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Tunneling nanotubes: A new route for the exchange of components between animal cells
Abstract
Recently, highly sensitive nanotubular structures mediating membrane continuity between mammalian cells have been discovered. With respect to their peculiar architecture, these membrane channels were termed tunneling nanotubes (TNTs). TNTs could form de novo between animal cells leading to the generation of complex cellular networks. They have been shown to facilitate the intercellular transfer of organelles as well as, on a limited scale, of membrane components and cytoplasmic molecules. It has been proposed that TNTs represent a novel and general biological principle of cell‐to‐cell communication and it becomes increasingly apparent that they fulfill important functions in the physiological processes of multicellular organisms.
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“Later, HIV-1 and HTLV-1 cell-to-cell transmission via TNT was reported.”
From HIV-1 and HTLV-1 Transmission Modes: Mechanisms and Importance for Virus Spread (2022) · cites this paper as [107]
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Metadata
- Authors
- Gerdes, H.-H., Bukoreshtliev, N. V., & Barroso, J. F. V.
- Affiliations
- University of Bergen (NO)
- Corresponding author
- Gerdes, Hans-Hermann
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2007-04-04
- Volume
- 581
- Issue
- 11
- Pages
- 2194-2201
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2044320361
- Cited by
- 304
- References
- 61
- Citations by year
- 2026: 9 · 2025: 6 · 2024: 18 · 2023: 11 · 2022: 18 · 2021: 20 · 2020: 18 · 2019: 18 · 2018: 21 · 2017: 16 · 2016: 14 · 2015: 13 · 2014: 11 · 2013: 14 · 2012: 22
- FWCI
- 1.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
- Keywords
- tunneling nanotubes, intercellular communication, membrane continuity, organelle transfer, multicellular organisms
- MeSH terms
- Animals, Biological Transport, Cell Communication, Cell Membrane, Humans, Plasmodesmata, Nanotubes
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