Upregulation of uncoupling proteins by oral administration of capsiate, a nonpungent capsaicin analog
Abstract
Capsiate is a nonpungent capsaicin analog, a recently identified principle of the nonpungent red pepper cultivar CH-19 Sweet. In the present study, we report that 2-wk treatment of capsiate increased metabolic rate and promoted fat oxidation at rest, suggesting that capsiate may prevent obesity. To explain these effects, at least in part, we examined uncoupling proteins (UCPs) and thyroid hormones. UCPs and thyroid hormones play important roles in energy expenditure, the maintenance of body weight, and thermoregulation. Two-week treatment of capsiate increased the levels of UCP1 protein and mRNA in brown adipose tissue and UCP2 mRNA in white adipose tissue. This dose of capsiate did not change serum triiodothyronine or thyroxine levels. A single dose of capsiate temporarily raised both UCP1 mRNA in brown adipose tissue and UCP3 mRNA in skeletal muscle. These results suggest that UCP1 and UCP2 may contribute to the promotion of energy metabolism by capsiate, but that thyroid hormones do not.
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Capsaicins and their derivatives induce upregulation of uncoupling proteins, even in vivo.
“Capsaicins and their derivatives are red-pepper components and are long known for their capacity to induce the upregulation of uncoupling proteins, even in vivo [62].”
From Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases (2019) · cites this paper as [62]
Cites
The capsaicin receptor: a heat-activated ion channel in the pain pathway
Caterina, M. J., Schumacher, M. A., Tominaga, M., Rosen, T. A., Levine, J. D., & Julius, D. J. (1997) · Nature · doi:10.1038/39807 · Cited by 9,132 · see citing works
Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia
Fleury, C., Neverova, M., Collins, S., Raimbault, S., Champigny, O., Lévi-Meyrueis, C., Bouillaud, F., Seldin, M. F., Surwit, R. S., Ricquier, D., et al. (1997) · Nature Genetics · doi:10.1038/ng0397-269 · Cited by 1,630 · see citing works
A role for brown adipose tissue in diet-induced thermogenesis
Rothwell, N. J., & Stock, M. J. (1979) · Nature · doi:10.1038/281031a0 · Cited by 1,606 · see citing works
A capsaicin-receptor homologue with a high threshold for noxious heat
Caterina, M. J., Rosen, T. A., Tominaga, M., Brake, A. J., & Julius, D. J. (1999) · Nature · doi:10.1038/18906 · Cited by 1,599 · see citing works
Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese
Enerbäck, S., Jacobsson, A., Simpson, E. M., Guerra, C., Yamashita, H., Harper, M.-E., & Kozak, L. P. (1997) · Nature · doi:10.1038/387090a0 · Cited by 1,379 · see citing works
Pharmacologically induced selective degeneration of chemosensitive primary sensory neurones
Jancsó, G., Király, E., & Jancsó‐Gábor, A. (1977) · Nature · doi:10.1038/270741a0 · Cited by 1,282 · see citing works
Arsenijevic, D., Onuma, H., Pecqueur, C., Raimbault, S., Manning, B. S., Miroux, B., Couplan, E., Alves‐Guerra, M., Goubern, M., Surwit, R. S., et al. (2000) · Nature Genetics · doi:10.1038/82565 · Cited by 1,079 · see citing works
Development of obesity in transgenic mice after genetic ablation of brown adipose tissue
Lowell, B. B., S-Susulic, V., Hamann, A., Lawitts, J. A., Himms-Hagen, J., Boyer, B. B., Kozak, L. P., & Flier, J. S. (1993) · Nature · doi:10.1038/366740a0 · Cited by 1,075 · see citing works
Boss, O., Samec, S., Paoloni‐Giacobino, A., Rossier, C., Dulloo, A. G., Seydoux, J., Muzzin, P., & Giacobino, J. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00384-0 · Cited by 1,041 · see citing works
Zhang, C.-Y., Baffy, G., Perret, P., Krauss, S., Peroni, O., Grujic, D., Hagen, T., Vidal-Puig, A. J., Boss, O., Kim, Y.-B., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00378-6 · Cited by 917 · see citing works
Vidal‐Puig, A., Solanes, G., Grujić, D., Flier, J. S., & Lowell, B. B. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6740 · Cited by 711 · see citing works
Gimeno, R. E., Dembski, M., Weng, X., Deng, N., Shyjan, A. W., Gimeno, C. J., Iris, F., Ellis, S. J., Woolf, E. A., & Tartaglia, L. A. (1997) · Diabetes · doi:10.2337/diab.46.5.900 · Cited by 496 · see citing works
Kb, S. (1965) · PubMed · Cited by 460 · see citing works
Gong, D., Monemdjou, S., Gavrilova, O., Leon, L. R., Marcus‐Samuels, B., Chou, C. J., Everett, C. A., Kozak, L. P., Li, C., Deng, C., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m910177199 · Cited by 385 · see citing works
