Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH

Carbonic anhydrase inhibitors

Supuran, C. T., Scozzafava, A., & Casini, A. (2002) · Medicinal Research Reviews · doi:10.1002/med.10025 · Cited by 1,477

Hypoxia-inducible expression of tumor-associated carbonic anhydrases.

Wykoff, C. C., Beasley, N. J. P., Watson, P. H., Turner, K., Pastorek, J., Sibtain, A., Wilson, G. D., Turley, H., Talks, K., Maxwell, P. H., et al. (2000) · PubMed · Cited by 1,260

Causes and consequences of tumour acidity and implications for treatment

Stubbs, M., McSheehy, P. M. J., Griffiths, J. R., & Bashford, C. L. (2000) · Molecular Medicine Today · doi:10.1016/s1357-4310(99)01615-9 · Cited by 781

Acidic pH enhances the invasive behavior of human melanoma cells

Mart�nez-Zaguil�n, R., Seftor, E. A., Seftor, R. E. B., Chu, Y.-W., Gillies, R. J., & Hendrix, M. J. C. (1996) · Clinical & Experimental Metastasis · doi:10.1007/bf00121214 · Cited by 507

Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo.

Fukumura, D., Xu, L., Chen, Y., Gohongi, T., Seed, B., & Jain, R. K. (2001) · PubMed · Cited by 438

Acid production in glycolysis-impaired tumors provides new insights into tumor metabolism.

Helmlinger, G., Sckell, A., Dellian, M., Forbes, N. S., & Jain, R. K. (2002) · PubMed · Cited by 417

Down-regulation of transmembrane carbonic anhydrases in renal cell carcinoma cell lines by wild-type von Hippel-Lindau transgenes

Ivanov, S. V., Kuzmin, I., Wei, M.-H., Pack, S., Geil, L., Johnson, B. E., Stanbridge, E. J., & Lerman, M. I. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.21.12596 · Cited by 394

HumanMN/CA9Gene, a Novel Member of the Carbonic Anhydrase Family: Structure and Exon to Protein Domain Relationships

Opavský, R., Pastoreková, S., Zelnı́k, V., Gibadulinová, A., Stanbridge, E. J., Závada, J., Kettmann, R., & Pastorek, J. (1996) · Genomics · doi:10.1006/geno.1996.0223 · Cited by 383

A Transport Metabolon

Sterling, D., Reithmeier, R. A. F., & Casey, J. R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105959200 · Cited by 367

Carbonic Anhydrase: Its Inhibitors and Activators

Supuran, C. T., Scozzafava, A., & Conway, J. D. (2007) · Medical Entomology and Zoology · Cited by 349

Quantitative assessment of specific carbonic anhydrase inhibitors effect on hypoxic cells using electrical impedance assays

Stănică, L., Gheorghiu, M., Stan, M. S., Polonschii, C., David, S., Bratu, D., Dinischiotu, A., Supuran, C. T., & Gheorghiu, E. (2017) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2017.1355306 · Cited by 15

Carbonic Anhydrase IX—Mouse versus Human

Takáčová, M., Baráthová, M., Zaťovičová, M., Golias, T., Kajanová, I., Jelenska, L., Sedlakova, O., Švastová, E., Kopáček, J., & Pastoreková, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms21010246 · Cited by 16

A translational program that suppresses metabolism to shield the genome

Balukoff, N. C., Ho, J. J. D., Theodoridis, P. R., Wang, M., Bokros, M., Llanio, L., Krieger, J. R., Schatz, J. H., & Lee, S. (2020) · Nature Communications · doi:10.1038/s41467-020-19602-2 · Cited by 16

In vivo tumour extracellular pH monitoring using electron paramagnetic resonance: the effect of X‐ray irradiation

Goodwin, J., Yachi, K., Nagane, M., Yasui, H., Miyake, Y., Inanami, O., Bobko, A. A., Khramtsov, V. V., & Hirata, H. (2014) · NMR in Biomedicine · doi:10.1002/nbm.3081 · Cited by 15

Matriptase activation and shedding through PDGF-D-mediated extracellular acidosis

Najy, A. J., Dyson, G. E., Jena, B. P., Lin, C., & Kim, H.-R. C. (2015) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00043.2015 · Cited by 15

Ligand Accessibility and Bioactivity of a Hormone–Dendrimer Conjugate Depend on pH and pH History

