Cited by 101Mitochondrial Function and PathologyCell death mechanisms and regulationPharmacological Receptor Mechanisms and Effects

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Fluoxetine (Prozac) interaction with the mitochondrial voltage‐dependent anion channel and protection against apoptotic cell death

Nahon, Edna, Israelson, Adrian, Abu-Hamad, Salah, Shoshan-Barmatz, Varda·2005·FEBS Letters

DOI 10.1016/j.febslet.2005.08.020

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Abstract

Here, we demonstrate that fluoxetine interacted with VDAC and decreased its conductance. Fluoxetine inhibited the opening of the mitochondrial permeability transition pore, the release of cytochrome c, and protected against staurosporine‐induced apoptotic cell death. These findings may explain some of the reported fluoxetine side effects.

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CROMPTON, M. (1999) · Biochemical Journal · doi:10.1042/bj3410233 · Cited by 2,432
The mitochondrial permeability transition
Zoratti, M., & Szabó, I. (1995) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(95)00003-a · Cited by 2,410
Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC
Shimizu, S., Narita, M., Tsujimoto, Y., & Tsujimoto, Y. (1999) · Nature · doi:10.1038/20959 · Cited by 2,178
Prozac (fluoxetine, lilly 110140), the first selective serotonin uptake inhibitor and an antidepressant drug: Twenty years since its first publication
Wong, D. T., Bymaster, F. P., & Engleman, E. A. (1995) · Life Sciences · doi:10.1016/0024-3205(95)00209-o · Cited by 643
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AZOULAY-ZOHAR, H., ISRAELSON, A., ABU-HAMAD, S., & SHOSHAN-BARMATZ, V. (2004) · Biochemical Journal · doi:10.1042/bj20031465 · Cited by 408
Self-citation
Calcium binding and translocation by the voltage-dependent anion channel: a possible regulatory mechanism in mitochondrial function
GINCEL, D., ZAID, H., & SHOSHAN-BARMATZ, V. (2001) · Biochemical Journal · doi:10.1042/bj3580147 · Cited by 396 · cited 6×
“However, these effects of fluoxetine on mitochondrial activities may result from interacting with VDAC and decreasing its conductance as a channel providing passage for Ca [19],”
BackgroundMethodInfluentialSelf-citation
Essential Role of Voltage-Dependent Anion Channel in Various Forms of Apoptosis in Mammalian Cells
Shimizu, S., Matsuoka, Y., Shinohara, Y., Yoneda, Y., & Tsujimoto, Y. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.152.2.237 · Cited by 368
VDAC channels mediate and gate the flow of ATP: implications for the regulation of mitochondrial function
Rostovtseva, T. K., & Colombini, M. (1997) · Biophysical Journal · doi:10.1016/s0006-3495(97)78841-6 · Cited by 360
Inhibition of Neuronal Na+ Channels by Antidepressant Drugs
Pancrazio, J. J., Kamatchi, G. L., Roscoe, A. K., & Lynch, C. I. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37206-4 · Cited by 309

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Authors: Nahon, E., Israelson, A., Abu-Hamad, S., & Shoshan-Barmatz, V.
Affiliations: Ben-Gurion University of the Negev (IL)
ORCID: Israelson, Adrian
Venue: FEBS Letters
Publisher: Wiley
Published: 2005-08-24
Volume: 579
Issue: 22
Pages: 5105-5110
ISSN: 0014-5793 (ISSN-L)
1873-3468
DOI: 10.1016/j.febslet.2005.08.020
OpenAlex: W1983099105
Cited by: 101
References: 34
Citations by year: 2026: 3 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 5 · 2020: 7 · 2019: 5 · 2018: 8 · 2017: 8 · 2016: 7 · 2015: 4 · 2014: 4 · 2013: 6 · 2012: 11
FWCI: 1.51
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: FEBS Letters (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacological Receptor Mechanisms and Effects
Keywords: fluoxetine, mitochondrial voltage-dependent anion channel, voltage-dependent anion channel, mitochondrial permeability transition pore, cytochrome c release, staurosporine-induced apoptosis, apoptosis, adverse drug reactions, serotonin reuptake inhibition
MeSH terms: Animals, Cell Line, Enzyme Inhibitors, Fluoxetine, Humans, Mitochondria, Liver, Apoptosis, Selective Serotonin Reuptake Inhibitors, Porins, Staurosporine, Cytochromes c, Voltage-Dependent Anion Channels, Rats

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Fluoxetine (Prozac) interaction with the mitochondrial voltage‐dependent anion channel and protection against apoptotic cell death

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