The Pathophysiology of Fragile X (and What It Teaches Us about Synapses)

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The FMR–1 protein is cytoplasmic, most abundant in neurons and appears normal in carriers of a fragile X premutation

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The protein product of the fragile X gene, FMR1, has characteristics of an RNA-binding protein.

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The Fragile X Syndrome Protein Represses Activity-Dependent Translation through CYFIP1, a New 4E-BP

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Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway

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Neuronal RNA Granules: Movers and Makers

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Evidence that fragile X mental retardation protein is a negative regulator of translation

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Dysregulation of mTOR signaling in fragile X syndrome

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Internalization of ionotropic glutamate receptors in response to mGluR activation

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Neuronal RNA Granules

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Protein kinases that phosphorylate activated G protein‐coupled receptors

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Fragile X mental retardation protein: Nucleocytoplasmic shuttling and association with somatodendritic ribosomes.

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Molecular Mechanisms of Fragile X Syndrome: A Twenty-Year Perspective

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Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression

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Suppression of two major Fragile X Syndrome mouse model phenotypes by the mGluR5 antagonist MPEP

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Elongation Factor 2 and Fragile X Mental Retardation Protein Control the Dynamic Translation of Arc/Arg3.1 Essential for mGluR-LTD

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A direct role for FMRP in activity-dependent dendritic mRNA transport links filopodial-spine morphogenesis to fragile X syndrome

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Fragile X-related protein and VIG associate with the RNA interference machinery

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A <i>Drosophila</i> fragile X protein interacts with components of RNAi and ribosomal proteins

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A PEDIGREE OF MENTAL DEFECT SHOWING SEX-LINKAGE

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Rapid Translation of Arc/Arg3.1 Selectively Mediates mGluR-Dependent LTD through Persistent Increases in AMPAR Endocytosis Rate

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Pharmacological Rescue of Synaptic Plasticity, Courtship Behavior, and Mushroom Body Defects in a Drosophila Model of Fragile X Syndrome

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Dynamic Translational and Proteasomal Regulation of Fragile X Mental Retardation Protein Controls mGluR-Dependent Long-Term Depression

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Minocycline promotes dendritic spine maturation and improves behavioural performance in the fragile X mouse model

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microRNAs at the synapse

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The fragile X mental retardation protein inhibits translation via interacting with mRNA

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Incidence of Fragile X Syndrome by Newborn Screening for Methylated FMR1 DNA

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Dysregulated Metabotropic Glutamate Receptor-Dependent Translation of AMPA Receptor and Postsynaptic Density-95 mRNAs at Synapses in a Mouse Model of Fragile X Syndrome

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Deletion of FMR1 in Purkinje Cells Enhances Parallel Fiber LTD, Enlarges Spines, and Attenuates Cerebellar Eyelid Conditioning in Fragile X Syndrome

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Chemical Induction of mGluR5- and Protein Synthesis–Dependent Long-Term Depression in Hippocampal Area CA1

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The fragile X mental retardation protein is a ribonucleoprotein containing both nuclear localization and nuclear export signals

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Hypersensitivity to mGluR5 and ERK1/2 Leads to Excessive Protein Synthesis in the Hippocampus of a Mouse Model of Fragile X Syndrome

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NMDA receptor-mediated control of protein synthesis at developing synapses

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Reversible Inhibition of PSD-95 mRNA Translation by miR-125a, FMRP Phosphorylation, and mGluR Signaling

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A new function for the fragile X mental retardation protein in regulation of PSD-95 mRNA stability

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Metabotropic Glutamate Receptor Activation Regulates Fragile X Mental Retardation Protein and <i>Fmr1</i> mRNA Localization Differentially in Dendrites and at Synapses

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Staufen- and FMRP-Containing Neuronal RNPs Are Structurally and Functionally Related to Somatic P Bodies

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Autistic behavior in children with fragile X syndrome: Prevalence, stability, and the impact of FMRP

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Phosphorylation influences the translation state of FMRP-associated polyribosomes

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The fragile X protein controls microtubule-associated protein 1B translation and microtubule stability in brain neuron development

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Rescue of behavioral phenotype and neuronal protrusion morphology in Fmr1 KO mice

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FMRP Mediates mGluR5-Dependent Translation of Amyloid Precursor Protein

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Metabotropic Receptor-Dependent Long-Term Depression Persists in the Absence of Protein Synthesis in the Mouse Model of Fragile X Syndrome

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Kissing complex RNAs mediate interaction between the Fragile-X mental retardation protein KH2 domain and brain polyribosomes

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Inhibition of p21-activated kinase rescues symptoms of fragile X syndrome in mice

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The fragile X mental retardation protein is required for type-I metabotropic glutamate receptor-dependent translation of PSD-95

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Fragile X mental retardation protein is associated with translating polyribosomes in neuronal cells

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Postadolescent Changes in Regional Cerebral Protein Synthesis: An<i>In Vivo</i>Study in the<i>Fmr1</i>Null Mouse

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Metabotropic glutamate receptors trigger postsynaptic protein synthesis.

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Toward Fulfilling the Promise of Molecular Medicine in Fragile X Syndrome

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Local functions for FMRP in axon growth cone motility and activity-dependent regulation of filopodia and spine synapses

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Deficits in trace fear memory and long-term potentiation in a mouse model for fragile X syndrome

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Extracellular Signal-Regulated Protein Kinase Activation Is Required for Metabotropic Glutamate Receptor-Dependent Long-Term Depression in Hippocampal Area CA1

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Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila

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The fragile X mental retardation protein is associated with ribosomes

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Localization of FMRP‐associated mRNA granules and requirement of microtubules for activity‐dependent trafficking in hippocampal neurons

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