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The urokinase receptor: Focused cell surface proteolysis, cell adhesion and signaling
Abstract
uPAR is highly expressed during tissue reorganization, inflammation, and in virtually all human cancers. Since its discovery, in vitro and in vivo models, as well as retrospective clinical studies have shown that over‐expression of components of the uPA/uPAR‐system correlates with increased proliferation, migration, and invasion affecting the malignant phenotype of cancer. uPAR regulates the cells–extracellular matrix interactions promoting its degradation and turnover through the plasminogen activation cascade.
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Cited by
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Räsänen, K., & Vaheri, A. (2010) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.04.032 · Cited by 499
Horowitz, A. M., Fan, X., Bieri, G., Smith, L. K., Sanchez-Diaz, C. I., Schroer, A. B., Gontier, G., Casaletto, K. B., Kramer, J. H., Williams, K. E., et al. (2020) · Science · doi:10.1126/science.aaw2622 · Cited by 496
Role of Urokinase Receptor in Tumor Progression and Development
Noh, H., Hong, S., & Huang, S. (2013) · Theranostics · doi:10.7150/thno.4218 · Cited by 129
Metrangolo, V., Ploug, M., & Engelholm, L. H. (2021) · Cancers · doi:10.3390/cancers13215376 · Cited by 44
“Besides uPAR’s well-established role in pericellular proteolysis, so-called non-proteolytic functions have emerged over the years, implying uPAR’s involvement in multiple intracellularsignaling pathways affecting several aspects of the neoplastic evolution such as cell proliferation, differentiation, survival, adhesio…”
BackgroundInfluentialYang, A., Dai, J., Xie, Z., Colman, R. W., Wu, Q., Birge, R. B., & Wu, Y. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302590 · Cited by 30
Metadata
- Authors
- Blasi, F., & Sidenius, N.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2009-12-27
- Volume
- 584
- Issue
- 9
- Pages
- 1923-1930
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2064911312
- Cited by
- 258
- References
- 0
- FWCI
- 6.22
- Type
- journal article
- Language
- en
- Open access
- closed
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- Blasi, F., & Sidenius, N. (2010). The urokinase receptor: Focused cell surface proteolysis, cell adhesion and signaling. FEBS Letters. https://doi.org/10.1016/j.febslet.2009.12.039
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
