The DOI matches its Crossref record; 111 of the 111 references it cites were found in a registry or an index.
Flavonoids as Antioxidants and Developmental Regulators: Relative Significance in Plants and Humans
Open accessAbstract
Phenylpropanoids, particularly flavonoids have been recently suggested as playing primary antioxidant functions in the responses of plants to a wide range of abiotic stresses. Furthermore, flavonoids are effective endogenous regulators of auxin movement, thus behaving as developmental regulators. Flavonoids are capable of controlling the development of individual organs and the whole-plant; and, hence, to contribute to stress-induced morphogenic responses of plants. The significance of flavonoids as scavengers of reactive oxygen species (ROS) in humans has been recently questioned, based on the observation that the flavonoid concentration in plasma and most tissues is too low to effectively reduce ROS. Instead, flavonoids may play key roles as signaling molecules in mammals, through their ability to interact with a wide range of protein kinases, including mitogen-activated protein kinases (MAPK), that supersede key steps of cell growth and differentiation. Here we discuss about the relative significance of flavonoids as reducing agents and signaling molecules in plants and humans. We show that structural features conferring ROS-scavenger ability to flavonoids are also required to effectively control developmental processes in eukaryotic cells.
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Cites
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Self-citationFlavonoids: antioxidants or signalling molecules?
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Cited by
Important Flavonoids and Their Role as a Therapeutic Agent
Ullah, A., Munir, S., Badshah, S. L., Khan, N., Ghani, L., Poulson, B. G., Emwas, A.-H., & Jaremko, M. (2020) · Molecules · doi:10.3390/molecules25225243 · Cited by 1,696
Oxidative Stress and Antioxidant Metabolism under Adverse Environmental Conditions: a Review
García-Caparrós, P., De Filippis, L., Gul, A., Hasanuzzaman, M., Ozturk, M., Altay, V., & Lao, M. T. (2021) · The Botanical Review · doi:10.1007/s12229-020-09231-1 · Cited by 555
Simunkova, M., Barbierikova, Z., Jomova, K., Hudecova, L., Lauro, P., Alwasel, S. H., Alhazza, I., Rhodes, C. J., & Valko, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041619 · Cited by 175
Barnes, P. W., Robson, T. M., Zepp, R. G., Bornman, J. F., Jansen, M. A. K., Ossola, R., Wang, Q.-W., Robinson, S. A., Foereid, B., Klekociuk, A. R., et al. (2023) · Photochemical & Photobiological Sciences · doi:10.1007/s43630-023-00376-7 · Cited by 113
Tuong, W., Walker, L., & Sivamani, R. K. (2015) · Journal of Dermatological Treatment · doi:10.3109/09546634.2014.991675 · Cited by 17
Metadata
- Authors
- Brunetti, C., Di Ferdinando, M., Fini, A., Pollastri, S., & Tattini, M.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2013-02-07
- Volume
- 14
- Issue
- 2
- Pages
- 3540-3555
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W2112019022
- Cited by
- 508
- References
- 111
- FWCI
- 15.52
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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