Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH

Carbonic anhydrase inhibitors

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Hypoxia-inducible expression of tumor-associated carbonic anhydrases.

Wykoff, C. C., Beasley, N. J. P., Watson, P. H., Turner, K., Pastorek, J., Sibtain, A., Wilson, G. D., Turley, H., Talks, K., Maxwell, P. H., et al. (2000) · PubMed · Cited by 1,260

Causes and consequences of tumour acidity and implications for treatment

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Acidic pH enhances the invasive behavior of human melanoma cells

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Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo.

Fukumura, D., Xu, L., Chen, Y., Gohongi, T., Seed, B., & Jain, R. K. (2001) · PubMed · Cited by 438

Acid production in glycolysis-impaired tumors provides new insights into tumor metabolism.

Helmlinger, G., Sckell, A., Dellian, M., Forbes, N. S., & Jain, R. K. (2002) · PubMed · Cited by 417

Down-regulation of transmembrane carbonic anhydrases in renal cell carcinoma cell lines by wild-type von Hippel-Lindau transgenes

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HumanMN/CA9Gene, a Novel Member of the Carbonic Anhydrase Family: Structure and Exon to Protein Domain Relationships

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A Transport Metabolon

Sterling, D., Reithmeier, R. A. F., & Casey, J. R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105959200 · Cited by 367

Carbonic Anhydrase: Its Inhibitors and Activators

Supuran, C. T., Scozzafava, A., & Conway, J. D. (2007) · Medical Entomology and Zoology · Cited by 349

CAIX-Mediated Control of LIN28/let-7 Axis Contributes to Metabolic Adaptation of Breast Cancer Cells to Hypoxia

Gibadulinová, A., Bullova, P., Strnad, H., Pohlodek, K., Jurkovičová, D., Takáčová, M., Pastoreková, S., & Švastová, E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124299 · Cited by 46

Bioreduction activated prodrugs of camptothecin: molecular design, synthesis, activation mechanism and hypoxia selective cytotoxicity

Zhang, Z., Tanabe, K., Hatta, H., & Nishimoto, S. (2005) · Organic & Biomolecular Chemistry · doi:10.1039/b502813b · Cited by 46

Carbonic anhydrase inhibitors: The X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors

Fiore, A. D., Pedone, C., Antel, J., Waldeck, H., Witte, A., Wurl, M., Scozzafava, A., Supuran, C. T., & Simone, G. D. (2008) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2008.03.023 · Cited by 46

Expression of Hypoxic Marker CA IX Is Regulated by Site-Specific DNA Methylation and Is Associated with the Histology of Gastric Cancer

Nakamura, J., Kitajima, Y., Kai, K., Hashiguchi, K., Hiraki, M., Noshirο, H., & Miyazaki, K. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2010.10.010 · Cited by 45

Carbonic anhydrase inhibitors. Inhibition of the cytosolic human isozymes I and II, and the transmembrane, tumor-associated isozymes IX and XII with substituted aromatic sulfonamides activatable in hypoxic tumors

Sa̧czewski, F., Slawinski, J. J., Kornicka, A., Brzozowski, Z., Pomarnacka, E., Innocenti, A., Scozzafava, A., & Supuran, C. T. (2006) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2006.06.064 · Cited by 45

Extramitochondrial domain rich in carbonic anhydrase activity improves myocardial energetics

Schroeder, M., Ali, M. A., Hulı́ková, A., Supuran, C. T., Clarke, K., Vaughan‐Jones, R. D., Tyler, D. J., & Swietach, P. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1213471110 · Cited by 45

Structural Basis of Nanomolar Inhibition of Tumor-Associated Carbonic Anhydrase IX: X‑Ray Crystallographic and Inhibition Study of Lipophilic Inhibitors with Acetazolamide Backbone

Andring, J. T., Fouch, M. E., Akocak, S., Angeli, A., Supuran, C. T., Ilies, M. A., & McKENNA, R. V. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c01390 · Cited by 45

Carbonic anhydrase activators: Activation of the human tumor-associated isozymes IX and XII with amino acids and amines

