The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
The amino acid sensitive TOR pathway from yeast to mammals
Open accessAbstract
The target of rapamycin (TOR) is an ancient effector of cell growth that integrates signals from growth factors and nutrients. Two downstream effectors of mammalian TOR, the translational components S6K1 and 4EBP1, are commonly used as reporters of mTOR activity. The conical signaling cascade initiated by growth factors is mediated by PI3K, PKB, TSC1/2 and Rheb. However, the process through which nutrients, i.e., amino acids, activate mTOR remains largely unknown. Evidence exists for both an intracellular and/or a membrane bound sensor for amino acid mediated mTOR activation. Research in eukaryotic models, has implicated amino acid transporters as nutrient sensors. This review describes recent advances in nutrient signaling that impinge on mTOR and its targets including hVps34, class III PI3K, a transducer of nutrient availability to mTOR.
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Cites
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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
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Self-citationInfluence of TOR kinase on lifespan in C. elegans
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Cited by
Watterson, K. R., Bestow, D., Gallagher, J., Hamilton, D. L., Ashford, F. B., Meakin, P. J., & Ashford, M. L. J. (2013) · Neurosignals · doi:10.1159/000334144 · Cited by 3,389
Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy
Nicklin, P., Bergman, P., Zhang, B., Triantafellow, E., Wang, H., Nyfeler, B., Yang, H., Hild, M., Kung, C., Wilson, C., et al. (2009) · Cell · doi:10.1016/j.cell.2008.11.044 · Cited by 1,798
Glutamine addiction: a new therapeutic target in cancer
Wise, D. R., & Thompson, C. B. (2010) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.05.003 · Cited by 1,770
mTOR controls mitochondrial oxidative function through a YY1–PGC-1α transcriptional complex
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The mTOR Signalling Pathway in Human Cancer
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Metadata
- Authors
- Dann, S. G., & Thomas, G.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2006-05-02
- Volume
- 580
- Issue
- 12
- Pages
- 2821-2829
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2041816969
- Cited by
- 213
- References
- 12
- FWCI
- 8.96
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
