TSC1/TSC2 signaling in the CNS

TOR signaling in growth and metabolism

Wullschleger, S., Loewith, R., & Hall, M. N. (2006) · Cell · doi:10.1016/j.cell.2006.01.016 · Cited by 5,787

TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

Inoki, K., Zhu, T., & Guan, K.-L. (2003) · Cell · doi:10.1016/s0092-8674(03)00929-2 · Cited by 3,914

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

Inoki, K., Li, Y., Zhu, T., Wu, J., & Guan, K.-L. (2002) · Nature Cell Biology · doi:10.1038/ncb839 · Cited by 3,083

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

Li, N., Lee, B., Liu, R.-J., Banasr, M., Dwyer, J. M., Iwata, M., Li, X.-Y., Aghajanian, G., & Duman, R. S. (2010) · Science · doi:10.1126/science.1190287 · Cited by 2,881

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

Sancak, Y., Peterson, T. R., Shaul, Y. D., Lindquist, R. A., Thoreen, C. C., Bar-Peled, L., & Sabatini, D. M. (2008) · Science · doi:10.1126/science.1157535 · Cited by 2,773

Molecular mechanisms of mTOR-mediated translational control

Ma, X. M., & Blenis, J. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2672 · Cited by 2,558

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

Sancak, Y., Bar-Peled, L., Zoncu, R., Markhard, A. L., Nada, S., & Sabatini, D. M. (2010) · Cell · doi:10.1016/j.cell.2010.02.024 · Cited by 2,464 · cited 1×

Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB

Sarbassov, D. D., Ali, S. M., Sengupta, S., Sheen, J.-H., Hsu, P. P., Bagley, A. F., Markhard, A. L., & Sabatini, D. M. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.03.029 · Cited by 2,365

Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway

Park, K. K., Liu, K., Hu, Y., Smith, P. D., Wang, C., Cai, B., Xu, B., Connolly, L., Kramvis, I., Sahin, M., et al. (2008) · Science · doi:10.1126/science.1161566 · Cited by 1,686

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

Manning, B. D., Tee, A. R., Logsdon, M. N., Blenis, J., & Cantley, L. C. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00568-3 · Cited by 1,555

Termination of autophagy and reformation of lysosomes regulated by mTOR

Yu, L., McPhee, C. K., Zheng, L., Mardones, G. A., Rong, Y., Peng, J., Mi, N., Zhao, Y., Liu, Z., Wan, F., et al. (2010) · Nature · doi:10.1038/nature09076 · Cited by 1,544

Regulation of TORC1 by Rag GTPases in nutrient response

Kim, E., Goraksha-Hicks, P., Li, L., Neufeld, T. P., & Guan, K.-L. (2008) · Nature Cell Biology · doi:10.1038/ncb1753 · Cited by 1,349

Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

Pause, A., Belsham, G. J., Gingras, A., Donzé, O., Lin, T.-A., Lawrence, J. C., & Sonenberg, N. (1994) · Nature · doi:10.1038/371762a0 · Cited by 1,242

Tuberous sclerosis

Curatolo, P., Bombardieri, R., & Jóźwiak, S. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61279-9 · Cited by 1,106

Everolimus for Subependymal Giant-Cell Astrocytomas in Tuberous Sclerosis

Krueger, D. A., Caré, M. M., Holland, K. D., Agricola, K. D., Tudor, C., Mangeshkar, P., Wilson, K. A., Byars, A. W., Sahmoud, T., & Franz, D. N. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1001671 · Cited by 1,003

Mutational Analysis in a Cohort of 224 Tuberous Sclerosis Patients Indicates Increased Severity of TSC2, Compared with TSC1, Disease in Multiple Organs

Dabora, S. L., Jóźwiak, S., Franz, D. N., Roberts, P. S., Nieto, A., Chung, J., Choy, Y.-S., Reeve, M. P., Thiele, E. A., Egelhoff, J. C., et al. (2001) · The American Journal of Human Genetics · doi:10.1086/316951 · Cited by 998

