Genome-wide meta-analysis identifies new susceptibility loci for migraine
Open accessAbstract
Migraine is the most common brain disorder, affecting approximately 14% of the adult population, but its molecular mechanisms are poorly understood. We report the results of a meta-analysis across 29 genome-wide association studies, including a total of 23,285 individuals with migraine (cases) and 95,425 population-matched controls. We identified 12 loci associated with migraine susceptibility (P<5×10(-8)). Five loci are new: near AJAP1 at 1p36, near TSPAN2 at 1p13, within FHL5 at 6q16, within C7orf10 at 7p14 and near MMP16 at 8q21. Three of these loci were identified in disease subgroup analyses. Brain tissue expression quantitative trait locus analysis suggests potential functional candidate genes at four loci: APOA1BP, TBC1D7, FUT9, STAT6 and ATP5B.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The PHACTR1 region at 6p24 is linked by genome-wide studies to five vascular conditions: high blood pressure, fibromuscular dysplasia, cervical artery dissection, migraine, and coronary heart disease.
“Genome-wide association studies (GWASs) implicate the PHACTR1 locus (6p24) in risk for five vascular diseases, including coronary artery disease, migraine headache, cervical artery dissection, fibro-muscular dysplasia, and hypertension.”
From A Genetic Variant Associated with Five Vascular Diseases Is a Distal Regulator of Endothelin-1 Gene Expression (2017) · cites this paper as Anttila et al., 2013
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482 · see citing works
Bolstad, B. M., Irizarry, R. A., Åstrand, M., & Speed, T. P. (2003) · Bioinformatics · doi:10.1093/bioinformatics/19.2.185 · Cited by 8,185 · see citing works
The International Classification of Headache Disorders: 2nd edition
Olesen, J., Goadsby, P. J., & Steiner, T. (2003) · The Lancet Neurology · doi:10.1016/s1474-4422(03)00590-8 · Cited by 5,046 · see citing works
A second generation human haplotype map of over 3.1 million SNPs
The International HapMap Consortium (2007) · Nature · doi:10.1038/nature06258 · Cited by 4,438 · see citing works
Hindorff, L. A., Sethupathy, P., Junkins, H. A., Ramos, E. M., Mehta, J. P., Collins, F. S., & Manolio, T. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903103106 · Cited by 4,013 · see citing works
Howie, B. N., Donnelly, P., & Marchini, J. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000529 · Cited by 3,928 · see citing works
Model-based analysis of oligonucleotide arrays: Expression index computation and outlier detection.
Li, C., & Wong, W. H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.1.31 · Cited by 3,133 · see citing works
Annotation of functional variation in personal genomes using RegulomeDB
Boyle, A. P., Hong, E. L., Hariharan, M., Cheng, Y., Schaub, M. A., Kasowski, M., Karczewski, K. J., Park, J., Hitz, B. C., Weng, S., et al. (2012) · Genome Research · doi:10.1101/gr.137323.112 · Cited by 2,722 · see citing works
LocusZoom: regional visualization of genome-wide association scan results
Pruim, R. J., Welch, R. P., Sanna, S., Teslovich, T. M., Chines, P. S., Gliedt, T. P., Boehnke, M., Abecasis, G. R., & Willer, C. J. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq419 · Cited by 2,707 · see citing works
The accessible chromatin landscape of the human genome
Thurman, R. E., Rynes, E., Humbert, R., Vierstra, J., Maurano, M. T., Haugen, E., Sheffield, N. C., Stergachis, A. B., Wang, H., Vernot, B., et al. (2012) · Nature · doi:10.1038/nature11232 · Cited by 2,679 · see citing works
Transcriptional regulation of macrophage polarization: enabling diversity with identity
Lawrence, T., & Natoli, G. (2011) · Nature Reviews Immunology · doi:10.1038/nri3088 · Cited by 2,284 · see citing works
Olesen, J. (2004) · Cephalalgia · doi:10.1111/j.1468-2982.2003.00824.x · Cited by 2,056 · see citing works
MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes
Li, Y., Willer, C. J., Ding, J., Scheet, P., & Abecasis, G. R. (2010) · Genetic Epidemiology · doi:10.1002/gepi.20533 · Cited by 1,843 · see citing works
Genetic Mapping in Human Disease
Altshuler, D., Daly, M. J., & Lander, E. S. (2008) · Science · doi:10.1126/science.1156409 · Cited by 1,452 · see citing works
Common variants at 30 loci contribute to polygenic dyslipidemia
Kathiresan, S., Willer, C. J., Peloso, G. M., Demissie, S., Musunuru, K., Schadt, E. E., Kaplan, L., Bennett, D., Li, Y., Tanaka, T., et al. (2009) · Nature Genetics · doi:10.1038/ng.291 · Cited by 1,364 · see citing works
Myocardial Infarction Genetics Consortium (2009) · Nature Genetics · doi:10.1038/ng.327 · Cited by 1,088 · see citing works
A human phenome-interactome network of protein complexes implicated in genetic disorders
Lage, K., Karlberg, E., Størling, Z. M., Olason, P., Pedersen, A., Rigina, O., Hinsby, A., Tümer, Z., Pociot, F., Tommerup, N., et al. (2007) · Nature Biotechnology · doi:10.1038/nbt1295 · Cited by 973 · see citing works
Migraine and cardiovascular disease: systematic review and meta-analysis
Schürks, M., Rist, P. M., Bigal, M., Buring, J. E., Lipton, R. B., & Kurth, T. (2009) · BMJ · doi:10.1136/bmj.b3914 · Cited by 839 · see citing works
Dash, P. K., Hochner, B., & Kandel, E. R. (1990) · Nature · doi:10.1038/345718a0 · Cited by 747 · see citing works
Heterozygous TGFBR2 mutations in Marfan syndrome
Mizuguchi, T., Collod‐Béroud, G., Akiyama, T., Abifadel, M., Harada, N., Morisaki, T., Allard, D., Varret, M., Claustres, M., Morisaki, H., et al. (2004) · Nature Genetics · doi:10.1038/ng1392 · Cited by 627 · see citing works
TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1
Dibble, C. C., Elis, W., Menon, S., Qin, W., Klekota, J., Asara, J. M., Finan, P. M., Kwiatkowski, D. J., Murphy, L. O., & Manning, B. D. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.06.009 · Cited by 612 · see citing works
GWAMA: software for genome-wide association meta-analysis
Mägi, R., & Morris, A. P. (2010) · BMC Bioinformatics · doi:10.1186/1471-2105-11-288 · Cited by 603 · see citing works
Segrè, A. V., DIAGRAM Consortium, MAGIC investigators, Groop, L., Mootha, V. K., Daly, M. J., & Altshuler, D. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001058 · Cited by 463 · see citing works
Flavell, S. W., Kim, T.-K., Gray, J. M., Harmin, D. A., Hemberg, M., Hong, E. J., Markenscoff-Papadimitriou, E., Bear, D. M., & Greenberg, M. E. (2008) · Neuron · doi:10.1016/j.neuron.2008.11.029 · Cited by 440 · see citing works
Rossin, E. J., Lage, K., Raychaudhuri, S., Xavier, R. J., Tatar, D., Benita, Y., Constortium, I. I. B. D. G., Cotsapas, C., & Daly, M. J. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1001273 · Cited by 438 · see citing works
