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Fluoxetine (Prozac) interaction with the mitochondrial voltage‐dependent anion channel and protection against apoptotic cell death
Abstract
Here, we demonstrate that fluoxetine interacted with VDAC and decreased its conductance. Fluoxetine inhibited the opening of the mitochondrial permeability transition pore, the release of cytochrome c, and protected against staurosporine‐induced apoptotic cell death. These findings may explain some of the reported fluoxetine side effects.
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“Nahon et al. (2005) demonstrated that fluoxetine was able to inhibit the opening of the mitochondrial permeability transition (MPT) pore, the release of cytochrome c (cytC) and protected against staurosporine-induced apoptotic cell death [8].”
From Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder (2012) · cites this paper as [8]
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Cites
The mitochondrial permeability transition pore and its role in cell death
CROMPTON, M. (1999) · Biochemical Journal · doi:10.1042/bj3410233 · Cited by 2,432
The mitochondrial permeability transition
Zoratti, M., & Szabó, I. (1995) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(95)00003-a · Cited by 2,410
Shimizu, S., Narita, M., Tsujimoto, Y., & Tsujimoto, Y. (1999) · Nature · doi:10.1038/20959 · Cited by 2,178
Wong, D. T., Bymaster, F. P., & Engleman, E. A. (1995) · Life Sciences · doi:10.1016/0024-3205(95)00209-o · Cited by 643
VDAC: The channel at the interface between mitochondria and the cytosol
Colombini, M. (2003) · Molecular and Cellular Biochemistry · doi:10.1023/b:mcbi.0000009862.17396.8d · Cited by 500
AZOULAY-ZOHAR, H., ISRAELSON, A., ABU-HAMAD, S., & SHOSHAN-BARMATZ, V. (2004) · Biochemical Journal · doi:10.1042/bj20031465 · Cited by 408
Self-citationGINCEL, D., ZAID, H., & SHOSHAN-BARMATZ, V. (2001) · Biochemical Journal · doi:10.1042/bj3580147 · Cited by 396 · cited 6×
“However, these effects of fluoxetine on mitochondrial activities may result from interacting with VDAC and decreasing its conductance as a channel providing passage for Ca [19],”
BackgroundMethodInfluentialSelf-citationEssential Role of Voltage-Dependent Anion Channel in Various Forms of Apoptosis in Mammalian Cells
Shimizu, S., Matsuoka, Y., Shinohara, Y., Yoneda, Y., & Tsujimoto, Y. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.152.2.237 · Cited by 368
Rostovtseva, T. K., & Colombini, M. (1997) · Biophysical Journal · doi:10.1016/s0006-3495(97)78841-6 · Cited by 360
Inhibition of Neuronal Na+ Channels by Antidepressant Drugs
Pancrazio, J. J., Kamatchi, G. L., Roscoe, A. K., & Lynch, C. I. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37206-4 · Cited by 309
The voltage-dependent anion channel-1 modulates apoptotic cell death
Zaid, H., Abu‐Hamad, S., Israelson, A., Nathan, I., & Shoshan‐Barmatz, V. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401599 · Cited by 303
Self-citationRegulation of Metabolite Flux through Voltage-Gating of VDAC Channels
Hodge, T., & Colombini, M. (1997) · The Journal of Membrane Biology · doi:10.1007/s002329900235 · Cited by 289
Shoshan‐Barmatz, V., & Gincel, D. (2003) · Cell Biochemistry and Biophysics · doi:10.1385/cbb:39:3:279 · Cited by 229
Self-citationStimulation of malignant growth in rodents by antidepressant drugs at clinically relevant doses.