Kim, S. H., Madak‐Erdogan, Z., Bae, S. C., Carlson, K. E., Mayne, C. G., Granick, S., Katzenellenbogen, B. S., & Katzenellenbogen, J. A. (2015) · Journal of the American Chemical Society · doi:10.1021/jacs.5b05952 · Cited by 15

Improving the carbonic anhydrase inhibition profile of the sulfamoylphenyl pharmacophore by attachment of carbohydrate moieties

Riafrecha, L. E., Bua, S., Supuran, C. T., & Colinas, P. A. (2017) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2017.10.020 · Cited by 15

Carbonic Anhydrases: Off Targets, Add‐On Activities, or Emerging Novel Targets?

Supuran, C. T. (2012) · Wiley eBooks · doi:10.1002/9781118098141.ch23 · Cited by 15

Glycerol-weighted chemical exchange saturation transfer nanoprobes allow 19F/1H dual-modality magnetic resonance imaging-guided cancer radiotherapy

Rong, A., Wang, H., Nie, C., Han, Z., Zhou, M., Atinuke, O. O., Wang, K., Wang, X., Liu, S., Zhao, J., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42286-3 · Cited by 14

A comparative study of diaryl urea molecules with and without sulfonamide group on Carbonic anhydrase IX and XII inhibition and its consequence on breast cancer cells

Debnath, J., Keshamasetthy, D., Combs, J. E., Leon, K., Vullo, D., Chatterjee, A., McKENNA, R. V., & Supuran, C. T. (2024) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2024.107192 · Cited by 14

Synthesis and inhibition potency of novel ureido benzenesulfonamides incorporating GABA as tumor-associated carbonic anhydrase IX and XII inhibitors

Ceruso, M., Antel, S., Scozzafava, A., & Supuran, C. T. (2015) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.3109/14756366.2015.1014477 · Cited by 14

Synthesis of an acridine orange sulfonamide derivative with potent carbonic anhydrase IX inhibitory action

Bragagni, M., Carta, F., Osman, S. M., ALOthman, Z. A., & Supuran, C. T. (2017) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2017.1302441 · Cited by 14

Mechanobiological Implications of Cancer Progression in Space

Kim, H., Shin, Y. J., & Kim, D. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.740009 · Cited by 19

Synthesis of rhodamine B–benzenesulfonamide conjugates and their inhibitory activity against human α- and bacterial/fungal β-carbonic anhydrases

Rami, M., Innocenti, A., Montero, J., Scozzafava, A., Winum, J., & Supuran, C. T. (2011) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2011.07.045 · Cited by 14

Sulfamate inhibitor S4 influences carbonic anhydrase IX ectodomain shedding in colorectal carcinoma cells

Hektoen, H. H., Ree, A. H., Redalen, K. R., & Flatmark, K. (2015) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.3109/14756366.2015.1069286 · Cited by 14

Carbonic Anhydrase IX Expression Correlates with FDG Uptake by Primary Non–Small Cell Lung Cancer

Mees, G., Vangestel, C., Dierckx, R. A. J. O., Pauwels, P., van Meerbeeck, J. P., & de Wiele, C. V. (2010) · Cancer Biotherapy and Radiopharmaceuticals · doi:10.1089/cbr.2009.0658 · Cited by 14

Targeting Carbonic Anhydrases

Supuran, C. T., & Capasso, C. (2014) · doi:10.4155/9781909453913 · Cited by 14

Exploiting tumor hypoxia for cancer treatment

Niemans (2018) · Research Publications (Maastricht University) · doi:10.26481/dis.20180626rn · Cited by 14

The Metabolic Landscape of Breast Cancer and Its Therapeutic Implications

Jiao, Z., Pan, Y., & Chen, F. (2023) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-023-00645-2 · Cited by 13

Carbonic anhydrase inhibitors: possible anticancer drugs with a novel mechanism of action

Supuran, C. T. (2008) · Drug Development Research · doi:10.1002/ddr.20262 · Cited by 13

Carbonic anhydrases II, IX, and XII in Barrett’s esophagus and adenocarcinoma

Nortunen, M., Huhta, H. I., Helminen, O., Parkkila, S., Kauppila, J. H., Karttunen, T. J., & Saarnio, J. (2018) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-018-2424-z · Cited by 13

Global transcriptional response to carbonic anhydrase IX deficiency in the mouse stomach

