Role of Urokinase Receptor in Tumor Progression and Development
Open accessAbstract
Elevated level of urokinase receptor (uPAR) is detected in various aggressive cancer types and is closely associated with poor prognosis of cancers. Binding of uPA to uPAR triggers the conversion of plasminogen to plasmin and the subsequent activation of metalloproteinases. These events confer tumor cells with the capability to degrade the components of the surrounding extracellular matrix, thus contributing to tumor cell invasion and metastasis. uPA-uPAR interaction also elicits signals that stimulate cell proliferation/survival and the expression of tumor-promoting genes, thus assisting tumor development. In addition to its interaction with uPA, uPAR also interacts with vitronectin and this interaction promotes cancer metastasis by activating Rac and stimulating cell migration. Although underlying mechanisms are yet to be fully elucidated, uPAR has been shown to facilitate epithelial-mesenchymal transition (EMT) and induce cancer stem cell-like properties in breast cancer cells. The fact that uPAR lacks intracellular domain suggests that its signaling must be mediated through its co-receptors. Indeed, uPAR interacts with diverse transmembrane proteins including integrins, ENDO180, G protein-coupled receptors and growth factor receptors in cancer cells and these interactions are proven to be critical for the role of uPAR in tumorigenesis. Inhibitory peptide that prevents uPA-uPAR interaction has shown the promise to prolong patients' survival in the early stage of clinical trial. The importance of uPAR's co-receptor in uPAR's tumor-promoting effects implicate that anti-cancer therapeutic agents may also be developed by disrupting the interactions between uPAR and its functional partners.
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The uPA-uPAR connection triggers signals that promote tumor-promoting gene expression and cell survival and proliferation.
“Additionally, the uPA-uPAR connection triggers signals that promote tumor-promoting gene expression and cell survival and proliferation.152”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [152]
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Smart nanoparticles for cancer therapy
Sun, L., Liu, H., Ye, Y., Lei, Y., Islam, R., Tan, S., Tong, R., Miao, Y.-B., & Cai, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01642-x · Cited by 1,073 · see citing works
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“Distinct regulatory mechanisms control uPAR expression in tumor and associated stromal cells at multiple levels, respectively, transcriptional, post-transcriptional, and posttranslational, with the former being considered the principal one [12,14,52,84,85,103,149].”
Background
- Authors
- Noh, H., Hong, S., & Huang, S.
- Affiliations
- Augusta University (US)
- Corresponding author
- Huang, Shuang
- Venue
- Theranostics
- Publisher
- Ivyspring International Publisher
- Published
- 2013
- Volume
- 3
- Issue
- 7
- Pages
- 487-495
- ISSN
- 1838-7640 (ISSN-L)
- PMC
- PMC3706692
- OpenAlex
- W1977264221
- Cited by
- 129
- References
- 118
- Citations by year
- 2026: 11 · 2025: 3 · 2024: 5 · 2023: 10 · 2022: 8 · 2021: 11 · 2020: 7 · 2019: 7 · 2018: 9 · 2017: 22 · 2016: 13 · 2015: 15 · 2014: 5 · 2013: 3
- FWCI
- 0.99
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Theranostics (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Shanghai Municipal Education Commission (E03008)
- National Institutes of Health
- E-Institutes of Shanghai Municipal Education Commission (E 03008)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Keywords
- urokinase receptor, urokinase, tumor progression, metastasis, extracellular matrix degradation, vitronectin, Rac activation, cell migration, epithelial-mesenchymal transition, cancer stem cells, breast cancer, integrins, Endo180, G protein-coupled receptors, co-receptors, cancer therapy, peptide inhibitors
- MeSH terms
- Animals, Humans, Neoplasms, Neoplastic Processes, Urokinase-Type Plasminogen Activator, Signal Transduction, Receptors, Urokinase Plasminogen Activator
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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