The DOI matches its Crossref record; 372 of the 372 references it cites were found in a registry or an index.
The central role of RNA in human development and cognition
Abstract
It appears that the genetic programming of humans and other complex organisms has been misunderstood for the past 50 years, due to the assumption that most genetic information is transacted by proteins. However, the human genome contains only about 20,000 protein‐coding genes, similar in number and with largely orthologous functions as those in nematodes that have only 1000 somatic cells. By contrast, the extent of non‐protein‐coding DNA increases with increasing complexity, reaching 98.8% in humans. The majority of these sequences are dynamically transcribed, mainly into non‐protein‐coding RNAs, with tens if not hundreds of thousands that show specific expression patterns and subcellular locations, as well as many classes of small regulatory RNAs. The emerging evidence indicates that these RNAs control the epigenetic states that underpin development, and that many are dysregulated in cancer and other complex diseases. Moreover it appears that animals, particularly primates, have evolved plasticity in these RNA regulatory systems, especially in the brain. Thus, it appears that what was dismissed as ‘junk’ because it was not understood holds the key to understanding human evolution, development, and cognition.
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Cites
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Long non-coding RNAs: insights into functions
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A Long Noncoding RNA Controls Muscle Differentiation by Functioning as a Competing Endogenous RNA
Cesana, M., Cacchiarelli, D., Legnini, I., Santini, T., Sthandier, O., Chinappi, M., Tramontano, A., & Bozzoni, I. (2011) · Cell · doi:10.1016/j.cell.2011.09.028 · Cited by 2,554
Morris, K. V., & Mattick, J. S. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3722 · Cited by 1,371
Self-citationDelcuve, G. P., Khan, D. H., & Davie, J. R. (2012) · Clinical Epigenetics · doi:10.1186/1868-7083-4-5 · Cited by 505
Long non-coding RNAs in Huntington's disease neurodegeneration
Johnson, R. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.12.006 · Cited by 398
The epigenetics of aging and neurodegeneration
Lardenoije, R., Iatrou, A., Kenis, G., Kompotis, K., Steinbusch, H. W. M., Mastroeni, D., Coleman, P., Lemere, C. A., Hof, P. R., van den Hove, D. L. A., et al. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.05.002 · Cited by 381
Metadata
- Authors
- Mattick, J. S.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2011-05-06
- Volume
- 585
- Issue
- 11
- Pages
- 1600-1616
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2010012954
- Cited by
- 274
- References
- 372
- FWCI
- 8.05
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
