The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Mia40, a novel factor for protein import into the intermembrane space of mitochondria is able to bind metal ions
Abstract
Many proteins located in the intermembrane space (IMS) of mitochondria are characterized by a low molecular mass, contain highly conserved cysteine residues and coordinate metal ions. Studies on one of these proteins, Tim13, revealed that net translocation across the outer membrane is driven by metal‐dependent folding in the IMS [1]. We have identified an essential component, Mia40/Tim40/Ykl195w, with a highly conserved domain in the IMS that is able to bind zinc and copper ions. In cells lacking Mia40, the endogenous levels of Tim13 and other metal‐binding IMS proteins are strongly reduced due to the impaired import of these proteins. Furthermore, Mia40 directly interacts with newly imported Tim13 protein. We conclude that Mia40 is the first essential component of a specific translocation pathway of metal‐binding IMS proteins.
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Cites
Functional Characterization of the S. cerevisiae Genome by Gene Deletion and Parallel Analysis
Winzeler, E. A., Shoemaker, D. D., Astromoff, A., Liang, H., Anderson, K., Andre, B., Bangham, R., Benito, R., Boeke, J. D., Bussey, H., et al. (1999) · Science · doi:10.1126/science.285.5429.901 · Cited by 3,953
Cited by
Mitochondrial protein import: from proteomics to functional mechanisms
Schmidt, O., Pfanner, N., & Meisinger, C. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2959 · Cited by 717
A Disulfide Relay System in the Intermembrane Space of Mitochondria that Mediates Protein Import
Mesecke, N., Terziyska, N., Kozany, C., Baumann, F., Neupert, W., Hell, K., & Herrmann, J. M. (2005) · Cell · doi:10.1016/j.cell.2005.04.011 · Cited by 557
Self-citationMitochondrial copper metabolism and delivery to cytochrome c oxidase
Horn, D., & Barrientos, A. (2008) · IUBMB Life · doi:10.1002/iub.50 · Cited by 283
Allen, S., Balabanidou, V., Sideris, D. P., Lisowsky, T., & Tokatlidis, K. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2005.08.049 · Cited by 235
The Ubiquitin-Proteasome System Regulates Mitochondrial Intermembrane Space Proteins
Bragoszewski, P., Gornicka, A., Sztolsztener, M. E., & Chacinska, A. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01579-12 · Cited by 149
Metadata
- Authors
- Terziyska, N., Lutz, T., Kozany, C., Mokranjac, D., Mesecke, N., Neupert, W., Herrmann, J. M., & Hell, K.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2004-12-07
- Volume
- 579
- Issue
- 1
- Pages
- 179-184
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2070622658
- Cited by
- 173
- References
- 1
- FWCI
- 4.15
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Terziyska, N., Lutz, T., Kozany, C., Mokranjac, D., Mesecke, N., Neupert, W., Herrmann, J. M., & Hell, K. (2005). Mia40, a novel factor for protein import into the intermembrane space of mitochondria is able to bind metal ions. FEBS Letters. https://doi.org/10.1016/j.febslet.2004.11.072
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