The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Compound C inhibits hypoxic activation of HIF‐1 independent of AMPK
Abstract
The key transcription factor that regulates the cellular responses to hypoxia is hypoxia inducible factor‐1 (HIF‐1). The signaling mechanisms that regulate the hypoxic activation of HIF‐1 are not fully understood. Our objective here was to test whether AMP‐activated kinase (AMPK) was an upstream regulator of HIF‐1. Our results show that AMPK is not required for the hypoxic activation of HIF‐1. Interestingly, the AMPK inhibitor, Compound C, inhibits the hypoxic activation of HIF‐1 independent of AMPK. Furthermore, we demonstrate that Compound C functions as a repressor of HIF‐1 by inhibiting respiration and suppressing mitochondrial generated ROS.
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“this drug has been observed to inhibit autophagy under conditions where AMPK is already inactive or knocked out [676, 677]”
From Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1 (2021) · cites this paper as [676]
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HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
Ivan, M., Kondo, K., Yang, H., Kim, W., Valiando, J., Ohh, M., Salic, A., Asara, J. M., Lane, W. S., & Kaelin Jr., W. G. (2001) · Science · doi:10.1126/science.1059817 · Cited by 4,735
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Self-citationMasson, N., Willam, C., Maxwell, P. H., Pugh, C. W., & Ratcliffe, P. J. (2001) · The EMBO Journal · doi:10.1093/emboj/20.18.5197 · Cited by 1,014
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Self-citationThe Regulation of AMP-Activated Protein Kinase by H2O2
Choi, S.-L., Kim, S.-J., Lee, K.-T., Kim, J., Mu, J., Birnbaum, M. J., Soo Kim, S., & Ha, J. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5544 · Cited by 294
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Research works printed but not linked: 18
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Autophagy · doi:10.1080/15548627.2015.1100356 · Cited by 5,894
Guidelines for the use and interpretation of assays for monitoring autophagy
Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J. A., et al. (2012) · Autophagy · doi:10.4161/auto.19496 · Cited by 3,996
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1
Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M. H., Abudu, Y. P., Acevedo-Arozena, A., et al. (2021) · Autophagy · doi:10.1080/15548627.2020.1797280 · Cited by 2,897
Self-citationAMPK inhibition in health and disease
Viollet, B., Horman, S., Leclerc, J., Lantier, L., Foretz, M., Billaud, M., Giri, S., & Andreelli, F. (2010) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2010.488215 · Cited by 383
Self-citationHypoxia decreases insulin signaling pathways in adipocytes.
Regazzetti, C., Peraldi, P., Grémeaux, T., Najem-Lendom, R., Ben-Sahra, I., Cormont, M., Bost, F., Le Marchand-Brustel, Y., Tanti, J.-F., & Giorgetti-Peraldi, S. (2009) · Diabetes · doi:10.2337/db08-0457 · Cited by 281
Metadata
- Authors
- Emerling, B. M., Viollet, B., Tormos, K. V., & Chandel, N. S.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2007-11-26
- Volume
- 581
- Issue
- 29
- Pages
- 5727-5731
- ISSN
- 0014-5793
- 1873-3468
- Cited by
- 96
- References
- 5
- Language
- en
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