The DOI matches its Crossref record; 143 of the 143 references it cites were found in a registry or an index.
Mechanisms of homocysteine neurotoxicity in neurodegenerative diseases with special reference to dementia
Open accessAbstract
Mild to moderate hyperhomocysteinemia is a risk factor for neurodegenerative diseases. Human studies suggest that homocysteine (Hcy) plays a role in brain damage, cognitive and memory decline. Numerous studies in recent years investigated the role of Hcy as a cause of brain damage. Hcy itself or folate and vitamin B12 deficiency can cause disturbed methylation and/or redox potentials, thus promoting calcium influx, amyloid and tau protein accumulation, apoptosis, and neuronal death. The Hcy effect may also be mediated by activating the N‐methyl‐d‐aspartate receptor subtype. Numerous neurotoxic effects of Hcy can be blocked by folate, glutamate receptor antagonists, or various antioxidants. This review describes the most important mechanisms of Hcy neurotoxicity and pharmacological agents known to reverse Hcy effects.
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Blood inflammatory markers and risk of dementia: The Conselice Study of Brain Aging
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Metadata
- Authors
- Obeid, R., & Herrmann, W.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2006-05-06
- Volume
- 580
- Issue
- 13
- Pages
- 2994-3005
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2056313120
- Cited by
- 490
- References
- 143
- FWCI
- 12.75
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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