Chasman, D. I., Schürks, M., Anttila, V., de Vries, B., Schminke, U., Launer, L. J., Terwindt, G. M., van den Maagdenberg, A. M. J. M., Fendrich, K., Völzke, H., et al. (2011) · Nature Genetics · doi:10.1038/ng.856 · Cited by 431 · see citing works
Raychaudhuri, S., Plenge, R. M., Rossin, E. J., Ng, A., Purcell, S., Sklar, P. B., Scolnick, E. M., Xavier, R. J., Altshuler, D., & Daly, M. J. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000534 · Cited by 422 · see citing works
Increased familial risk and evidence of genetic factor in migraine
Russell, M. B., & Olesen, J. (1995) · BMJ · doi:10.1136/bmj.311.7004.541 · Cited by 408 · see citing works
Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1
Anttila, V., Calafato, M., Dimas, A. S., Inouye, M., Alakurtti, K., Hämäläinen, E., Barrett, J. C., Peltonen, L., Palotie, A. V., Kaunisto, M. A., et al. (2010) · Nature Genetics · doi:10.1038/ng.652 · Cited by 404 · see citing works
The molecular and cellular biology of enhanced cognition
Lee, Y.-S., & Silva, A. J. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2572 · Cited by 361 · see citing works
Genome-wide association analysis identifies susceptibility loci for migraine without aura
Freilinger, T. M., Anttila, V., de Vries, B., Malik, R., Kallela, M., Terwindt, G. M., Pozo‐Rosich, P., Winsvold, B. S., Nyholt, D. R., van Oosterhout, W. P. J., et al. (2012) · Nature Genetics · doi:10.1038/ng.2307 · Cited by 345 · see citing works
Lage, K., Hansen, N. T., Karlberg, E. O., Eklund, A. C., Roque, F. S., Donahoe, P. K., Szallasi, Z., Jensen, T. S., & Brunak, S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810772105 · Cited by 292 · see citing works
Diniz, L. P., Almeida, J. C., Tortelli, V., Lopes, C. V., Setti-Perdigão, P., Stipursky, J., Kahn, S. A., Romão, L. F., Miranda, J. D., Alves‐Leon, S. V., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.380824 · Cited by 238 · see citing works
May, P., Rohlmann, A., Bock, H. H., Zurhove, K., Marth, J. D., Schomburg, E. D., Noebels, J. L., Beffert, U., Sweatt, J. D., Weeber, E. J., et al. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.20.8872-8883.2004 · Cited by 236 · see citing works
Fimia, G. M., Cesare, D. D., & Sassone‐Corsi, P. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.22.8613-8622.2000 · Cited by 191 · see citing works
Wilson, P. M., Fryer, R. H., Fang, Y., & Hatten, M. E. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0032-10.2010 · Cited by 169 · see citing works
Phactrs 1–4: A family of protein phosphatase 1 and actin regulatory proteins
Allen, P. B., Greenfield, A. T., Svenningsson, P., Haspeslagh, D., & Greengard, P. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401673101 · Cited by 161 · see citing works
Rozanov, D. V., Hahn-Dantona, E. A., Strickland, D. K., & Strongin, A. Y. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311569200 · Cited by 148 · see citing works
Menthol-Induced Ca2+Release from Presynaptic Ca2+Stores Potentiates Sensory Synaptic Transmission
Tsuzuki, K., Xing, H., Ling, J. J., & Gu, J. G. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4658-03.2004 · Cited by 128 · see citing works
Meta‐analysis of sex‐specific genome‐wide association studies
Mägi, R., Lindgren, C. M., & Morris, A. P. (2010) · Genetic Epidemiology · doi:10.1002/gepi.20540 · Cited by 115 · see citing works
TSC1/TSC2 signaling in the CNS
Han, J. M., & Sahin, M. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.02.001 · Cited by 105 · see citing works
Meta-analysis of genome-wide association for migraine in six population-based European cohorts
Ligthart, L., de Vries, B., Smith, A. V., Ikram, M. A., Amin, N., Hottenga, J., Koelewijn, S. C., Kattenberg, V. M., de Moor, M. H. M., Janssens, A. C. J. W., et al. (2011) · European Journal of Human Genetics · doi:10.1038/ejhg.2011.48 · Cited by 105 · see citing works
Lafleur, M. A., Xu, D., & Hemler, M. E. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-11-1149 · Cited by 85 · see citing works
Terada, N., Baracskay, K. L., Kinter, M. T., Melrose, S., Brophy, P., Boucheix, C., Bjartmar, C., Kidd, G. J., & Trapp, B. D. (2002) · Glia · doi:10.1002/glia.10134 · Cited by 80 · see citing works
alpha1,3-Fucosyltransferase IX (Fut9) determines Lewis X expression in brain
Nishihara, S. (2003) · Glycobiology · doi:10.1093/glycob/cwg048 · Cited by 79 · see citing works
Lieberoth, A., Splittstoesser, F., Katagihallimath, N., Jakovčevski, I., Loers, G., Ranscht, B., Karagogeos, D., Schachner, M., & KLEENE, R. B. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4361-08.2009 · Cited by 61 · see citing works
Sherman, E. A., Strauss, K. A., Tortorelli, S., Bennett, M. J., Knerr, I., Morton, D. H., & Puffenberger, E. G. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.09.018 · Cited by 55 · see citing works
Biroš, E., Walker, P. J., Nataatmadja, M. I., West, M., & Golledge, J. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.01.004 · Cited by 50 · see citing works
Jha, K. N., Shumilin, I. A., Digilio, L. C., Chertihin, O., Zheng, H., Schmitz, G., Visconti, P. E., Flickinger, C. J., Minor, W., & Herr, J. C. (2008) · Endocrinology · doi:10.1210/en.2007-0582 · Cited by 47 · see citing works
Schreiner, A., Ruonala, M. O., Jakob, V., Suthaus, J., Boles, E., Wouters, F. S., & Starzinski‐Powitz, A. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-07-0637 · Cited by 46 · see citing works
The Nogo-66 receptor family in the intact and diseased CNS
Borrie, S. C., Baeumer, B. E., & Bandtlow, C. E. (2012) · Cell and Tissue Research · doi:10.1007/s00441-012-1332-9 · Cited by 43 · see citing works
Park, S. J., Lee, J. H., Kim, H. Y., Choi, Y., Park, J. S., Suh, Y. H., Park, S. M., Joe, E.-H., & Jou, I. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1101600 · Cited by 40 · see citing works
Ferraro, G. B., Morrison, C., Overall, C. M., Strittmatter, S. M., & Fournier, A. E. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.249169 · Cited by 39 · see citing works
Gouveia, R. M., Schaffer, L., Papp, S. L., Grammel, N., Kandzia, S., Head, S. R., KLEENE, R. B., Schachner, M., Conradt, H. S., & Costa, J. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.09.004 · Cited by 31 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Analysis of shared heritability in common disorders of the brain
The Brainstorm Consortium, Anttila, V., Bulik-Sullivan, B., Finucane, H. K., Walters, R. K., Bras, J., Duncan, L., Escott-Price, V., Falcone, G. J., Gormley, P., et al. (2018) · Science · doi:10.1126/science.aap8757 · Cited by 1,924 · see citing works
“Generally, this occurs via the combination of many common variants—examples include Alzheimer’s disease (18), bipolar disorder (19), migraine (20), Parkinson’s disease (21), and schizophrenia (22)—each with a small individual effect.”
