The evolution of imprinting: chromosomal mapping of orthologues of mammalian imprinted domains in monotreme and marsupial mammals
Open accessAbstract
Background: The evolution of genomic imprinting, the parental-origin specific expression of genes, is the subject of much debate. There are several theories to account for how the mechanism evolved including the hypothesis that it was driven by the evolution of X-inactivation, or that it arose from an ancestrally imprinted chromosome. Results: Here we demonstrate that mammalian orthologues of imprinted genes are dispersed amongst autosomes in both monotreme and marsupial karyotypes. Conclusion: These data, along with the similar distribution seen in birds, suggest that imprinted genes were not located on an ancestrally imprinted chromosome or associated with a sex chromosome. Our results suggest imprinting evolution was a stepwise, adaptive process, with each gene/cluster independently becoming imprinted as the need arose.
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The autosomal localization of some imprinted orthologues in platypus is known.
“The autosomal localization of some imprinted orthologues in platypus is known 63”
From Genome analysis of the platypus reveals unique signatures of evolution (2008) · cites this paper as [63]
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- Authors
- Edwards, C. A., Rens, W., Clarke, O., Mungall, A. J., Hore, T., Graves, J. A. M., Dunham, I., Ferguson-Smith, A. C., & Ferguson-Smith, M. A.
- Affiliations
- University of Cambridge (GB)
- Wellcome Sanger Institute (GB)
- Australian National University (AU)
- Corresponding author
- Ferguson-Smith, Malcolm A
- ORCID
- Venue
- BMC Evolutionary Biology
- Published
- 2007-09-06
- Volume
- 7
- Issue
- 1
- Pages
- 157-157
- ISSN
- 1471-2148 (ISSN-L)
- PMC
- PMC2042987
- OpenAlex
- W2063401689
- Cited by
- 44
- References
- 42
- Citations by year
- 2026: 1 · 2021: 1 · 2018: 2 · 2017: 1 · 2015: 3 · 2014: 2 · 2013: 1 · 2012: 7
- FWCI
- 3.94
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- BMC Evolutionary Biology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- ANU Open Research (Australian National University) (submittedVersion, cc-by)
- Apollo (University of Cambridge) (submittedVersion, cc-by)
- Funders
- Wellcome Trust
- Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Keywords
- genomic imprinting, evolution of imprinting, imprinted genes, imprinted domains, monotremes, marsupials, autosomes, X chromosome inactivation, sex chromosomes, chromosome mapping
- MeSH terms
- Animals, Chromosome Mapping, Macropodidae, Platypus, DNA Probes, In Situ Hybridization, Fluorescence, Genomic Imprinting, Evolution, Molecular, Chromosomes, Artificial, Bacterial, X Chromosome Inactivation
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