Cited by 499Cancer Cells and MetastasisTGF-β signaling in diseasesPancreatic and Hepatic Oncology Research

Activation of fibroblasts in cancer stroma

Räsänen, Kati, Vaheri, Antti·2010·Experimental Cell Research

Abstract

Tumor microenvironment has emerged as an important target for cancer therapy. In particular, cancer-associated fibroblasts (CAF) seem to regulate many aspects of tumorigenesis. CAFs secrete a variety of soluble factors that act in a paracrine manner and thus affect not only cancer cells, but also other cell types present in the tumor stroma. Acting on cancer cells, CAFs promote tumor growth and invasion. They also enhance angiogenesis by secreting factors that activate endothelial cells and pericytes. Tumor immunity is mediated via cytokines secreted by immune cells and CAFs. Both immune cells and CAFs can exert tumor-suppressing and -promoting effects. CAFs, and the factors they produce, are attractive targets for cancer therapy, and they have proven to be useful as prognostic markers. In this review we focus mainly on carcinomas and discuss the recent findings regarding the role of activated fibroblasts in driving tumor progression.

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Crossref · 10.1016/j.yexcr.2010.04.032

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Authors
Räsänen, K., & Vaheri, A.
Affiliations
University of Helsinki (FI)
Corresponding author
Räsänen, Kati
Venue
Experimental Cell Research
Publisher
Elsevier BV
Published
2010-10
Volume
316
Issue
17
Pages
2713-2722
ISSN
0014-4827 (ISSN-L)
OpenAlex
W2082503761
Cited by
499
References
16
Citations by year
2026: 11 · 2025: 9 · 2024: 20 · 2023: 19 · 2022: 30 · 2021: 44 · 2020: 39 · 2019: 37 · 2018: 29 · 2017: 25 · 2016: 36 · 2015: 44 · 2014: 40 · 2013: 45 · 2012: 42
FWCI
4.05
Type
journal article
Language
en
Open access
closed
Locations
  • Experimental Cell Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
Magnus Ehrnroothin Säätiö
Topics
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
  • Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
Keywords
cancer-associated fibroblasts, tumor microenvironment, tumor stroma, paracrine signaling, tumor angiogenesis, tumor invasion, antitumor immunity, carcinoma, tumor progression, cancer therapy targets, prognostic factors
MeSH terms
Fibroblasts, Humans, Neoplasms, Stromal Cells, Paracrine Communication

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