AMPK inhibition in health and disease

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197 · see citing works

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760 · see citing works

TOR signaling in growth and metabolism

Wullschleger, S., Loewith, R., & Hall, M. N. (2006) · Cell · doi:10.1016/j.cell.2006.01.016 · Cited by 5,787 · see citing works

Role of AMP-Activated Protein Kinase in Mechanism of Metformin Action

Zhou, G., Myers, R., Li, Y., Chen, Y., Shen, X., Fenyk-Melody, J., Wu, M., Ventre, J., Doebber, T., Fujii, N., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13505 · Cited by 5,652 · see citing works

The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus

Randle, P. J., Garland, P. B., Hales, C. N., & Newsholme, E. A. (1963) · The Lancet · doi:10.1016/s0140-6736(63)91500-9 · Cited by 5,093 · see citing works

The hormone resistin links obesity to diabetes

Steppan, C. M., Bailey, S. T., Bhat, S., Brown, E. J., Banerjee, R. R., Wright, C. M., Patel, H. R., Ahima, R. S., & Lazar, M. A. (2001) · Nature · doi:10.1038/35053000 · Cited by 4,755 · see citing works

TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

Inoki, K., Zhu, T., & Guan, K.-L. (2003) · Cell · doi:10.1016/s0092-8674(03)00929-2 · Cited by 3,914 · see citing works

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

Gwinn, D. M., Shackelford, D. B., Egan, D. F., Mihaylova, M. M., Mery, A., Vasquez, D. S., Turk, B. E., & Shaw, R. J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.03.003 · Cited by 3,849 · see citing works

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L.-L., et al. (2003) · Nature · doi:10.1038/nature01960 · Cited by 3,796 · see citing works

TLR4 links innate immunity and fatty acid-induced insulin resistance

Shi, H., Kokoeva, M. V., Inouye, K., Tzameli, I., Yin, H., & Flier, J. S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28898 · Cited by 3,690 · see citing works

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

Kahn, B. B., Alquier, T., Carling, D., & Hardie, D. G. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.12.003 · Cited by 2,799 · see citing works

The selectivity of protein kinase inhibitors: a further update

Bain, J., Plater, L., Elliott, M., Shpiro, N., Hastie, C. J., McLauchlan, H., Klevernic, I. V., Arthur, J. S. C., Alessi, D. R., & Cohen, P. (2007) · Biochemical Journal · doi:10.1042/bj20070797 · Cited by 2,522 · see citing works

Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes.

Guilherme, A., Virbasius, J. V., Puri, V., & Czech, M. P. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2391 · Cited by 2,292 · see citing works

Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

Minokoshi, Y., Kim, Y.-B., Peroni, O. D., Fryer, L. G. D., Müller, C., Carling, D., & Kahn, B. B. (2002) · Nature · doi:10.1038/415339a · Cited by 2,053 · see citing works

Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance

Kern, P. A., Ranganathan, S., Li, C., Wood, L., & Ranganathan, G. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.5.e745 · Cited by 1,883 · see citing works

Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade

Hawley, S. A., Boudeau, J., Reid, J. L., Mustard, K. J., Udd, L., Mäkelä, T. P., Alessi, D. R., & Hardie, D. G. (2003) · Journal of Biology · doi:10.1186/1475-4924-2-28 · Cited by 1,666 · see citing works

LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

Woods, A., Johnstone, S. R., Dickerson, K., Leiper, F. C., Fryer, L. G. D., Neumann, D., Schlattner, U., Wallimann, T., Carlson, M., & Carling, D. (2003) · Current Biology · doi:10.1016/j.cub.2003.10.031 · Cited by 1,650 · see citing works

AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus

Minokoshi, Y., Alquier, T., Furukawa, N., Kim, Y.-B., Lee, A., Xue, B., Mu, J., Foufelle, F., Ferré, P., Birnbaum, M. J., et al. (2004) · Nature · doi:10.1038/nature02440 · Cited by 1,637 · see citing works

AMP-activated protein kinase induces a p53-dependent metabolic checkpoint

Jones, R. G., Plas, D. R., Kubek, S., Buzzai, M., Mu, J., Xu, Y., Birnbaum, M. J., & Thompson, C. B. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.03.027 · Cited by 1,619 · see citing works

Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase

Hawley, S. A., Pan, D. A., Mustard, K. J., Ross, L., Bain, J., Edelman, A. M., Frenguelli, B. G., & Hardie, D. G. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.05.009 · Cited by 1,589 · see citing works

Ca2+/calmodulin-dependent protein kinase kinase-β acts upstream of AMP-activated protein kinase in mammalian cells

Woods, A., Dickerson, K., Heath, R. B., Hong, S. P., Momcilovic, M., Johnstone, S. R., Carlson, M., & Carling, D. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.06.005 · Cited by 1,395 · see citing works

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR‐1

Lizcano, J. M., Göransson, O., Toth, R., Deak, M., Morrice, N. A., Boudeau, J., Hawley, S. A., Udd, L., Mäkelä, T. P., Hardie, D. G., et al. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600110 · Cited by 1,381 · see citing works

Relationship Between Carbohydrate and Lipid Metabolism and the Energy Balance of Heart Muscle

Neely, J. R., & Morgan, H. E. (1974) · Annual Review of Physiology · doi:10.1146/annurev.ph.36.030174.002213 · Cited by 1,266 · see citing works

5-Aminoimidazole-4-Carboxamide Ribonucleoside. A Specific Method for Activating AMP-Activated Protein Kinase in Intact Cells?