Himms‐Hagen, J., Cui, J. Z., Danforth, E., Taatjes, D. J., Lang, S. S., Waters, B. L., & Claus, T. H. (1994) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1994.266.4.r1371 · Cited by 382 · see citing works
Himms‐Hagen, J., & Harper, M. (2001) · Experimental Biology and Medicine · doi:10.1177/153537020122600204 · Cited by 325 · see citing works
Weigle, D. S., Selfridge, L. E., Schwartz, M. W., Seeley, R. J., Cummings, D. E., Havel, P. J., Kuijper, J. L., & BeltrandelRio, H. (1998) · Diabetes · doi:10.2337/diab.47.2.298 · Cited by 325 · see citing works
Effects of Capsaicin on Lipid Metabolism in Rats Fed a High Fat Diet
Kawada, T., Hagihara, K.-I., & Iwai, K. (1986) · Journal of Nutrition · doi:10.1093/jn/116.7.1272 · Cited by 307 · see citing works
The nucleotide sequence of Saccharomyces cerevisiae chromosome VII
Tettelin, H., Carbone, M. L. A., Albermann, K., Albers, M., Arroyo, J., Backes, U., BARREIROS, T., Bertani, I., Bjourson, A. J., Brückner, M., et al. (1997) · Nature · doi:10.1038/387s081 · Cited by 298 · see citing works
Bouchard, C., Përusse, L., Chagnon, Y. C., Warden, C. H., & Ricquier, D. (1997) · Human Molecular Genetics · doi:10.1093/hmg/6.11.1887 · Cited by 225 · see citing works
[8] Mitochondria from brown adipose tissue: Isolation and properties
Cannon, B., & Lindberg, O. (1979) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(79)55010-1 · Cited by 224 · see citing works
Takahashi, N., Kawada, T., Goto, T., Yamamoto, T., Taimatsu, A., Matsui, N., Kimura, K., Saito, M., Hosokawa, M., Miyashita, K., et al. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)02390-6 · Cited by 221 · see citing works
Tissue‐dependent upregulation of rat uncoupling protein‐2 expression in response to fasting or cold
Boss, O., Samec, S., Dulloo, A. G., Seydoux, J., Muzzin, P., & Giacobino, J. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00755-2 · Cited by 218 · see citing works
Kobata, K., Todo, T., Yazawa, S., Iwai, K., & Watanabe, T. (1998) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf980135c · Cited by 208 · see citing works
Nagase, I., Yoshida, T., Kumamoto, K., UMEKAWA, T., Sakane, N., Nikami, H., Kawada, T., & Saito, M. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118748 · Cited by 207 · see citing works
(2001) · Springer eBooks · doi:10.1007/978-3-642-59524-0 · Cited by 202 · see citing works
THE UNCOUPLING OF RESPIRATION AND PHOSPHORYLATION BY THYROID HORMONES
Hoch, F. L., & Lipmann, F. A. (1954) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.40.10.909 · Cited by 176 · see citing works
Ohnuki, K., Haramizu, S., Oki, K., Watanabe, T., Yazawa, S., & Fushiki, T. (2001) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.65.2735 · Cited by 169 · see citing works
Exclusive occurrence of thermogenin antigen in brown adipose tissue
Cannon, B., Hedin, A., & Nedergaard, J. (1982) · FEBS Letters · doi:10.1016/0014-5793(82)81319-7 · Cited by 164 · see citing works
Kizaki, T., Suzuki, K., Hitomi, Y., Taniguchi, N., Saitoh, D., Watanabe, K., Onoé, K., Day, N. K. B., Good, R. A., & Ohno, H. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.142206299 · Cited by 137 · see citing works
Effect of endurance training on mRNA expression of uncoupling proteins 1, 2, and 3 in the rat
Boss, O., Samec, S., Dominique Desplanches, C., Mayet, M. H., Seydoux, J., Muzzin, P., & Giacobino, J. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.3.335 · Cited by 133 · see citing works
Tsuboyama-Kasaoka, N., Tsunoda, N., Maruyama, K., Takahashi, M. M., Kim, H., Ikemoto, S., & Ezaki, O. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8818 · Cited by 131 · see citing works
Ohnuki, K., Shoji, N. I. W. A., Maeda, S., INOUE, N., Yazawa, S., & Fushiki, T. (2001) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.65.2033 · Cited by 124 · see citing works
Ishihara, K., OYAIZU, S., Onuki, K., Lim, K., & Fushiki, T. (2000) · Journal of Nutrition · doi:10.1093/jn/130.12.2990 · Cited by 122 · see citing works
Nordihydrocapsiate, a New Capsinoid from the Fruits of a Nonpungent Pepper, Capsicum annuum
Kobata, K., Sutoh, K., Todo, T., Yazawa, S., Iwai, K., & Watanabe, T. (1998) · Journal of Natural Products · doi:10.1021/np9803373 · Cited by 116 · see citing works
THE CONSTITUTION OF CAPSAICIN, THE PUNGENT PRINCIPLE OF CAPSICUM. II.