Kallio, H. M. L., Hilvo, M., Rodríguez, A., Lappalainen, E.-H., Lappalainen, A.-M., & Parkkila, S. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-397 · Cited by 13

Carbamoylphosphonates inhibit autotaxin and metastasis formationin vivo

Reich, R., Hoffman, A., Suresh, R. R., Shai, O., Frant, J., Maresca, A., Supuran, C. T., & Breuer, E. (2015) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.3109/14756366.2014.968146 · Cited by 13

Carbonic anhydrase inhibitors; Fluorinated phenyl sulfamates show strong inhibitory activity and selectivity for the inhibition of the tumor-associated isozymes IX and XII over the cytosolic ones I and II

Winum, J., Innocenti, A., Vullo, D., Montero, J., & Supuran, C. T. (2009) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2009.07.056 · Cited by 13

Biochemical hallmarks-targeting antineoplastic nanotherapeutics

Han, J. G., Dong, H., Zhu, T., Wei, Q., Wang, Y., Wang, Y., Lv, Y. B., Mu, H., Huang, S., Zeng, K., et al. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.05.042 · Cited by 14

Mitigating the resistance of MCF-7 cancer cells to Doxorubicin under hypoxic conditions with novel coumarin based carbonic anhydrase IX and XII inhibitors

Abdelaal, H. I., Mohamed, A. R., Abo-Ashour, M. F., Giovannuzzi, S., Fahim, S. H., Abdel‐Aziz, H. A., Supuran, C. T., & Abou‐Seri, S. M. (2024) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2024.107759 · Cited by 12

Dynamic scenario of metabolic pathway adaptation in tumors and therapeutic approach

Peppicelli, S., Bianchini, F., & Calorini, L. (2015) · Oncoscience · doi:10.18632/oncoscience.123 · Cited by 12

Engineered protein-small molecule conjugates empower selective enzyme inhibition

Lewis, A. K., Harthorn, A., Johnson, S. M., Lobb, R. R., & Hackel, B. J. (2021) · Cell chemical biology · doi:10.1016/j.chembiol.2021.07.013 · Cited by 12

TGF‐β upregulates tumor‐associated carbonic anhydrase IX gene expression in Hep3B cells

Yıldırım, H., & KOCKAR, F. T. (2009) · Cell Biology International · doi:10.1016/j.cellbi.2009.05.005 · Cited by 13

Quantitative structure–activity relationship (QSAR) studies on a series of 1,3,4-thiadiazole-2-thione derivatives as tumor-associated carbonic anhydrase IX inhibitors

Abdel‐Hamid, M. K., ABDEL‐HAFEZ, A. A., El‐Koussi, N. A., & Mahfouz, N. M. (2008) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756360802361514 · Cited by 12

Sulfonamide derivative targeting carbonic anhydrase IX as a nuclear imaging probe for colorectal cancer detectionin vivo

Guan, S., Cheng, C., Ho, A., Wang, C., Luo, T., Liao, T.-Z., Chang, J., Wu, C.-T., & Liu, S. (2015) · Oncotarget · doi:10.18632/oncotarget.5684 · Cited by 12

Stimuli-responsive nanosystems for drug-targeted delivery

Lopes, C. M., Barata, P., & Oliveira, R. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813689-8.00005-7 · Cited by 12

Renal tumor biomarkers (Review)

Bratu, O. G., Mischianu, D. L. D., Marcu, D., Spinu, D. A., Iorga, L., Cherciu, A., Bălescu, I., Bacalbașa, N., Diaconu, C. C., Savu, C. F., et al. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.10732 · Cited by 12

Detecting extracellular carbonic anhydrase activity using membrane inlet mass spectrometry

Delacruz, J. B., Mikulski, R. L., Tu, C., Li, Y., Wang, H., Shiverick, K. T., Frost, S. C., Horenstein, N. A., & Silverman, D. N. (2010) · Analytical Biochemistry · doi:10.1016/j.ab.2010.04.019 · Cited by 12

Carbonic Anhydrase Inhibitors: Binding of Indanesulfonamides to the Human Isoform II

D’Ambrosio, K., Masereel, B., Thiry, A., Scozzafava, A., Supuran, C. T., & Simone, G. D. (2007) · ChemMedChem · doi:10.1002/cmdc.200700274 · Cited by 12

Can hypoxia marker carbonic anhydrase IX serve as a potential new diagnostic marker and therapeutic target of non-small cell lung cancer?

