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Carbonic anhydrase inhibitors: Synthesis and inhibition studies against mammalian isoforms I–XV with a series of 2-(hydrazinocarbonyl)-3-substituted-phenyl-1H-indole-5-sulfonamides

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Role of hypoxia and EGF on expression, activity, localization and phosphorylation of carbonic anhydrase IX in MDA-MB-231 breast cancer cells

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4-Functionalized 1,3-diarylpyrazoles bearing 6-aminosulfonylbenzothiazole moiety as potent inhibitors of carbonic anhydrase isoforms hCA I, II, IX and XII

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Acid-sensing ion channels under hypoxia

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Carbonic anhydrase inhibitors. Biphenylsulfonamides with inhibitory action towards the transmembrane, tumor-associated isozymes IX possess cytotoxic activity against human colon, lung and breast cancer cell lines

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A highly selective space-folded photo-induced electron transfer fluorescent probe for carbonic anhydrase isozymes IX and its applications for biological imaging

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Carbohydrates: Potential Sweet Tools Against Cancer

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Mechano- and pH-sensing convergence on Ca2+-mobilising proteins – A recipe for cancer?

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Carbonic anhydrase inhibitors: Inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides

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Carbonic anhydrase XII in valve interstitial cells promotes the regression of calcific aortic valve stenosis

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Structural effect of phenyl ring compared to thiadiazole based adamantyl-sulfonamides on carbonic anhydrase inhibition

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Novel thiazolidinone-containing compounds, without the well-known sulphonamide zinc-binding group acting as human carbonic anhydrase IX inhibitors

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Emerging Immunotherapies against Novel Molecular Targets in Breast Cancer

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The relationship between carbonic anhydrase IX (CAIX) and patient survival in breast cancer: systematic review and meta-analysis

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Significance of pH regulation and carbonic anhydrases in tumour progression and implications for diagnostic and therapeutic approaches

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Inhibition of human carbonic anhydrase isoforms I–XIV with sulfonamides incorporating fluorine and 1,3,5-triazine moieties

Ceruso, M., Vullo, D., Scozzafava, A., & Supuran, C. T. (2013) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2013.09.031 · Cited by 25

Carbonic anhydrase inhibitors: Inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides

Özensoy, Ö., Puccetti, L., Fasolis, G., Arslan, O., Scozzafava, A., & Supuran, C. T. (2005) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2005.08.048 · Cited by 25

X‐Ray Crystallography of Carbonic Anhydrase Inhibitors and Its Importance in Drug Design

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Hypoxia and cytokines regulate carbonic anhydrase 9 expression in hepatocellular carcinoma cellsin vitro

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Targeting the Interplay between Cancer Metabolic Reprogramming and Cell Death Pathways as a Viable Therapeutic Path

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Induction of carbonic anhydrase IX by hypoxia and chemical disruption of oxygen sensing in rat fibroblasts and cardiomyocytes

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Carbonic anhydrase inhibitors: Selective inhibition of the extracellular, tumor-associated isoforms IX and XII over isozymes I and II with glycosyl-thioureido-sulfonamides

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Carbonic anhydrase inhibitors. Diazenylbenzenesulfonamides are potent and selective inhibitors of the tumor-associated isozymes IX and XII over the cytosolic isoforms I and II

Carta, F., Maresca, A., Scozzafava, A., Vullo, D., & Supuran, C. T. (2009) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2009.09.003 · Cited by 24

Longitudinal Measurements of Intra- and Extracellular pH Gradient in a Rat Model of Glioma

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Acetazolamide‐Loaded pH‐Responsive Nanoparticles Alleviating Tumor Acidosis to Enhance Chemotherapy Effects

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(R)-/(S)-10-Camphorsulfonyl-substituted aromatic/heterocyclic sulfonamides selectively inhibit mitochondrial over cytosolic carbonic anhydrases

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Carbonic anhydrase inhibitors: Inhibition of the human transmembrane isozyme XIV with a library of aromatic/heterocyclic sulfonamides

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Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds

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Toward Best Practices for Controlling Mammalian Cell Culture Environments

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Pharmacological inhibition of Carbonic Anhydrase IX and XII to enhance targeting of acute myeloid leukaemia cells under hypoxic conditions

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Carbonic anhydrase inhibitors. Synthesis of a novel series of 5-substituted 2,4-dichlorobenzenesulfonamides and their inhibition of human cytosolic isozymes I and II and the transmembrane tumor-associated isozymes IX and XII

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Development of small molecule carbonic anhydrase IX inhibitors

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Heterocyclic compounds as carbonic anhydrase inhibitor

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Fluorescent sulfonamide carbonic anhydrase inhibitors incorporating 1,2,3-triazole moieties: Kinetic and X-ray crystallographic studies

