Cited by 26Tuberculosis Research and EpidemiologyBacterial Genetics and BiotechnologyMycobacterium research and diagnosis

Comparative analysis of iron regulated genes in mycobacteria

Yellaboina, Sailu, Ranjan, Sarita, Vindal, Vaibhav, Ranjan, Akash·2006·FEBS Letters

Abstract

Iron dependent regulator, IdeR, regulates the expression of genes in response to intracellular iron levels in M. tuberculosis. Orthologs of IdeR are present in all the sequenced genomes of mycobacteria. We have used a computational approach to identify conserved IdeR regulated genes across the mycobacteria and the genes that are specific to each of the mycobacteria. Novel iron regulated genes that code for a predicted 4‐hydroxy benzoyl coA hydrolase (Rv1847) and a protease dependent antibiotic regulatory system (Rv1846c, Rv0185c) are conserved across the mycobacteria. Although Mycobacterium natural‐resistance‐associated macrophage protein (Mramp) is present in all mycobacteria, it is, as predicted, an iron‐regulated gene in only one species,M. avium subsp.paratuberculosis. We also observed an additional iron‐regulated exochelin biosynthetic operon, which is present only in non‐pathogenic Mycobacterium,M. smegmatis.

Integrity signals

Registry

Crossref · 10.1016/j.febslet.2006.03.090

Cites

27 of 27 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Yellaboina, S., Ranjan, S., Vindal, V., & Ranjan, A.
Affiliations
European Molecular Biology Network (EMBnet) (NL)
Corresponding author
Ranjan, Akash
Venue
FEBS Letters
Publisher
Wiley
Published
2006-04-12
Volume
580
Issue
11
Pages
2567-2576
ISSN
  • 0014-5793 (ISSN-L)
  • 1873-3468
OpenAlex
W2018576784
Cited by
26
References
27
Citations by year
2025: 1 · 2022: 1 · 2021: 3 · 2019: 2 · 2018: 1 · 2017: 1 · 2015: 2 · 2014: 2 · 2012: 2
FWCI
1.44
Type
journal article
Language
en
Open access
closed
Locations
  • FEBS Letters (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
  • Health Sciences › Medicine › Epidemiology › Mycobacterium research and diagnosis
Keywords
iron regulation, IdeR, Mycobacterium tuberculosis, mycobacteria, gene expression regulation, comparative genomics, Mycobacterium avium subsp. paratuberculosis, Mycobacterium smegmatis
MeSH terms
Amino Acid Sequence, Bacterial Proteins, Binding Sites, Iron, Molecular Sequence Data, Mycobacterium, Operon, Protein Binding, Repressor Proteins, Gene Expression Regulation, Bacterial, Sequence Alignment, Conserved Sequence, Sequence Homology, Amino Acid, Computational Biology

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review