Corton, J. M., Gillespie, J. G., Hawley, S. A., & Hardie, D. G. (1995) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1995.tb20498.x · Cited by 1,232 · see citing works

Insulin sensitivity: Modulation by nutrients and inflammation

Schenk, S., Saberi, M., & Olefsky, J. M. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34260 · Cited by 1,191 · see citing works

Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

Schafer, Z. T., Grassian, A. R., Song, L., Jiang, Z., Gerhart-Hines, Z., Irie, H. Y., Gao, S., Puigserver, P., & Brugge, J. S. (2009) · Nature · doi:10.1038/nature08268 · Cited by 1,031 · see citing works

The Ca2+/Calmodulin-dependent Protein Kinase Kinases Are AMP-activated Protein Kinase Kinases

Hurley, R. L., Anderson, K. A., Franzone, J. M., Kemp, B. E., Means, A. R., & Witters, L. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503824200 · Cited by 1,021 · see citing works

Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome

Cool, B. L., Zinker, B. A., Chiou, W. J. H., Kifle, L., Cao, N., Perham, M., Dickinson, R., Adler, A. L., Gagné, G. D., Iyengar, R., et al. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.05.005 · Cited by 932 · see citing works

Systemic Treatment with the Antidiabetic Drug Metformin Selectively Impairs p53-Deficient Tumor Cell Growth

Buzzai, M., Jones, R. G., Amaravadi, R. K., Lum, J. J., DeBerardinis, R. J., Zhao, F., Viollet, B., & Thompson, C. B. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4447 · Cited by 923 · see citing works

Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2

Abu-Elheiga, L., Matzuk, M. M., Abo-Hashema, K. A. H., & Wakil, S. J. (2001) · Science · doi:10.1126/science.1056843 · Cited by 903 · see citing works

Interleukin-6 induces cellular insulin resistance in hepatocytes.

Senn, J. J., Klover, P. J., Nowak, I. A., & Mooney, R. A. (2002) · Diabetes · doi:10.2337/diabetes.51.12.3391 · Cited by 883 · see citing works

Akt Promotes Survival of Cardiomyocytes In Vitro and Protects Against Ischemia-Reperfusion Injury in Mouse Heart

Fujio, Y., Nguyen, T. U., Wencker, D., Kitsis, R. N., & Walsh, K. (2000) · Circulation · doi:10.1161/01.cir.101.6.660 · Cited by 846 · see citing works

AMP‐activated protein kinase phosphorylation of endothelial NO synthase

Chen, Z.-P., Mitchelhill, K. I., Michell, B. J., Stapleton, D., Rodríguez‐Crespo, I., Witters, L. A., Power, D. A., de Montellano, P. R. O., & Kemp, B. E. (1999) · FEBS Letters · doi:10.1016/s0014-5793(98)01705-0 · Cited by 835 · see citing works

SIRT1 Modulation of the Acetylation Status, Cytosolic Localization, and Activity of LKB1

Lan, F., Cacicedo, J. M., Ruderman, N., & Ido, Y. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m805711200 · Cited by 825 · see citing works

Adenosine 5′-Monophosphate-Activated Protein Kinase Promotes Macrophage Polarization to an Anti-Inflammatory Functional Phenotype

Sağ, D., Carling, D., Stout, R. D., & Suttles, J. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.12.8633 · Cited by 798 · see citing works

AMP-activated Protein Kinase Plays a Role in the Control of Food Intake

Andersson-Hall, U. K., Filipsson, K., Abbott, C. R., Woods, A., Smith, K. L., Bloom, S. R., Carling, D., & Small, C. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c300557200 · Cited by 756 · see citing works

CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations

Scott, J. W., Hawley, S. A., Green, K. A., Anis, M., Stewart, G., Scullion, G. A., Norman, D. G., & Hardie, D. G. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19874 · Cited by 754 · see citing works

THE GLUCOSE-FATTY ACID CYCLE

Stanley, J. C. (1981) · British Journal of Anaesthesia · doi:10.1093/bja/53.2.123 · Cited by 731 · see citing works

Large-scale phosphorylation analysis of mouse liver

Villén, J., Beausoleil, S. A., Gerber, S. A., & Gygi, S. P. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609836104 · Cited by 730 · see citing works

Regulation of Fasted Blood Glucose by Resistin

Banerjee, R. R., Rangwala, S. M., Shapiro, J. S., Rich, A. S., Rhoades, B., Qi, Y., Wang, J., Rajala, M. W., Pocai, A., Scherer, P. E., et al. (2004) · Science · doi:10.1126/science.1092341 · Cited by 727 · see citing works

Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade

Sanders, M. J., Grondin, P., Hegarty, B. D., Snowden, M. A., & Carling, D. (2007) · Biochemical Journal · doi:10.1042/bj20061520 · Cited by 660 · see citing works

Characterization of AMP-activated protein kinase γ-subunit isoforms and their role in AMP binding

CHEUNG, P. C. F., SALT, I. P., DAVIES, S. P., HARDIE, D. G., & CARLING, D. (2000) · Biochemical Journal · doi:10.1042/bj3460659 · Cited by 637 · see citing works

5′‐AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP‐activated protein kinase. Studies using bacterially expressed human protein phosphatase‐2C <i>α</i> and native bovine protein phosphatase‐2A _c

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Structural basis for AMP binding to mammalian AMP-activated protein kinase

Xiao, B., Heath, R., Saiu, P., Leiper, F. C., Leone, P., Jing, C., Walker, P. A., Haire, L., Eccleston, J. F., Davis, C. T., et al. (2007) · Nature · doi:10.1038/nature06161 · Cited by 591 · see citing works

High Rates of Fatty Acid Oxidation during Reperfusion of Ischemic Hearts Are Associated with a Decrease in Malonyl-CoA Levels Due to an Increase in 5’-AMP-activated Protein Kinase Inhibition of Acetyl-CoA Carboxylase

Kudo, N., Barr, A., Barr, R. L., Desai, S. S., & Lopaschuk, G. D. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.29.17513 · Cited by 565 · see citing works

Translocation of myocardial GLUT-4 and increased glucose uptake through activation of AMPK by AICAR

Russell, R. R., Bergeron, R., Shulman, G. I., & Young, L. H. (1999) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1999.277.2.h643 · Cited by 553 · see citing works

Circulating Resistin Levels Are Not Associated with Obesity or Insulin Resistance in Humans and Are Not Regulated by Fasting or Leptin Administration: Cross-Sectional and Interventional Studies in Normal, Insulin-Resistant, and Diabetic Subjects

Lee, J. H., Chan, J. L., Yiannakouris, N., Kontogianni, M. D., Estrada, E., Seip, R. L., Orlova, C., & Mantzoros, C. S. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030519 · Cited by 546 · see citing works

The structure of a domain common to archaebacteria and the homocystinuria disease protein.