Fecikova, S., Csáderová, L., Belvončíková, P., Puzderova, B., Bernatova, K., Talac, T., Pastorek, J., & Baráthová, M. (2024) · Neoplasma · doi:10.4149/neo_2024_231219n652 · Cited by 11

Mechanistic Explanation of the Weak Carbonic Anhydrase’s Esterase Activity

Piazzetta, P., Marino, T., & Russo, N. (2017) · Molecules · doi:10.3390/molecules22061009 · Cited by 11

Efficient click reaction towards novel sulfonamide hybrids by molecular hybridization strategy as antiproliferative agents

Fu, D., Hou, Y.-H., Zhang, S., & Zhang, Y. (2018) · Journal of Chemical Sciences · doi:10.1007/s12039-017-1415-y · Cited by 11

Regulation of Tumor Metabolism and Extracellular Acidosis by the TIMP-10–CD63 Axis in Breast Carcinoma

Najy, A. J., Jung, Y., Kim, S., Fridman, R. A., & Kim, H.-R. C. (2021) · Cells · doi:10.3390/cells10102721 · Cited by 11

Discovery of new potent inhibitors for carbonic anhydrase IX by structure-based virtual screening

Wang, L., Yang, C., Lü, W., Liu, L., Gao, R., Liao, S., Zhao, Z., Zhu, L., Xu, Y. F., Li, H., et al. (2013) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2013.04.048 · Cited by 11

Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies

Temperini, C., Innocenti, A., Scozzafava, A., & Supuran, C. T. (2008) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2008.06.105 · Cited by 11

Carbonic Anhydrase Protects Fatty Liver Grafts against Ischemic Reperfusion Damage

Béjaoui, M., Pantazi, E. D., Luca, V. D., Rosello, A. P., Folch‐Puy, E., Hotter, G., Capasso, C., Supuran, C. T., & Roselló‐Catafau, J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0134499 · Cited by 11

Reconstitution of carbonic anhydrase activity of the cell-surface-binding protein of vaccinia virus

Ohradanova‐Repic, A., Vullo, D., Kopáček, J., Temperini, C., Betáková, T., Pastoreková, S., Pastorek, J., & Supuran, C. T. (2007) · Biochemical Journal · doi:10.1042/bj20070816 · Cited by 11

Impact of microRNA-34a and polymorphism of its target gene CA9 on susceptibility to uterine cervical cancer

Yang, S., Liu, Y.-F., Cheng, C., Yang, W., Lin, W.-L., Ko, J., & Wang, P.-H. (2017) · Oncotarget · doi:10.18632/oncotarget.20842 · Cited by 10

Structural modulation of the biological activity of gold nanoparticles functionalized with a carbonic anhydrase inhibitor

Bellissima, F., Carta, F., Innocenti, A., Scozzafava, A., Baglioni, P., Supuran, C. T., & Berti, D. (2013) · The European Physical Journal E · doi:10.1140/epje/i2013-13048-5 · Cited by 10

Design, synthesis, and antitumor screening of certain novel tetrahydroquinoline sulfonamides

Alafeefy, A. M. (2014) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.3109/14756366.2014.899595 · Cited by 10

Carbonic anhydrase IX proteoglycan-like and intracellular domains mediate pulmonary microvascular endothelial cell repair and angiogenesis

Stevens, R. P., ALEXEYEV, M. F., Kozhukhar, N., Pastukh, V., Paudel, S. S., Bell, J., Tambe, D. T., Stevens, T., & Lee, J. (2022) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00337.2021 · Cited by 10

Thermodynamic study on the mechanism of carbonic anhydrase XII inhibition with glycosyl coumarin as non-zinc mediated inhibitors: A quantum mechanical investigation

Ghiasi, M., & Seifi, M. (2017) · Computational and Theoretical Chemistry · doi:10.1016/j.comptc.2017.08.034 · Cited by 10

β carbonic anhydrase is required for female fertility in Drosophila melanogaster

Syrjänen, L., Valanne, S., Kuuslahti, M., Tuomela, T., Sriram, A., Sanz, A., Jacobs, H. T., Rämet, M., & Parkkila, S. (2015) · Frontiers in Zoology · doi:10.1186/s12983-015-0111-3 · Cited by 10

Cancer initiating-cells are enriched in the CA9 positive fraction of primary cervix cancer xenografts