Pathophysiology of migraine: a disorder of sensory processing
Goadsby, P. J., Holland, P. R., Martins-Oliveira, M., Hoffmann, J., Schankin, C., & Akerman, S. (2017) · Physiological Reviews · doi:10.1152/physrev.00034.2015 · Cited by 1,998 · see citing works
Migraine: Multiple Processes, Complex Pathophysiology
Burstein, R., Noseda, R., & Borsook, D. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0373-15.2015 · Cited by 845 · see citing works
“Since these early findings, large genome-wide association studies have identified 13 susceptibility gene variants for migraine with and without aura (Anttila et al., 2010, 2013; Chasman et al., 2011; Freilinger et al., 2012), three of which regulate glutaminergic neurotransmission (MTDH/AEG-1…”
Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine
Gormley, P., Anttila, V., Winsvold, B. S., Palta, P., Esko, T., Pers, T. H., Farh, K.-H., Cuenca-León, E., Muona, M., Furlotte, N. A., et al. (2016) · Nature Genetics · doi:10.1038/ng.3598 · Cited by 681 · see citing works
Dodick, D. W. (2018) · The Lancet · doi:10.1016/s0140-6736(18)30478-1 · Cited by 562 · see citing works
A Phase‐by‐Phase Review of Migraine Pathophysiology
Dodick, D. W. (2018) · Headache The Journal of Head and Face Pain · doi:10.1111/head.13300 · Cited by 511 · see citing works
“Large genome-wide association studies (GWAS) have identified genetic loci that predict for susceptibility to migraine with and without aura.(58,59) Among the identified susceptibility gene variants, some may regulate glutamate neurotransmission (MTDH, LRP1, and MEF2D),(63-65) while others regulate synaptic development…”
BackgroundGupta, R. M., Hadaya, J., Trehan, A., Zekavat, S. M., Roselli, C., Klarin, D., Emdin, C. A., Hilvering, C. R. E., Bianchi, V., Mueller, C., et al. (2017) · Cell · doi:10.1016/j.cell.2017.06.049 · Cited by 450 · see citing works
“…CAD (CARDIoGRAMplusC4D Consortium et al., 2013; Nikpay et al., 2015), coronary artery calcification (O’Donnell et al., 2011), migraine headache (Anttila et al., 2013), cervical artery dissection (Debette et al., 2015), fibromuscular dysplasia (Kiando et al., 2016), and hypertension (Surendran…”
BackgroundFirst International Consensus on the diagnosis and management of fibromuscular dysplasia
Gornik, H. L., Persu, A., Adlam, D., Aparicio, L. S., Azizi, M., Boulanger, M., Bruno, R. M., de Leeuw, P. W., Fendrikova-Mahlay, N., Froehlich, J. B., et al. (2019) · Vascular Medicine · doi:10.1177/1358863x18821816 · Cited by 433 · see citing works
Hautakangas, H. M., Winsvold, B. S., Ruotsalainen, S., Björnsdóttir, G., Harder, A. V. E., Kogelman, L. J. A., Thomas, L. F., Noordam, R., Benner, C., Gormley, P., et al. (2022) · Nature Genetics · doi:10.1038/s41588-021-00990-0 · Cited by 402 · see citing works
Migraine pathophysiology: lessons from mouse models and human genetics
Ferrari, M. D., Klever, R. R., Terwindt, G. M., Ayata, C., & van den Maagdenberg, A. M. J. M. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70220-0 · Cited by 387 · see citing works
Calcitonin Gene-Related Peptide (CGRP): A New Target for Migraine
Russo, A. F. (2014) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010814-124701 · Cited by 396 · see citing works
Gilles de la Tourette syndrome
Robertson, M. M., Eapen, V., Singer, H. S., Martino, D., Scharf, J. M., Paschou, P., Roessner, V., Woods, D. W., Hariz, M. I., Mathews, C. A., et al. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.97 · Cited by 364 · see citing works
Migraine: A Review on Its History, Global Epidemiology, Risk Factors, and Comorbidities
Amiri, P., Kazeminasab, S., Nejadghaderi, S. A., Mohammadinasab, R., Pourfathi, H., Araj‐Khodaei, M., Sullman, M. J. M., Kolahi, A., & Safiri, S. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2021.800605 · Cited by 343 · see citing works
Woo, D., Falcone, G. J., Devan, W. J., Brown, W. M., Biffi, A., Howard, T. D., Anderson, C. D., Brouwers, H. B., Valant, V., Battey, T. W. K., et al. (2014) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2014.02.012 · Cited by 290 · see citing works
Self-citationMaternal-Fetal Inflammation in the Placenta and the Developmental Origins of Health and Disease
Goldstein, J. A., Gallagher, K., Beck, C., Kumar, R., & Gernand, A. D. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.531543 · Cited by 255 · see citing works
“Interestingly, DCLRE1C variants have been associated with response to cognitive behavioral therapy in anxiety and migraine gesturing toward neurocognitive outcomes (56, 57).”
BackgroundWebb, T. R., Erdmann, J., Stirrups, K. E., Stitziel, N. O., Masca, N. G. D., Jansen, H., Kanoni, S., Nelson, C. P., Ferrario, P. G., König, I. R., et al. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.11.056 · Cited by 252 · see citing works
Common variation in PHACTR1 is associated with susceptibility to cervical artery dissection
International Stroke Genetics Consortium, Debette, S., the CADISP group, Kamatani, Y., Metso, T. M., Kloss, M., Chauhan, G., Engelter, S. T., Pezzini, A., Thijs, V., et al. (2015) · Nature Genetics · doi:10.1038/ng.3154 · Cited by 231 · see citing works
Advances in genetics of migraine
Sutherland, H. G. E., Albury, C. L., & Griffiths, L. R. (2019) · The Journal of Headache and Pain · doi:10.1186/s10194-019-1017-9 · Cited by 238 · see citing works
Pronicka, E., Piekutowska‐Abramczuk, D., Ciara, E., Trubicka, J., Rokicki, D., Karkucińska‐Więckowska, A., Pajdowska, M., Jurkiewicz, E., Halat-Wolska, P., Kosińska, J., et al. (2016) · Journal of Translational Medicine · doi:10.1186/s12967-016-0930-9 · Cited by 230 · see citing works
DNA Methylation Analysis Identifies Loci for Blood Pressure Regulation
Richard, M. A., Huan, T., Ligthart, S., Gondalia, R., Jhun, M. A., Brody, J. A., Irvin, M. R., Marioni, R. E., Shen, J., Tsai, P.-C., et al. (2017) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2017.09.028 · Cited by 225 · see citing works
Yin, X., Low, H. Q., Wang, L., Li, Y., Ellinghaus, E., Han, J., Estivill, X., Sun, L., Zuo, X., Shen, C., et al. (2015) · Nature Communications · doi:10.1038/ncomms7916 · Cited by 200 · see citing works
New Insights into Pathophysiology of Vestibular Migraine
Espinosa-Sánchez, J. M., & Lopez-Escamez, J. A. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00012 · Cited by 198 · see citing works
“GENETIC FACTORS Recently, several genome-wide association studies (GWAS) have identified common genetic variants at several loci significantly associated with migraine susceptibility (40, 41).”
