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Cited by 215

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

NPC1L1 and cholesterol transport

Open access
Betters, Jenna L., Yu, Liqing·2010·FEBS Letters
DOI 10.1016/j.febslet.2010.03.030
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Abstract

The polytopic transmembrane protein, Niemann–Pick C1‐Like 1 (NPC1L1), is enriched in the apical membrane of small intestine absorptive enterocytes where it mediates extracellular sterol transport across the brush border membrane. It is essential for intestinal sterol absorption and is the molecular target of ezetimibe, a potent cholesterol absorption inhibitor that lowers blood cholesterol in humans. NPC1L1 is also highly expressed in human liver. The hepatic function of NPC1L1 may be to limit excessive biliary cholesterol loss. NPC1L1‐dependent sterol uptake seems to be a clathrin‐mediated endocytic process and is regulated by cellular cholesterol content. Recently, NPC1L1 inhibition has been shown to have beneficial effects on components of the metabolic syndrome, such as obesity, insulin resistance, and fatty liver, in addition to atherosclerosis.

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Metadata

Authors
Betters, J. L., & Yu, L.
Venue
FEBS Letters
Publisher
Wiley
Published
2010-03-19
Volume
584
Issue
13
Pages
2740-2747
ISSN
  • 0014-5793 (ISSN-L)
  • 1873-3468
DOI
10.1016/j.febslet.2010.03.030
OpenAlex
W1989872528
Cited by
215
References
3
FWCI
12.42
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: NPC1L1 and cholesterol transport. https://app.cochat.ai/papers/10.1016/j.febslet.2010.03.030
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Betters, J. L., & Yu, L. (2010). NPC1L1 and cholesterol transport. FEBS Letters. https://doi.org/10.1016/j.febslet.2010.03.030

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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