The DOI matches its Crossref record; 78 of the 79 references it cites were found in a registry or an index.
Transition metal transport
Open accessAbstract
Transition metal transporters are of central importance in the plant metal homeostasis network which maintains internal metal concentrations within physiological limits. An overview is given of the functions of known transition metal transporters in the context of the unique chemical properties of their substrates. The modifications of the metal homeostasis network associated with the adaptation to an extreme metalliferous environment are illustrated in two Brassicaceae metal hyperaccumulator model plants based on cross-species transcriptomics studies. In a comparison between higher plants and unicellular algae, hypotheses are generated for evolutionary changes in metal transporter complements associated with the transition to multicellularity.
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“It is pertinent to mention that the expression of transporter genes very often varies concerning metal ion supply, tissue, organ, and populations of hyperaccumulators (Krämer et al., 2007; Verbruggen et al., 2009b; Küpper and Kochian, 2010; Visioli et al., 2014).”
From Plant hyperaccumulators: a state-of-the-art review on mechanism of heavy metal transport and sequestration (2025) · cites this paper as Krämer et al., 2007
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“Moreover, metal ion transport into vacuoles occurs through CDF (cation diffusion facilitator), MTP (metal tolerance protein), and P1B type ATPase HMA3 (Krämer et al., 2007; Verbruggen et al., 2009b; Andresen et al., 2018).”
From Plant hyperaccumulators: a state-of-the-art review on mechanism of heavy metal transport and sequestration (2025) · cites this paper as Krämer et al., 2007
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“A great deal of metal ion transport has been explored through studies on ZIP transporters, as they are involved mainly in the uptake of metal ions (Krämer et al., 2007; Andresen et al., 2018).”
From Plant hyperaccumulators: a state-of-the-art review on mechanism of heavy metal transport and sequestration (2025) · cites this paper as Krämer et al., 2007
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Citations
Cites
Toxic metal accumulation, responses to exposure and mechanisms of tolerance in plants
Clemens, S. (2006) · Biochimie · doi:10.1016/j.biochi.2006.07.003 · Cited by 2,098
Phytoremediation of toxic metals : using plants to clean up the environment
Raskin, I., & Ensley, B. D. (2000) · Wiley eBooks · Cited by 2,065
Femtomolar Sensitivity of Metalloregulatory Proteins Controlling Zinc Homeostasis
Outten, C. E., & O'Halloran, A. T. V. (2001) · Science · doi:10.1126/science.1060331 · Cited by 1,489 · cited 1×
“Based on metal binding affinities of apo-metalloproteins and metal sensors, cytoplasmic concentrations have been estimated at between 10 21 and 10 18 M for free aqueous copper ions [24], and at around 10 15 M for free aqueous zinc ions [9,25].”
BackgroundMcKie, A. T., Marciani, P., Rolfs, A., Brennan, K., Wehr, K., Barrow, D., Miret, S., Bomford, A., Peters, T. J., Farzaneh, F., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80425-6 · Cited by 1,422
A long way ahead: understanding and engineering plant metal accumulation
Clemens, S., Palmgren, M. G., & Krämer, U. (2002) · Trends in Plant Science · doi:10.1016/s1360-1385(02)02295-1 · Cited by 1,265
Self-citationThe biological chemistry of the elements
(1993) · The Science of The Total Environment · doi:10.1016/0048-9697(93)90224-t · Cited by 1,173
Transition Metal Speciation in the Cell: Insights from the Chemistry of Metal Ion Receptors
Finney, L. A., & O'Halloran, T. V. (2003) · Science · doi:10.1126/science.1085049 · Cited by 1,100
Metallochaperones, an Intracellular Shuttle Service for Metal Ions
O'Halloran, T. V., & Culotta, V. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.r000006200 · Cited by 806
The IRT1 protein from Arabidopsis thaliana is a metal transporter with a broad substrate range
Korshunova, Y. O., Eide, D., Clark, W. G., Guerinot, M. L., & Pakrasi, H. B. (1999) · Plant Molecular Biology · doi:10.1023/a:1026438615520 · Cited by 801
P-Type ATPase Heavy Metal Transporters with Roles in Essential Zinc Homeostasis in Arabidopsis
Hussain, D., Haydon, M. J., Wang, Y., Wong, E., Sherson, S. M., Young, J. C., Camakaris, J., Harper, J. F., & Cobbett, C. S. (2004) · The Plant Cell · doi:10.1105/tpc.020487 · Cited by 757
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1 of the 79 references couldn’t be matched to a known paper.
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- J.J.R. Fraústo da Silva R.J.P. Williams 2001 Clarendon Press Oxford UK
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White, P. J., & Broadley, M. R. (2009) · New Phytologist · doi:10.1111/j.1469-8137.2008.02738.x · Cited by 2,178
Remediation of heavy metal(loid)s contaminated soils – To mobilize or to immobilize?
Bolan, N. S., Kunhikrishnan, A., Thangarajan, R., Kumpienė, J., Park, J., Makino, T., Kirkham, M. B., & Scheckel, K. G. (2013) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2013.12.018 · Cited by 2,106
Heavy metal hyperaccumulating plants: how and why do they do it? And what makes them so interesting
Rascio, N., & Navari-Izzo, F. (2011) · Plant Science · doi:10.1016/j.plantsci.2010.08.016 · Cited by 2,012
Heavy Metal Tolerance in Plants: Role of Transcriptomics, Proteomics, Metabolomics, and Ionomics
Singh, S., Parihar, P., Singh, R., Singh, V. P., & Prasad, S. M. (2016) · Frontiers in Plant Science · doi:10.3389/fpls.2015.01143 · Cited by 1,354
Metal hyperaccumulation in plants
Krämer, U. (2010) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-042809-112156 · Cited by 1,284
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Metadata
- Authors
- Krämer, U., Talke, I. N., & Hanikenne, M.
- Affiliations
- Max Planck Institute of Molecular Plant Physiology (DE)
- University of Liège (BE)
- Corresponding author
- Krämer, Ute
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2007-04-17
- Volume
- 581
- Issue
- 12
- Pages
- 2263-2272
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2054518237
- Cited by
- 583
- References
- 79
- Citations by year
- 2026: 20 · 2025: 21 · 2024: 14 · 2023: 20 · 2022: 21 · 2021: 51 · 2020: 45 · 2019: 43 · 2018: 30 · 2017: 32 · 2016: 37 · 2015: 35 · 2014: 37 · 2013: 30 · 2012: 36
- FWCI
- 2.12
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- ORBi (University of Liège) (submittedVersion)
- Funders
- European Commission (FOOD‐CT‐2006‐016253)
- Deutsche Forschungsgemeinschaft
- Fonds De La Recherche Scientifique - FNRS
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Micronutrient Interactions and Effects
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant nutrient uptake and metabolism
- Keywords
- plant metal homeostasis, metal hyperaccumulation, Brassicaceae, metalliferous soils, cross-species transcriptomics, multicellularity, algae
- MeSH terms
- Biological Transport, Active, Cell Membrane, Chelating Agents, Biological Evolution, Multigene Family, Homeostasis, Iron, Models, Biological, Plant Proteins, Plants, Genes, Plant, Protein Structure, Tertiary, Chloroplast Proton-Translocating ATPases, Membrane Transport Proteins, Cation Transport Proteins, Transition Elements
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