BackgroundGenetic predictors of human chronic pain conditions
Zorina-Lichtenwalter, K., Meloto, C. B., Khoury, S., & Diatchenko, L. B. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.04.041 · Cited by 192 · see citing works
Kiando, S. R., Tucker, N. R., Castro‐Vega, L. J., Katz, A. E., d’Escamard, V., Tréard, C., Fraher, D., Albuisson, J., Kadian‐Dodov, D. L., Ye, Z., et al. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1006367 · Cited by 193 · see citing works
Association of the PHACTR1/EDN1 Genetic Locus With Spontaneous Coronary Artery Dissection
Adlam, D., Olson, T. M., Combaret, N., Kovacic, J. C., Iismaa, S. E., Al-Hussaini, A., O’Byrne, M. M., Bouajila, S., Georges, A. B., Mishra, K., et al. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.09.085 · Cited by 192 · see citing works
“In addition to providing an explanation for the clinical association between SCAD and FMD, rs9349379 also links SCAD with both CeAD, a rare condition defined as an intimal flap or intramural hematoma in a carotid or vertebral artery that can cause stroke (29) and migraine (28).”
BackgroundA Pain Research Agenda for the 21st Century
Gereau, R. W., Sluka, K. A., Maixner, W. D., Savage, S. R., Price, T. J., Murinson, B. B., Sullivan, M. D., & Fillingim, R. B. (2014) · Journal of Pain · doi:10.1016/j.jpain.2014.09.004 · Cited by 163 · see citing works
Genetic Risk Factors for Ischemic and Hemorrhagic Stroke
Chauhan, G., & Debette, S. (2016) · Current Cardiology Reports · doi:10.1007/s11886-016-0804-z · Cited by 161 · see citing works
Vagus nerve stimulation inhibits cortical spreading depression
Chen, S., Ay, İ., Morais, A., Qin, T., Zheng, Y. Z., Sadeghian, H., Oka, F., Simon, B. J., Eikermann‐Haerter, K., & Ayata, C. (2015) · Pain · doi:10.1097/j.pain.0000000000000437 · Cited by 160 · see citing works
Genetics of migraine: where are we now?
Grangeon, L., Lange, K. S., Waliszewska‐Prosół, M., Onan, D., Marschollek, K., Wiels, W. A., Mikulenka, P., Farham, F., Gollion, C., & Ducros, A. (2023) · The Journal of Headache and Pain · doi:10.1186/s10194-023-01547-8 · Cited by 158 · see citing works
From transformation to chronification of migraine: pathophysiological and clinical aspects
Torres‐Ferrús, M., Ursitti, F., Alpuente, A., Brunello, F., Chiappino, D., de Vries, T., Marco, S. D., Ferlisi, S., Guerritore, L., González-García, N., et al. (2020) · The Journal of Headache and Pain · doi:10.1186/s10194-020-01111-8 · Cited by 152 · see citing works
Defective glutamate and K+ clearance by cortical astrocytes in familial hemiplegic migraine type 2
Capuani, C., Melone, M., Tottene, A., Bragina, L., Crivellaro, G., Santello, M., Casari, G., Conti, F., & Pietrobon, D. (2016) · EMBO Molecular Medicine · doi:10.15252/emmm.201505944 · Cited by 149 · see citing works
“…transmission (Pietrobon & Moskowitz, 2013) and for which genome-wide association studies have identified susceptibility loci potentially leading to enhanced glutamatergic transmission and/or dysregulated brain E/I balance (Anttila et al, 2010, 2013; Chasman et al, 2011; Freilinger et al, 2012).”
Dobbyn, A. L., Huckins, L. M., Boocock, J., Sloofman, L. G., Glicksberg, B. S., Giambartolomei, C., Hoffman, G. E., Perumal, T. M., Girdhar, K., Jiang, Y., et al. (2018) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2018.04.011 · Cited by 142 · see citing works
Statistical methods to detect pleiotropy in human complex traits
Hackinger, S., & Zeggini, E. (2017) · Open Biology · doi:10.1098/rsob.170125 · Cited by 143 · see citing works
Premonitory and nonheadache symptoms induced by CGRP and PACAP38 in patients with migraine
Guo, S., Vollesen, A. L. H., Olesen, J., & Ashina, M. (2016) · Pain · doi:10.1097/j.pain.0000000000000702 · Cited by 133 · see citing works
Genetics of Migraine: Insights into the Molecular Basis of Migraine Disorders
Sutherland, H. G. E., & Griffiths, L. R. (2017) · Headache The Journal of Head and Face Pain · doi:10.1111/head.13053 · Cited by 134 · see citing works
“This study, involving 23,285 cases and 95,425 controls, brought the number of loci significantly associated with migraine to 13, with the reporting of new loci near AJAP1, TSPAN2, and within FHL5, C7orf10, and MMP16.”
BackgroundMitochondrial Dysfunction in Migraine
Yorns, W. R., & Hardison, H. H. (2013) · Seminars in Pediatric Neurology · doi:10.1016/j.spen.2013.09.002 · Cited by 125 · see citing works
Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes
Initiative, A. D. N., van der Meer, D., for the Pediatric Imaging, N. A. G. S., Rokicki, J., Kaufmann, T., Córdova‐Palomera, A., Moberget, T., Alnæs, D., Bettella, F., Frei, O., et al. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0262-7 · Cited by 126 · see citing works
Shared genetic basis for migraine and ischemic stroke
Malik, R., Freilinger, T. M., Winsvold, B. S., Anttila, V., Heiden, J. V., Traylor, M., de Vries, B., Holliday, E. G., Terwindt, G. M., Sturm, J. W., et al. (2015) · Neurology · doi:10.1212/wnl.0000000000001606 · Cited by 115 · see citing works
“One potential explanation is that genetic risk for MA may be more restricted to rare variants not captured by GWAS strategies as suggested by the larger number of genome-wide significant loci for MO compared to MA despite comparable sample sizes.(11) However, estimated heritability for MA is as least as high as for MO.”