Pastoreková, S., Vullo, D., Nishimori, I., Scozzafava, A., Pastorek, J., & Supuran, C. T. (2008) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2008.02.021 · Cited by 45

Carbonic anhydrase inhibitors: Synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides

Brzozowski, Z., Slawinski, J. J., Sa̧czewski, F., Innocenti, A., & Supuran, C. T. (2010) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2010.02.020 · Cited by 44

Novel fluorinated carbonic anhydrase IX inhibitors reduce hypoxia-induced acidification and clonogenic survival of cancer cells

Kazokaitė, J., Niemans, R., Dudutienė, V., Becker, H. M., Leitāns, J., Zubrienė, A., Baranauskienė, L., Gondi, G., Zeidler, R., Matulienė, J., et al. (2018) · Oncotarget · doi:10.18632/oncotarget.25508 · Cited by 44

pH-sensitive curcumin conjugated micelles for tumor triggered drug delivery

Rashidzadeh, H., Rezaei, S. J. T., Zamani, S., Sarijloo, E., & Ramazani, A. (2020) · Journal of Biomaterials Science Polymer Edition · doi:10.1080/09205063.2020.1833815 · Cited by 44

Carbonic Anhydrases as Drug Targets: General Presentation

Supuran, C. T. (2009) · doi:10.1002/9780470508169.ch2 · Cited by 44

Cyclooxygenase‐2/carbonic anhydrase‐IX up‐regulation promotes invasive potential and hypoxia survival in colorectal cancer cells

Sansone, P., Piazzi, G., Paterini, P., Strillacci, A., Ceccarelli, C., Minni, F., Biasco, G., Chieco, P., & Bonafè, M. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00580.x · Cited by 43

Novel approaches for designing drugs that interfere with pH regulation

Berrino, E., & Supuran, C. T. (2019) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2019.1567488 · Cited by 43

Carbonic anhydrase inhibitors. Inhibition of cytosolic isoforms I and II, and extracellular isoforms IV, IX, and XII with sulfamides incorporating sugar moieties

Colinas, P. A., Bravo, R. D., Vullo, D., Scozzafava, A., & Supuran, C. T. (2007) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2007.07.023 · Cited by 43

Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I and II with sulfonylated hydroxamates

Nuti, E., Orlandini, E., Nencetti, S., Rossello, A., Innocenti, A., Scozzafava, A., & Supuran, C. T. (2007) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2007.01.023 · Cited by 43

Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with N-hydroxysulfamides—a new zinc-binding function in the design of inhibitors

Winum, J., Innocenti, A., Nasr, J., Montero, J., Scozzafava, A., Vullo, D., & Supuran, C. T. (2005) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2005.02.091 · Cited by 43

Antibody inhibiting enzymatic activity of tumour-associated carbonic anhydrase isoform IX

Murri-Plesko, M. T., Hulı́ková, A., Oosterwijk, E., Scott, A. M., Zortea, A., Harris, A. L., Ritter, G., Old, L. J., Bauer, S., Swietach, P., et al. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.01.063 · Cited by 42

HIF mediated and DNA damage independent histone H2AX phosphorylation in chronic hypoxia

Wrann, S., Kaufmann, M. R., Wirthner, R., Stiehl, D. P., & Wenger, R. H. (2012) · Biological Chemistry · doi:10.1515/hsz-2012-0311 · Cited by 41

Control of Intracellular pH

Bevensee, M. O., & Boron, W. F. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-381462-3.00052-5 · Cited by 41

Targeting carbonic anhydrases for the management of hypoxic metastatic tumors

Supuran, C. T. (2023) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2023.2245971 · Cited by 41

A Systematic Review on Antitumor Agents with 1, 3, 5-triazines

Liu, B. (2015) · Medicinal Chemistry · doi:10.4172/2161-0444.1000255 · Cited by 42

Pyrazolylbenzo[d]imidazoles as new potent and selective inhibitors of carbonic anhydrase isoforms hCA IX and XII

