Influence of TOR kinase on lifespan in C. elegans

Vellai, Tibor; Takacs-Vellai, Krisztina; Zhang, Yue; Kovacs, Attila L.; Orosz, László; Müller, Fritz

doi:10.1038/426620a

Cited by 1,057Genetics, Aging, and Longevity in Model OrganismsPI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

Influence of TOR kinase on lifespan in C. elegans

Vellai, Tibor, Takacs-Vellai, Krisztina, Zhang, Yue, Kovacs, Attila L., Orosz, László, Müller, Fritz·2003·Nature

DOI 10.1038/426620a

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TOR inactivation extends lifespan in yeast, flies, worms and mice.
“Of significance, TOR inactivation extends lifespan in yeast (Kaeberlein et al., 2005), flies (Kapahi et al., 2004), worms (Vellai et al., 2003) and mice (Harrison et al., 2009).”
From The Search for Antiaging Interventions: From Elixirs to Fasting Regimens (2014) · cites this paper as Vellai et al., 2003
In many organisms, decreased TOR signalling is associated with extension of lifespan.
“In many organisms, decreased TOR signalling is associated with the extension of life span 87, 88, 89 .”
From The common biology of cancer and ageing (2007) · cites this paper as [87]

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“…& Sons Ltd. INSR depletion requires DAF-16 (Lin et al., 1997; Ogg et al., 1997), whereas increase to lifespan provided by TOR depletion does not (Vellai et al., 2003), showing that these two pathways can have distinct downstream mediators of lifespan effects in addition to the shared ones…”
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Role of TOR signaling in aging and related biological processes in Drosophila melanogaster
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The role of MAP4K3 in lifespan regulation of Caenorhabditis elegans
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Authors: Vellai, T., Takacs-Vellai, K., Zhang, Y., Kovacs, A. L., Orosz, L., & Müller, F.
Affiliations: University of Fribourg (CH)
Eötvös Loránd University (HU)
Corresponding author: Müller, Fritz
ORCID: Vellai, Tibor
Zhang, Yue
Orosz, László
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2003-12-11
Volume: 426
Issue: 6967
Pages: 620-620
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/426620a
OpenAlex: W2045201133
Cited by: 1,057
References: 10
Citations by year: 2026: 17 · 2025: 33 · 2024: 31 · 2023: 67 · 2022: 44 · 2021: 48 · 2020: 54 · 2019: 61 · 2018: 48 · 2017: 40 · 2016: 60 · 2015: 58 · 2014: 47 · 2013: 45 · 2012: 48
FWCI: 7.12
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
reroDoc Digital Library (submittedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: TOR kinase, lifespan, aging, Caenorhabditis elegans, nutrient signaling, growth regulation, longevity
MeSH terms: Aging, Animals, Energy Metabolism, Epistasis, Genetic, Insulin, Insulin-Like Growth Factor I, Larva, Longevity, Phenotype, Receptor, Insulin, Temperature, Time Factors, Transcription Factors, Signal Transduction, Caenorhabditis elegans, Phosphotransferases (Alcohol Group Acceptor), Cell Respiration, Caenorhabditis elegans Proteins, RNA Interference, Forkhead Transcription Factors

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