Bateman, A. (1997) · TIBS -Trends in Biochemical Sciences. Regular ed · doi:10.1016/s0968-0004(96)30046-7 · Cited by 544 · see citing works

Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity

Hahn-Windgassen, A., Nogueira, V., Chen, C.-C., Skeen, J. E., Sonenberg, N., & Hay, N. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502876200 · Cited by 539 · see citing works

Activation of AMP‐activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders

Viollet, B., Foretz, M., Guigas, B., Horman, S., Dentin, R., Bertrand, L., Hue, L., & Andréelli, F. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.108506 · Cited by 529 · see citing works

Anti-obesity effects of α-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase

Kim, M., Park, J., NamKoong, C., Jang, P., Ryu, J., Song, H.-S., Yun, J.-Y., Nam‐Goong, I. S., Ha, J., Park, I.-S., et al. (2004) · Nature Medicine · doi:10.1038/nm1061 · Cited by 522 · see citing works

AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons

Claret, M., Smith, M. A., Batterham, R. L., Selman, C., Choudhury, A. I., Fryer, L. G. D., Clements, M., Al‐Qassab, H., Heffron, H., Xu, A. W., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31516 · Cited by 506 · see citing works

The AMP-activated protein kinase α2 catalytic subunit controls whole-body insulin sensitivity

Viollet, B., Andreelli, F., Jørgensen, S. B., Perrin, C., Geloen, A., Flamez, D., Mu, J., Lenzner, C., Baud, O., Bennoun, M., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16567 · Cited by 499 · see citing works

AMP‐activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives

Viollet, B., Guigas, B., Leclerc, J., Hébrard, S., Lantier, L., Mounier, R., Andréelli, F., & Foretz, M. (2009) · Acta Physiologica · doi:10.1111/j.1748-1716.2009.01970.x · Cited by 486 · see citing works

Mammalian TAK1 Activates Snf1 Protein Kinase in Yeast and Phosphorylates AMP-activated Protein Kinase in Vitro

Momcilovic, M., Hong, S. P., & Carlson, M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604399200 · Cited by 474 · see citing works

Dissecting the Role of 5′-AMP for Allosteric Stimulation, Activation, and Deactivation of AMP-activated Protein Kinase

Suter, M., Riek, U., Tuerk, R. D., Schlattner, U., Wallimann, T., & Neumann, D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606357200 · Cited by 473 · see citing works

Activation of the AMP-Activated Kinase by Antidiabetes Drug Metformin Stimulates Nitric Oxide Synthesis In Vivo by Promoting the Association of Heat Shock Protein 90 and Endothelial Nitric Oxide Synthase

Davis, B. J., Xie, Z., Viollet, B., & Zou, M. (2006) · Diabetes · doi:10.2337/diabetes.55.02.06.db05-1064 · Cited by 467 · see citing works

Constitutively active AMP kinase mutations cause glycogen storage disease mimicking hypertrophic cardiomyopathy

Arad, M., Benson, D. W., Pérez‐Atayde, A. R., McKenna, W. J., Sparks, E. A., Kanter, R. J., McGarry, K., Seidman, J. G., & Seidman, C. E. (2002) · Journal of Clinical Investigation · doi:10.1172/jci14571 · Cited by 460 · see citing works

Berberine suppresses proinflammatory responses through AMPK activation in macrophages

Jeong, H. W., Hsu, K. C., Lee, J.-W., Ham, M., Huh, J. Y., Shin, H. J., Kim, W. S., & Kim, J. B. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90599.2008 · Cited by 454 · see citing works

AMP-activated Protein Kinase Is Required for the Lipid-lowering Effect of Metformin in Insulin-resistant Human HepG2 Cells

Zang, M., Zuccollo, A., Hou, X., Nagata, D., Walsh, K., Herscovitz, H., Brecher, P. I., Ruderman, N. B., & Cohen, R. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408149200 · Cited by 453 · see citing works

AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome

Ruderman, N., & Prentki, M. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1344 · Cited by 451 · see citing works

Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2

Savage, D. B. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27300 · Cited by 447 · see citing works

What Are the Physical Characteristics Associated with a Normal Metabolic Profile Despite a High Level of Obesity in Postmenopausal Women?1

Brochu, M., Tchernof, A., Dionne, I. J., Sites, C. K., Eltabbakh, G. H., Sims, E. A. H., & Poehlman, E. T. (2001) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jcem.86.3.7365 · Cited by 443 · see citing works

5′-AMP-Activated Protein Kinase (AMPK) Is Induced by Low-Oxygen and Glucose Deprivation Conditions Found in Solid-Tumor Microenvironments

Laderoute, K. R., Amin, K., Calaoagan, J. M., Knapp, M., Le, T., Orduna, J. M., Foretz, M., & Viollet, B. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00166-06 · Cited by 443 · see citing works

Constitutively active AMP kinase mutations cause glycogen storage disease mimicking hypertrophic cardiomyopathy

Arad, M., Benson, D. W., Pérez‐Atayde, A. R., McKenna, W. J., Sparks, E. A., Kanter, R. J., McGarry, K., Seidman, J. G., & Seidman, C. E. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0214571 · Cited by 441 · see citing works

Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis.

Horman, S., Browne, G., Krause, U., Patel, J., Vertommen, D., Bertrand, L., Lavoinne, A., Hue, L., Proud, C. G., & Rider, M. (2002) · Current Biology · doi:10.1016/s0960-9822(02)01077-1 · Cited by 440 · see citing works

AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the α2 isoform

Salt, I. P., Celler, J. W., Hawley, S. A., Prescott, A. R., Woods, A., Carling, D., & Hardie, D. G. (1998) · Biochemical Journal · doi:10.1042/bj3340177 · Cited by 437 · see citing works

The Glycogen-Binding Domain on the AMPK β Subunit Allows the Kinase to Act as a Glycogen Sensor

McBride, A., Ghilagaber, S., Nikolaev, A., & Hardie, D. G. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2008.11.008 · Cited by 432 · see citing works

AMPK β Subunit Targets Metabolic Stress Sensing to Glycogen

Polekhina, G., Gupta, A., Michell, B. J., van Denderen, B., Murthy, S., Feil, S. C., Jennings, I. G., Campbell, D. J., Witters, L. A., Parker, M. W., et al. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00292-6 · Cited by 423 · see citing works

Purification and characterization of the AMP‐activated protein kinase

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Tumor necrosis factor α-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling

Steinberg, G. R., Michell, B. J., van Denderen, B. J. W., Watt, M. J., Carey, A. L., Fam, B. C., Andrikopoulos, S., Proietto, J., Görgün, C. Z., Carling, D., et al. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.11.005 · Cited by 418 · see citing works

Energy-dependent regulation of cell structure by AMP-activated protein kinase

Lee, J. H., Koh, H., Kim, M.-J., Kim, Y., Lee, S. Y., Karess, R. E., Lee, S. H., Shong, M., Kim, J., Kim, J., et al. (2007) · Nature · doi:10.1038/nature05828 · Cited by 418 · see citing works

Yeast SNF1 is functionally related to mammalian AMP-activated protein kinase and regulates acetyl-CoA carboxylase in vivo.