Nelson, E. K. (1920) · Journal of the American Chemical Society · doi:10.1021/ja01448a023 · Cited by 116 · see citing works
Noradrenaline controls the concentration of the uncoupling protein in brown adipose tissue
Mory, G., Bouillaud, F., Combes‐George, M., & Ricquier, D. (1984) · FEBS Letters · doi:10.1016/0014-5793(84)80120-9 · Cited by 113 · see citing works
THE CONSTITUTION OF CAPSAICIN, THE PUNGENT PRINCIPLE OF CAPSICUM. III
Nelson, E. K., & Dawson, L. E. (1923) · Journal of the American Chemical Society · doi:10.1021/ja01662a023 · Cited by 103 · see citing works
Maley, G. F., & Lardy, H. A. (1955) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)66046-6 · Cited by 101 · see citing works
Bézaire, V., Hofmann, W. E., Kramer, J. K. G., Kozak, L. P., & Harper, M.-E. (2001) · American Journal of Physiology. Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.281.5.e975 · Cited by 90 · see citing works
Reduction of dietary obesity in aP2-Ucp transgenic mice: mechanism and adipose tissue morphology
Kopecký, J., Rossmeisl, M., Hodný, Z., Syrový, I., Horáková, M., & Kolarova, P. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.270.5.e776 · Cited by 81 · see citing works
Yazawa, S., SUETOM, N., OKAMOTO, K., & Namiki, T. (1989) · Journal of the Japanese Society for Horticultural Science · doi:10.2503/jjshs.58.601 · Cited by 80 · see citing works
Increase in Swimming Endurance Capacity of Mice by Capsaicin-induced Adrenal Catecholamine Secretion
Kim, K., Kawada, T., Ishihara, K., Inoue, K., & Fushiki, T. (1997) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.61.1718 · Cited by 73 · see citing works
Up-Regulation of Uncoupling Protein-3 by Fatty Acid in C2C12 Myotubes
Hwang, C.-S., & Lane, M. D. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0662 · Cited by 72 · see citing works
Brown fat is essential for cold-induced thermogenesis but not for obesity resistance in aP2-Ucp mice
Stefl, B., Janovská, A., Hodný, Z., Rossmeisl, M., Horáková, M., Syrový, I., Bémová, J., Bendlová, B., & Kopecký, J. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.274.3.e527 · Cited by 69 · see citing works
Reduced gene expression of UCP2 but not UCP3 in skeletal muscle of human obese subjects
Nordfors, L., Hoffstedt, J., Nyberg, B., Thörne, A., Arner, P., Schalling, M., & Lönnqvist, F. (1998) · Diabetologia · doi:10.1007/s001250051010 · Cited by 60 · see citing works
Effects of capsaicin analogs on adrenal catecholamine secretion in rats
Watanabe, T., Kawada, T., Katô, T., Harada, T., & Iwai, K. (1994) · Life Sciences · doi:10.1016/0024-3205(94)00793-4 · Cited by 55 · see citing works
Schrauwen, P., Schrauwen‐Hinderling, V. B., Hesselink, M. K. C., Schaart, G., Moonen‐Kornips, E., Saris, W. H. M., Westerterp‐Plantenga, M. S., & Langhans, W. (2002) · The FASEB Journal · doi:10.1096/fj.02-0275fje · Cited by 53 · see citing works
Osaka, T., Kobayashi, A., Namba, Y., Ezaki, O., Inoue, S., Kimura, S., & Lee, T. H. (1998) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s004240050743 · Cited by 48 · see citing works
Ohnuki, K., Haramizu, S., Watanabe, T., Yazawa, S., & Fushiki, T. (2001) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.47.295 · Cited by 45 · see citing works
Tsukazaki, K., Nikami, H., Shimizu, Y., Kawada, T., Yoshida, T., & Saito, M. (1995) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a124728 · Cited by 38 · see citing works
Ohnuki, K., Moritani, T., Ishihara, K., & Fushiki, T. (2001) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.65.638 · Cited by 36 · see citing works
Kawada, T., Sakabe, S., Aoki, N., Watanabe, T., Higeta, K., Iwai, K., & Sugimoto, E. (1991) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf00004a004 · Cited by 36 · see citing works
Kratky, D., Bogner‐Strauß, J. G., & Zechner, R. (2001) · Biochemical Journal · doi:10.1042/bj3550647 · Cited by 28 · see citing works
Differentiation of Brown Adipose Cells in Three-Dimensional Collagen Gel Culture
Hikichi, Y., Sugihara, H., & Sugimoto, E. (1993) · Pathology - Research and Practice · doi:10.1016/s0344-0338(11)80119-6 · Cited by 15 · see citing works
Effects of intrathecal capsaicin on autonomic and behavioral heat loss responses in the rat
Dib, B. (1987) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(87)90013-x · Cited by 14 · see citing works
Heat Production of Lean and Obese (Ob/Ob) Mice in Response to Fasting, Food Restriction or Thyroxine
Tuig, J. G. V., Trostler, N., Romsos, D. R., & Leveille, G. A. (1979) · Experimental Biology and Medicine · doi:10.3181/00379727-160-40432 · Cited by 13 · see citing works