Kumar, S., Ceruso, M., Tuccinardi, T., Supuran, C. T., & Sharma, P. K. (2016) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2016.04.061 · Cited by 41

Dual-tail approach to discovery of novel carbonic anhydrase IX inhibitors by simultaneously matching the hydrophobic and hydrophilic halves of the active site

Hou, Z., Lin, B., Bao, Y. J., Yan, H., Zhang, M., Chang, X., Zhang, X., Wang, Z.-J., Wei, G., Cheng, M., et al. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.03.023 · Cited by 41

Lactate stimulates CA IX expression in normoxic cancer cells

Pánisová, E., Kery, M., Sedlakova, O., Brisson, L., Debreova, M., Sboarina, M., Sonveaux, P., Pastoreková, S., & Švastová, E. (2017) · Oncotarget · doi:10.18632/oncotarget.20836 · Cited by 41

Carbonic anhydrase inhibitors: Cloning and sulfonamide inhibition studies of a carboxyterminal truncated α-carbonic anhydrase from Helicobacter pylori

Nishimori, I., Vullo, D., Minakuchi, T., Morimoto, K., Onishi, S., Scozzafava, A., & Supuran, C. T. (2006) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2006.01.044 · Cited by 40

Inhibition of mammalian carbonic anhydrases I-XIV with grayanotoxin III: solution and in silico studies

Durdağı, S., Scozzafava, G., Vullo, D., Şahin, H., Kolaylı, S., & Supuran, C. T. (2013) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.3109/14756366.2013.804072 · Cited by 40

Novel sulfonamide incorporating piperazine, aminoalcohol and 1,3,5-triazine structural motifs with carbonic anhydrase I, II and IX inhibitory action

Havránková, E., Csöllei, J., Vullo, D., Garaj, V., Pazdera, P., & Supuran, C. T. (2018) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2017.12.034 · Cited by 40

Inhibitory activity against carbonic anhydrase IX and XII as a candidate selection criterion in the development of new anticancer agents

Krasavin, M., Kalinin, S., Sharonova, T. V., & Supuran, C. T. (2020) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2020.1801674 · Cited by 41

Proton Transport in Cancer Cells: The Role of Carbonic Anhydrases

Becker, H. M., & Deitmer, J. W. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063171 · Cited by 39

Polymeric mesoporous silica nanoparticles as a pH-responsive switch to control doxorubicin intracellular delivery

Tian, Y., Głogowska, A., Zhong, W., Klonisch, T. C., & Xing, M. M. Q. (2013) · Journal of Materials Chemistry B · doi:10.1039/c3tb20544d · Cited by 40

Carbonic anhydrase inhibitors. Inhibition of transmembrane isozymes XII (cancer-associated) and XIV with anions

Innocenti, A., Vullo, D., Pastorek, J., Scozzafava, A., Pastoreková, S., Nishimori, I., & Supuran, C. T. (2007) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2006.12.113 · Cited by 40

Carbonic anhydrase inhibitors: Binding of an antiglaucoma glycosyl-sulfanilamide derivative to human isoform II and its consequences for the drug design of enzyme inhibitors incorporating sugar moieties

Fiore, A. D., Scozzafava, A., Winum, J., Montero, J., Pedone, C., Supuran, C. T., & Simone, G. D. (2007) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2006.12.099 · Cited by 40

Carbonic anhydrase inhibitors: X-ray crystal structure of a benzenesulfonamide strong CA II and CA IX inhibitor bearing a pentafluorophenylaminothioureido tail in complex with isozyme II

Fiore, A. D., Simone, G. D., Menchise, V., Pedone, C., Casini, A., Scozzafava, A., & Supuran, C. T. (2005) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2005.01.086 · Cited by 40

Beyond silver sulfadiazine: A dive into more than 50 years of research and development on metal complexes of sulfonamides in medicinal inorganic chemistry

Nunes, J. H. B., Nakahata, D. H., Corbi, P. P., & de Paiva, R. E. F. (2023) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2023.215228 · Cited by 39