Marie-Egyptienne, D. T., Chaudary, N., Kalliomäki, T., Hedley, D. W., & Hill, R. P. (2016) · Oncotarget · doi:10.18632/oncotarget.13625 · Cited by 10

Phenylethynylbenzenesulfonamide regioisomers strongly and selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic isoforms I and II

Knaus, E. E., Innocenti, A., Scozzafava, A., & Supuran, C. T. (2011) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2011.07.090 · Cited by 9

Prolyl hydroxylase domain inhibitors: a new era in the management of renal anemia

Kurata, Y., Tanaka, T., & Nangaku, M. (2019) · Annals of Translational Medicine · doi:10.21037/atm.2019.09.118 · Cited by 9

Sodium bicarbonate transporter NBCe1 regulates proliferation and viability of human prostate cancer cells LNCaP and PC3

Li, J., Lee, S., Zafar, R., Shin, E., & Choi, I. (2021) · Oncology Reports · doi:10.3892/or.2021.8080 · Cited by 9

Development of Nanoparticles Incorporating a Novel Liposomal Membrane Destabilization Peptide for Efficient Release of Cargos into Cancer Cells

Itakura, S., Hama, S., Ohgita, T., & Kogure, K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111181 · Cited by 9

Prediction of biological activity of compounds containing a 1,3,5-triazinyl sulfonamide scaffold by artificial neural networks using simple molecular descriptors

Havránková, E., Peña‐Méndez, E. M., Csöllei, J., & Havel, J. (2020) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2020.104565 · Cited by 9

Polypharmacology of carbonic anhydrase inhibitors

Supuran, C. T., & Mugelli, A. (2019) · doi:10.36118/pharmadvances.00.2019.06 · Cited by 9

Carbonic-anhydrase IX expression is increased in thyroid cancer tissue and represents a potential therapeutic target to eradicate thyroid tumor-initiating cells

Schmidt, J., Oppermann, E., Blaheta, R. A., Schreckenbach, T., Lunger, I., Rieger, M. A., Bechstein, W. O., Holzer, K., & Malkomes, P. T. Z. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111382 · Cited by 9

Interplay between Carbonic Anhydrases and Metallothioneins: Structural Control of Metalation

Wong, D. L., Yuan, A. T., Korkola, N. C., & Stillman, M. J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165697 · Cited by 9

Carbonic anhydrase inhibitors. Inhibition of red blood cell ostrich (Struthio camelus) carbonic anhydrase with a series of aromatic and heterocyclic sulfonamides

Özensoy, Ö., Işık, S., Arslan, O., Arslan, M., Scozzafava, A., & Supuran, C. T. (2005) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756360500141960 · Cited by 9

Di- meta -Substituted Fluorinated Benzenesulfonamides as Potent and Selective Anticancer Inhibitors of Carbonic Anhydrase IX and XII

Vaškevičius, A., Žvirblis, M., Kurtenoka, M., Leitāns, J., Manakova, E., Paketurytė, V., Kvietkauskaitė, A., Kazāks, A., Eimonta, V., Čerepenkaitė, K., et al. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c01142 · Cited by 8

Unlocking the potential of mandelic acid derivatives: chemical and biological applications – a comprehensive review

Banerjee, A., & Mitra, A. K. (2026) · RSC Advances · doi:10.1039/d5ra07369c · Cited by 8

Chemometric modeling of breast cancer associated carbonic anhydrase IX inhibitors belonging to the ureido-substituted benzene sulfonamide class

Singh, S. T., & Supuran, C. T. (2014) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.3109/14756366.2013.864652 · Cited by 8

Biophysical Characterization of Cancer-Related Carbonic Anhydrase IX

Koruza, K., Murray, A. B., Mahon, B. P., Hopkins, J. B., Knecht, W., McKENNA, R. V., & Fisher, S. Z. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155277 · Cited by 8

Effective Anticancer Potential of a New Sulfonamide as a Carbonic Anhydrase IX Inhibitor Against Aggressive Tumors

Koyuncu, İ., Temiz, E., Güler, E. M., Durgun, M., Yüksekdağ, Ö., Giovannuzzi, S., & Supuran, C. T. (2024) · ChemMedChem · doi:10.1002/cmdc.202300680 · Cited by 8

Harnessing Nitric Oxide-Donating Benzofuroxans for Targeted Inhibition of Carbonic Anhydrase IX in Cancer