Thermoregulatory responses of the inbred heat-tolerant FOK rat to cold
Yahata, T., Furuyama, F., Nagashima, T., Moriya, M., Kikuchi-Utsumi, K., Kawada, T., & KUROSHIMA, A. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.277.2.r362 · Cited by 5 · see citing works
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Garber, J. R., Cobin, R. H., Gharib, H., Hennessey, J. V., Klein, I., Mechanick, J. I., Pessah-Pollack, R., Singer, P. A., & Woeber, K. A. (2012) · Endocrine Practice · doi:10.4158/ep12280.gl · Cited by 1,567 · see citing works
Garber, J. R., Cobin, R. H., Gharib, H., Hennessey, J. V., Klein, I., Mechanick, J. I., Pessah-Pollack, R., Singer, P. A., & Woeber for the American Association, K. A. (2012) · Thyroid · doi:10.1089/thy.2012.0205 · Cited by 1,053 · see citing works
Maeda, H., Hosokawa, M., Sashima, T., Funayama, K., & Miyashita, K. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.05.002 · Cited by 641 · see citing works
Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases
Demine, S., Renard, P., & Arnould, T. (2019) · Cells · doi:10.3390/cells8080795 · Cited by 476 · see citing works
“Capsaicins and their derivatives are red-pepper components and are long known for their capacity to induce the upregulation of uncoupling proteins, even in vivo [62].”
BackgroundKajimura, S., & Saito, M. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021113-170252 · Cited by 428 · see citing works
The functions of TRPA1 and TRPV1: moving away from sensory nerves
Fernandes, E. S., Fernandes, M. A., & Keeble, J. E. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.01851.x · Cited by 415 · see citing works
Lee, P., Greenfield, J. R., Ho, K. K. Y., & FULHAM, M. J. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00298.2010 · Cited by 314 · see citing works
Snitker, S., Fujishima, Y., Shen, H., Ott, S., Pi-Sunyer, X., Furuhata, Y., Sato, H., & Takahashi, M. (2008) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26561 · Cited by 292 · see citing works
Yoneshiro, T., Aita, S., Kawai, Y., Iwanaga, T., & Saito, M. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.018606 · Cited by 271 · see citing works
Joo, J. I., Kim, D. H., Choi, J., & Yun, J. W. (2010) · Journal of Proteome Research · doi:10.1021/pr901175w · Cited by 174 · see citing works
Rupasinghe, H. P. V., Sekhon-Loodu, S., Mantso, T., & Panayiotidis, M. I. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.06.005 · Cited by 175 · see citing works
TRPV1‐null mice are protected from diet‐induced obesity
Motter, A. L., & Ahern, G. P. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.05.021 · Cited by 160 · see citing works
Thermogenic ingredients and body weight regulation
Hursel, R., & Westerterp‐Plantenga, M. S. (2010) · International Journal of Obesity · doi:10.1038/ijo.2009.299 · Cited by 152 · see citing works
INOUE, N., MATSUNAGA, Y., Satoh, H., & Takahashi, M. (2007) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.60341 · Cited by 140 · see citing works
Saito, M., & Yoneshiro, T. (2013) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32835a4f40 · Cited by 138 · see citing works
Kawabata, F., INOUE, N., MASAMOTO, Y., Matsumura, S., KIMURA, W., Kadowaki, M., Higashi, T., Tominaga, M., Inoue, K., & Fushiki, T. (2009) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.90555 · Cited by 123 · see citing works
Shamsi, F., Piper, M. E., Ho, L., Huang, T. L., Gupta, A., Streets, A., Lynes, M. D., & Tseng, Y. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00373-z · Cited by 121 · see citing works
Lang, Y., Kisaka, H., Sugiyama, R., Nomura, K., Morita, A., Watanabe, T., Tanaka, Y., Yazawa, S., & Miwa, T. (2009) · The Plant Journal · doi:10.1111/j.1365-313x.2009.03921.x · Cited by 118 · see citing works
Natural products in anti-obesity therapy
Vermaak, I., Viljoen, A. M., & Hamman, J. H. (2011) · Natural Product Reports · doi:10.1039/c1np00035g · Cited by 117 · see citing works
MASAMOTO, Y., Kawabata, F., & Fushiki, T. (2009) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.80796 · Cited by 111 · see citing works
Kawabata, F., INOUE, N., Yazawa, S., Kawada, T., Inoue, K., & Fushiki, T. (2006) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.60206 · Cited by 110 · see citing works
Ono, K., Tsukamoto‐Yasui, M., Hara-Kimura, Y., Inoue, N., Nogusa, Y., Okabe, Y., Nagashima, K., & Kato, F. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00128.2010 · Cited by 104 · see citing works
Beiging of white adipose tissue as a therapeutic strategy for weight loss in humans