New series of sulfonamides containing amino acid moiety act as effective and selective inhibitors of tumor-associated carbonic anhydrase XII

Ceruso, M., Bragagni, M., ALOthman, Z. A., Osman, S. M., & Supuran, C. T. (2014) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.3109/14756366.2014.942659 · Cited by 39

Carbonic anhydrase inhibitors: Copper(II) complexes of polyamino-polycarboxylamido aromatic/heterocyclic sulfonamides are very potent inhibitors of the tumor-associated isoforms IX and XII

Rami, M., Winum, J., Innocenti, A., Montero, J., Scozzafava, A., & Supuran, C. T. (2007) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2007.11.025 · Cited by 39

Cancer‐associated, hypoxia‐inducible carbonic anhydrase IX facilitates CO 2 diffusion

Swietach, P., Wigfield, S., Supuran, C. T., Harris, A. L., & Vaughan‐Jones, R. D. (2008) · British Journal of Urology · doi:10.1111/j.1464-410x.2008.07644.x · Cited by 39

A novel VHH nanobody against the active site (the CA domain) of tumor-associated, carbonic anhydrase isoform IX and its usefulness for cancer diagnosis

Araste, F., Ebrahimizadeh, W., Rasooli, I., Rajabibazl, M., & Gargari, S. L. M. (2013) · Biotechnology Letters · doi:10.1007/s10529-013-1340-1 · Cited by 38

A class of carbonic anhydrase I – selective activators

Licsandru, E., Tanç, M., Kocsis, I., Barboiu, M. D., & Supuran, C. T. (2016) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2016.1232254 · Cited by 38

Copper-Free ‘Click’ Chemistry-Based Synthesis and Characterization of Carbonic Anhydrase-IX Anchored Albumin-Paclitaxel Nanoparticles for Targeting Tumor Hypoxia

Tatiparti, K., Sau, S., Gawde, K. A., & Iyer, A. K. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030838 · Cited by 38

CA IX Stabilizes Intracellular pH to Maintain Metabolic Reprogramming and Proliferation in Hypoxia

Benej, M., Švastová, E., Banova, R., Kopáček, J., Gibadulinová, A., Kery, M., Arena, S., Scaloni, A., Vitale, M., Zambrano, N., et al. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01462 · Cited by 42

Click chemistry approaches for developing carbonic anhydrase inhibitors and their applications

Angeli, A., & Supuran, C. T. (2023) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2023.2166503 · Cited by 38

Hypoxia in larynx carcinomas assessed by pimonidazole binding and the value of CA-IX and vascularity as surrogate markers of hypoxia

Hoogsteen, I. J., Lok, J., Marres, H. A. M., Takes, R. P., Rijken, P. F. J. W., van der Kogel, A. J., & Kaanders, J. H. A. M. (2009) · European Journal of Cancer · doi:10.1016/j.ejca.2009.07.012 · Cited by 38

Distinct patterns of hypoxic expression of carbonic anhydrase IX (CA IX) in human malignant glioma cell lines

Said, H. M., Staab, A., Hagemann, C., Vince, G. H., Katzer, A., Flentje, M. P., & Vordermark, D. (2006) · Journal of Neuro-Oncology · doi:10.1007/s11060-006-9205-2 · Cited by 38

Design, Synthesis, and Biological Evaluation of Novel Carbohydrate-Based Sulfamates as Carbonic Anhydrase Inhibitors

Lopez, M., Trajkovic, J., Bornaghi, L. F., Innocenti, A., Vullo, D., Supuran, C. T., & Poulsen, S. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm101525j · Cited by 37

Acid Evoked Thermal Hyperalgesia Involves Peripheral P2Y1 Receptor Mediated TRPV1 Phosphorylation in a Rodent Model of Thrombus Induced Ischemic Pain

Kwon, S. G., Roh, D., Yoon, S. Y., Moon, J.-Y., Choi, S., Choi, H., Kang, S.-Y., Han, H. J., Beitz, A. J., Oh, S. B., et al. (2014) · Molecular Pain · doi:10.1186/1744-8069-10-2 · Cited by 37

