The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Intrinsically disordered proteins as crucial constituents of cellular aqueous two phase systems and coacervates
Open accessAbstract
Here, we hypothesize that intrinsically disordered proteins (IDPs) serve as important drivers of the intracellular liquid–liquid phase separations that generate various membrane‐less organelles. This hypothesis is supported by the overwhelming abundance of IDPs in these organelles. Assembly and disassembly of these organelles are controlled by changes in the concentrations of IDPs, their posttranslational modifications, binding of specific partners, and changes in the pH and/or temperature of the solution. Each resulting phase provides a distinct solvent environment for other solutes leading to their unequal distribution within phases. The specificity and efficiency of such partitioning is determined by the nature of the IDP(s) and defines “targeted” enrichment of specific molecules in the resulting membrane‐less organelles that determines their specific activities.
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Citations
Cites
Intrinsically unstructured proteins and their functions
Dyson, H. J., & Wright, P. E. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1589 · Cited by 3,871
Macromolecular crowding: obvious but underappreciated
Ellis, R. J. (2001) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(01)01938-7 · Cited by 2,309
Intrinsic Disorder and Protein Function
Dunker, A. K., Brown, C. J., Lawson, J. D., Iakoucheva, L. M., & Obradović, Z. (2002) · Biochemistry · doi:10.1021/bi012159+ · Cited by 1,731
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The interplay between structure and function in intrinsically unstructured proteins
Tompa, P. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.03.072 · Cited by 717
Implications of macromolecular crowding for protein assembly
Minton, A. P. (2000) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(99)00045-7 · Cited by 649
Influence of excluded volume upon macromolecular structure and associations in ‘crowded” media
Minton, A. P. (1997) · Current Opinion in Biotechnology · doi:10.1016/s0958-1669(97)80159-0 · Cited by 212
Cited by
Elbaum-Garfinkle, S., Kim, Y., Szczepaniak, K., Chen, C. C.-H., Eckmann, C. R., Myong, S., & Brangwynne, C. P. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1504822112 · Cited by 1,278
Uversky, V. N. (2017) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2016.10.015 · Cited by 707
Self-citationAumiller, W. M., Pir Cakmak, F., Davis, B. W., & Keating, C. D. (2016) · Langmuir · doi:10.1021/acs.langmuir.6b02499 · Cited by 325
Active coacervate droplets as a model for membraneless organelles and protocells
Donau, C., Späth, F., Sosson, M., Kriebisch, B. A. K., Schnitter, F., Tena-Solsona, M., Kang, H.-S., Salibi, E., Sattler, M., Mutschler, H., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18815-9 · Cited by 309
Disentangling the complexity of low complexity proteins
Mier, P., Paladin, L., Tamana, S., Petrosian, S., Hajdu-Soltész, B., Urbanek, A., Gruca, A., Plewczynski, D., Grynberg, M., Bernadó, P., et al. (2020) · Briefings in Bioinformatics · doi:10.1093/bib/bbz007 · Cited by 104
Chaotic aging: intrinsically disordered proteins in aging-related processes
Manyilov, V. D., Ilyinsky, N. S., Nesterov, S. V., Saqr, B. M. G. A., Dayhoff, G. W., Zinovev, E. V., Matrenok, S. S., Fonin, A. V., Kuznetsova, I. M., Turoverov, K. K., et al. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-04897-3 · Cited by 14
Self-citationFused in sarcoma undergoes cold denaturation: Implications for phase separation
Félix, S. S., Laurents, D. V., Oroz, J., & Cabrita, E. J. (2023) · Protein Science · doi:10.1002/pro.4521 · Cited by 12
Metadata
- Authors
- Uversky, V. N., Kuznetsova, I. M., Turoverov, K. K., & Zaslavsky, B.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2014-11-29
- Volume
- 589
- Issue
- 1
- Pages
- 15-22
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2031787395
- Cited by
- 277
- References
- 7
- FWCI
- 5.72
- Type
- journal article
- Language
- en
- Open access
- bronze
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