Thyagarajan, B., & Foster, M. T. (2017) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2017-0016 · Cited by 104 · see citing works
Vaughan, C. H., & Bartness, T. J. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00640.2011 · Cited by 103 · see citing works
Zsiborás, C., Mátics, R., Hegyi, P. J., Balaskó, M., Pétervári, E., Szabó, I., Sarlós, P., Mikó, A., Tenk, J., Rostás, I., et al. (2016) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2016.1262324 · Cited by 97 · see citing works
Involvement of thermosensitive TRP channels in energy metabolism
Uchida, K., Dezaki, K., Yoneshiro, T., Watanabe, T., Yamazaki, J., Saito, M., Yada, T., Tominaga, M., & Iwasaki, Y. (2017) · The Journal of Physiological Sciences · doi:10.1007/s12576-017-0552-x · Cited by 95 · see citing works
Effects of capsinoid ingestion on energy expenditure and lipid oxidation at rest and during exercise
Josse, A. R., Sherriffs, S. S., Holwerda, A. M., Andrews, R. V., Staples, A. W., & Phillips, S. M. (2010) · Nutrition & Metabolism · doi:10.1186/1743-7075-7-65 · Cited by 93 · see citing works
Uarrota, V. G., Maraschin, M., de Bairros, Â. D. F. M., & Pedreschi, R. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1743642 · Cited by 82 · see citing works
Yamada, Y., Muraki, A., Mariko, O., Kanegawa, N., Oda, A., Sawashi, Y., Kaneko, K., Yoshikawa, M., Goto, T., Takahashi, N., et al. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00161.2011 · Cited by 78 · see citing works
Venkatakrishnan, K., Chiu, H., & Wang, C. (2019) · Food & Function · doi:10.1039/c9fo00293f · Cited by 75 · see citing works
TRP channels and their implications in metabolic diseases
Zhu, Z., Luo, Z., Ma, S., & Liu, D. (2010) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-010-0902-5 · Cited by 72 · see citing works
Saito, M. (2015) · Advances in food and nutrition research · doi:10.1016/bs.afnr.2015.07.002 · Cited by 69 · see citing works
Activation of transient receptor potential A1 by a non‐pungent capsaicin‐like compound, capsiate
Shintaku, K., Uchida, K., Suzuki, Y., Zhou, Y., Fushiki, T., Watanabe, T., Yazawa, S., & Tominaga, M. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01634.x · Cited by 65 · see citing works
Ang, Q. Y., Goh, H. J., Cao, Y., Li, Y., Chan, S., Swain, J. L., Henry, C. J., & Leow, M. K. (2016) · The Journal of Physiological Sciences · doi:10.1007/s12576-016-0472-1 · Cited by 65 · see citing works
A nutritional perspective on UCP1-dependent thermogenesis
Bonet, M. L., Mercader, J., & Palou, A. (2017) · Biochimie · doi:10.1016/j.biochi.2016.12.014 · Cited by 66 · see citing works
Effect of capsinoids on energy metabolism in human subjects
Galgani, J. E., Ryan, D. H., & Ravussin, É. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114509991358 · Cited by 62 · see citing works
Role of brown adipose tissue in metabolic syndrome, aging, and cancer cachexia
Dong, M., Lin, J., Lim, W., Jin, W., & Lee, H. J. (2017) · Frontiers of Medicine · doi:10.1007/s11684-017-0555-2 · Cited by 61 · see citing works
Ohyama, K., Nogusa, Y., Suzuki, K., Shinoda, K., Kajimura, S., & Bannai, M. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00354.2014 · Cited by 61 · see citing works
Tanaka, Y., Hosokawa, M., Miwa, T., Watanabe, T., & Yazawa, S. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf903282r · Cited by 60 · see citing works
Cerium(III) chloride-promoted chemoselective esterification of phenolic alcohols
Torregiani, E., Seu, G., Minassi, A., & Appendino, G. (2005) · Tetrahedron Letters · doi:10.1016/j.tetlet.2005.02.042 · Cited by 59 · see citing works
Maharjan, A., Vasamsetti, B. M. K., & Park, J. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e39721 · Cited by 60 · see citing works
Skeletal muscle mitochondrial uncoupling, adaptive thermogenesis and energy expenditure
van den Berg, S. A., Lichtenbelt, W. D. V. M., van Dijk, K. W., & Schrauwen, P. (2011) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e3283455d7a · Cited by 53 · see citing works
Fortier, M., Wang, S. P., Mauriège, P., Semache, M., Mfuma, L., Li, H., Levy, E. H., Richard, D., & Mitchell, G. A. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00203.2003 · Cited by 55 · see citing works
Effect of dihydrocapsiate on resting metabolic rate in humans
Galgani, J. E., & Ravussin, É. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.30036 · Cited by 53 · see citing works
McNeill, B. T., Suchacki, K. J., & Stimson, R. H. (2021) · European Journal of Endocrinology · doi:10.1530/eje-20-1439 · Cited by 52 · see citing works
