Cited by 143Adipose Tissue and MetabolismRegulation of Appetite and ObesityIon Channels and Receptors

Upregulation of uncoupling proteins by oral administration of capsiate, a nonpungent capsaicin analog

Masuda, Yoriko, Haramizu, Satoshi, Oki, Kasumi, Ohnuki, Koichiro, Watanabe, Tatsuo, Yazawa, Susumu, Kawada, Teruo, Hashizume, Shu-ichi +1 more·2003·Journal of Applied Physiology

Abstract

Capsiate is a nonpungent capsaicin analog, a recently identified principle of the nonpungent red pepper cultivar CH-19 Sweet. In the present study, we report that 2-wk treatment of capsiate increased metabolic rate and promoted fat oxidation at rest, suggesting that capsiate may prevent obesity. To explain these effects, at least in part, we examined uncoupling proteins (UCPs) and thyroid hormones. UCPs and thyroid hormones play important roles in energy expenditure, the maintenance of body weight, and thermoregulation. Two-week treatment of capsiate increased the levels of UCP1 protein and mRNA in brown adipose tissue and UCP2 mRNA in white adipose tissue. This dose of capsiate did not change serum triiodothyronine or thyroxine levels. A single dose of capsiate temporarily raised both UCP1 mRNA in brown adipose tissue and UCP3 mRNA in skeletal muscle. These results suggest that UCP1 and UCP2 may contribute to the promotion of energy metabolism by capsiate, but that thyroid hormones do not.

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Crossref · 10.1152/japplphysiol.00828.2002

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Authors
Masuda, Y., Haramizu, S., Oki, K., Ohnuki, K., Watanabe, T., Yazawa, S., Kawada, T., Hashizume, S.-I., & Fushiki, T.
Affiliations
Kyoto University (JP)
Venue
Journal of Applied Physiology
Published
2003-12
Volume
95
Issue
6
Pages
2408-2415
ISSN
  • 0161-7567 (ISSN-L)
  • 8750-7587
  • 1522-1601
OpenAlex
W2168851175
Cited by
143
References
58
Citations by year
2026: 2 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 9 · 2020: 11 · 2019: 3 · 2018: 12 · 2017: 8 · 2016: 5 · 2015: 5 · 2014: 10 · 2013: 6 · 2012: 11
FWCI
1.53
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Applied Physiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords
capsiate, uncoupling proteins, UCP1, UCP2, UCP3, brown adipose tissue, white adipose tissue, skeletal muscle, fat oxidation, metabolic rate, energy expenditure, obesity prevention, thyroid hormones, triiodothyronine, thyroxine, oral administration
MeSH terms
Uncoupling Protein 2, Uncoupling Protein 3, Uncoupling Protein 1, Adipose Tissue, Animals, Adipose Tissue, Brown, Capsaicin, Carrier Proteins, Epididymis, Gases, Ion Channels, Male, Membrane Proteins, Organ Size, Oxygen Consumption, RNA, Thyroid Hormones, Blotting, Western, Up-Regulation, Muscle, Skeletal, Reverse Transcriptase Polymerase Chain Reaction, Mitochondrial Proteins, Membrane Transport Proteins, Carbohydrate Metabolism, Mice

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