PTEN deletion enhances the regenerative ability of adult corticospinal neurons

Liu, K., Lü, Y., Lee, J. K., Samara, R. F., Willenberg, R., Sears‐Kraxberger, I., Tedeschi, A., Park, K. K., Jin, D., Cai, B., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2603 · Cited by 987

Pten Regulates Neuronal Arborization and Social Interaction in Mice

Kwon, C.-H., Luikart, B. W., Powell, C. M., Zhou, J., Matheny, S. A., Zhang, W., Li, Y., Baker, S. J., & Parada, L. F. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.023 · Cited by 970

Akt regulates growth by directly phosphorylating Tsc2

Potter, C. J., Pedraza, L. G., & Xu, T. (2002) · Nature Cell Biology · doi:10.1038/ncb840 · Cited by 959

Hierarchical phosphorylation of the translation inhibitor 4E-BP1

Gingras, A.-C., Raught, B., Gygi, S. P., Niedzwiecka, A., Miron, M., Burley, S. K., Polakiewicz, R. D., Wyslouch-Cieszynska, A., Aebersold, R., & Sonenberg, N. (2001) · Genes & Development · doi:10.1101/gad.912401 · Cited by 883

Reversal of learning deficits in a Tsc2+/− mouse model of tuberous sclerosis

Ehninger, D., Han, S., Shilyansky, C., Zhou, Y., Li, W., Kwiatkowski, D. J., Ramesh, V., & Silva, A. J. (2008) · Nature Medicine · doi:10.1038/nm1788 · Cited by 882

Regulation of elongation factor 2 kinase by p90RSK1 and p70 S6 kinase

Wang, X.-M., Li, W., Williams, M. R., Terada, N., Alessi, D., & Proud, C. G. (2001) · EMBO Journal · doi:10.1093/emboj/20.16.4370 · Cited by 862

Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation

Choo, A. Y., Yoon, S.-O., Kim, S. G., Roux, P. P., & Blenis, J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809136105 · Cited by 829

Chemotropic Responses of Retinal Growth Cones Mediated by Rapid Local Protein Synthesis and Degradation

Campbell, D. S., & Holt, C. E. (2001) · Neuron · doi:10.1016/s0896-6273(01)00551-7 · Cited by 815

Ribosomal protein S6 phosphorylation: from protein synthesis to cell size

Ruvinsky, I., & Meyuhas, O. (2006) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2006.04.003 · Cited by 800

Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations

Butler, M. G., Dasouki, M. J., Zhou, X.-P., Talebizadeh, Z., Brown, M., Takahashi, T. N., Miles, J. H., Wang, C. H., Stratton, R., Pilarski, R., et al. (2005) · Journal of Medical Genetics · doi:10.1136/jmg.2004.024646 · Cited by 778

mTORC1-Mediated Cell Proliferation, But Not Cell Growth, Controlled by the 4E-BPs

Dowling, R. J. O., Topisirović, I., Alain, T., Bidinosti, M., Fonseca, B. D., Petroulakis, E., Wang, X., Larsson, O. S., Selvaraj, A., Liu, Y., et al. (2010) · Science · doi:10.1126/science.1187532 · Cited by 733

S6K1- and ßTRCP-Mediated Degradation of PDCD4 Promotes Protein Translation and Cell Growth

Dorrello, N. V., Peschiaroli, A., Guardavaccaro, D., Colburn, N. H., Sherman, N. E., & Pagano, M. (2006) · Science · doi:10.1126/science.1130276 · Cited by 731

ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

Alexander, A., Cai, S.-L., Kim, J., Nanez, A., Sahin, M., MacLean, K. H., Inoki, K., Guan, K.-L., Shen, J., Person, M. D., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913860107 · Cited by 717

Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasisPreprint

Ruvinsky, I., Sharon, N., Lerer, T., Cohen, H., Stolovich-Rain, M., Nir, T., Dor, Y., Zisman, P., & Meyuhas, O. (2005) · Genes & Development · doi:10.1101/gad.351605 · Cited by 668

Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex.

