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The ABC of auxin transport: The role of p‐glycoproteins in plant development

Geisler, Markus, Murphy, Angus S.·2006·FEBS Letters

Abstract

A surprising outcome of the Arabidopsis genome project was the annotation of a large number of sequences encoding members of the ABC transporter superfamily, including 22 genes encoding the p‐glycoprotein (PGP) subfamily. As mammalian PGP orthologs are associated with multiple drug resistance, plant PGPs were initially presumed to function in detoxification, but were soon seen to have a developmental role. Here, we summarise recent studies of plant PGPs indicating that PGPs mediate the cellular and long‐distance transport of the plant hormone auxin. One class of PGPs, represented by AtPGP1, catalyze auxin export, while another class with at least one member, AtPGP4, appears to function in auxin import. Current models on the physiological role of PGPs, their functional interaction and their involvement in cell‐to cell (polar) auxin transport are discussed.

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Metadata

Authors
Geisler, M., & Murphy, A. S.
Venue
FEBS Letters
Publisher
Wiley
Published
2005-12-06
Volume
580
Issue
4
Pages
1094-1102
ISSN
  • 0014-5793 (ISSN-L)
  • 1873-3468
OpenAlex
W2015431474
Cited by
394
References
0
FWCI
26.39
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: The ABC of auxin transport: The role of p‐glycoproteins in plant development. https://app.cochat.ai/papers/10.1016/j.febslet.2005.11.054
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Geisler, M., & Murphy, A. S. (2006). The ABC of auxin transport: The role of p‐glycoproteins in plant development. FEBS Letters. https://doi.org/10.1016/j.febslet.2005.11.054

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.