The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Fluoxetine (Prozac) interaction with the mitochondrial voltage‐dependent anion channel and protection against apoptotic cell death
Abstract
Here, we demonstrate that fluoxetine interacted with VDAC and decreased its conductance. Fluoxetine inhibited the opening of the mitochondrial permeability transition pore, the release of cytochrome c, and protected against staurosporine‐induced apoptotic cell death. These findings may explain some of the reported fluoxetine side effects.
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“Nahon et al. (2005) demonstrated that fluoxetine was able to inhibit the opening of the mitochondrial permeability transition (MPT) pore, the release of cytochrome c (cytC) and protected against staurosporine-induced apoptotic cell death [8].”
From Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder (2012) · cites this paper as [8]
Citations
Cites
The mitochondrial permeability transition pore and its role in cell death
CROMPTON, M. (1999) · Biochemical Journal · doi:10.1042/bj3410233 · Cited by 2,432
The mitochondrial permeability transition
Zoratti, M., & Szabó, I. (1995) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(95)00003-a · Cited by 2,410
Shimizu, S., Narita, M., Tsujimoto, Y., & Tsujimoto, Y. (1999) · Nature · doi:10.1038/20959 · Cited by 2,178
Wong, D. T., Bymaster, F. P., & Engleman, E. A. (1995) · Life Sciences · doi:10.1016/0024-3205(95)00209-o · Cited by 643
VDAC: The channel at the interface between mitochondria and the cytosol
Colombini, M. (2003) · Molecular and Cellular Biochemistry · doi:10.1023/b:mcbi.0000009862.17396.8d · Cited by 500
AZOULAY-ZOHAR, H., ISRAELSON, A., ABU-HAMAD, S., & SHOSHAN-BARMATZ, V. (2004) · Biochemical Journal · doi:10.1042/bj20031465 · Cited by 408
Self-citationGINCEL, D., ZAID, H., & SHOSHAN-BARMATZ, V. (2001) · Biochemical Journal · doi:10.1042/bj3580147 · Cited by 396 · cited 6×
“However, these effects of fluoxetine on mitochondrial activities may result from interacting with VDAC and decreasing its conductance as a channel providing passage for Ca [19],”
BackgroundMethodInfluentialSelf-citationEssential Role of Voltage-Dependent Anion Channel in Various Forms of Apoptosis in Mammalian Cells
Shimizu, S., Matsuoka, Y., Shinohara, Y., Yoneda, Y., & Tsujimoto, Y. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.152.2.237 · Cited by 368
Rostovtseva, T. K., & Colombini, M. (1997) · Biophysical Journal · doi:10.1016/s0006-3495(97)78841-6 · Cited by 360
Inhibition of Neuronal Na+ Channels by Antidepressant Drugs
Pancrazio, J. J., Kamatchi, G. L., Roscoe, A. K., & Lynch, C. I. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37206-4 · Cited by 309
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Items 101–101 of 101
Nascimento, M. L., Rodrigues, W. E., Silva, I. C., Santos, V. B., & Oliveira, S. C. B. (2026) · Journal of Electroanalytical Chemistry · doi:10.1016/j.jelechem.2026.120288
Metadata
- Authors
- Nahon, E., Israelson, A., Abu-Hamad, S., & Shoshan-Barmatz, V.
- Affiliations
- Ben-Gurion University of the Negev (IL)
- ORCID
- Israelson, Adrian
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2005-08-24
- Volume
- 579
- Issue
- 22
- Pages
- 5105-5110
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1983099105
- Cited by
- 101
- References
- 34
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 5 · 2020: 7 · 2019: 5 · 2018: 8 · 2017: 8 · 2016: 7 · 2015: 4 · 2014: 4 · 2013: 6 · 2012: 11
- FWCI
- 1.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacological Receptor Mechanisms and Effects
- Keywords
- fluoxetine, mitochondrial voltage-dependent anion channel, voltage-dependent anion channel, mitochondrial permeability transition pore, cytochrome c release, staurosporine-induced apoptosis, apoptosis, adverse drug reactions, serotonin reuptake inhibition
- MeSH terms
- Animals, Cell Line, Enzyme Inhibitors, Fluoxetine, Humans, Mitochondria, Liver, Apoptosis, Selective Serotonin Reuptake Inhibitors, Porins, Staurosporine, Cytochromes c, Voltage-Dependent Anion Channels, Rats
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