Cited by 289Adipose Tissue and MetabolismRegulation of Appetite and ObesityLipid metabolism and biosynthesis

Sensory and sympathetic nervous system control of white adipose tissue lipolysis

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Bartness, Timothy J., Shrestha, Y.B., Vaughan, C.H., Schwartz, G.J., Song, C.K.·2010·Molecular and Cellular Endocrinology

Abstract

Circulating factors are typically invoked to explain bidirectional communication between the CNS and white adipose tissue (WAT). Thus, initiation of lipolysis has been relegated primarily to adrenal medullary secreted catecholamines and the inhibition of lipolysis primarily to pancreatic insulin, whereas signals of body fat levels to the brain have been ascribed to adipokines such as leptin. By contrast, evidence is given for bidirectional communication between brain and WAT occurring via the sympathetic nervous system (SNS) and sensory innervation of this tissue. Using retrograde transneuronal viral tract tracers, the SNS outflow from brain to WAT has been defined. Functionally, sympathetic denervation of WAT blocks lipolysis to a variety of lipolytic stimuli. Using anterograde transneuronal viral tract tracers, the sensory input from WAT to brain has been defined. Functionally, these WAT sensory nerves respond electrophysiologically to increases in WAT SNS drive suggesting a possible neural negative feedback loop to regulate lipolysis.

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Crossref · 10.1016/j.mce.2009.08.031

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  1. Clement G La mobilisation des glycerides de reserve chez le rat. II. Influence due systeme nerveux sympathique. Etablissement d'un procede de mesure de I'intensite de la mobilisation. Arch.Sci.Physiol 1950 4 13 29 24537458

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Authors
Bartness, T. J., Shrestha, Y. B., Vaughan, C. H., Schwartz, G. J., & Song, C. K.
Affiliations
  • Georgia State University (US)
  • Albert Einstein College of Medicine (US)
Corresponding author
Bartness, Timothy J.
Venue
Molecular and Cellular Endocrinology
Publisher
Elsevier BV
Published
2010-04
Volume
318
Issue
1-2
Pages
34-43
ISSN
0303-7207 (ISSN-L)
OpenAlex
W1990112639
Cited by
289
References
180
Citations by year
2026: 10 · 2025: 11 · 2024: 16 · 2023: 22 · 2022: 23 · 2021: 15 · 2020: 12 · 2019: 21 · 2018: 14 · 2017: 19 · 2016: 13 · 2015: 27 · 2014: 18 · 2013: 15 · 2012: 24
FWCI
1.94
Type
journal article
Language
en
Open access
Locations
  • Molecular and Cellular Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (R37DK35254, R37DK035254)
Topics
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords
white adipose tissue, lipolysis, sympathetic nervous system, sensory innervation, sympathetic denervation, anterograde and retrograde tracing, catecholamines, insulin, leptin, adipokines
MeSH terms
Animals, Humans, Lipolysis, Sensory Receptor Cells, Sympathetic Nervous System, Adipose Tissue, White

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