Comparative analysis of iron regulated genes in mycobacteria
Abstract
Iron dependent regulator, IdeR, regulates the expression of genes in response to intracellular iron levels in M. tuberculosis. Orthologs of IdeR are present in all the sequenced genomes of mycobacteria. We have used a computational approach to identify conserved IdeR regulated genes across the mycobacteria and the genes that are specific to each of the mycobacteria. Novel iron regulated genes that code for a predicted 4‐hydroxy benzoyl coA hydrolase (Rv1847) and a protease dependent antibiotic regulatory system (Rv1846c, Rv0185c) are conserved across the mycobacteria. Although Mycobacterium natural‐resistance‐associated macrophage protein (Mramp) is present in all mycobacteria, it is, as predicted, an iron‐regulated gene in only one species,M. avium subsp.paratuberculosis. We also observed an additional iron‐regulated exochelin biosynthetic operon, which is present only in non‐pathogenic Mycobacterium,M. smegmatis.
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Fur and IdeR are the two key proteins that regulate expression of other Fe-dependent genes.
“Fur and Fe-dependent repressors and activators or IdeR are the two key proteins that regulate expression of other Fe-dependent genes [28, 63].”
From Strategies of intracellular pathogens for obtaining iron from the environment (2015) · cites this paper as [63]
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- Authors
- Yellaboina, S., Ranjan, S., Vindal, V., & Ranjan, A.
- Affiliations
- European Molecular Biology Network (EMBnet) (NL)
- Corresponding author
- Ranjan, Akash
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2006-04-12
- Volume
- 580
- Issue
- 11
- Pages
- 2567-2576
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2018576784
- Cited by
- 26
- References
- 27
- Citations by year
- 2025: 1 · 2022: 1 · 2021: 3 · 2019: 2 · 2018: 1 · 2017: 1 · 2015: 2 · 2014: 2 · 2012: 2
- FWCI
- 1.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Health Sciences › Medicine › Epidemiology › Mycobacterium research and diagnosis
- Keywords
- iron regulation, IdeR, Mycobacterium tuberculosis, mycobacteria, gene expression regulation, comparative genomics, Mycobacterium avium subsp. paratuberculosis, Mycobacterium smegmatis
- MeSH terms
- Amino Acid Sequence, Bacterial Proteins, Binding Sites, Iron, Molecular Sequence Data, Mycobacterium, Operon, Protein Binding, Repressor Proteins, Gene Expression Regulation, Bacterial, Sequence Alignment, Conserved Sequence, Sequence Homology, Amino Acid, Computational Biology
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