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Tumor-Associated Carbonic Anhydrases IX and XII

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Propranolol, Promising Chemosensitizer and Candidate for the Combined Therapy through Disruption of Tumor Microenvironment Homeostasis by Decreasing the Level of Carbonic Anhydrase IX

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Impairment of carbonic anhydrase IX ectodomain cleavage reinforces tumorigenic and metastatic phenotype of cancer cells

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Potentiometric responses of ion-selective microelectrode with bovine serum albumin adsorption

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Kinetic and X-ray crystallographic investigations of substituted 2-thio-6-oxo-1,6-dihydropyrimidine–benzenesulfonamides acting as carbonic anhydrase inhibitors

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An update on anticancer drug development and delivery targeting carbonic anhydrase IX

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Improving the Efficacy of Anticancer Drugs via Encapsulation and Acoustic Release

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Post-translational modifications in tumor-associated carbonic anhydrases

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Silencing of hypoxia-inducible tumor suppressor lysyl oxidase gene by promoter methylation activates carbonic anhydrase IX in nasopharyngeal carcinoma.

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Novel humanized monoclonal antibodies for targeting hypoxic human tumors via two distinct extracellular domains of carbonic anhydrase IX

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Detection of carbonic anhydrase 9–expressing tumor cells in the lymph nodes of vulvar carcinoma patients by RT‐PCR

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Synthesis of 5-arylidine amino-1,3,4-thiadiazol-2-[(N-substituted benzyol)]sulphonamides endowed with potent antioxidants and anticancer activity induces growth inhibition in HEK293, BT474 and NCI-H226 cells

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A physically interpretable quantum-theoretic QSAR for some carbonic anhydrase inhibitors with diverse aromatic rings, obtained by a new QSAR procedure

Clare, B. W., & Supuran, C. T. (2005) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2004.12.055 · Cited by 21

Understanding metabolic alterations and heterogeneity in cancer progression through validated immunodetection of key molecular components: a case of carbonic anhydrase IX

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Quantitative intravital imaging for real-time monitoring of pancreatic tumor cell hypoxia and stroma in an orthotopic mouse model

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The Sulfamate Small Molecule CAIX Inhibitor S4 Modulates Doxorubicin Efficacy

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Combined 3-O-acetylbetulin treatment and carbonic anhydrase IX inhibition results in additive effects on human breast cancer cells

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Carbonic anhydrase inhibitors. Synthesis of 2,4,6-trimethylpyridinium derivatives of 2-(hydrazinocarbonyl)-3-aryl-1H-indole-5-sulfonamides acting as potent inhibitors of the tumor-associated isoform IX and XII

Güzel-Akdemir, Ö., Maresca, A., Scozzafava, A., Salman, A., Balaban, A. T., & Supuran, C. T. (2009) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2009.04.068 · Cited by 20

Design, solid-phase synthesis, and biological evaluation of novel 1,5-diarylpyrrole-3-carboxamides as carbonic anhydrase IX inhibitors

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Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V and IX with complex fluorides, chlorides and cyanides

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Next-generation primary sulfonamide carbonic anhydrase inhibitors

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Human Carbonic Anhydrase Inhibitors

Supuran, C. T. (2025) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.5c00443 · Cited by 19

Carbonic anhydrase inhibitors. Selective inhibition of human tumor-associated isozymes IX and XII and cytosolic isozymes I and II with some substituted-2-mercapto-benzenesulfonamides

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Role of the HBx oncoprotein in carbonic anhydrase 9 induction

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Carbonic anhydrase III is a new target of HIF1α in prostate cancer model

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Intrinsically disordered features of carbonic anhydrase IX proteoglycan-like domain

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Carbonic anhydrase inhibitors: Transepithelial transport of thioureido sulfonamide inhibitors of the cancer-associated isozyme IX is dependent on efflux transporters

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Dual-Mode Tumor Imaging Using Probes That Are Responsive to Hypoxia-Induced Pathological Conditions

Subasinghe, S. A. A. S., Pautler, R. G., Samee, M. A. H., Yustein, J. T., & Allen, M. J. (2022) · Biosensors · doi:10.3390/bios12070478 · Cited by 18

Dickkopf-1 (DKK-1) interrupts FAK/PI3K/mTOR pathway by interaction of carbonic anhydrase IX (CA9) in tumorigenesis

Kim, B.-R., Shin, H., Kim, J., Byun, H., Lee, J. H., Sung, Y. K., & Rho, S. B. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2012.03.002 · Cited by 18

Intracellular pH-mediated induction of apoptosis in HeLa cells by a sulfonamide carbonic anhydrase inhibitor

Koyuncu, İ., Temiz, E., Durgun, M., Koçyiğit, A., Yüksekdağ, Ö., & Supuran, C. T. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.12.190 · Cited by 18