Tanaka, Y., Hosokawa, M., Miwa, T., Watanabe, T., & Yazawa, S. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf1019642 · Cited by 49 · see citing works
Transient receptor potential channels and energy homeostasis
Ahern, G. P. (2013) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2013.06.005 · Cited by 48 · see citing works
Food Components with Anti-Obesity Effect
Kim, K., & Park, Y. (2011) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-022510-133656 · Cited by 47 · see citing works
The Role of Transient Receptor Potential Channels in Metabolic Syndrome
Liu, D., Zhu, Z., & Tepel, M. (2008) · Hypertension Research · doi:10.1291/hypres.31.1989 · Cited by 46 · see citing works
Functional foods and nutraceuticals in the management of obesity
Kasbia, G. S. (2005) · Nutrition & Food Science · doi:10.1108/00346650510625557 · Cited by 45 · see citing works
Lipolytic Effects of Citrus Peel Oils and Their Components
Choi, H. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf052409j · Cited by 42 · see citing works
Haramizu, S., Mizunoya, W., Masuda, Y., Ohnuki, K., Watanabe, T., Yazawa, S., & Fushiki, T. (2006) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.70.774 · Cited by 40 · see citing works
Assessment of Capsiconinoid Composition, Nonpungent Capsaicinoid Analogues, in Capsicum Cultivars
Tanaka, Y., Hosokawa, M., Otsu, K., Watanabe, T., & Yazawa, S. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf900634s · Cited by 39 · see citing works
Manipulating molecular switches in brown adipocytes and their precursors: A therapeutic potential
Birerdinc, A., Jarrar, M. H., Stotish, T., Randhawa, M., & Baranova, A. V. (2012) · Progress in Lipid Research · doi:10.1016/j.plipres.2012.08.001 · Cited by 39 · see citing works
Skeletal muscle non-shivering thermogenesis as an attractive strategy to combat obesity
Li, H., Wang, C., Li, L., & Li, L. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119024 · Cited by 38 · see citing works
Role of Thermo-Sensitive Transient Receptor Potential Channels in Brown Adipose Tissue
Uchida, K., Sun, W., Yamazaki, J., & Tominaga, M. (2018) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b18-00063 · Cited by 38 · see citing works
Transient Receptor Potential Channels and Metabolism.
Dhakal, S., & Lee, Y. (2019) · PubMed Central · doi:10.14348/molcells.2019.0007 · Cited by 38 · see citing works
Lee, T. A., Li, Z., Zerlin, A., & Heber, D. (2010) · Nutrition & Metabolism · doi:10.1186/1743-7075-7-78 · Cited by 38 · see citing works
Yamazaki, T., Morimoto-Kobayashi, Y., Koizumi, K., Takahashi, C., Nakajima, S., Kitao, S., Taniguchi, Y., Katayama, M., & Ogawa, Y. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.10.009 · Cited by 37 · see citing works
Singletary, K. W. (2011) · Nutrition Today · doi:10.1097/nt.0b013e3182076ff2 · Cited by 37 · see citing works
Glabridin induces glucose uptake via the AMP-activated protein kinase pathway in muscle cells
Sawada, K., Yamashita, Y., Zhang, T., Nakagawa, K., & Ashida, H. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.06.009 · Cited by 36 · see citing works
Troglitazone activates TRPV1 and causes deacetylation of PPARγ in 3T3-L1 cells
Krishnan, V., Baskaran, P., & Thyagarajan, B. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.11.004 · Cited by 36 · see citing works
Adipose and non-adipose perspectives of plant derived natural compounds for mitigation of obesity
Borah, A. K., Sharma, P., Singh, A., Kalita, K. J., Saha, S., & Borah, J. C. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114410 · Cited by 35 · see citing works
Capsinoids suppress fat accumulation via lipid metabolism
HONG, Q., XIA, C., Hu, X., & Yuan, Q. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.2996 · Cited by 35 · see citing works
Plant natural products as an anti-lipid droplets accumulation agent
Wong, C. P., Kaneda, T., & Morita, H. (2014) · Journal of Natural Medicines · doi:10.1007/s11418-014-0822-3 · Cited by 33 · see citing works
Faraut, B., Giannesini, B., Matarazzo, V. A., Fur, Y. L., Rougon, G. N., Cozzone, P. J., & Bendahan, D. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.182 · Cited by 33 · see citing works
Mori, N., Kawabata, F., Matsumura, S., Hosokawa, H., Kobayashi, S., Inoue, K., & Fushiki, T. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00645.2009 · Cited by 32 · see citing works
Zunun-Pérez, A. Y., Guevara-Figueroa, T., Jimenez-Garcia, S. N., Feregrino‐Pérez, A. A., Gautier, F., & Guevara-González, R. G. (2017) · Journal of Biosciences · doi:10.1007/s12038-017-9682-9 · Cited by 32 · see citing works