Dipotassium-trioxohydroxytetrafluorotriborate, K2[B3O3F4OH], is a potent inhibitor of human carbonic anhydrases

Vullo, D., Miloš, M., Galić, B., Scozzafava, A., & Supuran, C. T. (2014) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.3109/14756366.2014.918610 · Cited by 37

Circulating oncoproteins HER2/neu, EGFR and CAIX (MN) as novel cancer biomarkers

Carney, W. P. (2007) · Expert Review of Molecular Diagnostics · doi:10.1586/14737159.7.3.309 · Cited by 37

Sinonasal renal cell–like adenocarcinomas: robust carbonic anhydrase expression

Shen, T., Shi, Q., Velosa, C., Bai, S., Thompson, L. D. �., Simpson, R. H. W., Wei, S., & Brandwein‐Gensler, M. S. (2015) · Human Pathology · doi:10.1016/j.humpath.2015.06.017 · Cited by 37

Cancer-Associated Fibroblast Diversity Shapes Tumor Metabolism in Pancreatic Cancer

Peiffer, R., Boumahd, Y., Gullo, C., Crake, R., Letellier, E., Bellahcène, A., & Peulen, O. (2022) · Cancers · doi:10.3390/cancers15010061 · Cited by 38

Carbonic anhydrase isozymes II, IX, and XII in uterine tumors

Hynninen, P., Parkkila, S., Huhtala, H., Pastoreková, S., Pastorek, J., Waheed, A., Sly, W. S., & Tomás, E. I. (2011) · Apmis · doi:10.1111/j.1600-0463.2011.02820.x · Cited by 36

Design and synthesis of novel 4-(4-oxo-2-arylthiazolidin-3-yl)benzenesulfonamides as selective inhibitors of carbonic anhydrase IX over I and II with potential anticancer activity

Suthar, S. K., Bansal, S., Lohan, S., Modak, V., Chaudhary, A., & Tiwari, A. K. (2013) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2013.06.003 · Cited by 36

Intact intracellular tail is critical for proper functioning of the tumor‐associated, hypoxia‐regulated carbonic anhydrase IX

Hulı́ková, A., Zaťovičová, M., Švastová, E., Ditte, P., Brasseur, R., Kettmann, R., Supuran, C. T., Kopáček, J., Pastorek, J., & Pastoreková, S. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.10.060 · Cited by 36

Carbonic anhydrase inhibitors: Thioxolone versus sulfonamides for obtaining isozyme-selective inhibitors?

Innocenti, A., Maresca, A., Scozzafava, A., & Supuran, C. T. (2008) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2008.06.024 · Cited by 36

LDH-A influences hypoxia-inducible factor 1α (HIF1 α) and is critical for growth of HT29 colon carcinoma cells in vivo

Langhammer, S., Najjar, M., Hess‐Stumpp, H., & Thierauch, K. (2011) · Targeted Oncology · doi:10.1007/s11523-011-0184-7 · Cited by 36

Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of 5-amino-1,3,4-thiadiazole-2-sulfonamide and 5-(4-amino-3-chloro-5-fluorophenylsulfonamido)-1,3,4-thiadiazole-2-sulfonamide to human isoform II

Menchise, V., Simone, G. D., Fiore, A. D., Scozzafava, A., & Supuran, C. T. (2006) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2006.09.022 · Cited by 36

Carbonic anhydrase inhibitors: Inhibition of cytosolic/tumor-associated isoforms I, II, and IX with iminodiacetic carboxylates/hydroxamates also incorporating benzenesulfonamide moieties

Santos, M. A., Marques, S. M., Vullo, D., Innocenti, A., Scozzafava, A., & Supuran, C. T. (2007) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2006.12.107 · Cited by 35

Expression Pattern of Carbonic Anhydrase IX in Medullary Thyroid Carcinoma Supports a Role for RET-Mediated Activation of the HIF Pathway