Carbonic anhydrase inhibitors: The membrane-associated isoform XV is highly inhibited by inorganic anions

Innocenti, A., Hilvo, M., Parkkila, S., Scozzafava, A., & Supuran, C. T. (2008) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2008.12.082 · Cited by 18

Synthesis and Biological Evaluation of 4‐Sulfamoylphenyl/Sulfocoumarin Carboxamides as Selective Inhibitors of Carbonic Anhydrase Isoforms hCA II, IX, and XII

Angapelly, S., Angeli, A., Khan, A. J., Ramya, P., Supuran, C. T., & Arifuddin, M. (2018) · ChemMedChem · doi:10.1002/cmdc.201800180 · Cited by 18

Synthesis, Molecular Docking Analysis, and Carbonic Anhydrase Inhibitory Evaluations of Benzenesulfonamide Derivatives Containing Thiazolidinone

Zhang, Z.-P., Yin, Z.-F., Li, J., Wang, Z., Wu, Q.-J., Wang, J., Liu, Y., & Cheng, M. (2019) · Molecules · doi:10.3390/molecules24132418 · Cited by 18

Carbonic anhydrase inhibitors: Design of spin-labeled sulfonamides incorporating TEMPO moieties as probes for cytosolic or transmembrane isozymes

Cecchi, A., Ciani, L., Winum, J., Montero, J., Scozzafava, A., Ristori, S., & Supuran, C. T. (2008) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2008.05.051 · Cited by 18

Carbonic anhydrase inhibitors. Regioselective synthesis of novel series 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the human cytosolic isozymes I and II and transmembrane cancer-associated isozymes IX and XII

Brzozowski, Z., Slawinski, J. J., Vullo, D., & Supuran, C. T. (2012) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2012.08.006 · Cited by 18

Prognostic value of CAIX expression in oral squamous cell carcinoma: a systematic review and meta-analysis

Lorenzo‐Pouso, A. I., Gallas, M., Pérez‐Sayáns, M., Chamorro-Petronacci, C. M., Álvarez-Calderón-Iglesias, Ó., Takkouche, B., Supuran, C. T., & Garcı́a, A. G. (2020) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2020.1772250 · Cited by 17

New designed pH-responsive histidine-rich peptides with antitumor activity

Chang, L., Bao, H., Yao, J., Liu, H., Gou, S., Zhong, C., Zhang, Y., & Ni, J. (2021) · Journal of drug targeting · doi:10.1080/1061186x.2021.1873351 · Cited by 17

Overexpression of carbonic anhydrase IX (CAIX) in vulvar cancer is associated with tumor progression and development of locoregional lymph node metastases

Choschzick, M., Woelber, L. L., Hess, S., zu Eulenburg, C., Schwarz, J., Simon, R., Mahner, S., Jaenicke, F., & Müller, V. (2010) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-010-0905-9 · Cited by 17

A multivariate approach for the determination of isoelectric point of human carbonic anhydrase isoforms by capillary isoelectric focusing

Lecoeur-Lorin, M., Goossens, J., Vaccher, C., Bonte, J., & Foulon, C. F. (2011) · Electrophoresis · doi:10.1002/elps.201100219 · Cited by 17

Structure and Dynamics of the Isozymes II and IX of Human Carbonic Anhydrase

Rai, D., Khatua, S., & Taraphder, S. (2022) · ACS Omega · doi:10.1021/acsomega.2c03356 · Cited by 16

Indoline-5-Sulfonamides: A Role of the Core in Inhibition of Cancer-Related Carbonic Anhydrases, Antiproliferative Activity and Circumventing of Multidrug Resistance

Krymov, S. K., Scherbakov, A. M., Dezhenkova, L. G., Salnikova, D. I., Solov’eva, S. E., Sorokin, D. V., Vullo, D., Luca, V. D., Capasso, C., Supuran, C. T., et al. (2022) · Pharmaceuticals · doi:10.3390/ph15121453 · Cited by 16

Biomedical engineering targeting cancer stem cells to reinforce cancer therapy

Sun, S., Yang, N., Pei, Z., Gong, F., & Cheng, L. (2025) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2025.216494 · Cited by 16

Sulfonamides incorporating boroxazolidone moieties are potent inhibitors of the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII

Rami, M., Maresca, A., Smaine, F.-Z., Montero, J., Scozzafava, A., Winum, J., & Supuran, C. T. (2011) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2011.03.055 · Cited by 16

Recent developments of small molecule chemical probes for fluorescence-based detection of human carbonic anhydrase II and IX

Teruya, K., Tonissen, K. F., & Poulsen, S. (2016) · MedChemComm · doi:10.1039/c6md00296j · Cited by 16

