil, S., Ota, K. T., Wohleb, E. S., Rasmussen, K., & Duman, R. S. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.357 · Cited by 355 · see citing works
Self-citationYue, N., Huang, H., Zhu, X., Han, Q., Wang, Y., Li, B., Liu, Q., Wu, G., Zhang, Y., & Yu, J. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0865-y · Cited by 334 · see citing works
Neuroplastic changes in depression: A role for the immune system
Eyre, H., & Baune, B. T. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.03.019 · Cited by 319 · see citing works
Metabolic disturbances connecting obesity and depression
Hryhorczuk, C., Sharma, S., & Fulton, S. E. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00177 · Cited by 322 · see citing works
Pace, T. W. W., & Heim, C. M. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.10.003 · Cited by 321 · see citing works
Induction of innate immune genes in brain create the neurobiology of addiction
Crews, F. T., Zou, J., & Qin, L. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2011.03.003 · Cited by 313 · see citing works
Wohleb, E. S., McKim, D. B., Shea, D. T., Powell, N. D., Tarr, A. J., Sheridan, J. F., & Godbout, J. P. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.11.029 · Cited by 300 · see citing works
IκB Kinase Regulates Social Defeat Stress-Induced Synaptic and Behavioral Plasticity
Christoffel, D. J., Golden, S. A., Dumitriu, D., Robison, A. J., Janssen, W. G., Ahn, H. F., Krishnan, V., Reyes, C. M., Han, M.-H., Ables, J. L., et al. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.4763-10.2011 · Cited by 267 · see citing works
Self-citationNeuroinflammation and neurodegeneration in overnutrition-induced diseases
Cai, D. (2013) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2012.11.003 · Cited by 256 · see citing works
Modulation of learning and memory by cytokines: Signaling mechanisms and long term consequences
Donzis, E. J., & Tronson, N. C. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2014.08.008 · Cited by 254 · see citing works
Hippocampal gene expression changes underlying stress sensitization and recovery
Gray, J. D., Rubin, T. G., Hunter, R. G., & McEwen, B. S. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.175 · Cited by 242 · see citing works
Yamanashi, T., Iwata, M., Kamiya, N., Tsunetomi, K., Kajitani, N., Wada, N., Iitsuka, T., Yamauchi, T., Miura, A., Pu, S., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-08055-1 · Cited by 214 · see citing works
Depression and sterile inflammation: essential role of danger associated molecular patterns
Franklin, T. C., Xu, C., & Duman, R. S. (2018) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.10.025 · Cited by 204 · see citing works
Self-citationWohleb, E. S., Patterson, J. M., Sharma, V., Quan, N., Godbout, J. P., & Sheridan, J. F. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.3723-13.2014 · Cited by 209 · see citing works
Yamawaki, Y., Yoshioka, N., Nozaki, K., Ito, H., Oda, K., Harada, K., Shirawachi, S., Asano, S., Aizawa, H., Yamawaki, S., et al. (2018) · Brain Research · doi:10.1016/j.brainres.2017.12.004 · Cited by 204 · see citing works
Molecular mechanisms in the regulation of adult neurogenesis during stress
Egeland, M., Zunszain, P. A., & Pariante, C. M. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3855 · Cited by 203 · see citing works
Jung, S., Choe, S., Woo, H., Jeong, H., An, H.-K., Moon, H., Ryu, H. Y., Yeo, B. K., Lee, Y. W., Choi, H., et al. (2020) · Autophagy · doi:10.1080/15548627.2019.1630222 · Cited by 183 · see citing works
Inflammatory cytokine-associated depression
Lotrich, F. E. (2015) · Brain Research · doi:10.1016/j.brainres.2014.06.032 · Cited by 183 · see citing works
Monje, F. J., Cabatic, M., Divisch, I., Kim, E.-J., Herkner, K. R., Binder, B. R., & Pollak, D. D. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1537-11.2011 · Cited by 178 · see citing works
Peripheral and central mechanisms of stress resilience