Zeng, L., Xu, L., Gutmann, D. H., & Wong, M. (2008) · Annals of Neurology · doi:10.1002/ana.21331 · Cited by 639

IKKβ Suppression of TSC1 Links Inflammation and Tumor Angiogenesis via the mTOR Pathway

Lee, D., Kuo, H.-P., Chen, C., Hsu, J.-M., Chou, C., Wei, Y., Sun, H., Li, L., Ping, B., Huang, W., et al. (2007) · Cell · doi:10.1016/j.cell.2007.05.058 · Cited by 639

The NF1 tumor suppressor critically regulates TSC2 and mTOR

Johannessen, C. M., Reczek, E. E., James, M. F., Brems, H., Legius, E., & Cichowski, K. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503224102 · Cited by 605

The Autistic Neuron: Troubled Translation?

Kelleher, R. J., & Bear, M. F. (2008) · Cell · doi:10.1016/j.cell.2008.10.017 · Cited by 598

Control of Dendritic Arborization by the Phosphoinositide-3′-Kinase–Akt–Mammalian Target of Rapamycin Pathway

Jaworski, J., Spangler, S. A., Seeburg, D. P., Hoogenraad, C. C., & Sheng, M. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2270-05.2005 · Cited by 597

Regulation of Dendritic Morphogenesis by Ras–PI3K–Akt–mTOR and Ras–MAPK Signaling Pathways

Kumar, V., Zhang, M.-X., Swank, M. W., Kunz, J., & Wu, G.-Y. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2284-05.2005 · Cited by 588

Dysregulation of mTOR signaling in fragile X syndrome

Sharma, A., Hoeffer, C. A., Takayasu, Y., Miyawaki, T., McBride, S. M., Klann, E., & Zukin, R. S. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.3696-09.2010 · Cited by 557

The Drosophila Tuberous Sclerosis Complex Gene Homologs Restrict Cell Growth and Cell Proliferation

Tapon, N., Ito, N., Dickson, B. J., Treisman, J. E., & Hariharan, I. K. (2001) · Cell · doi:10.1016/s0092-8674(01)00332-4 · Cited by 542

Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity

Hahn-Windgassen, A., Nogueira, V., Chen, C.-C., Skeen, J. E., Sonenberg, N., & Hay, N. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502876200 · Cited by 539

The TSC1-TSC2 Complex Is Required for Proper Activation of mTOR Complex 2

Huang, J., Dibble, C. C., Matsuzaki, M., & Manning, B. D. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00289-08 · Cited by 520

Response of a Neuronal Model of Tuberous Sclerosis to Mammalian Target of Rapamycin (mTOR) Inhibitors: Effects on mTORC1 and Akt Signaling Lead to Improved Survival and Function

Meikle, L. M., Pollizzi, K. N., Egnor, A., Kramvis, I., Lane, H. A., Şahin, M., & Kwiatkowski, D. J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0955-08.2008 · Cited by 509

Neurotrophin Regulation of Cortical Dendritic Growth Requires Activity

McAllister, A. K., Katz, L. C., & Lo, D. C. (1996) · Neuron · doi:10.1016/s0896-6273(00)80239-1 · Cited by 503

Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2

Tavazoie, S. F., Alvarez, V. A., Ridenour, D. A., Kwiatkowski, D. J., & Sabatini, B. L. (2005) · Nature Neuroscience · doi:10.1038/nn1566 · Cited by 497

Fragile X syndrome

Garber, K. B., Visootsak, J., & Warren, S. T. (2008) · European Journal of Human Genetics · doi:10.1038/ejhg.2008.61 · Cited by 491

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth.Preprint

Gao, X., & Pan, D. (2001) · Genes & Development · doi:10.1101/gad.901101 · Cited by 484

Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases

Raught, B., Peiretti, F., Gingras, A., Livingstone, M., Shahbazian, D., Mayeur, G. L., Polakiewicz, R. D., Sonenberg, N., & Hershey, J. W. B. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600193 · Cited by 473

A Mouse Model of Tuberous Sclerosis: Neuronal Loss of Tsc1 Causes Dysplastic and Ectopic Neurons, Reduced Myelination, Seizure Activity, and Limited Survival

