Interactions among PIN-FORMED and P-Glycoprotein Auxin Transporters in Arabidopsis
Open accessAbstract
Directional transport of the phytohormone auxin is established primarily at the point of cellular efflux and is required for the establishment and maintenance of plant polarity. Studies in whole plants and heterologous systems indicate that PIN-FORMED (PIN) and P-glycoprotein (PGP) transport proteins mediate the cellular efflux of natural and synthetic auxins. However, aromatic anion transport resulting from PGP and PIN expression in nonplant systems was also found to lack the high level of substrate specificity seen in planta. Furthermore, previous reports that PGP19 stabilizes PIN1 on the plasma membrane suggested that PIN–PGP interactions might regulate polar auxin efflux. Here, we show that PGP1 and PGP19 colocalized with PIN1 in the shoot apex in Arabidopsis thaliana and with PIN1 and PIN2 in root tissues. Specific PGP–PIN interactions were seen in yeast two-hybrid and coimmunoprecipitation assays. PIN–PGP interactions appeared to enhance transport activity and, to a greater extent, substrate/inhibitor specificities when coexpressed in heterologous systems. By contrast, no interactions between PGPs and the AUXIN1 influx carrier were observed. Phenotypes of pin and pgp mutants suggest discrete functional roles in auxin transport, but pin pgp mutants exhibited phenotypes that are both additive and synergistic. These results suggest that PINs and PGPs characterize coordinated, independent auxin transport mechanisms but also function interactively in a tissue-specific manner.
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Activation of phytochromes and cryptochromes significantly inhibits ABCB19 expression, which inhibits auxin transport to the base of Arabidopsis hypocotyls and enhances plant phototropism.
“Activation of phytochromes and cryptochromes can significantly inhibit the expression of ABCB19, which inhibits the transport of auxin to the base of Arabidopsis hypocotyls and enhances phototropism of the plants”
From The action of enhancing weak light capture via phototropic growth and chloroplast movement in plants (2022) · cites this paper as Blakeslee et al., 2007
The PGP19 mRNA and Protein Localization section (p. 2) reports fivefold higher PGP19 expression in dark-grown seedlings than in light-grown seedlings. The Discussion (p. 12) links PGP19 to polar auxin flow, but says its contribution to auxin redistribution during tropic bending is unclear. The paper does not establish that phytochrome or cryptochrome activation inhibits ABCB19 expression or that this enhances phototropism. (LLM, conf=0.88)
Experimental — accuracy not yet measuredPhytochromes and cryptochromes can affect phototropism by affecting transcription and by regulating auxin transport.
“Phytochromes and cryptochromes can affect phototropism by affecting transcription, as well as by regulating auxin transport.”
From The action of enhancing weak light capture via phototropic growth and chloroplast movement in plants (2022) · cites this paper as Blakeslee et al., 2007
The Discussion (p. 13) says light regulates PIN and PGP gene expression and protein distribution, and the colocalization section (p. 6) mentions possible auxin-transporter interactions in phototropic bending. Our copy does not identify phytochromes or cryptochromes as the regulators or establish that they affect phototropism through transcription and auxin transport. (LLM, conf=0.76)
Experimental — accuracy not yet measuredPhytochromes can regulate other auxin transporters such as PIN1, PIN3, PIN7 and PID.
“Phytochromes can also regulate other auxin transporters such as PIN1, PIN3, PIN7 and PID”
From The action of enhancing weak light capture via phototropic growth and chloroplast movement in plants (2022) · cites this paper as Blakeslee et al., 2007
The Discussion (p. 13) says that light regulates PIN gene expression and protein distribution, and the Figure 1 caption (p. 5) describes PIN1 and PIN7 in light- and dark-grown seedlings. The paper does not establish that phytochromes regulate PIN1, PIN3, PIN7, or PID specifically. (LLM, conf=0.84)
Experimental — accuracy not yet measuredABCB19 interacts with PIN1 to stabilize PIN1 membrane localization and regulate its activity.
“ABCB19 also interacts with PIN1 to stabilize PIN1 membrane localization and regulate its activity (Blakeslee et al., 2007; Titapiwatanakun et al., 2009).”
From The action of enhancing weak light capture via phototropic growth and chloroplast movement in plants (2022) · cites this paper as Blakeslee et al., 2007
The Coimmunoprecipitation Assays (pp. 8–9) support an interaction between PIN1 and PGP19 (ABCB19), and Functional Interactions in Heterologous Systems (p. 11) show that coexpression changes auxin efflux. The Introduction (p. 2) says previous reports *suggested* that PGPs regulate PIN plasma-membrane stability and describes PIN1 delocalization in pgp19 hypocotyls. It does not establish that the ABCB19–PIN1 interaction itself stabilizes PIN1 membrane localization. (LLM, conf=0.84)
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“(2014) demonstrated that PINOID kinase (PID) can regulate the phosphorylation state of PINs and affect their localization.”
BackgroundInfluential
- Authors
- Blakeslee, J. J., Bandyopadhyay, A., Lee, O. R., Mravec, J., Titapiwatanakun, B., Sauer, M., Makam, S. N., Cheng, Y., Bouchard, R., Adamec, J., Geisler, M., Nagashima, A., Sakai, T., Martinoia, E., Friml, J., Peer, W. A., & Murphy, A. S.
- Affiliations
- Purdue University West Lafayette (US)
- University of Tübingen (DE)
- University of Zurich (CH)
- Purdue Discovery Park, West Lafayette, Indiana 47907-2010
- RIKEN (JP)
- Center for Plant Molecular Biology, University of Tübingen, D-72076 Tübingen, Germany
- ORCID
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-01-01
- Volume
- 19
- Issue
- 1
- Pages
- 131-147
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- PMC
- PMC1820964
- OpenAlex
- W2112660950
- Cited by
- 434
- References
- 72
- Citations by year
- 2026: 2 · 2025: 15 · 2024: 14 · 2023: 19 · 2022: 20 · 2021: 30 · 2020: 15 · 2019: 13 · 2018: 18 · 2017: 19 · 2016: 17 · 2015: 25 · 2014: 33 · 2013: 36 · 2012: 30
- FWCI
- 39.70
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- The Plant Cell (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant nutrient uptake and metabolism
- Keywords
- auxin transport, PIN-FORMED proteins, Pin1, PIN2, protein-protein interaction, substrate specificity, plant polarity, shoot apex, root development, Arabidopsis thaliana
- MeSH terms
- Biological Transport, Indoleacetic Acids, Mutation, RNA, Messenger, Arabidopsis, ATP Binding Cassette Transporter, Subfamily B, Plant Roots, ATP-Binding Cassette Transporters, Hypocotyl, Two-Hybrid System Techniques, Membrane Transport Proteins, Arabidopsis Proteins
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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