Pfau, M. L., & Russo, S. J. (2015) · Neurobiology of Stress · doi:10.1016/j.ynstr.2014.09.004 · Cited by 170 · see citing works
Self-citationWalker, F. R. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.10.002 · Cited by 175 · see citing works
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Alcocer-Gómez, E., Ulecia-Morón, C., Marín-Aguilar, F., Rybkina, T., Casas-Barquero, N., Ruiz-Cabello, J., Ryffel, B., Apetoh, L., Ghiringhelli, F., Bullón, P., et al. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9408-7 · Cited by 172 · see citing works
Antidepressant Effects of Fibroblast Growth Factor-2 in Behavioral and Cellular Models of Depression
Elsayed, M., Banasr, M., Duric, V., Fournier, N. M., Licznerski, P., & Duman, R. S. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.03.003 · Cited by 169 · see citing works
Self-citationKéri, S., Szabó, C., & Kelemen, O. (2014) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.03.020 · Cited by 165 · see citing works
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Johnson, J. D., Barnard, D. F., Kulp, A. C., & Mehta, D. M. (2019) · Journal of the Endocrine Society · doi:10.1210/js.2019-00053 · Cited by 135 · see citing works
Theberge, F. R., Li, X., Kambhampati, S., Pickens, C. L., St. Laurent, R., Bossert, J. M., Baumann, M. H., Hutchinson, M. R., Rice, K. C., Watkins, L. R., et al. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.12.019 · Cited by 119 · see citing works
Crider, A., Feng, T., Pandya, C. D., Davis, T., Nair, A., Ahmed, A. O., Baban, B., Turecki, G., & Pillai, A. (2018) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2018.03.004 · Cited by 112 · see citing works
Imipramine attenuates neuroinflammatory signaling and reverses stress-induced social avoidance
Ramirez, K., Shea, D. T., McKim, D. B., Reader, B. F., & Sheridan, J. F. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.01.016 · Cited by 108 · see citing works
Décarie-Spain, L., Sharma, S., Hryhorczuk, C., Issa-Garcia, V., Barker, P. A., Arbour, N., Alquier, T., & Fulton, S. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.01.018 · Cited by 107 · see citing works
Stress–response pathways are altered in the hippocampus of chronic alcoholics
McClintick, J. N., Xuei, X., Tischfield, J. A., Goate, A., Foroud, T., Wetherill, L., Ehringer, M. A., & Edenberg, H. J. (2013) · Alcohol · doi:10.1016/j.alcohol.2013.07.002 · Cited by 105 · see citing works
A model for streamlining psychotherapy in the RDoC era: the example of ‘Engage’
Alexopoulos, G. S., & Arean, P. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.150 · Cited by 95 · see citing works
Yue, N., Li, B., Yang, L., Han, Q.-Q., Huang, H.-J., Wang, Y.-L., Wang, J., Yu, R., Wu, G.-C., Liu, Q., et al. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00149 · Cited by 100 · see citing works
Dang, R., Zhou, X., Tang, M., Xu, P., Gong, X., Liu, Y., Jiao, H., & Jiang, P. (2018) · European Journal of Nutrition · doi:10.1007/s00394-016-1373-z · Cited by 93 · see citing works
Neuroplasticity and the next wave of antidepressant strategies
Hayley, S., & Litteljohn, D. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00218 · Cited by 92 · see citing works
Lotrich, F. E., Albusaysi, S., & Ferrell, R. E. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.263 · Cited by 92 · see citing works
Role of Inflammation in Depression: Implications for Phenomenology, Pathophysiology and Treatment
Raison, C. L., & Miller, A. H. (2013) · Modern Trends in Psychiatry · doi:10.1159/000343966 · Cited by 88 · see citing works
Aguilar-Valles, A., Haji, N., De Gregorio, D., Matta-Camacho, E., Eslamizade, M. J., Popic, J., Sharma, V., Cao, R., Rummel, C., Tanti, A., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04883-5 · Cited by 82 · see citing works
GSK3β: a master player in depressive disorder pathogenesis and treatment responsiveness
Duda, P., Hajka, D., Wójcicka, O., Rakus, D., & Gizak, A. (2020) · Cells · doi:10.3390/cells9030727 · Cited by 84 · see citing works
