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The ABC of auxin transport: The role of p‐glycoproteins in plant development
Abstract
A surprising outcome of the Arabidopsis genome project was the annotation of a large number of sequences encoding members of the ABC transporter superfamily, including 22 genes encoding the p‐glycoprotein (PGP) subfamily. As mammalian PGP orthologs are associated with multiple drug resistance, plant PGPs were initially presumed to function in detoxification, but were soon seen to have a developmental role. Here, we summarise recent studies of plant PGPs indicating that PGPs mediate the cellular and long‐distance transport of the plant hormone auxin. One class of PGPs, represented by AtPGP1, catalyze auxin export, while another class with at least one member, AtPGP4, appears to function in auxin import. Current models on the physiological role of PGPs, their functional interaction and their involvement in cell‐to cell (polar) auxin transport are discussed.
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Cited by
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Christie, J. M. (2007) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.58.032806.103951 · Cited by 937
Flavonoids as Antioxidants and Developmental Regulators: Relative Significance in Plants and Humans
Brunetti, C., Di Ferdinando, M., Fini, A., Pollastri, S., & Tattini, M. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14023540 · Cited by 508
Interactions among PIN-FORMED and P-Glycoprotein Auxin Transporters in Arabidopsis
Blakeslee, J. J., Bandyopadhyay, A., Lee, O. R., Mravec, J., Titapiwatanakun, B., Sauer, M., Makam, S. N., Cheng, Y., Bouchard, R., Adamec, J., et al. (2007) · The Plant Cell · doi:10.1105/tpc.106.040782 · Cited by 434
Self-citationAuxin Transporters--Why So Many?
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Metadata
- Authors
- Geisler, M., & Murphy, A. S.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2005-12-06
- Volume
- 580
- Issue
- 4
- Pages
- 1094-1102
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2015431474
- Cited by
- 394
- References
- 0
- FWCI
- 26.39
- Type
- journal article
- Language
- en
- Open access
- closed
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