Meikle, L., Talos, D. M., Onda, H., Pollizzi, K., Rotenberg, A., Sahin, M., Jensen, F. E., & Kwiatkowski, D. J. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5540-06.2007 · Cited by 462

Retinal Ganglion Cells Do Not Extend Axons by Default

Goldberg, J. L., Espinosa, J. S., Xu, Y., Davidson, N., Kovacs, G. T. A., & Barres, B. A. (2002) · Neuron · doi:10.1016/s0896-6273(02)00602-5 · Cited by 460

mTORC1-Activated S6K1 Phosphorylates Rictor on Threonine 1135 and Regulates mTORC2 Signaling

Julien, L.-A., Carriere, A., Moreau, J., & Roux, P. P. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00601-09 · Cited by 452

ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy

Qin, L., Wang, Z., Tao, L., & Wang, Y. (2010) · Autophagy · doi:10.4161/auto.6.2.11062 · Cited by 446

Local translation of RhoA regulates growth cone collapse

Wu, K. Y., Hengst, U., Cox, L. J., Macosko, E. Z., Jeromin, A., Urquhart, E. R., & Jaffrey, S. R. (2005) · Nature · doi:10.1038/nature03885 · Cited by 423

Axonal Protein Synthesis and Degradation Are Necessary for Efficient Growth Cone Regeneration

Verma, P., Chierzi, S., Codd, A. M., Campbell, D. S., Meyer, R. L., Holt, C. E., & Fawcett, J. W. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3073-04.2005 · Cited by 408

Astrocyte‐specific TSC1 conditional knockout mice exhibit abnormal neuronal organization and seizures

Uhlmann, E. J., Wong, M., Baldwin, R. L., Bajenaru, M. L., Onda, H., Kwiatkowski, D. J., Yamada, K., & Gutmann, D. H. (2002) · Annals of Neurology · doi:10.1002/ana.10283 · Cited by 372

A Functional Role for Intra-Axonal Protein Synthesis during Axonal Regeneration from Adult Sensory Neurons

Zheng, J.-Q., Kelly, T. K., Chang, B., Ryazantsev, S., Rajasekaran, A. K., Martin, K. C., & Twiss, J. L. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-23-09291.2001 · Cited by 339

Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways

Kwiatkowski, D. J., & Manning, B. D. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi260 · Cited by 332

Akt Signals through the Mammalian Target of Rapamycin Pathway to Regulate CNS Myelination

Narayanan, S. P., Flores, A. I., Wang, F., & Macklin, W. B. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0232-09.2009 · Cited by 328

Axonal mRNA in Uninjured and Regenerating Cortical Mammalian Axons

Taylor, A. M., Berchtold, N. C., Perreau, V. M., Tu, C. H., Jeon, N. L., & Cotman, C. W. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.6130-08.2009 · Cited by 328

Subcellular Profiling Reveals Distinct and Developmentally Regulated Repertoire of Growth Cone mRNAs

Zivraj, K. H., Tung, Y. C. L., Piper, M., Gumy, L., Fawcett, J. W., Yeo, G. S. H., & Holt, C. E. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1800-10.2010 · Cited by 315

Neuro‐epileptic determinants of autism spectrum disorders in tuberous sclerosis complex

Bolton, P., Park, R. J., Higgins, N. J., Griffiths, P. D., & Pickles, A. R. (2002) · Brain · doi:10.1093/brain/awf124 · Cited by 295

Long-Distance Axon Regeneration in the Mature Optic Nerve: Contributions of Oncomodulin, cAMP, andptenGene Deletion

Kurimoto, T., Yin, Y., Omura, K., Gilbert, H.-Y., Kim, D., Cen, L., Moko, L. E., Kügler, S., & Benowitz, L. I. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4340-10.2010 · Cited by 283

Activation of the Mammalian Target of Rapamycin (mTOR) Is Essential for Oligodendrocyte Differentiation