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AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic β cells, and may regulate insulin release

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Akt Activity Negatively Regulates Phosphorylation of AMP-activated Protein Kinase in the Heart

Kovacic, S., Soltys, C.-L. M., Barr, A., Shiojima, I., Walsh, K., & Dyck, J. R. B. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305371200 · Cited by 407 · see citing works

Contraction-Induced Myokine Production and Release: Is Skeletal Muscle an Endocrine Organ?

Febbraio, M. A., & Pedersen, B. K. (2005) · Exercise and Sport Sciences Reviews · doi:10.1097/00003677-200507000-00003 · Cited by 402 · see citing works

Brain Regulation of Appetite and Satiety

Ahima, R. S., & Antwi, D. A. (2008) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2008.08.005 · Cited by 387 · see citing works

Insulin Resistance and Type 2 Diabetes Are Not Related to Resistin Expression in Human Fat Cells or Skeletal Muscle

Nagaev, I., & Smith, U. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5173 · Cited by 379 · see citing works

Role of resistin in diet-induced hepatic insulin resistance

Muse, E. D., Obici, S., Bhanot, S., Monia, B. P., McKay, R. A., Rajala, M. W., Scherer, P. E., & Rossetti, L. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21270 · Cited by 371 · see citing works

Functional Domains of the α1 Catalytic Subunit of the AMP-activated Protein Kinase

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AMP-Activated Protein Kinase: An Ultrasensitive System for Monitoring Cellular Energy Charge

HARDIE, D. G., SALT, I. P., HAWLEY, S. A., & DAVIES, S. P. (1999) · Biochemical Journal · doi:10.1042/bj3380717 · Cited by 362 · see citing works

Macrophages block insulin action in adipocytes by altering expression of signaling and glucose transport proteins

Lumeng, C. N., Deyoung, S. M., & Saltiel, A. R. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00284.2006 · Cited by 359 · see citing works

AMP-Activated Protein Kinase in the Heart

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Regulation of ketogenesis and the renaissance of carnitine palmitoyltransferase

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Insulin Antagonizes Ischemia-induced Thr172 Phosphorylation of AMP-activated Protein Kinase α-Subunits in Heart via Hierarchical Phosphorylation of Ser485/491

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A pivotal role for endogenous TGF-β-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway

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AMPK signaling in contracting human skeletal muscle: acetyl-CoA carboxylase and NO synthase phosphorylation

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AMP-Activated Protein Kinase is Highly Expressed in Neurons in the Developing Rat Brain and Promotes Neuronal Survival Following Glucose Deprivation

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Pharmacological inhibition of AMP-activated protein kinase provides neuroprotection in stroke

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A novel domain in AMP-activated protein kinase causes glycogen storage bodies similar to those seen in hereditary cardiac arrhythmias

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AMP-activated protein kinase (AMPK) signaling in endothelial cells is essential for angiogenesis in response to hypoxic stress

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Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes

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Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity

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Anti-lipolytic Action of AMP-activated Protein Kinase in Rodent Adipocytes

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Hyperglycemia-Induced Apoptosis in Human Umbilical Vein Endothelial Cells

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Dual regulation of the AMP‐activated protein kinase provides a novel mechanism for the control of creatine kinase in skeletal muscle

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Macrophage-secreted factors induce adipocyte inflammation and insulin resistance

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C75, a Fatty Acid Synthase Inhibitor, Reduces Food Intake via Hypothalamic AMP-activated Protein Kinase*

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Activation of AMPK attenuates neutrophil proinflammatory activity and decreases the severity of acute lung injury

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Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR

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Predominant α2/β2/γ3 AMPK activation during exercise in human skeletal muscle

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AMPK activity is diminished in tissues of IL-6 knockout mice: the effect of exercise.

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Role of AMP-activated Protein Kinase in Cyclic AMP-dependent Lipolysis In 3T3-L1 Adipocytes

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A role for AMP-activated protein kinase in diabetes-induced renal hypertrophy

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Diet-induced Obesity Alters AMP Kinase Activity in Hypothalamus and Skeletal Muscle

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PKA phosphorylates and inactivates AMPKα to promote efficient lipolysis

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Post-translational modifications of the β-1 subunit of AMP-activated protein kinase affect enzyme activity and cellular localization

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Insulin signalling in the heart

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An imbalance between glycolysis and glucose oxidation is a possible explanation for the detrimental effects of high levels of fatty acids during aerobic reperfusion of ischemic hearts.

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Adenovirus-mediated chronic “hyper-resistinemia” leads to in vivo insulin resistance in normal rats

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AMP-activated protein kinase functionally phosphorylates endothelial nitric oxide synthase Ser633

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Regulation of AMP-activated Protein Kinase by Multisite Phosphorylation in Response to Agents That Elevate Cellular cAMP

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Cellular Distribution and Developmental Expression of AMP‐Activated Protein Kinase Isoforms in Mouse Central Nervous System

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Glycogen-Dependent Effects of 5-Aminoimidazole-4-Carboxamide (AICA)-Riboside on AMP-Activated Protein Kinase and Glycogen Synthase Activities in RatSkeletal Muscle

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Molecular mechanisms for the control of translation by insulin

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Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression

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Identification of Phosphorylation Sites in AMP-activated Protein Kinase (AMPK) for Upstream AMPK Kinases and Study of Their Roles by Site-directed Mutagenesis*

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AMP-activated Protein Kinase Is Activated as a Consequence of Lipolysis in the Adipocyte

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Glucose and palmitate oxidation in isolated working rat hearts reperfused after a period of transient global ischemia.