Effects of Inhibitor of κB Kinase Activity in the Nucleus Accumbens on Emotional Behavior
Christoffel, D. J., Golden, S. A., Heshmati, M., Graham, A., Birnbaum, S., Neve, R. L., Hodes, G. E., & Russo, S. J. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.121 · Cited by 78 · see citing works
Self-citationMolecular and cell signaling targets for PTSD pathophysiology and pharmacotherapy
Hauger, R. L., Olivares-Reyes, J. A., Dautzenberg, F. M., Lohr, J. B., Braun, S., & Oakley, R. H. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.11.007 · Cited by 71 · see citing works
The Biological Measurements of Mindfulness-based Stress Reduction: A Systematic Review
Reive, C. (2019) · EXPLORE · doi:10.1016/j.explore.2019.01.001 · Cited by 63 · see citing works
Moons, W. G., & Shields, G. S. (2015) · Emotion · doi:10.1037/emo0000055 · Cited by 64 · see citing works
Wieck, A., Grassi-Oliveira, R., do Prado, C. H., Rizzo, L. B., de Oliveira, A. S., Kommers-Molina, J., Viola, T. W., Teixeira, A. L., & Bauer, M. E. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2013.07.005 · Cited by 63 · see citing works
Domi, E., Uhrig, S., Soverchia, L., Spanagel, R., Hansson, A. C., Barbier, E., Heilig, M., Ciccocioppo, R., & Ubaldi, M. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.4127-15.2016 · Cited by 61 · see citing works
Addiction, Adolescence, and Innate Immune Gene Induction
Crews, F. T., & Vetreno, R. P. (2011) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2011.00019 · Cited by 52 · see citing works
Recent advances in psychoneuroimmunology: Inflammation in psychiatric disorders
Debnath, M., Doyle, K., Langan, C., McDonald, C., Leonard, B., & Cannon, D. (2011) · Translational Neuroscience · doi:10.2478/s13380-011-0019-0 · Cited by 28 · see citing works
Sun, T., Chen, Q., & Li, Y. (2021) · BMC Psychiatry · doi:10.1186/s12888-021-03509-3 · Cited by 19 · see citing works
Kalkman, H. O. (2023) · Biomedicines · doi:10.3390/biomedicines11030806 · Cited by 18 · see citing works
Greaney, J. L., Saunders, E. F. H., & Alexander, L. M. (2022) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00643.2021 · Cited by 17 · see citing works
Genomewide interaction and enrichment analysis on antidepressant response
Antypa, N., Drago, A., & Serretti, A. (2014) · Psychological Medicine · doi:10.1017/s0033291713001554 · Cited by 9 · see citing works
Stress-induced blood brain barrier disruption: Molecular mechanisms and signaling pathways
Welcome, M. O., & Mastorakis, N. E. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104769 · Cited by 139 · see citing works
- Authors
- Koo, J. W., Russo, S. J., Ferguson, D., Nestler, E. J., & Duman, R. S.
- Affiliations
- Yale University (US)
- Icahn School of Medicine at Mount Sinai (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2010-01-26
- Volume
- 107
- Issue
- 6
- Pages
- 2669-2674
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2823860
- OpenAlex
- W2001997781
- Cited by
- 607
- References
- 13
- Citations by year
- 2026: 20 · 2025: 28 · 2024: 34 · 2023: 40 · 2022: 38 · 2021: 53 · 2020: 46 · 2019: 27 · 2018: 40 · 2017: 46 · 2016: 36 · 2015: 45 · 2014: 29 · 2013: 39 · 2012: 42
- FWCI
- 12.36
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (2-PO1-MH25642, MH-45481, R01 MH-51399, R01MH051399, R37MH045481, P01MH025642, R01MH045481)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- NF-κB signaling, chronic stress, neurogenesis, hippocampus, depression, IL-1β, inflammatory cytokines, neural progenitor cells, neurogenesis inhibition, depression-like behavior, mood disorders
- MeSH terms
- Animals, Cells, Cultured, Depressive Disorder, Female, Hippocampus, Male, Mice, Transgenic, Neurons, Phenylenediamines, Restraint, Physical, Stem Cells, Stress, Psychological, Thiophenes, Signal Transduction, NF-kappa B, Rats, Sprague-Dawley, Cell Proliferation, Mice, Rats, Interleukin-1beta, Neurogenesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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