The DOI matches its Crossref record; 132 of the 132 references it cites were found in a registry or an index.
Promiscuity and specificity in BMP receptor activation
Open accessAbstract
Bone Morphogenetic Proteins (BMPs), together with Transforming Growth Factor (TGF)‐β and Activins/Inhibins constitute the TGF‐β superfamily of ligands. This superfamily is formed by more than 30 structurally related secreted proteins. Since TGF‐β members act as morphogens, either a strict relation between a particular ligand to a distinct cellular receptor and/or temporospatial expression patterns of ligands and receptors is expected. Instead, only a limited number of receptors exist implicating promiscuous interactions of ligands and receptors. Furthermore, in complex tissues a multitude of different ligands can be found, which signal via overlapping subsets of receptors. This raises the intriguing question how concerted interactions of different ligands and receptors generate highly specific cellular signals, which are required during development and tissue homeostasis.
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Cites
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Cited by
Ho-Shui-Ling, A., Bolander, J., Rustom, L. E., Johnson, A. W., Luyten, F. P., & Picart, C. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.07.017 · Cited by 961
Loffredo, F. S., Steinhauser, M. L., Jay, S. M., Gannon, J., Pancoast, J. R., Yalamanchi, P., Sinha, M., Dall’Osso, C., Khong, D., Shadrach, J. L., et al. (2013) · Cell · doi:10.1016/j.cell.2013.04.015 · Cited by 948
“We speculate that the differential effect may be due to differences in the activity of endogenous inhibitors and/or subtle differences in receptor affinity (Mueller and Nickel, 2012).”
Bohlen, C. J., Bennett, F. C., Tucker, A. F., Collins, H. Y., Mulinyawe, S. B., & Barres, B. A. (2017) · Neuron · doi:10.1016/j.neuron.2017.04.043 · Cited by 658
The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL
Emmerson, P. J., Wang, F., Du, Y., Liu, Q., Pickard, R. T., Gonciarz, M. D., Coskun, T., Hamang, M. J., Sindelar, D. K., Ballman, K. K., et al. (2017) · Nature Medicine · doi:10.1038/nm.4393 · Cited by 675
The Drosophila embryo at single-cell transcriptome resolution
Karaiskos, N., Wahle, P., Alles, J., Boltengagen, A., Ayoub, S., Kipar, C., Kocks, C., Rajewsky, N., & Zinzen, R. P. (2017) · Science · doi:10.1126/science.aan3235 · Cited by 428
Metadata
- Authors
- Mueller, T. D., & Nickel, J.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2012-03-08
- Volume
- 586
- Issue
- 14
- Pages
- 1846-1859
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2061635827
- Cited by
- 289
- References
- 132
- FWCI
- 7.90
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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