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The α2–5′AMP-Activated Protein Kinase Is a Site 2 Glycogen Synthase Kinase in Skeletal Muscle and Is Responsive to Glucose Loading

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AMP-Activated Protein Kinase Signaling Stimulates VEGF Expression and Angiogenesis in Skeletal Muscle

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AMPK inhibits fatty acid-induced increases in NF-κB transactivation in cultured human umbilical vein endothelial cells

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PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury

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Insulin activation of acetyl-CoA carboxylase accompanied by inhibition of the 5'-AMP-activated protein kinase.

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Suppressor of Cytokine Signaling 3 Is a Physiological Regulator of Adipocyte Insulin Signaling

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Interleukin-6 Directly Increases Glucose Metabolism in Resting Human Skeletal Muscle

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Neuroprotective Effects of Adenosine Monophosphate- Activated Protein Kinase Inhibition and Gene Deletion in Stroke

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Leptin Stimulates Fatty Acid Oxidation and Peroxisome Proliferator-Activated Receptor α Gene Expression in Mouse C2C12 Myoblasts by Changing the Subcellular Localization of the α2 Form of AMP-Activated Protein Kinase

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Sustained activation of AMP‐activated protein kinase induces c‐Jun N‐terminal kinase activation and apoptosis in liver cells

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Role of AMP-activated protein kinase in the regulation by glucose of islet beta cell gene expression

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Structural insight into the autoinhibition mechanism of AMP-activated protein kinase

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Post-translational modifications of the β-1 subunit of AMP-activated protein kinase affect enzyme activity and cellular localization

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Critical roles of AMP-activated protein kinase in constitutive tolerance of cancer cells to nutrient deprivation and tumor formation

Kato, K., Ogura, T., Kishimoto, A., Minegishi, Y., Nakajima, N., Miyazaki, M., & Esumi, H. (2002) · Oncogene · doi:10.1038/sj.onc.1205737 · Cited by 193 · see citing works

Interleukin-6 Regulation of AMP-Activated Protein Kinase

Ruderman, N. B., Keller, C., Richard, A.-M. T., Saha, A. K., Luo, Z., Xiang, X., Giralt, M., Ritov, V. B., Menshikova, E. V., Kelley, D. E., et al. (2006) · Diabetes · doi:10.2337/db06-s007 · Cited by 190 · see citing works

Does AMP-activated Protein Kinase Couple Inhibition of Mitochondrial Oxidative Phosphorylation by Hypoxia to Calcium Signaling in O2-sensing Cells?

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Phospho-Dependent Functional Modulation of GABAB Receptors by the Metabolic Sensor AMP-Dependent Protein Kinase

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S6 Kinase Deletion Suppresses Muscle Growth Adaptations to Nutrient Availability by Activating AMP Kinase

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Regulation of fatty acid and cholesterol metabolism by the AMP-activated protein kinase

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Crystal Structures of the Adenylate Sensor from Fission Yeast AMP-Activated Protein Kinase

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The Role of AMPK and mTOR in Nutrient Sensing in Pancreatic β-Cells

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Metformin, but not leptin, regulates AMP-activated protein kinase in pancreatic islets: impact on glucose-stimulated insulin secretion

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Dissociation of AMP-activated protein kinase activation and glucose transport in contracting slow-twitch muscle.

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Downregulation of AMP‐activated protein kinase by Cidea‐mediated ubiquitination and degradation in brown adipose tissue

Qi, J., Gong, J., Zhao, T., Zhao, J., Lam, P., Ye, J., Li, J. Z., Wu, J., Hai‐Meng, Z. H. O. U., & Li, P. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.92 · Cited by 166 · see citing works

Induced adiposity and adipocyte hypertrophy in mice lacking the AMP-activated protein kinase-alpha2 subunit.

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Exercise Increases Nuclear AMPK α2 in Human Skeletal Muscle

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Posttranslational Modifications of the 5′-AMP-activated Protein Kinase β1 Subunit

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Nutrient Stress Activates Inflammation and Reduces Glucose Metabolism by Suppressing AMP-Activated Protein Kinase in the Heart

Ko, H. J., Zhang, Z., Jung, D. Y., Jun, J. Y., Ma, Z., Jones, K. E., Chan, S. Y., & Kim, J. K. (2009) · Diabetes · doi:10.2337/db08-1361 · Cited by 157 · see citing works

Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity

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Small Molecule Antagonizes Autoinhibition and Activates AMP-activated Protein Kinase in Cells

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Fatal Congenital Heart Glycogenosis Caused by a Recurrent Activating R531Q Mutation in the γ2-Subunit of AMP-Activated Protein Kinase (PRKAG2), Not by Phosphorylase Kinase Deficiency

Burwinkel, B., Scott, J. W., Bührer, C., van Landeghem, F. K. H., Cox, G. F., Wilson, C. J., Hardie, D. G., & Kilimann, M. W. (2005) · The American Journal of Human Genetics · doi:10.1086/430840 · Cited by 152 · see citing works

Leptinomimetic effects of the AMP kinase activator AICAR in leptin-resistant rats: prevention of diabetes and ectopic lipid deposition

Yu, X., McCorkle, S. K., Wang, M., Lee, Y., Li, J., Saha, A. K., Unger, R. H., & Ruderman, N. B. (2004) · Diabetologia · doi:10.1007/s00125-004-1570-9 · Cited by 149 · see citing works

Hypothalamic AMP-activated protein kinase mediates counter-regulatory responses to hypoglycaemia in rats

Han, S. M., NamKoong, C., Jang, P., Park, I.-S., Hong, S. W., Katakami, H., Chun, S., Kim, S., Park, J.-Y., Lee, K.-U., et al. (2005) · Diabetologia · doi:10.1007/s00125-005-1913-1 · Cited by 147 · see citing works

Pioglitazone improves insulin sensitivity through reduction in muscle lipid and redistribution of lipid into adipose tissue

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AICA riboside both activates AMP‐activated protein kinase and competes with adenosine for the nucleoside transporter in the CA1 region of the rat hippocampus

Gadalla, A. E., Pearson, T., Currie, A. J., Dale, N., Hawley, S. A., Sheehan, M., Hirst, W. D., Michel, A. D., Randall, A. D., Hardie, D. G., et al. (2004) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02253.x · Cited by 145 · see citing works

AMPK activation restores the stimulation of glucose uptake in an in vitro model of insulin-resistant cardiomyocytes via the activation of protein kinase B