Sweet pepper and its principle constituent capsiate: functional properties and health benefits
Gupta, R., Kapoor, B., Gulati, M., Kumar, B., Gupta, M., Singh, S. K., & Awasthi, A. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1913989 · Cited by 31 · see citing works
Kim, H., Choe, J., Choi, J. H., Kim, H. J., Park, S. H., Lee, M. W., Kim, W., & Go, G. (2017) · Lipids · doi:10.1007/s11745-017-4277-7 · Cited by 30 · see citing works
Haramizu, S., Kawabata, F., Masuda, Y., Ohnuki, K., Watanabe, T., Yazawa, S., & Fushiki, T. (2011) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.100577 · Cited by 29 · see citing works
Horváth, C., & Wolfrum, C. (2020) · Proceedings of The Nutrition Society · doi:10.1017/s0029665120006928 · Cited by 28 · see citing works
Protective effect of capsinoid on lipid peroxidation in rat tissues induced by Fe-NTA
Rosa, A., Deiana, M., Corona, G., Atzeri, A., Incani, A., Appendino, G., & Dessì, M. (2005) · Free Radical Research · doi:10.1080/10715760500178094 · Cited by 28 · see citing works
Faraut, B., Giannesini, B., Matarazzo, V. A., Marqueste, T., Dalmasso, C., Rougon, G. N., Cozzone, P. J., & Bendahan, D. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00292.2006 · Cited by 28 · see citing works
Capsinoids suppress diet-induced obesity through uncoupling protein 1-dependent mechanism in mice
Okamatsu‐Ogura, Y., Tsubota, A., Ohyama, K., Nogusa, Y., Saito, M., & Kimura, K. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.09.005 · Cited by 27 · see citing works
Osuna‐Prieto, F. J., Martínez‐Téllez, B., Sánchez‐Delgado, G., Aguilera, C. M., Lozano‐Sánchez, J., Arraéz-Román, D., Segura‐Carretero, A., & Ruiz, J. R. (2018) · Advances in Nutrition · doi:10.1093/advances/nmy067 · Cited by 26 · see citing works
Fuse, S., Endo, T., Tanaka, R., Kuroiwa, M., Ando, A., Kume, A., Yamamoto, A., Kuribayashi, K., Somekawa, S., Takeshita, M., et al. (2020) · Nutrients · doi:10.3390/nu12092676 · Cited by 27 · see citing works
Isodihydrocapsiate stimulates plasma glucose uptake by activation of AMP-activated protein kinase
Hwang, S., Yang, B.-K., Lee, J.-Y., Kim, J., Kim, B.-H., Suh, K.-H., Kim, D.-Y., Kim, M. S., Song, H., Park, B., et al. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.04.061 · Cited by 27 · see citing works
Yashiro, K., Tonson, A., Pecchi, É., Dalmasso, C., Vilmen, C., Fur, Y. L., Bernard, M., Bendahan, D., & Giannesini, B. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00520.2013 · Cited by 26 · see citing works
Yashiro, K., Tonson, A., Pecchi, É., Vilmen, C., Fur, Y. L., Bernard, M., Bendahan, D., & Giannesini, B. (2015) · PLoS ONE · doi:10.1371/journal.pone.0128016 · Cited by 26 · see citing works
Translational Pharmacology and Physiology of Brown Adipose Tissue in Human Disease and Treatment
Larson, C. J. (2018) · Handbook of experimental pharmacology · doi:10.1007/164_2018_184 · Cited by 25 · see citing works
Osuna‐Prieto, F. J., Martínez‐Téllez, B., Segura‐Carretero, A., & Ruiz, J. R. (2021) · Advances in Nutrition · doi:10.1093/advances/nmab084 · Cited by 25 · see citing works
Nutraceuticals in Brown Adipose Tissue Activation
Armani, A., Feraco, A., Camajani, E., Gorini, S., Lombardo, M., & Caprio, M. (2022) · Cells · doi:10.3390/cells11243996 · Cited by 21 · see citing works
Li, Z., Zhang, J., Cheng, K., Zhang, L., & Wang, T. Z. (2023) · Journal of Functional Foods · doi:10.1016/j.jff.2023.105749 · Cited by 20 · see citing works
Mun, J.-M., Ok, H. M., & Kwon, O. (2014) · Nutrition Research · doi:10.1016/j.nutres.2014.04.009 · Cited by 20 · see citing works
Studies on the metabolism and toxicology of emerging capsinoids
Watanabe, T., Ohnuki, K., & Kobata, K. (2011) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.2011.562193 · Cited by 20 · see citing works
Methods and Applications of Phosphorus NMR Spectroscopy In Vivo
Lee, J. H., Komoroski, R. A., Chu, W., & Dudley, J. A. (2012) · Annual reports on NMR spectroscopy · doi:10.1016/b978-0-12-397018-3.00003-x · Cited by 19 · see citing works
Haramizu, S., Kawabata, F., Ohnuki, K., Inoue, N., Watanabe, T., Yazawa, S., & Fushiki, T. (2011) · Biomedical Research · doi:10.2220/biomedres.32.279 · Cited by 18 · see citing works
Nutrigenomics and Proteomics in Health and Disease
Mine, Y., Miyashita, K., & Shahidi, F. (2009) · Wiley eBooks · doi:10.1002/9780813807263 · Cited by 18 · see citing works
Effect of Gocho(苦椒) Extract Mesotherapy on Regional Fat Loss in Obese Korean Women.