BackgroundMethodInfluentialTrynka, G., Westra, H.-J., Slowikowski, K., Hu, X., Xu, H., Stranger, B. E., Klein, R. J., Han, B., & Raychaudhuri, S. (2015) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2015.05.016 · Cited by 114 · see citing works
First international consensus on the diagnosis and management of fibromuscular dysplasia
Gornik, H. L., Persu, A., Adlam, D., Aparicio, L. S., Azizi, M., Boulanger, M., Bruno, R. M., De Leeuw, P., Fendrikova-Mahlay, N., Froehlich, J., et al. (2019) · Journal of Hypertension · doi:10.1097/hjh.0000000000002019 · Cited by 113 · see citing works
Geller, F., Feenstra, B., Carstensen, L., Pers, T. H., van Rooij, I. A. L. M., Körberg, I. B., Choudhry, S., Karjalainen, J. M., Schnack, T. H., Hollegaard, M. V., et al. (2014) · Nature Genetics · doi:10.1038/ng.3063 · Cited by 111 · see citing works
Human local adaptation of the TRPM8 cold receptor along a latitudinal cline
Key, F. M., Abdul‐Aziz, M. A., Mundry, R., Peter, B. M., Sekar, A., D’Amato, M., Dennis, M. Y., Schmidt, J. M., & Andrés, A. M. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007298 · Cited by 110 · see citing works
Saw, J., Yang, M., Trinder, M., Tcheandjieu, C., Xu, C., Starovoytov, A., Birt, I., Mathis, M. R., Hunker, K. L., Schmidt, E. M., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17558-x · Cited by 107 · see citing works
Common Variant Burden Contributes to the Familial Aggregation of Migraine in 1,589 Families
Gormley, P., Kurki, M., Hiekkala, M. E., Veerapen, K., Häppölä, P., Mitchell, A. A., Lal, D., Palta, P., Surakka, I. L., Kaunisto, M. A., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.04.014 · Cited by 101 · see citing works
“The polygenic nature of migraine is well documented by GWAS that have identified over 40 loci associated to common forms of migraine (Anttila et al., 2010, 2013; Chasman et al., 2011; Freilinger et al., 2012; Gormley et al., 2016).”
BackgroundAdvance in genetics of migraine
de Boer, I., van den Maagdenberg, A. M. J. M., & Terwindt, G. M. (2019) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000687 · Cited by 100 · see citing works
“Given the robustness of the associated SNPs in the migraine GWAS and the fact that six of the loci identified in the headache GWAS were also identified in clinicalbased migraine GWAS, this scenario seems unlikely [10,14].”
BackgroundNutrient Sensing, Signaling and Ageing: The Role of IGF-1 and mTOR in Ageing and Age-Related Disease
Johnson, S. C. (2018) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-981-13-2835-0_3 · Cited by 102 · see citing works
Lipton, R. B., Fanning, K. M., Buse, D. C., Martin, V. T., Reed, M. L., Adams, A. M., & Goadsby, P. J. (2018) · Headache The Journal of Head and Face Pain · doi:10.1111/head.13342 · Cited by 94 · see citing works
Choquet, H., Yin, J., Jacobson, A. S., HORTON, B. H., Hoffmann, T. J., Jorgenson, E., Avins, A. L., & Pressman, A. R. (2021) · Communications Biology · doi:10.1038/s42003-021-02356-y · Cited by 93 · see citing works
Identification of Susceptibility Loci for Spontaneous Coronary Artery Dissection
Turley, T. N., O’Byrne, M. M., Kosel, M., de Andrade, M., Gulati, R., Hayes, S. N., Tweet, M. S., & Olson, T. M. (2020) · JAMA Cardiology · doi:10.1001/jamacardio.2020.0872 · Cited by 89 · see citing works
The integrated landscape of causal genes and pathways in schizophrenia
Ma, C., Gu, C., Huo, Y., Li, X., & Luo, X. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0114-x · Cited by 85 · see citing works
Hübel, C., Gaspar, H. A., Coleman, J. R. I., Hanscombe, K. B., Purves, K. L., Prokopenko, I., Graff, M., Ngwa, J. S., Workalemahu, T., O’Reilly, P. F., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13544-0 · Cited by 79 · see citing works
“…available from the UK Biobank (URLs), for the behavioural traits years of education 87 by the Social Science Genetic Association Consortium (SSGAC) (URLs), for neuroticism 41 by our own group (Supplementary Data 1) and for migraine 88,89 by International Headache Genetics Consortium (IHGC).”
MethodGenetic and biochemical changes of the serotonergic system in migraine pathobiology
Gasparini, C., Smith, R. A., & Griffiths, L. R. (2017) · The Journal of Headache and Pain · doi:10.1186/s10194-016-0711-0 · Cited by 87 · see citing works
“identified a single risk variant, rs2651899 in the PRDM16 gene among 12 single nucleotide polymorphisms (SNPs) genotyped chosen based on prior GWAS findings by Antilla [65] to be significantly associated with efficacy of triptans [60].”
MethodAnalysis of Shared Heritability in Common Disorders of the Brain
(2016) · doi:10.1101/048991 · Cited by 82 · see citing works
“In most cases, this occurs via many common variants, each 93 of small effect, with examples in Alzheimer’s disease(18), bipolar disorder(19), migraine(20), 94 Parkinson’s disease(21), and schizophrenia(22).”
BackgroundMolecular genetic overlap between migraine and major depressive disorder
Yang, Y., Zhao, H., Boomsma, D. I., Ligthart, L., Belin, A. C., Smith, G. D., Esko, T., Freilinger, T. M., Hansen, T. F., Ikram, M. A., et al. (2018) · European Journal of Human Genetics · doi:10.1038/s41431-018-0150-2 · Cited by 84 · see citing works
Meng, W., Adams, M. J., Hébert, H. L., Deary, I. J., McIntosh, A. M., & Smith, B. H. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.01.023 · Cited by 77 · see citing works
Jovanović, F., Candido, K. D., & Knežević, N. N. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176045 · Cited by 79 · see citing works
Inhibition of Neuroinflammation by AIBP: Spinal Effects upon Facilitated Pain States
Woller, S. A., Choi, S.-H., An, E. J., Low, H., Schneider, D. A., Ramachandran, R., Kim, J., Bae, Y. S., Sviridov, D., Corr, M., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.04.110 · Cited by 79 · see citing works
“A genome-wide meta-analysis identified APOA1BP (the gene encoding the AIBP protein) as a susceptibility locus for migraine (Anttila et al., 2013).”
BackgroundAltered neurochemical coupling in the occipital cortex in migraine with visual aura
Bridge, H., Stagg, C. J., Near, J., Lau, C. I., Zisner, A. R., & Cader, M. Z. (2015) · Cephalalgia · doi:10.1177/0333102414566860 · Cited by 78 · see citing works
“Nevertheless, disturbance of glutamate metabolism and neurotransmission is also supported by genetic studies (18).”
BackgroundHuman pain genetics database: a resource dedicated to human pain genetics research
Meloto, C. B., Benavides, R., Lichtenwalter, R. N., Wen, X., Tugarinov, N., Zorina-Lichtenwalter, K., Chabot‐Doré, A., Piltonen, M., Cattaneo, S., Verma, V., et al. (2017) · Pain · doi:10.1097/j.pain.0000000000001135 · Cited by 78 · see citing works
“As a notable exception, GWASs have already been conducted on many migraine cohorts.(3,4,17,26,34) Databases hosting human genetic association data currently”
BackgroundCervical Artery Dissections: Etiopathogenesis and Management
Keser, Z., Chiang, C., Benson, J. C., Pezzini, A., & Lanzino, G. S. (2022) · Vascular Health and Risk Management · doi:10.2147/vhrm.s362844 · Cited by 77 · see citing works
Genetic epidemiology of migraine and depression
Yang, Y., Ligthart, L., Terwindt, G. M., Boomsma, D. I., Rodriguez‐Acevedo, A. J., & Nyholt, D. R. (2016) · Cephalalgia · doi:10.1177/0333102416638520 · Cited by 74 · see citing works
“zip) and the 2013 International Headache Genetics Consortium (IHGC) migraine GWAS (101).”