Tyler, W. A., Gangoli, N., Gokina, P., Kim, H. A., Covey, M., Levison, S. W., & Wood, T. L. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.0234-09.2009 · Cited by 263

Tuberous sclerosis complex proteins control axon formationPreprint

Choi, Y.-J., Nardo, A. D., Kramvis, I., Meikle, L. M., Kwiatkowski, D. J., Şahin, M., & He, X. (2008) · Genes & Development · doi:10.1101/gad.1685008 · Cited by 260

The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination

Benvenuto, G., Li, S., Brown, S. J., Braverman, R., Vass, W. C., Cheadle, J. P., Halley, D. J. J., Sampson, J. R., Wienecke, R., & DeClue, J. E. (2000) · Oncogene · doi:10.1038/sj.onc.1204009 · Cited by 253

Transmembrane Receptor DCC Associates with Protein Synthesis Machinery and Regulates Translation

Tcherkezian, J., Brittis, P. A., Thomas, F., Roux, P. P., & Flanagan, J. G. (2010) · Cell · doi:10.1016/j.cell.2010.04.008 · Cited by 248

Tsc2-Rheb signaling regulates EphA-mediated axon guidance

Nie, D. A., Nardo, A. D., Han, J. M., Baharanyi, H., Kramvis, I., Huynh, T., Dabora, S. L., Codeluppi, S., Pandolfi, P. P., Pasquale, E. B., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2477 · Cited by 243

Excess phosphoinositide 3-kinase subunit synthesis and activity as a novel therapeutic target in fragile X syndrome

Gross, C., Nakamoto, M., Yao, X., Chan, C.-B., Yim, S. Y., Ye, K., Warren, S. T., & Bassell, G. J. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.0402-10.2010 · Cited by 241

Tsc2 gene inactivation causes a more severe epilepsy phenotype than Tsc1 inactivation in a mouse model of Tuberous Sclerosis Complex

Zeng, L.-H., Rensing, N. R., Zhang, B., Gutmann, D. H., Gambello, M. J., & Wong, M. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq491 · Cited by 233

Cognitive deficits in Tsc1+/−mice in the absence of cerebral lesions and seizures

Goorden, S. M. I., van Woerden, G. M., van der Weerd, L., Cheadle, J. P., & Elgersma, Y. (2007) · Annals of Neurology · doi:10.1002/ana.21317 · Cited by 230

S6K1 Phosphorylates and Regulates Fragile X Mental Retardation Protein (FMRP) with the Neuronal Protein Synthesis-dependent Mammalian Target of Rapamycin (mTOR) Signaling Cascade

Narayanan, U., Nalavadi, V., Nakamoto, M., Thomas, G., Ceman, S., Bassell, G. J., & Warren, S. T. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.c800055200 · Cited by 216

Loss of Tsc2 in radial glia models the brain pathology of tuberous sclerosis complex in the mouse

Way, S. W., McKenna, J., Mietzsch, U., Reith, R. M., Wu, H. C., & Gambello, M. J. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp025 · Cited by 213

Mutant mouse models of insulin-like growth factor actions in the central nervous system

D’Ercole, J. A., Ye, P., & OʼKusky, J. R. (2002) · Neuropeptides · doi:10.1054/npep.2002.0893 · Cited by 210

Cognitive impairment in tuberous sclerosis complex is a multifactorial condition

Jansen, F. E., Vincken, K. L., Algra, A., Anbeek, P., Braams, O. B., Nellist, M. D., Zonnenberg, B. A., Jennekens-Schinkel, A., van den Ouweland, A. M. W., Halley, D. J. J., et al. (2007) · Neurology · doi:10.1212/01.wnl.0000280579.04974.c0 · Cited by 205

TORC1 Is Essential for NF1-Associated Malignancies

Johannessen, C. M., Johnson, B. W., Williams, S. M. G., Chan, A. W., Reczek, E. E., Lynch, R. C., Rioth, M. J., McClatchey, A. I., Ryeom, S. W., & Cichowski, K. M. (2008) · Current Biology · doi:10.1016/j.cub.2007.11.066 · Cited by 202