Bua, S., Nocentini, A., Bonardi, A., Palma, G., Ciampi, G., Giliberti, A., Iannelli, F., Bruzzese, F., Supuran, C. T., & de Nigris, F. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c01563 · Cited by 8

Carbonic anhydrase inhibitors: Gd(iii) complexes of DOTA- and TETA-sulfonamide conjugates targeting the tumor associated carbonic anhydrase isozymes IX and XII

Rami, M., Montero, J., Dubois, L. J., Lambin, P., Scozzafava, A., Winum, J., & Supuran, C. T. (2010) · New Journal of Chemistry · doi:10.1039/c0nj00214c · Cited by 8

The Relationship Between the Tumor Cell Expression of Hypoxic Markers and Survival in Patients With ER-positive Invasive Ductal Breast Cancer

Shamis, S. A. K., Quinn, J. A., Mallon, E., Edwards, J., & McMillan, D. C. (2022) · Journal of Histochemistry & Cytochemistry · doi:10.1369/00221554221110280 · Cited by 8

ADAM10 mediates shedding of carbonic anhydrase IX ectodomain non‑redundantly to ADAM17

Zaťovičová, M., Kajanová, I., Takáčová, M., Jelenska, L., Sedlakova, O., Labudová, M., & Pastoreková, S. (2022) · Oncology Reports · doi:10.3892/or.2022.8464 · Cited by 9

Differential CMS-Related Expression of Cell Surface Carbonic Anhydrases IX and XII in Colorectal Cancer Models—Implications for Therapy

Rotermund, A., Brandt, S., Staege, M. S., Luetzkendorf, J., Mueller, L. P., & Mueller, T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065797 · Cited by 8

Synthesis of Enantiomeric Aminoalkylcarbamoylphosphonates and Their Evaluation as Dual‐Action Anticancer MMP and Carbonic Anhydrase Inhibitors

Veerendhar, A., Cohen, S., Frant, J., Supuran, C. T., Reich, R., & Breuer, E. (2015) · Heteroatom Chemistry · doi:10.1002/hc.21256 · Cited by 8

Carbonic anhydrase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozymes I and II with some 1,3,4-oxadiazole-thiols

Zareef, M., Innocenti, A., Iqbal, R., Zaidi, J. H., Arfan, M., Scozzafava, A., & Supuran, C. T. (2006) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756360600741503 · Cited by 8

CP-MLR directed QSAR study of carbonic anhydrase inhibitors: sulfonamide and sulfamate inhibitors

Sharma, B. K., Pilania, P., Singh, P., Sharma, S., & Prabhakar, Y. S. (2009) · Open Chemistry · doi:10.2478/s11532-009-0073-4 · Cited by 8

Synthesis and antimicrobial activities evaluation of some new thiadiazinone and thiadiazepinone derivatives bearing sulfonamide moiety

Dalloul, H. M., El-Nwairy, K. A., Shorafa, A. Z., & Samaha, A. S. A. (2017) · Phosphorus, sulfur, and silicon and the related elements · doi:10.1080/10426507.2017.1417292 · Cited by 8

Pyruvate dehydrogenase kinase 1 and carbonic anhydrase IX targeting in hypoxic tumors

Kery, M., Oravcova, N. V., Radenkovic, S., Iuliano, F., Tomášková, J., & Golias, T. (2018) · Neoplasma · doi:10.4149/neo_2018_180531n357 · Cited by 8

Zinc(II) Complexation Behaviour of Sulfonamide‐Based Enzyme Inhibitors

Chaves, S., Marques, S. M., Cachudo, A., Esteves, M. A., & Santos, M. A. (2006) · European Journal of Inorganic Chemistry · doi:10.1002/ejic.200600443 · Cited by 8

A comprehensive review of the structural basis for the selectivity of sulfonamide-based inhibitors for carbonic anhydrase isoforms IX and XII over carbonic anhydrase II based on the available high quality crystallographic data

Ahmad, S., Mirza, M. U., Nazir, M., Kee, L. Y., Rahman, N. A., Abdullah, I., & Trant, J. F. (2025) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2025.110682 · Cited by 7

Drug Delivery to Hypoxic Tumors Targeting Carbonic Anhydrase IX

Shabana, A. M., & Ilies, M. A. (2019) · ACS symposium series · doi:10.1021/bk-2019-1309.ch010 · Cited by 7