Lai, D., Wetherill, L. F., Bertelsen, S. E., Carey, C. E., Kamarajan, C., Kapoor, M., Meyers, J. L., Anokhin, A. P., Bennett, D. A., Bucholz, K. K., et al. (2019) · Genes Brain & Behavior · doi:10.1111/gbb.12579 · Cited by 71 · see citing works
“RABGAP1L is broadly expressed in brain regions and showed association with cerebrospinal fluid biomarker levels(54) and migraine.(55) Other genes near this region seem interesting too, for example, KIAA0040, which is downstream of this region, was associated with alcohol dependence.”
BackgroundGramer, G., Weber, B. H. F., & Gramer, E. (2015) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.15-17274 · Cited by 73 · see citing works
“Recently, several new susceptibility loci for migraine have been identified, many of them located in genes with known functions in synaptic or neuronal regulation.(35,36) Suzuki and colleagues(37) have found homozygous mutations in SLC4A4, encoding the Na-HCO3 cotransporter NBCe1, in two sisters with ocular abnormalit…”
BackgroundClinical spectrum of hemiplegic migraine and chances of finding a pathogenic mutation
Pelzer, N., Haan, J., Stam, A. H., Vijfhuizen, L. S., Koelewijn, S. C., Smagge, A., de Vries, B., Ferrari, M. D., van den Maagdenberg, A. M. J. M., & Terwindt, G. M. (2018) · Neurology · doi:10.1212/wnl.0000000000004966 · Cited by 73 · see citing works
Genetics of chronic post-surgical pain: a crucial step toward personal pain medicine
Clarke, H. A., Katz, J. D., Flor, H., Rietschel, M., Diehl, S. R., & Seltzer, Z. (2014) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/s12630-014-0287-6 · Cited by 71 · see citing works
Genetic analysis for a shared biological basis between migraine and coronary artery disease
Winsvold, B. S., Nelson, C. P., Malik, R., Gormley, P., Anttila, V., Heiden, J. V., Elliott, K. S., Jacobsen, L. M., Palta, P., Amin, N., et al. (2015) · Neurology Genetics · doi:10.1212/nxg.0000000000000010 · Cited by 70 · see citing works
“It is possible that MA is a more heterogeneous disorder or is influenced by rare and low-frequency variants not captured by current imputation panels.(12,28) Larger studies that also interrogate rare variants will be needed to determine the genetic basis of MA and its potential overlap with cardiovascular disease.”
BackgroundMethodInfluentialChen, S., Fuh, J., Chung, M., Lin, Y., Liao, Y., Wang, Y.-F., Hsu, C., Yang, U., Lin, M., Chiou, J.-J., et al. (2017) · Cephalalgia · doi:10.1177/0333102417695105 · Cited by 69 · see citing works
“First, patients with migraine with aura were excluded for two reasons: (a) The low prevalence of aura in Taiwanese migraine patients (10%) made it difficult to achieve an adequate sample size for acceptable statistical power; (b) a meta-analysis of GWASs found that with the same sample size, the power to identify risk…”
BackgroundMethodResultInfluentialBunyavanich, S., Schadt, E. E., Himes, B. E., Lasky-Su, J. A., Qiu, W., Lazarus, R. M., Ziniti, J. P., Cohain, A. T., Linderman, M. D., Torgerson, D. G., et al. (2014) · BMC Medical Genomics · doi:10.1186/1755-8794-7-48 · Cited by 69 · see citing works
“Finally, pathway analysis can help decipher the functional implications of coherent groups of genes with respect to gene ontology functional categories [18,21-23].”
Exploiting the GTEx resources to decipher the mechanisms at GWAS lociPreprint
Barbeira, A., Bonazzola, R., Gamazon, E. R., Liang, Y., Park, Y., Kim-Hellmuth, S., Wang, G. T., Jiang, Z., Zhou, D., Hormozdiari, F., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/814350 · Cited by 70 · see citing works
Mawet, J., Debette, S., Bousser, M., & Ducros, A. (2016) · Headache The Journal of Head and Face Pain · doi:10.1111/head.12798 · Cited by 68 · see citing works
“Interestingly, a genome-wide association study in migraine has identified a genetic variant associated with migraine vulnerability implicated in MMP pathways (rs 10504861, near MMP 16).(48) However, up to now, no genetic risk locus related to MMP pathway has been found in CeAD.”
BackgroundBeyond Indigestion: Emerging Roles for Lysosome-Based Signaling in Human Disease
Ferguson, S. (2015) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2015.04.014 · Cited by 64 · see citing works
Gene-based pleiotropy across migraine with aura and migraine without aura patient groups
Zhao, H., Eising, E., de Vries, B., Vijfhuizen, L. S., Anttila, V., Winsvold, B. S., Kurth, T., Stefánsson, H., Kallela, M., Malik, R., et al. (2015) · Cephalalgia · doi:10.1177/0333102415591497 · Cited by 66 · see citing works
“For more detailed descriptions of the cohorts, please see the original report (11).”
InfluentialFrancis, C., Futschik, M. E., Huang, J. V., Bai, W., Sargurupremraj, M., Teumer, A., Breteler, M. M. B., Petretto, E. G., Ho, A. S. R., Amouyel, P., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-32219-x · Cited by 66 · see citing works
Altered cognition-related brain activity and interactions with acute pain in migraine
Mathur, V. A., Khan, S. A., Keaser, M. L., Hubbard, C. S., Goyal, M., & Seminowicz, D. A. (2015) · NeuroImage Clinical · doi:10.1016/j.nicl.2015.01.003 · Cited by 65 · see citing works
“Furthermore, others have examined chronic and episodic migraine patients together, which has led to a number of recent advances in the understanding ofmigraine (e.g. Anttila et al., 2013; Hamedani et al., 2013; Hunter et al., 2014).”
The Genetics of Pain: Implications for Therapeutics
Sexton, J. E., Cox, J. J., Zhao, J., & Wood, J. N. (2017) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010617-052554 · Cited by 65 · see citing works
Guo, S., Vollesen, A. L. H., Hansen, Y. B. L., Frandsen, E., Andersen, M. R., Amin, F. M., Fahrenkrug, J., Olesen, J., & Ashina, M. (2016) · Cephalalgia · doi:10.1177/0333102416639517 · Cited by 63 · see citing works
“Briefly, the patients were recruited from a cohort of 1010 unrelated MO patients from the Danish Headache Center who were genotyped for the 12 identified SNPs associated with migraine, including the risk allele C of rs2274316 (MEF2D) (13).”
Exploring the Hereditary Nature of Migraine
Bron, C., Sutherland, H. G. E., & Griffiths, L. R. (2021) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s282562 · Cited by 62 · see citing works
Genetic Susceptibility Loci in Genomewide Association Study of Cluster Headache
Harder, A. V. E., Winsvold, B. S., Noordam, R., Vijfhuizen, L. S., Børte, S., Kogelman, L. J. A., de Boer, I., Tronvik, E., Rosendaal, F. R., van Dijk, K. W., et al. (2021) · Annals of Neurology · doi:10.1002/ana.26146 · Cited by 62 · see citing works
“that regulates cAMP-responsive elements CREB6 and CREM, which play a role in synaptic plasticity and memory formation.(40) UFL1 codes for the ubiquitin-fold modifier 1 (UFM1)-specific ligase 1, an ubiquitin-like protein that allows UFL1 to conjugate to its substrates.”
BackgroundGenetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits
Graßmann, F., Kiel, C., Zimmermann, M. E., Gorski, M., Grassmann, V., Stark, K. J., Heid, I. M., & Weber, B. H. F. (2017) · Genome Medicine · doi:10.1186/s13073-017-0418-0 · Cited by 61 · see citing works
de Vries, B., Anttila, V., Freilinger, T. M., Wessman, M., Kaunisto, M. A., Kallela, M., Artto, V., Vijfhuizen, L. S., Göbel, H., Dichgans, M., et al. (2015) · Cephalalgia · doi:10.1177/0333102414566820 · Cited by 61 · see citing works
“patients who are clinic-based), we restricted our investigations to GWAS data of clinic-based migraine patients only (8,9,11).”
InfluentialMigrainomics — identifying brain and genetic markers of migraine
Nyholt, D. R., Borsook, D., & Griffiths, L. R. (2017) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.151 · Cited by 60 · see citing works
Winsvold, B. S., Bettella, F., Witoelar, A., Anttila, V., Gormley, P., Kurth, T., Terwindt, G. M., Freilinger, T. M., Frei, O., Shadrin, A. A., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0185663 · Cited by 59 · see citing works
“Migraine GWAS summary statistics results (P-values and z-scores) were obtained from the International Headache Genetics Consortium (IHGC) [24] and entailed 23,285 migraine cases and 95,425 controls.”
BackgroundMethodInfluentialFMD and SCAD: Sex-Biased Arterial Diseases With Clinical and Genetic Pleiotropy
Kim, E. S. H., Saw, J., Kadian‐Dodov, D. L., Wood, M. J., & Ganesh, S. K. (2021) · Circulation Research · doi:10.1161/circresaha.121.318300 · Cited by 60 · see citing works
Diamine Oxidase rs 10156191 and rs 2052129 Variants Are Associated With the Risk for Migraine
García‐Martín, E., Martínez, C., Serrador, M., Alonso‐Navarro, H., Ayuso, P., Navacerrada, F., Agúndez, J. A. G., & Jiménez‐Jiménez, F. J. (2015) · Headache The Journal of Head and Face Pain · doi:10.1111/head.12493 · Cited by 57 · see citing works
Eising, E., Huisman, S. M. H., Mahfouz, A. E., Vijfhuizen, L. S., Anttila, V., Winsvold, B. S., Kurth, T., Ikram, M. A., Freilinger, T. M., Kaprio, J. A., et al. (2016) · Human Genetics · doi:10.1007/s00439-016-1638-x · Cited by 55 · see citing works
Spreading Depolarization May Link Migraine and Stroke
Eikermann‐Haerter, K. (2014) · Headache The Journal of Head and Face Pain · doi:10.1111/head.12386 · Cited by 54 · see citing works
“Importantly, increased cerebral excitability is implicated in common types of migraine as well, as suggested by genome-wide association studies.(92,93) Therefore, enhanced stroke susceptibility in mutant”
BackgroundGavva, N. R., Sandrock, R. W., Arnold, G. E., Davis, M., Lamas, E., Lindvay, C., Li, C.-M., Smith, B. P., Bačkonja, M., Gabriel, K., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-56295-0 · Cited by 54 · see citing works
Current progress in clinical, molecular, and genetic aspects of adult fibromuscular dysplasia
Persu, A., Dobrowolski, P., Gornik, H. L., Olin, J. W., Adlam, D., Azizi, M., Boutouyrie, P., Bruno, R. M., Boulanger, M., Demoulin, J., et al. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab086 · Cited by 53 · see citing works
“based on Anttila et al.(39) and UK Biobank, 7995 cases and 116 409 controls.”
MethodYounger, D. S. (2016) · Neurologic Clinics · doi:10.1016/j.ncl.2016.06.011 · Cited by 53 · see citing works
Linking migraine frequency with family history of migraine
Pelzer, N., Louter, M. A., van Zwet, E. W., Nyholt, D. R., Ferrari, M. D., van den Maagdenberg, A. M. J. M., Haan, J., & Terwindt, G. M. (2018) · Cephalalgia · doi:10.1177/0333102418783295 · Cited by 53 · see citing works
“We also confirmed the association of genetic load and having migraine with aura (2,6), but except for a single variant (30) current GWAS have not been able to discover robust associations for this migraine subtype.”
BackgroundInfluentialLocal genetic effects on gene expression across 44 human tissuesPreprint
Aguet, F., Brown, A. A., Castel, S. E., Davis, J. R., Mohammadi, P., Segrè, A. V., Zappala, Z., Abell, N. S., Frésard, L., Gamazon, E. R., et al. (2016) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/074450 · Cited by 58 · see citing works
Discovery of susceptibility loci associated with tuberculosis in Han Chinese
Qi, H. M., Zhang, Y., Sun, L., Chen, C., Xu, B., Xu, F., Liu, J., Liu, J., Chen, C., Jiao, W., et al. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx365 · Cited by 52 · see citing works
Appelt‐Menzel, A., Oerter, S., Mathew, S., Haferkamp, U., Hartmann, C., Jung, M., Neuhaus, W., & Pleß, O. (2020) · Current Protocols in Stem Cell Biology · doi:10.1002/cpsc.122 · Cited by 54 · see citing works
Perivascular neurotransmitters: Regulation of cerebral blood flow and role in primary headaches
Frederiksen, S., Haanes, K. A., Warfvinge, K., & Edvinsson, L. I. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x17747188 · Cited by 51 · see citing works
Implications of Transient Receptor Potential Cation Channels in Migraine Pathophysiology
Shibata, M., & Tang, C. (2020) · Neuroscience Bulletin · doi:10.1007/s12264-020-00569-5 · Cited by 50 · see citing works
Psychiatric Comorbidity in Childhood and Adolescence Headache
Dyb, G. A., Stensland, S. Ø., & Zwart, J. (2015) · Current Pain and Headache Reports · doi:10.1007/s11916-015-0479-y · Cited by 51 · see citing works
CGRP as a neuropeptide in migraine: lessons from mice
Russo, A. F. (2015) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12686 · Cited by 48 · see citing works
Genome-wide association studies of late-onset cardiovascular disease
Smith, J. G., & Newton‐Cheh, C. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.04.004 · Cited by 49 · see citing works
“The other is a locus on chromosome 6p24 associated with increased expression of the gene PHACTR1 and CAD,migraine and cervical artery dissection although the possiblemechanism remains unclear [66, 67].”