In Search of Advanced Tumor Diagnostics and Treatment: Achievements and Perspectives of Carbonic Anhydrase IX Targeted Delivery

Janonienė, A., & Petrikaitė, V. (2020) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.0c00180 · Cited by 19

In vivo noninvasive preclinical tumor hypoxia imaging methods: a review

D’Alonzo, R. A., Gill, S., Rowshanfarzad, P., Keam, S., MacKinnon, K. M., Cook, A., & Ebert, M. A. (2021) · International Journal of Radiation Biology · doi:10.1080/09553002.2021.1900943 · Cited by 16

Expression of carbonic anhydrase IX in craniopharyngiomas

Proescholdt, M. A., Merrill, M. J., Stoerr, E.-M., Lohmeier, A., Dietmaier, W., & Brawanski, A. T. (2011) · Journal of neurosurgery · doi:10.3171/2011.6.jns1168 · Cited by 16

Plasma Membrane-Associated Glycohydrolases Activation by Extracellular Acidification due to Proton Exchangers

Aureli, M., Loberto, N., Bassi, R., Ferraretto, A., Perego, S., Lanteri, P., Chigorno, V., Sonnino, S., & Prinetti, A. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0725-1 · Cited by 16

Novel metronidazole-sulfonamide derivatives as potent and selective carbonic anhydrase inhibitors: design, synthesis and biology analysis

Wang, Z.-C., Duan, Y., Qiu, H., Huang, W., Wang, P., Yan, X., Zhang, S., & Zhu, H. (2014) · RSC Advances · doi:10.1039/c4ra03819c · Cited by 16

Carbonic anhydrase inhibitors. The nematode α-carbonic anhydrase of Caenorhabditis elegans CAH-4b is highly inhibited by 2-(hydrazinocarbonyl)-3-substituted-phenyl-1H-indole-5-sulfonamides

Güzel-Akdemir, Ö., Innocenti, A., Hall, R. A., Scozzafava, A., Mühlschlegel, F. A., & Supuran, C. T. (2009) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2009.01.048 · Cited by 16

Hydrophobic Substituents of the Phenylmethylsulfamide Moiety Can Be Used for the Development of New Selective Carbonic Anhydrase Inhibitors

Simone, G. D., Pizika, G., Monti, S. M., Fiore, A. D., Ivanova, J., Vozny, I., Trapencieris, P., Žalubovskis, R., Supuran, C. T., & Alterio, V. (2014) · BioMed Research International · doi:10.1155/2014/523210 · Cited by 16

Role of pH Regulatory Proteins and Dysregulation of pH in Prostate Cancer

Fliegel, L. (2020) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/112_2020_18 · Cited by 16

An evaluation of cytosolic erythrocyte carbonic anhydrase and catalase in carcinoma patients: An elevation of carbonic anhydrase activity

Özensoy, Ö., KOCKAR, F. T., Arslan, O., Işık, S., Supuran, C. T., & Lyon, M. (2006) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2006.03.001 · Cited by 16

Lactate signaling and immune suppression in tumors: mechanisms and therapeutic implications

Wang, X., Xiong, D., Cui, S., Duan, B., Ding, G., Huang, Y., & Wang, Q. (2026) · Cellular Oncology · doi:10.1007/s13402-026-01186-6 · Cited by 16

Carbonic anhydrase IX, a hypoxia-induced catalytic component of the pH regulating machinery in tumors

Sedlakova, O. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2013.00400 · Cited by 213

Phosphorylation of Carbonic Anhydrase IX Controls Its Ability to Mediate Extracellular Acidification in Hypoxic Tumors

Ditte, P., Dequiedt, F., Švastová, E., Hulı́ková, A., Ohradanova‐Repic, A., Zaťovičová, M., Csáderová, L., Kopáček, J., Supuran, C. T., Pastoreková, S., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-2520 · Cited by 142

Hypoxia-Inducible Carbonic Anhydrase IX and XII Promote Tumor Cell Growth by Counteracting Acidosis through the Regulation of the Intracellular pH

Chiche, J., Ilc, K., Laferrière, J., Trottier, E., Dayan, F., Mazure, N. M., Brahimi-Horn, M. C., & Pouysségur, J. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-2470 · Cited by 751

CA IX Stabilizes Intracellular pH to Maintain Metabolic Reprogramming and Proliferation in Hypoxia

Benej, M., Švastová, E., Banova, R., Kopáček, J., Gibadulinová, A., Kery, M., Arena, S., Scaloni, A., Vitale, M., Zambrano, N., et al. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01462 · Cited by 42

Carbonic Anhydrase IX: Regulation and Role in Cancer

Benej, M., Pastoreková, S., & Pastorek, J. (2013) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-7359-2_11 · Cited by 148