Bertrand, L., Ginion, A., Beauloye, C., Hebert, A. D., Guigas, B., Hue, L., & Vanoverschelde, J. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01269.2005 · Cited by 144 · see citing works

Activation of AMP-Activated Protein Kinase by Interleukin-6 in Rat Skeletal Muscle

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Intracoronary, Adenovirus-mediated Akt Gene Transfer in Heart Limits Infarct Size Following Ischemia-reperfusion Injury in Vivo

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An antibody VH domain with a lox‐Cre site integrated into its coding region: bacterial recombination within a single polypeptide chain

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mTOR, AMPK, and GCN2 coordinate the adaptation of hepatic energy metabolic pathways in response to protein intake in the rat

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Glucose Autoregulates Its Uptake in Skeletal Muscle

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Structural Properties of AMP-activated Protein Kinase

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AMP-Activated Protein Kinase (AMPK) Controls the Aging Process via an Integrated Signaling Network

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Placental Origins of Chronic Disease

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Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis

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Chronic inflammation and the hallmarks of aging

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Targeting AMPK for cancer prevention and treatment

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An AMPK–caspase-6 axis controls liver damage in nonalcoholic steatohepatitis

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The AMPK Inhibitor Compound C Is a Potent AMPK-Independent Antiglioma Agent

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TBK1 at the Crossroads of Inflammation and Energy Homeostasis in Adipose Tissue

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Mitochondrial Biogenesis: A Therapeutic Target for Neurodevelopmental Disorders and Neurodegenerative Diseases

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AMPK improves gut epithelial differentiation and barrier function via regulating Cdx2 expression

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The relationship of autophagy defects to cartilage damage during joint aging in a mouse model

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A Metabolic Roadmap for Somatic Stem Cell Fate

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Quercetin, a functional compound of onion peel, remodels white adipocytes to brown-like adipocytes

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ANGPTL4 mediates shuttling of lipid fuel to brown adipose tissue during sustained cold exposure

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On the Clinical Pharmacology of Reactive Oxygen Species

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SIRT3 Protects Rotenone-induced Injury in SH-SY5Y Cells by Promoting Autophagy through the LKB1-AMPK-mTOR Pathway

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Isoproterenol instigates cardiomyocyte apoptosis and heart failure via AMPK inactivation-mediated endoplasmic reticulum stress

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Evolving Lessons on the Complex Role of AMPK in Normal Physiology and Cancer

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Leishmania survival in the macrophage: where the ends justify the means

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AMP-activated protein kinase inhibits TGF-β-, angiotensin II-, aldosterone-, high glucose-, and albumin-induced epithelial-mesenchymal transition

Lee, J. H., Kim, J. H., Kim, J. S., Chang, J. W., Kim, S. B., Park, J. S., & Lee, S. K. (2013) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00148.2012 · Cited by 107 · see citing works

mTOR, AMPK, and Sirt1: Key Players in Metabolic Stress Management

Cetrullo, S., D’Adamo, S., Tantini, B., Borzı̀, R. M., & Flamigni, F. (2015) · Critical Reviews in Eukaryotic Gene Expression · doi:10.1615/critreveukaryotgeneexpr.2015012975 · Cited by 106 · see citing works

Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptor-associated kinase-4 phosphorylation

Mancini, S. J., White, A. D., Bijland, S., Rutherford, C. L., Graham, D., Richter, E. A., Viollet, B., Touyz, R. M., Palmer, T. M., & Salt, I. P. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.11.010 · Cited by 103 · see citing works

Glycogen metabolism in cancer

Zois, C. E., Favaro, E., & Harris, A. L. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.09.001 · Cited by 102 · see citing works

Salidroside attenuates hypoxia-induced pulmonary arterial smooth muscle cell proliferation and apoptosis resistance by upregulating autophagy through the AMPK-mTOR-ULK1 pathway

Gui, D., Cui, Z., Zhang, L., Chang, Y., Yao, D., Xu, M., Chen, M., Wu, P., Li, G., Wang, L., et al. (2017) · BMC Pulmonary Medicine · doi:10.1186/s12890-017-0477-4 · Cited by 98 · see citing works

Targeting of lipid metabolism with a metabolic inhibitor cocktail eradicates peritoneal metastases in ovarian cancer cells

Chen, R. R., Yung, M. M. H., Yang, X., Zhan, S., Leung, L. L., Liang, R. R., Leung, T. H. Y., Yang, H., Xu, D., Sharma, R., et al. (2019) · Communications Biology · doi:10.1038/s42003-019-0508-1 · Cited by 98 · see citing works

From overnutrition to liver injury: AMP-activated protein kinase in nonalcoholic fatty liver diseases

Zhao, P., & Saltiel, A. R. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.rev120.011356 · Cited by 101 · see citing works

Brain-specific repression of AMPKα1 alleviates pathophysiology in Alzheimer’s model mice

Zimmermann, H. R., Yang, W., Kasica, N. P., Zhou, X., Wang, X., Beckelman, B. C., Lee, J., Furdui, C. M., Keene, C. D., & Ma, T. (2020) · Journal of Clinical Investigation · doi:10.1172/jci133982 · Cited by 86 · see citing works

Noise-Induced Loss of Hair Cells and Cochlear Synaptopathy Are Mediated by the Activation of AMPK

Hill, K., Yuan, H., Wang, X., & Sha, S. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0782-16.2016 · Cited by 97 · see citing works

AMP-Activated Protein Kinase Alpha 2 Deletion Induces VSMC Phenotypic Switching and Reduces Features of Atherosclerotic Plaque Stability

Ye, D., Zhang, M., Zhang, W., Lu, Q., Cai, Z., Song, P., Okon, I. S., Xiao, L., & Zou, M. (2016) · Circulation Research · doi:10.1161/circresaha.116.308689 · Cited by 96 · see citing works

ATP-Induced Inflammasome Activation and Pyroptosis Is Regulated by AMP-Activated Protein Kinase in Macrophages

Zha, Q.-B., Wei, H.-X., Li, C.-G., Liang, Y.-D., Xu, L.-H., Bai, W.-J., Pan, H., He, X.-H., & Ouyang, D.-Y. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00597 · Cited by 95 · see citing works

AMPK Activation via Modulation of De Novo Purine Biosynthesis with an Inhibitor of ATIC Homodimerization