Migraine Prophylaxis, Ischemic Depolarizations, and Stroke Outcomes in Mice
Eikermann‐Haerter, K., Lee, J. H., Yalcin, N., Yu, E. S., Daneshmand, A., Wei, Y., Zheng, Y. Z., Can, A., Sengul, B., Ferrari, M. D., et al. (2014) · Stroke · doi:10.1161/strokeaha.114.006982 · Cited by 48 · see citing works
Tspan2: a tetraspanin protein involved in oligodendrogenesis and cancer metastasis
Yaseen, I., Monk, P. N., & Partridge, L. J. (2017) · Biochemical Society Transactions · doi:10.1042/bst20160022 · Cited by 47 · see citing works
- Authors
- North American Brain Expression Consortium, Anttila, V., UK Brain Expression Consortium, the International Headache Genetics Consortium, Winsvold, B. S., Gormley, P., Kurth, T., Bettella, F., McMahon, G., Kallela, M., Malik, R., de Vries, B., Terwindt, G., Medland, S. E., Todt, U., McArdle, W. L., Quaye, L., Koiranen, M., Ikram, M. A., Lehtimäki, T., Stam, A. H., Ligthart, L., Wedenoja, J., Dunham, I., Neale, B. M., Palta, P., Hamalainen, E., Schürks, M., Rose, L. M., Buring, J. E., Ridker, P. M., Steinberg, S., Stefansson, H., Jakobsson, F., Lawlor, D. A., Evans, D. M., Ring, S. M., Färkkilä, M., Artto, V., Kaunisto, M. A., Freilinger, T., Schoenen, J., Frants, R. R., Pelzer, N., Weller, C. M., Zielman, R., Heath, A. C., Madden, P. A. F., Montgomery, G. W., Martin, N. G., Borck, G., Göbel, H., Heinze, A., Heinze-Kuhn, K., Williams, F. M. K., Hartikainen, A.-L., Pouta, A., van den Ende, J., Uitterlinden, A. G., Hofman, A., Amin, N., Hottenga, J.-J., Vink, J. M., Heikkilä, K., Alexander, M., Muller-Myhsok, B., Schreiber, S., Meitinger, T., Wichmann, H. E., Aromaa, A., Eriksson, J. G., Traynor, B. J., Trabzuni, D., Rossin, E., Lage, K., Jacobs, S. B. R., Gibbs, J. R., Birney, E., Kaprio, J., Penninx, B. W., Boomsma, D. I., van Duijn, C., Raitakari, O., Jarvelin, M.-R., Zwart, J.-A., Cherkas, L., Strachan, D. P., Kubisch, C., Ferrari, M. D., van den Maagdenberg, A. M. J. M., Dichgans, M., Wessman, M., Smith, G. D., Stefansson, K., & Daly, M. J.
- Affiliations
- Broad Institute (US)
- Oslo University Hospital (NO)
- Wellcome Sanger Institute (GB)
- Brigham and Women's Hospital (US)
- deCODE Genetics (Iceland) (IS)
- University of Bristol (GB)
- Helsinki University Hospital (FI)
- Institut für Schlaganfall- und Demenzforschung (DE)
- Leiden University Medical Center (NL)
- QIMR Berghofer Medical Research Institute (AU)
- Universität Ulm (DE)
- King's College London (GB)
- Oulu University Hospital (FI)
- Erasmus MC (NL)
- Tampere University (FI)
- Amsterdam Public Health (NL)
- University of Helsinki (FI)
- European Bioinformatics Institute (GB)
- Essen University Hospital (DE)
- National University Hospital of Iceland (IS)
- University of Liège (BE)
- Washington University in St. Louis (US)
- Vrije Universiteit Amsterdam (NL)
- University of Bonn (DE)
- Christian-Albrechts-Universität zu Kiel (DE)
- TUM Klinikum (DE)
- Helmholtz Munich (DE)
- Finnish Institute for Health and Welfare (FI)
- National Institutes of Health (US)
- King Faisal Specialist Hospital & Research Centre (SA)
- University Medical Center Groningen (NL)
- University of Turku (FI)
- St George's, University of London (GB)
- Munich Cluster for Systems Neurology (DE)
- Corresponding author
- Anttila, Verneri
- ORCID
- Anttila, Verneri
- Winsvold, Bendik S
- Gormley, Padhraig
- Kurth, Tobias
- Bettella, Francesco
- Kallela, Mikko
- Malik, Rainer
- Terwindt, Gisela
- Medland, Sarah E
- McArdle, Wendy L
- Koiranen, Markku
- Ikram, M Arfan
- Lehtimäki, Terho
- Ligthart, Lannie
- Wedenoja, Juho
- Dunham, Ian
- Neale, Benjamin M
- Palta, Priit
- Schürks, Markus
- Rose, Lynda M
- Buring, Julie E
- Ridker, Paul M
- Steinberg, Stacy
- Lawlor, Debbie A
- Evans, David M
- Ring, Susan M
- Artto, Ville
- Kaunisto, Mari A
- Freilinger, Tobias
- Schoenen, Jean
- Pelzer, Nadine
- Heath, Andrew C
- Madden, Pamela A F
- Montgomery, Grant W
- Martin, Nicholas G
- Borck, Guntram
- Göbel, Hartmut
- Heinze, Axel
- Williams, Frances M K
- Amin, Najaf
- Hottenga, Jouke-Jan
- Vink, Jacqueline M
- Schreiber, Stefan
- Meitinger, Thomas
- Wichmann, Heinz Erich
- Eriksson, Johan G
- Traynor, Bryan J
- Trabzuni, Daniah
- Rossin, Elizabeth
- Lage, Kasper
- Jacobs, Suzanne B R
- Gibbs, J Raphael
- Birney, Ewan
- Kaprio, Jaakko
- Penninx, Brenda W
- Boomsma, Dorret I
- Raitakari, Olli
- Zwart, John-Anker
- Strachan, David P
- Kubisch, Christian
- Ferrari, Michel D
- Dichgans, Martin
- Smith, George Davey
- Daly, Mark J
- Venue
- Nature Genetics
- Published
- 2013-06-23
- Volume
- 45
- Issue
- 8
- Pages
- 912-917
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- PMC
- PMC4041123
- OpenAlex
- W2136453726
- Cited by
- 410
- References
- 54
- Citations by year
- 2026: 12 · 2025: 27 · 2024: 23 · 2023: 20 · 2022: 32 · 2021: 30 · 2020: 24 · 2019: 30 · 2018: 32 · 2017: 44 · 2016: 53 · 2015: 40 · 2014: 33 · 2013: 10
- FWCI
- 6.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Genetics (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
- VU Research Portal (publishedVersion, other-oa)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (acceptedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- St George's Online Research Archive (St George's University of London) (acceptedVersion)
- ORBi (University of Liège) (submittedVersion, other-oa)
- Pure Amsterdam UMC (submittedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Site cant be reached (submittedVersion)
- Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Explore Bristol Research (submittedVersion)
- Spiral (Imperial College London) (submittedVersion)
- STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- Wellcome Trust (089062, 092731)
- National Institutes of Health (Z01-AG000949)
- National Institute on Alcohol Abuse and Alcoholism (K05AA017688)
- National Institute of General Medical Sciences (T32GM007753)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Migraine and Headache Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Keywords
- migraine, migraine with aura, migraine without aura, AJAP1, MMP16, expression quantitative trait loci, brain tissue gene expression, FUT9, STAT6, ATP5B, genetic risk
- MeSH terms
- Cerebellum, Frontal Lobe, Humans, Migraine Disorders, Computational Biology, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Genome-Wide Association Study, Genetic Loci
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