Kim, E. J., Brodsky, M., Cho, J., Cho, Y.-J., & Song, M. (2011) · 대한한의학회지 · Cited by 17 · see citing works
Dietary factors evoke thermogenesis in adipose tissues
Sakamoto, T., Takahashi, N., Goto, T., & Kawada, T. (2014) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2013.12.002 · Cited by 17 · see citing works
Yokoyama, K., Yamada, Y., Akamatsu, Y., Yoshinaka, Y., Yamamoto, A., Koizumi, T., Ohyama, K., Suzuki, K., Hashimoto, M., Sato, H., et al. (2020) · Nutrients · doi:10.3390/nu12010212 · Cited by 18 · see citing works
Gannon, N. P., Lambalot, E. L., & Vaughan, R. A. (2016) · BioFactors · doi:10.1002/biof.1273 · Cited by 16 · see citing works
Capsaicin and its Human Therapeutic Development
Mózsik, G. (2018) · InTech eBooks · doi:10.5772/intechopen.73124 · Cited by 15 · see citing works
Food-derived regulatory factors against obesity and metabolic syndrome
Kawada, T. (2018) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2017.1401912 · Cited by 14 · see citing works
Kim, N., & Park, S. (2014) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.6685 · Cited by 14 · see citing works
Iwami, M., Shiina, T., Hirayama, H., & Shimizu, Y. (2011) · Biomedical Research · doi:10.2220/biomedres.32.181 · Cited by 14 · see citing works
Thermogenic Fat as a New Obesity Management Tool: From Pharmaceutical Reagents to Cell Therapies
Cheng, Y., Liang, S., Zhang, S., & Hui, X. H. (2024) · Biomedicines · doi:10.3390/biomedicines12071474 · Cited by 13 · see citing works
The two faces of capsiate: Nutraceutical and therapeutic potential
Gupta, R., Kapoor, B., Gulati, M., Singh, S. K., & Saxena, D. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2021.02.012 · Cited by 13 · see citing works
Recent developments in natural products for white adipose tissue browning
Ma, P., He, P., Xu, C., Hou, B., Qiang, G., & Du, G. (2020) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(20)60021-8 · Cited by 13 · see citing works
- Authors
- Masuda, Y., Haramizu, S., Oki, K., Ohnuki, K., Watanabe, T., Yazawa, S., Kawada, T., Hashizume, S.-I., & Fushiki, T.
- Affiliations
- Kyoto University (JP)
- ORCID
- Kawada, Teruo
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2003-12
- Volume
- 95
- Issue
- 6
- Pages
- 2408-2415
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2168851175
- Cited by
- 143
- References
- 58
- Citations by year
- 2026: 2 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 9 · 2020: 11 · 2019: 3 · 2018: 12 · 2017: 8 · 2016: 5 · 2015: 5 · 2014: 10 · 2013: 6 · 2012: 11
- FWCI
- 1.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- capsiate, uncoupling proteins, UCP1, UCP2, UCP3, brown adipose tissue, white adipose tissue, skeletal muscle, fat oxidation, metabolic rate, energy expenditure, obesity prevention, thyroid hormones, triiodothyronine, thyroxine, oral administration
- MeSH terms
- Uncoupling Protein 2, Uncoupling Protein 3, Uncoupling Protein 1, Adipose Tissue, Animals, Adipose Tissue, Brown, Capsaicin, Carrier Proteins, Epididymis, Gases, Ion Channels, Male, Membrane Proteins, Organ Size, Oxygen Consumption, RNA, Thyroid Hormones, Blotting, Western, Up-Regulation, Muscle, Skeletal, Reverse Transcriptase Polymerase Chain Reaction, Mitochondrial Proteins, Membrane Transport Proteins, Carbohydrate Metabolism, Mice
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