Asby, D. J., Cuda, F., Beyaert, M., Houghton, F. D., Cagampang, F. R. A., & Tavassoli, A. (2015) · Chemistry & Biology · doi:10.1016/j.chembiol.2015.06.008 · Cited by 89 · see citing works

Interactions between dietary carbohydrate and metformin: Implications on energy sensing, insulin signaling pathway, glycolipid metabolism and glucose tolerance in blunt snout bream Megalobrama amblycephala

Xu, C., Liu, W., Zhang, D., Cao, X., Shi, H., & Li, X. (2017) · Aquaculture · doi:10.1016/j.aquaculture.2017.10.022 · Cited by 89 · see citing works

A synbiotic consisting of Lactobacillus plantarum S58 and hull-less barley β-glucan ameliorates lipid accumulation in mice fed with a high-fat diet by activating AMPK signaling and modulating the gut microbiota

Tang, T., Song, J., Li, J., Wang, H., Zhang, Y., & Suo, H. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.116398 · Cited by 89 · see citing works

Induction of AMPK activity corrects early pathophysiological alterations in the subtotal nephrectomy model of chronic kidney disease

Satriano, J. A., Sharma, K., Blantz, R. C., & Deng, A. (2013) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00293.2013 · Cited by 86 · see citing works

Hypothalamic histamine H1 receptor-AMPK signaling time-dependently mediates olanzapine-induced hyperphagia and weight gain in female rats

He, M. X., Zhang, Q., Deng, C., Wang, H., Lian, J., & Huang, X. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.01.018 · Cited by 87 · see citing works

The immunomodulatory role of irisin on osteogenesis via AMPK-mediated macrophage polarization

Ye, W., Wang, J., Lin, D., & Ding, Z. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.12.028 · Cited by 86 · see citing works

Six types of tea reduce high-fat-diet-induced fat accumulation in mice by increasing lipid metabolism and suppressing inflammation

Liu, C., Guo, Y., Sun, L., Lai, X., Li, Q., Zhang, W., Xiang, L., Sun, S., & Cao, F. (2019) · Food & Function · doi:10.1039/c8fo02334d · Cited by 86 · see citing works

AMP-Activated Protein Kinase and Host Defense against Infection

Silwal, P., Kim, J. K., Yuk, J., & Jo, E. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113495 · Cited by 81 · see citing works

Quercetin induces bladder cancer cells apoptosis by activation of AMPK signaling pathway.

Su, Q., Peng, M., Zhang, Y., Xu, W., Darko, K. O., Tao, T., Huang, Y., Tao, X., & Yang, X. (2016) · PubMed Central · Cited by 84 · see citing works

Small-Molecule Activators of AMP-Activated Protein Kinase (AMPK), RSVA314 and RSVA405, Inhibit Adipogenesis

Vingtdeux, V., Chandakkar, P., Zhao, H., Davies, P., & Marambaud, P. (2011) · Molecular Medicine · doi:10.2119/molmed.2011.00163 · Cited by 81 · see citing works

Atrial remodelling in atrial fibrillation: CaMKII as a nodal proarrhythmic signal

Mesubi, O. O., & Anderson, M. E. (2016) · Cardiovascular Research · doi:10.1093/cvr/cvw002 · Cited by 81 · see citing works

Efficacy and safety of PXL770, a direct AMP kinase activator, for the treatment of non-alcoholic fatty liver disease (STAMP-NAFLD): a randomised, double-blind, placebo-controlled, phase 2a study

Cusi, K. J., Alkhouri, N., Harrison, S. A., Fouqueray, P., Moller, D. E., Hallakou‐Bozec, S., Bolze, S., Grouin, J., Megnien, S. J., Dubourg, J., et al. (2021) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(21)00300-9 · Cited by 78 · see citing works

Metformin-stimulated AMPK-α1 promotes microvascular repair in acute lung injury

Jian, M., ALEXEYEV, M. F., Wolkowicz, P. E., Zmijewski, J. W., & Creighton, J. R. (2013) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00173.2013 · Cited by 78 · see citing works

Formononetin, an isoflavone, activates AMP-activated protein kinase/β-catenin signalling to inhibit adipogenesis and rescues C57BL/6 mice from high-fat diet-induced obesity and bone loss

Gautam, J., Khedgikar, V., Kushwaha, P., Choudhary, D., Nagar, G. K., Dev, K., Dixit, P., Singh, D. R., Maurya, R., & Trivedi, R. (2017) · British Journal Of Nutrition · doi:10.1017/s0007114517000149 · Cited by 78 · see citing works

Metformin Decreases GnRH- and Activin-Induced Gonadotropin Secretion in Rat Pituitary Cells: Potential Involvement of Adenosine 5' Monophosphate-Activated Protein Kinase (PRKA)

Tosca, L., Froment, P., Ramé, C., McNEILLY, J. R., McNeilly, A. S., Maillard, V., & Dupont, J. (2010) · Biology of Reproduction · doi:10.1095/biolreprod.110.087023 · Cited by 78 · see citing works

Arrhythmia causes lipid accumulation and reduced glucose uptake

Lenski, M., Schleider, G., Kohlhaas, M., Adrian, L., Adam, O., Tian, X. Y., Kaestner, L., Lipp, P., Lehrke, M., Maack, C., et al. (2015) · Basic Research in Cardiology · doi:10.1007/s00395-015-0497-2 · Cited by 76 · see citing works

Aspalathin from Rooibos (Aspalathus linearis): A Bioactive C-glucosyl Dihydrochalcone with Potential to Target the Metabolic Syndrome

Johnson, R., de Beer, D., Dludla, P. V., Ferreira, D., Muller, C. J. F., & Joubert, E. (2018) · Planta Medica · doi:10.1055/s-0044-100622 · Cited by 76 · see citing works

The Bewildering Effect of AMPK Activators in Alzheimer’s Disease: Review of the Current Evidence

Assefa, B. T., Tafere, G. G., Wondafrash, D. Z., & Gidey, M. T. (2020) · BioMed Research International · doi:10.1155/2020/9895121 · Cited by 75 · see citing works

AMP-activated protein kinase: Structure, function, and role in pathological processes

