The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
TRPV1‐null mice are protected from diet‐induced obesity
Open accessAbstract
We explored a role for the capsaicin receptor, transient receptor potential channel vanilloid type 1 (TRPV1), in the regulation of feeding and body mass. On a 4.5% fat diet, wild‐type and TRPV1‐null mice gained equivalent body mass. On an 11% fat diet, however, TRPV1‐null mice gained significantly less mass and adiposity; at 44 weeks the mean body weights of wild‐type and TRPV1‐null mice were ∼51 and 34 g, respectively. Both groups of mice consumed equivalent energy and absorbed similar amounts of lipids. TRPV1‐null mice, however, exhibited a significantly greater thermogenic capacity. Interestingly, we found that 3T3‐L1 preadipocytes expressed functional calcitonin gene‐related peptide receptors. Thus, these data support a potential neurogenic mechanism by which TRPV1‐sensitive sensory nerves may regulate energy and fat metabolism.
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Masuda, Y., Haramizu, S., Oki, K., Ohnuki, K., Watanabe, T., Yazawa, S., Kawada, T., Hashizume, S.-I., & Fushiki, T. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00828.2002 · Cited by 143
Cited by
Transient receptor potential (TRP) channels: a clinical perspective
Kaneko, Y., & Szallasi, A. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12414 · Cited by 370
Sensory and sympathetic nervous system control of white adipose tissue lipolysis
Bartness, T. J., Shrestha, Y. B., Vaughan, C. H., Schwartz, G. J., & Song, C. K. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.08.031 · Cited by 289
McCoy, E. S., Taylor-Blake, B., Street, S. E., Pribisko, A. L., Zheng, J., & Zylka, M. J. (2013) · Neuron · doi:10.1016/j.neuron.2013.01.030 · Cited by 263
The transient receptor potential vanilloid-1 channel in thermoregulation: a thermosensor it is not
Romanovsky, A. A., Almeida, M. C., Garami, A., Steiner, A. A., Norman, M. H., Morrison, S. F., Nakamura, K., Burmeister, J. J., & Nucci, T. B. (2009) · Pharmacological Reviews · doi:10.1124/pr.109.001263 · Cited by 253
A Role for TRPV1 in Influencing the Onset of Cardiovascular Disease in Obesity
Marshall, N. J., Liang, L., Bodkin, J., Dessapt-Baradez, C., Nandi, M., Collot-Teixeira, S., Smillie, S.-J., Lalgi, K., Fernandes, E. S., Gnudi, L., et al. (2013) · Hypertension · doi:10.1161/hypertensionaha.112.201434 · Cited by 95
Metadata
- Authors
- Motter, A. L., & Ahern, G. P.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2008-05-27
- Volume
- 582
- Issue
- 15
- Pages
- 2257-2262
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1964302331
- Cited by
- 160
- References
- 1
- FWCI
- 5.14
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Motter, A. L., & Ahern, G. P. (2008). TRPV1‐null mice are protected from diet‐induced obesity. FEBS Letters. https://doi.org/10.1016/j.febslet.2008.05.021
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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