Impaired glial glutamate transport in a mouse tuberous sclerosis epilepsy model

Wong, M., Ess, K. C., Uhlmann, E. J., Jansen, L. A., Li, W., Crino, P. B., Mennerick, S. J., Yamada, K. A., & Gutmann, D. H. (2003) · Annals of Neurology · doi:10.1002/ana.10648 · Cited by 201

Spatially restricting gene expression by local translation at synapses

Wang, D. O., Martin, K. C., & Zukin, R. S. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.01.005 · Cited by 196

Characterization of Autism in Young Children With Tuberous Sclerosis Complex

Jeste, S., Şahin, M., Bolton, P., Ploubidis, G. B., & Humphrey, A. (2007) · Journal of Child Neurology · doi:10.1177/0883073807309788 · Cited by 194

Local translation and directional steering in axons

Lin, A. C., & Holt, C. E. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601808 · Cited by 192

TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity

Yang, Q., Inoki, K., Kim, E., & Guan, K. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602282103 · Cited by 183

A functional equivalent of endoplasmic reticulum and Golgi in axons for secretion of locally synthesized proteins

Merianda, T. T., Lin, A. C., Lam, J. S. Y., Vuppalanchi, D., Willis, D. E., Karin, N. J., Holt, C. E., & Twiss, J. L. (2008) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2008.09.008 · Cited by 175

Brain Abnormalities in Tuberous Sclerosis Complex

DiMario, F. J. (2004) · Journal of Child Neurology · doi:10.1177/08830738040190090401 · Cited by 166

Glycogen synthase kinase-3β phosphorylation of MAP1B at Ser1260 and Thr1265 is spatially restricted to growing axons

Trivedi, N., Marsh, P. J., Goold, R., Wood‐Kaczmar, A., & Gordon‐Weeks, P. R. (2005) · Journal of Cell Science · doi:10.1242/jcs.01697 · Cited by 166

Tuberous Sclerosis Complex Activity Is Required to Control Neuronal Stress Responses in an mTOR-Dependent Manner

Di Nardo, A., Kramvis, I., Cho, N., Sadowski, A., Meikle, L., Kwiatkowski, D. J., & Sahin, M. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.0778-09.2009 · Cited by 165

Oligodendrocyte PTEN is required for myelin and axonal integrity, not remyelination

Harrington, E. P., Zhao, C., Fancy, S. P. J., Kaing, S., Franklin, R. J. M., & Rowitch, D. H. (2010) · Annals of Neurology · doi:10.1002/ana.22090 · Cited by 163

Cell‐specific alterations of glutamate receptor expression in tuberous sclerosis complex cortical tubers

Talos, D. M., Kwiatkowski, D. J., Cordero, K., Black, P. M., & Jensen, F. E. (2008) · Annals of Neurology · doi:10.1002/ana.21342 · Cited by 156

Activation of mammalian target of rapamycin in cytomegalic neurons of human cortical dysplasia

Ljungberg, M. C., Bhattacharjee, M. B., Lu, Y., Armstrong, D. L., Yoshor, D., Swann, J. W., Sheldon, M., & D’Arcangelo, G. (2006) · Annals of Neurology · doi:10.1002/ana.20949 · Cited by 155

The tuberous sclerosis gene products hamartin and tuberin are multifunctional proteins with a wide spectrum of interacting partners

Rosner, M., Hanneder, M., Siegel, N., Valli, A., & Hengstschläger, M. (2008) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2008.01.001 · Cited by 147

Specification of Neuronal Polarity Regulated by Local Translation of CRMP2 and Tau via the mTOR-p70S6K Pathway

Morita, T., & Sobue, K. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.008177 · Cited by 145

Altered ultrasonic vocalizations in a tuberous sclerosis mouse model of autism

Young, D. M., Schenk, A. K., Yang, S., Jan, Y. N., & Jan, L. Y. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005620107 · Cited by 145

Identification of S664 TSC2 Phosphorylation as a Marker for Extracellular Signal-Regulated Kinase–Mediated mTOR Activation in Tuberous Sclerosis and Human Cancer

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