Protein-Labeling Fluorescent Probe Reveals Ectodomain Shedding of Transmembrane Carbonic Anhydrases

Lin, F.-L., Yen, J.-T., Fang, P.-W., Xu, S.-Q., Lin, J.-C., & Tan, K. (2022) · ACS Chemical Biology · doi:10.1021/acschembio.2c00679 · Cited by 7

Expression Dynamics of CA IX Epitope in Cancer Cells under Intermittent Hypoxia Correlates with Extracellular pH Drop and Cell Killing by Ureido-Sulfonamide CA IX Inhibitors

Sufian, M. A., Zamanova, S., Shabana, A. M., Kemp, B., Mondal, U. K., Supuran, C. T., & Ilies, M. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054595 · Cited by 9

Synergistic Effect of Saccharin and Caffeine on Antiproliferative Activity in Human Ovarian Carcinoma Ovcar-3 Cells

Lee, S. J., Park, S., Bak, S., Lee, M. W., Lim, D. J., Kim, H.-D., Kim, D.-G., & Kim, S. W. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914445 · Cited by 7

Hypoxia-inducible expression of the mouse carbonic anhydrase IX demonstrated by new monoclonal antibodies

Zaťovičová, M., Pastoreková, S., Pastorek, J., Parkkila, S., Hulı́ková, A., Ohradanova‐Repic, A., Kopáček, J., Baráthová, M., & Takáčová, M. (2007) · International Journal of Oncology · doi:10.3892/ijo.31.5.1103 · Cited by 7

Synthesis of Sulfonamides Incorporating Piperidinyl-Hydrazidoureido and Piperidinyl-Hydrazidothioureido Moieties and Their Carbonic Anhydrase I, II, IX and XII Inhibitory Activity

Moi, D., Deplano, A., Angeli, A., Balboni, G., Supuran, C. T., & Onnis, V. (2022) · Molecules · doi:10.3390/molecules27175370 · Cited by 7

Single nucleotide polymorphisms and haplotypes of carbonic anhydrase 9 can predict invasive squamous cell carcinoma of uterine cervix

Shen, H., Hsiao, Y.-H., Yang, S., Liu, Y., Ko, J., & Wang, P.-H. (2018) · International Journal of Medical Sciences · doi:10.7150/ijms.23359 · Cited by 7

Carbonic anhydrase inhibitors for the treatment of tumors

Ilies, M. A., & Winum, J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816476-1.00016-2 · Cited by 7

Hypoxia and prognosis: the oxygen tension mounts

Wilson, G. D. (2007) · Frontiers in bioscience · doi:10.2741/2330 · Cited by 8

PIMT Binding to C-Terminal Ala459 of CAIX Is Involved in Inside-Out Signaling Necessary for Its Catalytic Activity

Simko, V., Belvončíková, P., Csáderová, L., Labudová, M., Grossmannova, K., Zaťovičová, M., Kajanová, I., Škultéty, Ľ., Baráthová, M., & Pastorek, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228545 · Cited by 6

pH-Dependent Structure and Dynamics of the Catalytic Domains of Human Carbonic Anhydrase II and IX

Rai, D., Mondal, D., & Taraphder, S. (2023) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.3c04721 · Cited by 6

Design, synthesis and in vitro evaluation of novel thiazole-coumarin hybrids as selective and potent human carbonic anhydrase IX and XII inhibitors

Singh, P., Nerella, S. G., Swain, B., Angeli, A., Ullah, Q., Supuran, C. T., & Arifuddin, M. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.131548 · Cited by 6

Working with Hypoxia

Bowler, E., & Ladomery, M. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9463-2_10 · Cited by 8

Diagnostic potential of hypoxia-induced genes in liquid biopsies of breast cancer patients

Peiró, C. H. F., Perez, M. M., Aquino, G. S. A., Encinas, J. F. A., Sousa, L. V. D. A., da Veiga, G. L., del Giglio, A., Fonseca, F. L. A., & Alves, B. D. C. A. (2021) · Scientific Reports · doi:10.1038/s41598-021-87897-2 · Cited by 6

Carbonic Anhydrases II and IX in Non-ampullary Duodenal Adenomas and Adenocarcinoma

Nortunen, M., Parkkila, S., Saarnio, J., Huhta, H. I., & Karttunen, T. J. (2021) · Journal of Histochemistry & Cytochemistry · doi:10.1369/00221554211050133 · Cited by 6