Takáčová, M., Bullova, P., Simko, V., Škvarková, L., Poturnajova, M., Feketeová, L., Babál, P., Kivelä, A., Kuopio, T., Kopáček, J., et al. (2014) · American Journal Of Pathology · doi:10.1016/j.ajpath.2014.01.002 · Cited by 35

Involvement of ion channels and transporters in carcinoma angiogenesis and metastasis

Martial, S. (2016) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00218.2015 · Cited by 36

Pre-clinical evaluation of a 3-nitro-1,2,4-triazole analogue of [18F]FMISO as hypoxia-selective tracer for PET

Béjot, R., Kersemans, V., Kelly, M., Carroll, L. S., King, R. C., & Gouverneur, V. (2010) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2010.03.011 · Cited by 34

Novel organometallic cationic ruthenium(II) pentamethylcyclopentadienyl benzenesulfonamide complexes targeted to inhibit carbonic anhydrase

Loughrey, B. T., Williams, M. L., Healy, P. C., Innocenti, A., Vullo, D., Supuran, C. T., Parsons, P. G., & Poulsen, S. (2009) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-009-0506-8 · Cited by 35

N-β-Glycosyl sulfamides are selective inhibitors of the cancer associated carbonic anhydrase isoforms IX and XII

Rodríguez, O. M., Maresca, A., Témpera, C. A., Bravo, R. D., Colinas, P. A., & Supuran, C. T. (2011) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2011.06.031 · Cited by 34

Translational regulator eIF2α in tumor

Zheng, Q., Ye, J., & Cao, J. (2014) · Tumor Biology · doi:10.1007/s13277-014-1789-0 · Cited by 33

Therapeutic applications of the carbonic anhydrase inhibitors

Supuran, C. T. (2007) · Therapy · doi:10.2217/14750708.4.3.355 · Cited by 33

Role of Carbonic Anhydrases in the Progression of Renal Cell Carcinoma Subtypes: Proposal of a Unified Hypothesis

Dorai, T., Sawczuk, I. S., Pastorek, J., Wiernik, P. H., & Dutcher, J. P. (2006) · Cancer Investigation · doi:10.1080/07357900601062321 · Cited by 32

Carbonic anhydrase inhibitors: Inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with benzo[b]thiophene 1,1-dioxide sulfonamides

Innocenti, A., Villar, R., Martínez‐Merino, V., Gil, M. J., Scozzafava, A., Vullo, D., & Supuran, C. T. (2005) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2005.04.078 · Cited by 33

Changes in the expression and/or activation of regulatory proteins in rat hearts adapted to chronic hypoxia.

Strnisková, M., Ravíngerová, T., Neckář, J., Kolář, F., Pastoreková, S., & Barančı́k, M. (2006) · PubMed · Cited by 33

Multifaceted Interplay between Hormones, Growth Factors and Hypoxia in the Tumor Microenvironment

Lappano, R., Todd, L. A., Stanic, M., Cai, Q., Maggiolini, M., Marincola, F., & Pietrobon, V. (2022) · Cancers · doi:10.3390/cancers14030539 · Cited by 32

Online monitoring of cell metabolism to assess the toxicity of nanoparticles: The case of cobalt ferrite

Mariani, V., Ponti, J., Giudetti, G., Broggi, F., Marmorato, P., Gioria, S., Franchini, F., Rauscher, H., & Rossi, F. (2011) · Nanotoxicology · doi:10.3109/17435390.2011.572302 · Cited by 32

Carbonic anhydrase inhibitors: Inhibition of human cytosolic isozymes I and II and tumor-associated isozymes IX and XII with S-substituted 4-chloro-2-mercapto-5-methyl-benzenesulfonamides

Sa̧czewski, F., Innocenti, A., Slawinski, J. J., Kornicka, A., Brzozowski, Z., Pomarnacka, E., Scozzafava, A., Temperini, C., & Supuran, C. T. (2008) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2008.01.034 · Cited by 31

Carbonic anhydrase 9 is associated with chemosensitivity and prognosis in breast cancer patients treated with taxane and anthracycline

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