Cited by 64Genetic Syndromes and ImprintingBirth, Development, and HealthEpigenetics and DNA Methylation

Genomic imprinting as an adaptative model of developmental plasticity

Open access
Radford, Elizabeth J., Ferrón, Sacri R., Ferguson-Smith, Anne C.·2011·FEBS Letters

Abstract

Developmental plasticity can be defined as the ability of one genotype to produce a range of phenotypes in response to environmental conditions. Such plasticity can be manifest at the level of individual cells, an organ, or a whole organism. Imprinted genes are a group of approximately 100 genes with functionally monoallelic, parental‐origin specific expression. As imprinted genes are critical for prenatal growth and metabolic axis development and function, modulation of imprinted gene dosage has been proposed to play a key role in the plastic development of the unborn foetus in response to environmental conditions. Evidence is accumulating that imprinted dosage may also be involved in controlling the plastic potential of individual cells or stem cell populations. Imprinted gene dosage can be modulated through canonical, transcription factor mediated mechanisms, or through the relaxation of imprinting itself, reactivating the normally silent allele.

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Crossref · 10.1016/j.febslet.2011.05.063

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89 of 89 references verified0 citation errors · 0 not checkable

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  • Imprinted genes have an important role in the developmental plasticity of the placenta, particularly with respect to resource allocation.

    “Imprinted genes, therefore, have an important role in the developmental plasticity of the placenta, particularly with respect to resource allocation (189, 445).”

    From Placental Origins of Chronic Disease (2016) · cites this paper as [445]

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Authors
Radford, E. J., Ferrón, S. R., & Ferguson-Smith, A. C.
Affiliations
University of Cambridge (GB)
Venue
FEBS Letters
Publisher
Wiley
Published
2011-06-13
Volume
585
Issue
13
Pages
2059-2066
ISSN
  • 0014-5793 (ISSN-L)
  • 1873-3468
OpenAlex
W2052890109
Cited by
64
References
91
Citations by year
2026: 2 · 2025: 4 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 4 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 1 · 2015: 8 · 2014: 4 · 2013: 8 · 2012: 14
FWCI
0.91
Type
journal article
Language
en
Open access
Locations
  • FEBS Letters (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
Wellcome Trust (095606/Z/11/Z)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Keywords
genomic imprinting, developmental plasticity, imprinted genes, monoallelic expression, gene dosage, fetal growth, stem cell plasticity, transcription factor regulation, environmental response
MeSH terms
Animals, Humans, Models, Biological, Genomic Imprinting, DNA Methylation, Epigenomics

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