Brandes, L. J., Arron, R. J., Bogdanovic, R. P., TONG, J. J., Zaborniak, C. L., Hogg, G. R., Warrington, R. C., Fang, W., & LaBella, F. S. (1992) · PubMed · Cited by 211
Zheng, Y., Shi, Y., Tian, C., Jiang, C., Jin, H., Chen, J., Almasan, A., Tang, H., & Chen, Q. (2003) · Oncogene · doi:10.1038/sj.onc.1207205 · Cited by 206
Lee, H. J., Kim, J. W., Yim, S. V., Kim, M. J., Kim, S. A., Kim, Y. J., Kim, C., & Chung, J. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000947 · Cited by 205
Fluoxetine, a selective inhibitor of serotonin uptake
Fuller, R. W., Wong, D. T., & Robertson, D. W. (1991) · Medicinal Research Reviews · doi:10.1002/med.2610110103 · Cited by 197
Inhibition of apoptosis as a mechanism of tumor promotion
Wright, S. C., Zhong, J., & Larrick, J. W. (1994) · The FASEB Journal · doi:10.1096/fasebj.8.9.8005393 · Cited by 196
Brambilla, P., Cipriani, A., Hotopf, M., & Barbui, C. (2005) · Pharmacopsychiatry · doi:10.1055/s-2005-837806 · Cited by 181
Serafeim, A., Holder, M. J., Grafton, G., Chamba, A., Drayson, M. T., Luong, Q. T., Bunce, C. M., Gregory, C. D., Barnes, N. M., & Gordon, J. (2003) · Blood · doi:10.1182/blood-2002-07-2044 · Cited by 174
Leonardi, E. T. K., & Azmitia, E. C. (1994) · Neuropsychopharmacology · doi:10.1038/npp.1994.26 · Cited by 162
Blockage of muscle and neuronal nicotinic acetylcholine receptors by fluoxetine (Prozac)
García‐Colunga, J., AWAD, J., & Miledi, R. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.5.2041 · Cited by 149
Antidepressant Medication Use and Breast Cancer Risk
Cotterchio, M., Kreiger, N., Darlington, G., & Steingart, A. B. (2000) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a010138 · Cited by 132
Inhibition of voltage-gated calcium channels by fluoxetine in rat hippocampal pyramidal cells
Deák, F., Lasztóczi, B., Pacher, P., Petheö, G. L., Kecskeméti, V., & Spät, A. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(99)00206-3 · Cited by 124
Elinder, F., Akanda, N., Tofighi, R., Shimizu, S., Tsujimoto, Y., Orrenius, S., & Ceccatelli, S. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401646 · Cited by 116
Cesura, A. M., Pinard, E., Schubenel, R., Goetschy, V., Friedlein, A., Langen, H., Polčic, P., Forte, M. A., Bernardi, P., & Kemp, J. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304748200 · Cited by 110
Peer, D., Dekel, Y., Melikhov, D., & Margalit, R. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-4046 · Cited by 100
Fluoxetine increases the content of neurotrophic protein S100β in the rat hippocampus
Manev, R. M., Uz, T., & Manev, H. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)00989-x · Cited by 87
Curti, C., Mingattao, F. E., Polizello, A. C. M., Galastri, L. O., Uyemura, S. A., & Santos, A. C. (1999) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006912010550 · Cited by 74
Antidepressant use and the risk of breast cancer
Wang, P. S., Walker, A. M., Tsuang, M. T., Orav, E. J., Levin, R., & Avorn, J. (2001) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(00)00354-1 · Cited by 55
VDAC and peripheral channelling complexes in health and disease
Vyssokikh, M. Y., & Brdiczka, D. G. (2003) · Molecular and Cellular Biochemistry · doi:10.1023/b:mcbi.0000009863.69249.d9 · Cited by 54
Gincel, D., & Shoshan‐Barmatz, V. (2004) · Journal of Bioenergetics and Biomembranes · doi:10.1023/b:jobb.0000023621.72873.9e · Cited by 53
Self-citationMukherjee, J., Das, M. K., Yang, Z.-Y., & Lew, R. (1998) · Nuclear Medicine and Biology · doi:10.1016/s0969-8051(98)00043-2 · Cited by 47
THINNES, F. P. (2005) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2004.12.008 · Cited by 19
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VDAC, a multi-functional mitochondrial protein regulating cell life and death
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Self-citationThe mitochondrial permeability transition from in vitro artifact to disease target
Bernardi, P., Krauskopf, A., Basso, E., Petronilli, V., Blalchy‐Dyson, E., Di Lisa, F., & Forte, M. A. (2006) · The FEBS Journal · doi:10.1111/j.1742-4658.2006.05213.x · Cited by 627
Anisman, H., Merali, Z., & Hayley, S. P. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.01.004 · Cited by 341
Gardner, A., & Boles, R. G. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.07.030 · Cited by 333
Maes, M., Fišar, Z., Medina, M., Scapagnini, G., Nowak, G., & Berk, M. (2012) · Inflammopharmacology · doi:10.1007/s10787-011-0111-7 · Cited by 325
Metadata
- Authors
- Nahon, E., Israelson, A., Abu-Hamad, S., & Shoshan-Barmatz, V.
- Affiliations
- Ben-Gurion University of the Negev (IL)
- ORCID
- Israelson, Adrian
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2005-08-24
- Volume
- 579
- Issue
- 22
- Pages
- 5105-5110
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1983099105
- Cited by
- 101
- References
- 34
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 5 · 2020: 7 · 2019: 5 · 2018: 8 · 2017: 8 · 2016: 7 · 2015: 4 · 2014: 4 · 2013: 6 · 2012: 11
- FWCI
- 1.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacological Receptor Mechanisms and Effects
- Keywords
- fluoxetine, mitochondrial voltage-dependent anion channel, voltage-dependent anion channel, mitochondrial permeability transition pore, cytochrome c release, staurosporine-induced apoptosis, apoptosis, adverse drug reactions, serotonin reuptake inhibition
- MeSH terms
- Animals, Cell Line, Enzyme Inhibitors, Fluoxetine, Humans, Mitochondria, Liver, Apoptosis, Selective Serotonin Reuptake Inhibitors, Porins, Staurosporine, Cytochromes c, Voltage-Dependent Anion Channels, Rats
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