Novikova, D., Garabadzhiu, A. V., Melino, G., Barlev, N. A., & Tribulovich, V. G. (2015) · Biochemistry (Moscow) · doi:10.1134/s0006297915020017 · Cited by 74 · see citing works

Palmitate activates mTOR/p70S6K through AMPK inhibition and hypophosphorylation of raptor in skeletal muscle cells: Reversal by oleate is similar to metformin

Kwon, B., & Querfurth, H. W. (2015) · Biochimie · doi:10.1016/j.biochi.2015.09.006 · Cited by 73 · see citing works

A spatiotemporal hypothesis for the regulation, role, and targeting of AMPK in prostate cancer

Khan, A., & Frigo, D. E. (2017) · Nature Reviews Urology · doi:10.1038/nrurol.2016.272 · Cited by 72 · see citing works

Loss of the E3 ubiquitin ligase MKRN1 represses diet-induced metabolic syndrome through AMPK activation

Lee, M.-S., Han, H.-J., Han, S. Y., Kim, I. Y., Chae, S., Lee, C.-S., Kim, S. E., Yoon, S. G., Park, J.-W., Kim, J.-H., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05721-4 · Cited by 73 · see citing works

New Insights into AMPK, as a Potential Therapeutic Target in Metabolic Dysfunction-Associated Steatotic Liver Disease and Hepatic Fibrosis

An, H., Jang, Y., Choi, J.-I., Hur, J., Kim, S., & Kwon, Y. (2024) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2024.188 · Cited by 72 · see citing works

Hypoxia, AMPK activation and uterine artery vasoreactivity

Skeffington, K. L., Higgins, J. S., Mahmoud, A. D., Evans, A. M., Sferruzzi‐Perri, A. N., Fowden, A. L., Yung, H. W., Burton, G. J., Giussani, D. A., & Moore, L. G. (2016) · The Journal of Physiology · doi:10.1113/jp270995 · Cited by 69 · see citing works

5′-AMP-activated Protein Kinase (AMPK) Supports the Growth of Aggressive Experimental Human Breast Cancer Tumors

Laderoute, K. R., Calaoagan, J. M., Chao, W., Dinh, D., Denko, N. C., Duellman, S. J., Kalra, J., Liu, X., Papandreou, I., Sambucetti, L. C., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.576371 · Cited by 68 · see citing works

Nuclear Transport: A Switch for the Oxidative Stress—Signaling Circuit?

Kodiha, M., & Stochaj, U. (2011) · Journal of Signal Transduction · doi:10.1155/2012/208650 · Cited by 70 · see citing works

A Narrative Review on the Role of AMPK on De Novo Lipogenesis in Non-Alcoholic Fatty Liver Disease: Evidence from Human Studies

von Loeffelholz, C., Coldewey, S. M., & Birkenfeld, A. L. (2021) · Cells · doi:10.3390/cells10071822 · Cited by 67 · see citing works

Metformin activation of AMPK suppresses AGE-induced inflammatory response in hNSCs

Chung, M.-M., Nicol, C. J., Cheng, Y.-C., Lin, K.-H., Chen, Y.-L., Pei, D., Lin, C.-H., Shih, Y.-N., Yen, C.-H., Chen, S.-J., et al. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.01.017 · Cited by 66 · see citing works

AMP-activated protein kinase-α1 as an activating kinase of TGF-β-activated kinase 1 has a key role in inflammatory signals

Kim, S. Y., Jeong, S., Jung, E., Baik, K.-H., Chang, M. H., Kim, S. A., Shim, J.-H., Chun, E., & Lee, K. (2012) · Cell Death and Disease · doi:10.1038/cddis.2012.95 · Cited by 65 · see citing works

AMP-activated protein kinase: a therapeutic target in intestinal diseases

Sun, X., & Zhu, M. J. (2017) · Open Biology · doi:10.1098/rsob.170104 · Cited by 65 · see citing works

AMPK–Akt Double-Negative Feedback Loop in Breast Cancer Cells Regulates Their Adaptation to Matrix Deprivation

Saha, M., Kumar, S., Bukhari, S., Andugulapati, S. B., Kumar, P., Hindupur, S. K., & Rangarajan, A. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-2090 · Cited by 64 · see citing works

Profile of Circulatory Metabolites in an Animal Model of Multiple Sclerosis using Global Metabolomics

Mangalam, A. K. (2013) · Journal of Clinical & Cellular Immunology · doi:10.4172/2155-9899.1000150 · Cited by 63 · see citing works

Have guidelines addressing physical activity been established in nonalcoholic fatty liver disease?

Finelli, C. (2012) · World Journal of Gastroenterology · doi:10.3748/wjg.v18.i46.6790 · Cited by 63 · see citing works

Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release

Scott, J. W., Galić, S., Graham, K. L., Foitzik, R. C., Ling, N. X. Y., Dite, T. A., Issa, S. M. A., Langendorf, C. G., Weng, Q. P., Thomas, H. E., et al. (2015) · Chemistry & Biology · doi:10.1016/j.chembiol.2015.05.011 · Cited by 61 · see citing works

AMPK Inhibition Blocks ROS-NFκB Signaling and Attenuates Endotoxemia-Induced Liver Injury

Guo, Y., Zhang, Y., Hong, K. M., Luo, F., Gu, Q., Lü, N., & Bai, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0086881 · Cited by 61 · see citing works

Page /1 19 AMPK inhibition in health and disease

Rev, C., Mol, B., Viollet, B., Horman, R., Leclerc, J., Lantier, L., Foretz, M., Billaud, M., Giri, S., & Andréelli, F. (2015)

AMPK in Health and Disease

Steinberg, G. R., & Kemp, B. E. (2009) · Physiological Reviews · doi:10.1152/physrev.00011.2008 · Cited by 1,633 · see citing works

Maintaining Energy Balance in Health and Disease: Role of the AMP-Activated Protein Kinase

Scott, J. W. (2010) · Springer eBooks · doi:10.1007/978-1-4419-6382-6_9 · Cited by 2 · see citing works

AMPK: positive and negative regulation, and its role in whole-body energy homeostasis

Hardie, D. G. (2015) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2014.09.004 · Cited by 485 · see citing works

AMPK: a metabolic gauge regulating whole-body energy homeostasis

Lage, R., Diéguez, C., Vidal‐Puig, A., & López, M. (2008) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2008.09.007 · Cited by 503 · see citing works