Carbonic anhydrase 9 expression is associated with poor prognosis, tumor proliferation, and radiosensitivity of thymic carcinomas

Ohtaki, Y., Shimizu, K., Kawabata‐Iwakawa, R., Gombodorj, N., Altan, B., Rokudai, S., Yamane, A., Kaira, K., Yokobori, T., Nagashima, T., et al. (2019) · Oncotarget · doi:10.18632/oncotarget.26657 · Cited by 6

Carbonic Anhydrase Inhibitors Targeting Cancer: Therapeutic, Immunologic, and Diagnostic Tools Targeting Isoforms IX and XII

Pastoreková, S., Baráthová, M., Kopáček, J., & Pastorek, J. (2009) · doi:10.1002/9780470508169.ch8 · Cited by 6

Synthesis and in vitro evaluation of radioiodine labeled hypoxia-targeted drugs containing 2-nitroimidazole and benzenesulfonamide groups

Liu, W., & Chu, T. (2025) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2025.117443 · Cited by 5

A systematic review verified by bioinformatic analysis based on TCGA reveals week prognosis power of CAIX in renal cancer

Zhang, Z., Wu, B., Shao, Y., Chen, Y., & Wang, D. (2022) · PLoS ONE · doi:10.1371/journal.pone.0278556 · Cited by 5

Molecular Mechanisms Regulating Expression and Function of Cancer-Associated Carbonic Anhydrase IX

Pastorek, J., & Pastoreková, S. (2010) · Springer eBooks · doi:10.1007/978-1-4419-6615-5_4 · Cited by 5

Molecular Signatures in Urologic Tumors

Larkin, S., & Kyprianou, N. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140918421 · Cited by 5

Carbonic Anhydrase IX: From Biology to Therapy

Pastoreková, S., & Supuran, C. T. (2013) · Cancer drug discovery and develogment/Cancer drug discovery and development · doi:10.1007/978-1-4614-9167-5_6 · Cited by 5

Evaluation of Some Sulfonamide Derivatives as a Potential Inhibitors of The Carbonic Anhydrase IX/XII by ADME and Molecular Docking Method

Yorulmaz, N., Öztürk, H., & Durgun, M. (2022) · Adıyaman üniversitesi fen bilimleri dergisi · doi:10.37094/adyujsci.1091227 · Cited by 5

Virtual Design of Novel Coumarinyl-Substituted Sulfonamide Inhibitors of Carbonic Anhydrase II as Potential Drugs against Glaucoma

Ziki, E., Akonan, L., Kouman, K. C., Dali, B., Megnassan, E., Rita Kakou-yao, A., Tenon, A. J., Frecer, V., & Miertuš, S. (2023) · Journal of Pharmaceutical Research International · doi:10.9734/jpri/2023/v35i247424 · Cited by 5

Carbonic anhydrase IX, a hypoxia-induced catalytic component of the pH regulating machinery in tumors

Sedlakova, O. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2013.00400 · Cited by 213

Phosphorylation of Carbonic Anhydrase IX Controls Its Ability to Mediate Extracellular Acidification in Hypoxic Tumors

Ditte, P., Dequiedt, F., Švastová, E., Hulı́ková, A., Ohradanova‐Repic, A., Zaťovičová, M., Csáderová, L., Kopáček, J., Supuran, C. T., Pastoreková, S., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-2520 · Cited by 142

Hypoxia-Inducible Carbonic Anhydrase IX and XII Promote Tumor Cell Growth by Counteracting Acidosis through the Regulation of the Intracellular pH

Chiche, J., Ilc, K., Laferrière, J., Trottier, E., Dayan, F., Mazure, N. M., Brahimi-Horn, M. C., & Pouysségur, J. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-2470 · Cited by 751

CA IX Stabilizes Intracellular pH to Maintain Metabolic Reprogramming and Proliferation in Hypoxia

Benej, M., Švastová, E., Banova, R., Kopáček, J., Gibadulinová, A., Kery, M., Arena, S., Scaloni, A., Vitale, M., Zambrano, N., et al. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01462 · Cited by 42

Carbonic Anhydrase IX: Regulation and Role in Cancer

Benej, M., Pastoreková, S., & Pastorek, J. (2013) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-7359-2_11 · Cited by 148